{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:08:52Z","timestamp":1777525732115,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.ejpb.2015.09.005","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T14:44:25Z","timestamp":1442069065000},"page":"388-395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Efficacy study of two novel hyaluronic acid-based formulations for viscosupplementation therapy in an early osteoarthrosic rabbit model"],"prefix":"10.1016","volume":"96","author":[{"given":"Sema","family":"Kaderli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Viguier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doroth\u00e9e","family":"Watrelot-Virieux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Roger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Gurny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Scapozza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Boulocher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2015.09.005_b0005","unstructured":"D. Symmons, C. Mathers, B. Pfleger, Global burden of osteoarthritis in the year 2000, in: World Health Organization, 2000, pp. <http:\/\/www.who.int\/healthinfo\/statistics\/bod_osteoarthritis.pdf>."},{"key":"10.1016\/j.ejpb.2015.09.005_b0010","first-page":"278","article-title":"Viscosupplementation for osteoarthritis. from initial discovery to current status and results","volume":"12","author":"Balazs","year":"2004","journal-title":"Surg. Technol. Int."},{"key":"10.1016\/j.ejpb.2015.09.005_b0015","first-page":"3","article-title":"Viscosupplementation \u2013 a new concept in the treatment of osteoarthritis","volume":"20","author":"Balazs","year":"1993","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.ejpb.2015.09.005_b0020","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/art.1780260709","article-title":"A new model of osteoarthritis in rabbits. I. Development of knee joint pathology following lateral meniscectomy and section of the fibular collateral and sesamoid ligaments","volume":"26","author":"Colombo","year":"1983","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ejpb.2015.09.005_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2008.06.001","article-title":"The disease modifying osteoarthritis drug (DMOAD): is it in the horizon?","volume":"58","author":"Qvist","year":"2008","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejpb.2015.09.005_b0030","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1177\/0363546508326984","article-title":"Hyaluronic acid viscosupplementation and osteoarthritis: current uses and future directions","volume":"37","author":"Strauss","year":"2009","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.ejpb.2015.09.005_b0035","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/ar623","article-title":"Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action","volume":"5","author":"Moreland","year":"2003","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejpb.2015.09.005_b0040","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.1021\/cr030441b","article-title":"Chitosan chemistry and pharmaceutical perspectives","volume":"104","author":"Kumar","year":"2004","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejpb.2015.09.005_b0045","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/S0142-9612(99)00097-6","article-title":"Effects of chitosan on rat knee cartilages","volume":"20","author":"Lu","year":"1999","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2015.09.005_b0050","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/ard.2003.019406","article-title":"Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis","volume":"64","author":"Shikhman","year":"2004","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejpb.2015.09.005_b0055","doi-asserted-by":"crossref","first-page":"5983","DOI":"10.1016\/j.biomaterials.2005.03.016","article-title":"Chitosan: a versatile biopolymer for orthopaedic tissue-engineering","volume":"26","author":"Di Martino","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2015.09.005_b0060","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s10856-007-3245-9","article-title":"Comparison of various mixtures of beta-chitin and chitosan as a scaffold for three-dimensional culture of rabbit chondrocytes","volume":"19","author":"Suzuki","year":"2008","journal-title":"J. Mater. Sci. \u2013 Mater. M"},{"issue":"1\u20132","key":"10.1016\/j.ejpb.2015.09.005_b0065","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijpharm.2015.01.052","article-title":"A novel biocompatible hyaluronic acid-chitosan hybrid hydrogel for osteoarthrosis therapy","volume":"483","author":"Kaderli","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2015.09.005_b0070","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0891-5849(96)00042-1","article-title":"Direct detection and identification of radicals generated during the hydroxyl radical-induced degradation of hyaluronic acid and related materials","volume":"21","author":"Hawkins","year":"1996","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.ejpb.2015.09.005_b0075","article-title":"A novel oxido-viscosifying hyaluronic acid-antioxidant conjugate for osteoarthritis therapy: biocompatibility assessments","author":"Kaderli","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2015.09.005_b0080","first-page":"804","article-title":"Oxidant