{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:09:12Z","timestamp":1777435752803,"version":"3.51.4"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Graduate Excellence Fellowship"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.ejpb.2016.09.018","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T06:33:11Z","timestamp":1475735591000},"page":"81-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Inhibition of carbonic anhydrase IX in glioblastoma multiforme"],"prefix":"10.1016","volume":"109","author":[{"given":"Abdolali","family":"Amiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phuong Uyen","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Moquin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayane","family":"Machkalyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Petrecca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Gillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Yoganathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dusica","family":"Maysinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2016.09.018_b0005","unstructured":"CBTRUS, Statistical report: primary brain tumors in the United States, 2000\u20132004, Central Brain Tumor Registry of the United States: Chicago, 2008."},{"issue":"11","key":"10.1016\/j.ejpb.2016.09.018_b0010","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.15252\/emmm.201302627","article-title":"Emerging treatment strategies for glioblastoma multiforme","volume":"6","author":"Carlsson","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ejpb.2016.09.018_b0015","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/B978-0-12-397927-8.00004-X","article-title":"Targeting the metabolic microenvironment of tumors","volume":"65","author":"Bailey","year":"2012","journal-title":"Adv. Pharmacol."},{"issue":"12","key":"10.1016\/j.ejpb.2016.09.018_b0020","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nrg2665","article-title":"Generating specificity and diversity in the transcriptional response to hypoxia","volume":"10","author":"Lendahl","year":"2009","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.ejpb.2016.09.018_b0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.gde.2010.10.006","article-title":"Hypoxia and energetic tumour metabolism","volume":"21","author":"Brahimi-Horn","year":"2011","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"Suppl 2","key":"10.1016\/j.ejpb.2016.09.018_b0030","doi-asserted-by":"crossref","first-page":"24s","DOI":"10.2967\/jnumed.107.047258","article-title":"Causes and consequences of increased glucose metabolism of cancers","volume":"49","author":"Gillies","year":"2008","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.ejpb.2016.09.018_b0035","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.biomaterials.2015.03.035","article-title":"3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways","volume":"55","author":"DelNero","year":"2015","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.ejpb.2016.09.018_b0040","first-page":"162","article-title":"Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: a one transcription factor (HIF-1) show?","volume":"1795","author":"Kaluz","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.ejpb.2016.09.018_b0045","doi-asserted-by":"crossref","first-page":"84","DOI":"10.18632\/oncotarget.422","article-title":"Recent developments in targeting carbonic anhydrase IX for cancer therapeutics","volume":"3","author":"McDonald","year":"2012","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.ejpb.2016.09.018_b0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11060-006-9205-2","article-title":"Distinct patterns of hypoxic expression of carbonic anhydrase IX (CA IX) in human malignant glioma cell lines","volume":"81","author":"Said","year":"2007","journal-title":"J. Neurooncol."},{"issue":"11","key":"10.1016\/j.ejpb.2016.09.018_b0055","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1054\/bjoc.2000.1111","article-title":"Human tumour-associated cell adhesion protein MN\/CA IX: identification of M75 epitope and of the region mediating cell adhesion","volume":"82","author":"Zavada","year":"2000","journal-title":"Br. J. Cancer"},{"issue":"3","key":"10.1016\/j.ejpb.2016.09.018_b0060","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1006\/geno.1996.0223","article-title":"Human MN\/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships","volume":"33","author":"Opavsky","year":"1996","journal-title":"Genomics"},{"issue":"2","key":"10.1016\/j.ejpb.2016.09.018_b0065","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10555-007-9064-0","article-title":"Regulation of tumor pH and the role of carbonic anhydrase 9","volume":"26","author":"Swietach","year":"2007","journal-title":"Cancer Metastasis Rev."