{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:36:01Z","timestamp":1760549761221},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Japan Student Services Organization (JASSO)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.ejpb.2015.04.030","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T06:48:32Z","timestamp":1431067712000},"page":"42-51","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Effect of different intestinal conditions on the intermolecular interaction between insulin and cell-penetrating peptide penetratin and on its contribution to stimulation of permeation through intestinal epithelium"],"prefix":"10.1016","volume":"94","author":[{"given":"Noriyasu","family":"Kamei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukina","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El-Sayed","family":"Khafagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Henmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Takeda-Morishita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2015.04.030_b0005","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.drudis.2013.05.011","article-title":"Future directions for peptide therapeutics development","volume":"18","author":"Kaspar","year":"2013","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejpb.2015.04.030_b0010","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.drudis.2006.08.005","article-title":"Is the oral route possible for peptide and protein drug delivery?","volume":"11","author":"Morishita","year":"2006","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejpb.2015.04.030_b0015","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1517\/17425247.2012.737779","article-title":"Novel non-invasive methods of insulin delivery","volume":"9","author":"Soares","year":"2012","journal-title":"Expert Opin. Drug Delivery"},{"key":"10.1016\/j.ejpb.2015.04.030_b0020","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/193229680900300322","article-title":"Oral insulin: the rationale for this approach and current developments","volume":"3","author":"Arbit","year":"2009","journal-title":"J. Diabetes Sci. Technol."},{"issue":"11","key":"10.1016\/j.ejpb.2015.04.030_b0025","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1007\/s11095-005-6137-z","article-title":"Region-dependent role of the mucous\/glycocalyx layers in insulin permeation across rat small intestinal membrane","volume":"22","author":"Aoki","year":"2005","journal-title":"Pharm. Res."},{"issue":"2","key":"10.1016\/j.ejpb.2015.04.030_b0030","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.addr.2008.09.008","article-title":"Barrier properties of mucus","volume":"61","author":"Cone","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.ejpb.2015.04.030_b0035","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.biopha.2004.01.006","article-title":"Principles of transmucosal delivery of therapeutic agents","volume":"58","author":"Blanchette","year":"2004","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejpb.2015.04.030_b0040","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0074-7696(06)48005-0","article-title":"Tight junctions: molecular architecture and function","volume":"248","author":"Aijaz","year":"2006","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.ejpb.2015.04.030_b0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jconrel.2008.08.001","article-title":"Usefulness of cell-penetrating peptides to improve intestinal insulin absorption","volume":"132","author":"Kamei","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2015.04.030_b0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jconrel.2014.06.022","article-title":"In vivo proof of concept of oral insulin delivery based on a co-administration strategy with the cell-penetrating peptide penetratin","volume":"189","author":"Nielsen","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2015.04.030_b0055","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1476-5381.2009.00057.x","article-title":"Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics","volume":"157","author":"Heitz","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejpb.2015.04.030_b0060","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.addr.2009.06.001","article-title":"Recent advances in the use of cell-penetrating peptides for medical and biological applications","volume":"61","author":"Fonseca","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2015.04.030_b0065","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/jps.21117","article-title":"On the biomedical promise of cell penetrating peptides: limits versus prospects","volume":"97","author":"Foerg","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2015.04.030_b0070","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jps.23364","article-title":"Determination of the optimal cell-penetrating peptide sequence for intestinal insulin delivery based on molecular orbital analysis with self-organizing maps","volume":"102","author":"Kamei","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2015.04.030_b0075","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jconrel.2009.02.015","article-title":"Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide\/protein absorption using cell-penetrating peptides","volume":"136","author":"Kamei","year":"2009","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2015.04.030_b0080","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1002\/jps.23708","article-title":"Mechanistic study of the uptake\/permeation of cell-penetrating peptides across a Caco-2 monolayer and their stimulatory effect on epithelial insulin transport","volume":"102","author":"Kamei","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2015.04.030_b0085","doi-asserted-by":"crossref","first-page":"10444","DOI":"10.1016\/S0021-9258(17)34080-2","article-title":"The third helix of the Antennapedia homeodomain translocates through biological membranes","volume":"269","author":"Derossi","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejpb.2015.04.030_b0090","doi-asserted-by":"crossref","first-page":"18188","DOI":"10.1074\/jbc.271.30.18188","article-title":"Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent","volume":"271","author":"Derossi","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejpb.2015.04.030_b0095","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1023\/A:1011910801212","article-title":"Evaluation of various dissolution media for predicting in vivo performance of class I and II Drugs","volume":"15","author":"Galia","year":"1998","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2015.04.030_b0100","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1002\/jps.20691","article-title":"Effect of food intake on the oral absorption of poorly water-soluble drugs: in vivo assessment of drug dissolution and permeation assay system","volume":"95","author":"Kataoka","year":"2006","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2015.04.030_b0105","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/bj2520275","article-title":"Spectrophotometric determination of the critical micellar concentration of bile salts using bilirubin monoglucuronide as a micellar probe","volume":"252","author":"Spivak","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejpb.2015.04.030_b0110","doi-asserted-by":"crossref","first-page":"6","DOI":"10.14227\/DT170310P6","article-title":"Study of a standardized taurocholate-lecithin powder for preparing the biorelevant media FaSSIF and FeSSIF","volume":"17","author":"Kloefer","year":"2010","journal-title":"Dissol. Technol."},{"key":"10.1016\/j.ejpb.2015.04.030_b0115","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1432-1033.2004.04022.x","article-title":"Membrane interaction and cellular internalization of penetratin peptides","volume":"271","author":"Christiaens","year":"2004","journal-title":"Eur. J. Biochem."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641115002106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641115002106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T14:19:29Z","timestamp":1651933169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641115002106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":23,"alternative-id":["S0939641115002106"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2015.04.030","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of different intestinal conditions on the intermolecular interaction between insulin and cell-penetrating peptide penetratin and on its contribution to stimulation of permeation through intestinal epithelium","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2015.04.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}