and anti-oxidant systems of synovial fluid from patients with knee post-traumatic arthritis","author":"Ostalowska","year":"2006","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.ejpb.2015.09.005_b0085","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.joca.2005.04.002","article-title":"Oxygen and reactive oxygen species in cartilage degradation: friends or foes?","volume":"13","author":"Henrotin","year":"2005","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.ejpb.2015.09.005_b0090","first-page":"103","article-title":"Biomarkers in osteoarthritis","volume":"2","author":"Wildi","year":"2011","journal-title":"Research Signpost"},{"key":"10.1016\/j.ejpb.2015.09.005_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2342-10-3","article-title":"Radiographic assessment of the femorotibial joint of the CCLT rabbit experimental model of osteoarthritis","volume":"10","author":"Boulocher","year":"2010","journal-title":"BMC Med. Imag."},{"key":"10.1016\/j.ejpb.2015.09.005_b0100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.joca.2010.05.029","article-title":"The OARSI histopathology initiative: recommendations for histological assessments of osteoarthritis in the rabbit","volume":"18","author":"Laverty","year":"2010","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.ejpb.2015.09.005_b0105","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.joca.2011.07.003","article-title":"Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis","volume":"19","author":"Bellido","year":"2011","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.ejpb.2015.09.005_b0110","doi-asserted-by":"crossref","first-page":"R152","DOI":"10.1186\/ar3103","article-title":"Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis","volume":"12","author":"Bellido","year":"2010","journal-title":"Arthritis. Res. Ther."},{"key":"10.1016\/j.ejpb.2015.09.005_b0115","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1136\/annrheumdis-2013-204111","article-title":"The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?","volume":"73","author":"Karsdal","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejpb.2015.09.005_b0120","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrrheum.2012.130","article-title":"Bone remodelling in osteoarthritis","volume":"8","author":"Burr","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ejpb.2015.09.005_b0125","doi-asserted-by":"crossref","first-page":"19805","DOI":"10.3390\/ijms141019805","article-title":"Interplay between cartilage and subchondral bone contributing to pathogenesis of osteoarthritis","volume":"14","author":"Sharma","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejpb.2015.09.005_b0130","doi-asserted-by":"crossref","DOI":"10.1186\/ar4405","article-title":"Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes","volume":"15","author":"Li","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejpb.2015.09.005_b0135","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1063-4584(05)80318-8","article-title":"Characterization of a model of osteoarthritis in the rabbit knee","volume":"4","author":"Yoshioka","year":"1996","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.ejpb.2015.09.005_b0140","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.joca.2004.08.010","article-title":"Ex vivo characterization of articular cartilage and bone lesions in a rabbit ACL transection model of osteoarthritis using MRI and micro-CT","volume":"12","author":"Batiste","year":"2004","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.ejpb.2015.09.005_b0145","first-page":"296","article-title":"Effects of high-molecular-weight sodium hyaluronate on experimental osteoarthrosis induced by the resection of rabbit anterior cruciate ligament","author":"Yoshimi","year":"1994","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.ejpb.2015.09.005_b0150","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/jor.21240","article-title":"Intra-articular injection of hyaluronan restores the aberrant expression of matrix metalloproteinase-13 in osteoarthritic subchondral bone","volume":"29","author":"Hiraoka","year":"2011","journal-title":"J. Orthopaedic Res.: Official Publ. Orthopaedic Res. Soc."},{"key":"10.1016\/j.ejpb.2015.09.005_b0155","first-page":"1713","article-title":"Effect of hyaluronan on chondrocyte apoptosis and nitric oxide production in experimentally induced osteoarthritis","volume":"27","author":"Takahashi","year":"2000","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.ejpb.2015.09.005_b0160","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1063-4584(05)80319-X","article-title":"Effect of high molecular weight hyaluronan on cartilage degeneration in a rabbit model of osteoarthritis","volume":"4","author":"Kikuchi","year":"1996","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.ejpb.2015.09.005_b0165","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3349\/ymj.1991.32.2.139","article-title":"Effect of sodium hyaluronate on prevention of osteoarthritis","volume":"32","author":"Kim","year":"1991","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.ejpb.2015.09.005_b0170","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.joca.2013.04.017","article-title":"Protective effect of a new biomaterial against the development