},{"issue":"3","key":"10.1016\/j.ejpb.2016.09.018_b0070","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1006\/bbrc.2001.5824","article-title":"The catalytic properties of human carbonic anhydrase IX","volume":"288","author":"Wingo","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"44","key":"10.1016\/j.ejpb.2016.09.018_b0075","doi-asserted-by":"crossref","first-page":"5210","DOI":"10.1038\/onc.2012.550","article-title":"Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche","volume":"32","author":"Lock","year":"2013","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.ejpb.2016.09.018_b0080","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.4161\/cc.24902","article-title":"Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells","volume":"12","author":"Fiaschi","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ejpb.2016.09.018_b0085","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.nbd.2015.06.007","article-title":"Hypoxia in astrocytic tumors and implications for therapy","volume":"85","author":"Cavazos","year":"2016","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.ejpb.2016.09.018_b0090","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.radonc.2011.05.045","article-title":"Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation","volume":"99","author":"Dubois","year":"2011","journal-title":"Radiother. Oncol."},{"issue":"3","key":"10.1016\/j.ejpb.2016.09.018_b0095","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0002-9440(10)64038-2","article-title":"Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer","volume":"158","author":"Ivanov","year":"2001","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.ejpb.2016.09.018_b0100","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4161\/cc.3.2.618","article-title":"Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target","volume":"3","author":"Potter","year":"2004","journal-title":"Cell Cycle"},{"issue":"17","key":"10.1016\/j.ejpb.2016.09.018_b0105","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1158\/0008-5472.CAN-03-2224","article-title":"Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion","volume":"64","author":"Robertson","year":"2004","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.ejpb.2016.09.018_b0110","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/jcp.22400","article-title":"PH control mechanisms of tumor survival and growth","volume":"226","author":"Parks","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejpb.2016.09.018_b0115","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.biomaterials.2016.01.061","article-title":"Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: a review","volume":"85","author":"Kanamala","year":"2016","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.ejpb.2016.09.018_b0120","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/neuonc\/nos216","article-title":"Function of carbonic anhydrase IX in glioblastoma multiforme","volume":"14","author":"Proescholdt","year":"2012","journal-title":"Neuro Oncol."},{"issue":"3","key":"10.1016\/j.ejpb.2016.09.018_b0125","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1124\/jpet.110.167270","article-title":"Selective inhibition of carbonic anhydrase IX decreases cell proliferation and induces ceramide-mediated apoptosis in human cancer cells","volume":"334","author":"Cianchi","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.ejpb.2016.09.018_b0130","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.radonc.2007.04.018","article-title":"Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors","volume":"83","author":"Dubois","year":"2007","journal-title":"Radiother. Oncol."},{"issue":"6","key":"10.1016\/j.ejpb.2016.09.018_b0135","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/07357900802653464","article-title":"Expression and activity of carbonic anhydrase IX is associated with metabolic dysfunction in MDA-MB-231 breast cancer cells","volume":"27","author":"Li","year":"2009","journal-title":"Cancer Invest."},{"issue":"9","key":"10.1016\/j.ejpb.2016.09.018_b0140","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1158\/0008-5472.CAN-10-4261","article-title":"Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors","volume":"71","author":"Lou","year":"2011","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.ejpb.2016.09.018_b0145","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.biomaterials.2010.11.056","article-title":"The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy","volume":"32","author":"Roger","year":"2011","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.ejpb.2016.09.018_b0150","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1002\/stem.98","article-title":"Proliferation of human glioblastoma stem cells occurs independently of exogenous mitogens","volume":"27","author":"Kelly","year":"2009","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/j.ejpb.2016.09.018_b0155","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1021\/mp700086j","article-title":"Methotrexate loaded polyether-copolyester dendrimers for the treatment of gliomas: enhanced efficacy and intratumoral transport capability","volume":"5","author":"Dhanikula","year":"2008","journal-title":"Mol. Pharm."},{"issue":"7","key":"10.1016\/j.ejpb.2016.09.018_b0160","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Meth."},{"issue":"1","key":"10.1016\/j.ejpb.2016.09.018_b0165","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1002\/lary.24933","article-title":"Prognostic value of hypoxia-associated markers in advanced larynx and hypopharynx squamous cell carcinoma","volume":"125","author":"Bernstein","year":"2015","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.ejpb.2016.09.018_b0170","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1010-6030(98)00359-1","article-title":"Photolysis and photosensitized degradation of the diuretic drug acetazolamide","volume":"118","author":"Vargas","year":"1998","journal-title":"J. Photochem. Photobiol., A"},{"issue":"11","key":"10.1016\/j.ejpb.2016.09.018_b0175","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/j.1552-4604.1992.tb03806.x","article-title":"Elucidating the relationship between acetazolamide plasma protein binding and renal clearance using an albumin infusion","volume":"32","author":"Gomolin","year":"1992","journal-title":"J. Clin. Pharmacol."},{"issue":"Pt 16","key":"10.1016\/j.ejpb.2016.09.018_b0180","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1242\/jcs.038166","article-title":"Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis","volume":"122","author":"Dewson","year":"2009","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.ejpb.2016.09.018_b0185","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1089\/ten.teb.2013.0227","article-title":"Toward 3D biomimetic models to understand the behavior of glioblastoma multiforme cells","volume":"20","author":"Rao","year":"2014","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.ejpb.2016.09.018_b0190","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3389\/fonc.2013.00199","article-title":"Additive influence of extracellular pH, oxygen tension, and pressure on invasiveness and survival of human osteosarcoma cells","volume":"3","author":"Matsubara","year":"2013","journal-title":"Front. Oncol."},{"issue":"4","key":"10.1016\/j.ejpb.2016.09.018_b0195","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.yexcr.2012.12.010","article-title":"The hypoxic tumor microenvironment regulates invasion of aggressive oral carcinoma cells","volume":"319","author":"Teppo","year":"2013","journal-title":"Exp. Cell Res."},{"issue":"7","key":"10.1016\/j.ejpb.2016.09.018_b0200","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1136\/gut.2004.047340","article-title":"Expression of carbonic anhydrase 9 at the invasion front of gastric cancers","volume":"54","author":"Chen","year":"2005","journal-title":"Gut"},{"issue":"13","key":"10.1016\/j.ejpb.2016.09.018_b0205","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1016\/j.bmc.2013.03.068","article-title":"Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma","volume":"21","author":"Said","year":"2013","journal-title":"Bioorg. Med. Chem."},{"issue":"5547","key":"10.1016\/j.ejpb.2016.09.018_b0210","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1126\/science.1064829","article-title":"Taking cell-matrix adhesions to the third dimension","volume":"294","author":"Cukierman","year":"2001","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.ejpb.2016.09.018_b0215","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cell.2007.08.006","article-title":"Modeling tissue morphogenesis and cancer in 3D","volume":"130","author":"Yamada","year":"2007","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.ejpb.2016.09.018_b0220","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.3892\/or.2015.3767","article-title":"Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer","volume":"33","author":"Imamura","year":"2015","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.ejpb.2016.09.018_b0225","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1080\/07357900701788080","article-title":"Modulatory effects of acetazolomide and dexamethasone on temozolomide-mediated apoptosis in human glioblastoma T98G and U87MG cells","volume":"26","author":"Das","year":"2008","journal-title":"Cancer Invest."},{"issue":"7","key":"10.1016\/j.ejpb.2016.09.018_b0230","first-page":"2585","article-title":"Temozolomide and treatment of malignant glioma","volume":"6","author":"Friedman","year":"2000","journal-title":"Clin. Cancer Res."},{"issue":"50","key":"10.1016\/j.ejpb.2016.09.018_b0235","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1038\/onc.2010.455","article-title":"New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation","volume":"29","author":"Swietach","year":"2010","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.ejpb.2016.09.018_b0240","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1002\/stem.2359","article-title":"Multiple subsets of brain tumor initiating cells co-exist in glioblastoma","volume":"34","author":"Rennert","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.ejpb.2016.09.018_b0245","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5728438","article-title":"Glioma stem cells and their microenvironments: providers of challenging therapeutic targets","volume":"2016","author":"Codrici","year":"2016","journal-title":"Stem Cells Int."