of experimental osteoarthritis lesions in rabbit: a pilot study evaluating the intra-articular injection of alginate-chitosan beads dispersed in an hydrogel","volume":"21","author":"Oprenyeszk","year":"2013","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.ejpb.2015.09.005_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/joca.1997.0086","article-title":"Long-term effects of hyaluronan on experimental osteoarthritis in the rabbit knee","volume":"6","author":"Shimizu","year":"1998","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.ejpb.2015.09.005_b0180","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1063-4584(97)80021-0","article-title":"The effects of hyaluronan during the development of osteoarthritis","volume":"5","author":"Yoshioka","year":"1997","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.ejpb.2015.09.005_b0185","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1053\/joca.1998.0207","article-title":"The effects of hyaluronan on matrix metalloproteinase-3 (MMP-3), interleukin-1beta (IL-1beta), and tissue inhibitor of metalloproteinase-1 (TIMP-1) gene expression during the development of osteoarthritis","volume":"7","author":"Takahashi","year":"1999","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.ejpb.2015.09.005_b0190","first-page":"8","article-title":"The effect of sodium hyaluronate on mRNA expressions of matrix metalloproteinase-1,3 and tissue inhibitor of metalloproteinase-1 in cartilage and synovium of traumatic osteoarthritis model","volume":"8","author":"Bo","year":"2005","journal-title":"Chinese J. Traumatol."},{"key":"10.1016\/j.ejpb.2015.09.005_b0195","first-page":"115","article-title":"Effects of sodium hyaluronate on experimental osteoarthritis in rabbit knee joints","volume":"6","author":"Han","year":"1999","journal-title":"Nagoya J. Med. Sci."},{"key":"10.1016\/j.ejpb.2015.09.005_b0200","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.bone.2004.12.010","article-title":"Effects of hyaluronan on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis","volume":"36","author":"Ding","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.ejpb.2015.09.005_b0205","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1177\/0363546510369547","article-title":"Scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages","volume":"38","author":"Hoemann","year":"2010","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.ejpb.2015.09.005_b0210","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.joca.2006.08.007","article-title":"Chitosan-glycerol phosphate\/blood implants increase cell recruitment, transient vascularization and subchondral bone remodeling in drilled cartilage defects","volume":"15","author":"Chevrier","year":"2007","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.ejpb.2015.09.005_b0215","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2474-14-27","article-title":"Subchondral pre-solidified chitosan\/blood implants elicit reproducible early osteochondral wound-repair responses including neutrophil and stromal cell chemotaxis, bone resorption and repair, enhanced repair tissue integration and delayed matrix deposition","volume":"14","author":"Lafantaisie-Favreau","year":"2013","journal-title":"BMC Musculoskeletal Disorders"},{"key":"10.1016\/j.ejpb.2015.09.005_b0220","doi-asserted-by":"crossref","first-page":"96","DOI":"10.22203\/eCM.v019a10","article-title":"In vitro osteoclastogenesis on textile chitosan scaffolds","volume":"19","author":"Heinemann","year":"2010","journal-title":"Eur. Cells Mater."},{"key":"10.1016\/j.ejpb.2015.09.005_b0225","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.joca.2013.12.011","article-title":"Subchondral chitosan\/blood implant-guided bone plate resorption and woven bone repair is coupled to hyaline cartilage regeneration from microdrill holes in aged rabbit knees","volume":"22","author":"Guzman-Morales","year":"2014","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.ejpb.2015.09.005_b0230","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.joca.2013.03.012","article-title":"Stereological analysis of subchondral angiogenesis induced by chitosan and coagulation factors in microdrilled articular cartilage defects","volume":"21","author":"Mathieu","year":"2013","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.ejpb.2015.09.005_b0235","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1136\/ard.2009.121426","article-title":"Relation of synovitis to knee pain using contrast-enhanced MRIs","volume":"69","author":"Baker","year":"2010","journal-title":"Ann. Rheum. Dis."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641115003720?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641115003720?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T08:56:44Z","timestamp":1537347404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641115003720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":47,"alternative-id":["S0939641115003720"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2015.09.005","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy study of two novel hyaluronic acid-based formulations for viscosupplementation therapy in an early osteoarthrosic rabbit model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2015.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}