},{"issue":"1","key":"10.1016\/j.ejpb.2016.09.018_b0250","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12974-016-0523-9","article-title":"Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke","volume":"13","author":"Sakuma","year":"2016","journal-title":"J. Neuroinflamm."},{"issue":"7","key":"10.1016\/j.ejpb.2016.09.018_b0255","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1586\/14737175.2015.1051968","article-title":"The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence","volume":"15","author":"Auffinger","year":"2015","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.ejpb.2016.09.018_b0260","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1100\/2011\/736480","article-title":"The three-layer concentric model of glioblastoma: cancer stem cells, microenvironmental regulation, and therapeutic implications","volume":"11","author":"Persano","year":"2011","journal-title":"Sci. World J."},{"issue":"4","key":"10.1016\/j.ejpb.2016.09.018_b0265","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bbrc.2013.04.008","article-title":"The usefulness of three-dimensional cell culture in induction of cancer stem cells from esophageal squamous cell carcinoma cell lines","volume":"434","author":"Fujiwara","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.ejpb.2016.09.018_b0270","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5306\/wjco.v5.i1.19","article-title":"Temozolomide for treatment of brain metastases: a review of 21 clinical trials","volume":"5","author":"Zhu","year":"2014","journal-title":"World J. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.ejpb.2016.09.018_b0275","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.nec.2012.04.003","article-title":"Clinical trials with immunotherapy for high-grade glioma","volume":"23","author":"Ruzevick","year":"2012","journal-title":"Neurosurg. Clin. N Am."},{"issue":"11","key":"10.1016\/j.ejpb.2016.09.018_b0280","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1002\/ijc.24171","article-title":"Potent antitumor effect of SN-38-incorporating polymeric micelle, NK012, against malignant glioma","volume":"124","author":"Kuroda","year":"2009","journal-title":"Int. J. Cancer"},{"issue":"4","key":"10.1016\/j.ejpb.2016.09.018_b0285","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.3892\/mmr.2014.3017","article-title":"Efficient delivery of docetaxel for the treatment of brain tumors by cyclic RGD-tagged polymeric micelles","volume":"11","author":"Li","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"9","key":"10.1016\/j.ejpb.2016.09.018_b0290","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/jps.2600770906","article-title":"Effect of salicylate on serum protein binding and red blood cell uptake of acetazolamide in vitro","volume":"77","author":"Sweeney","year":"1988","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2016.09.018_b0295","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejpb.2015.12.008","article-title":"Pharmacological inhibition of lipid droplet formation enhances the effectiveness of curcumin in glioblastoma","volume":"100","author":"Zhang","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"7","key":"10.1016\/j.ejpb.2016.09.018_b0300","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nm1263","article-title":"Caspase-independent cell death","volume":"11","author":"Kroemer","year":"2005","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.ejpb.2016.09.018_b0305","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/sj.cdd.4402060","article-title":"Caspase function in programmed cell death","volume":"14","author":"Kumar","year":"2007","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.ejpb.2016.09.018_b0310","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/sj.cdd.4402047","article-title":"Caspases in cell survival, proliferation and differentiation","volume":"14","author":"Lamkanfi","year":"2007","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.ejpb.2016.09.018_b0315","doi-asserted-by":"crossref","first-page":"402","DOI":"10.15252\/embj.201592789","article-title":"Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis","volume":"35","author":"Grosse","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.ejpb.2016.09.018_b0320","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fphys.2015.00038","article-title":"Non-apoptotic cell death associated with perturbations of macropinocytosis","volume":"6","author":"Maltese","year":"2015","journal-title":"Front. Physiol."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641116306221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641116306221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T09:19:01Z","timestamp":1568452741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641116306221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":64,"alternative-id":["S0939641116306221"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2016.09.018","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of carbonic anhydrase IX in glioblastoma multiforme","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2016.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}