{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:43:45Z","timestamp":1789055025112,"version":"build-2803163510"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean government","award":["2009-0083533"],"award-info":[{"award-number":["2009-0083533"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.ejpb.2017.01.026","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T09:55:43Z","timestamp":1486979743000},"page":"1-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Estimation of the minimum permeability coefficient in rats for perfusion-limited tissue distribution in whole-body physiologically-based pharmacokinetics"],"prefix":"10.1016","volume":"115","author":[{"given":"Yoo-Seong","family":"Jeong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Soon","family":"Yim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heon-Min","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Kyoung","family":"Noh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo-Kyung","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk-Jae","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2017.01.026_b0005","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1208\/s12248-009-9088-1","article-title":"Modelling and PBPK simulation in drug discovery","volume":"11","author":"Jones","year":"2009","journal-title":"AAPS J."},{"key":"10.1016\/j.ejpb.2017.01.026_b0010","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1517\/17425255.4.9.1143","article-title":"Whole body physiologically-based pharmacokinetic models: their use in clinical drug development","volume":"4","author":"Edginton","year":"2008","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0015","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1002\/jps.20322","article-title":"Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases","volume":"94","author":"Rodgers","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0020","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1002\/jps.20502","article-title":"Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions","volume":"95","author":"Rodgers","year":"2006","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0025","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s10822-009-9309-9","article-title":"Development of QSAR models for microsomal stability: identification of good and bad structural features for rat, human and mouse microsomal stability","volume":"24","author":"Hu","year":"2010","journal-title":"J. Comput. \u2013 Aided Mol. Des."},{"key":"10.1016\/j.ejpb.2017.01.026_b0030","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s10822-007-9124-0","article-title":"Development of in silico models for human liver microsomal stability","volume":"21","author":"Lee","year":"2007","journal-title":"J. Comput. \u2013 Aided Mol. Des."},{"key":"10.1016\/j.ejpb.2017.01.026_b0035","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1007\/s11095-013-1023-6","article-title":"The use of pseudo-equilibrium constant affords improved QSAR models of human plasma protein binding","volume":"30","author":"Zhu","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2017.01.026_b0040","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1023\/B:MODI.0000006562.93049.36","article-title":"In silico prediction of aqueous solubility, human plasma protein binding and volume of distribution of compounds from calculated pKa and AlogP98 values","volume":"7","author":"Lobell","year":"2003","journal-title":"Mol. Diversity"},{"key":"10.1016\/j.ejpb.2017.01.026_b0045","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s10928-012-9280-2","article-title":"Applications of minimal physiologically-based pharmacokinetic models","volume":"39","author":"Cao","year":"2012","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"10.1016\/j.ejpb.2017.01.026_b0050","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1021\/mp200275j","article-title":"In silico modeling for the nonlinear absorption kinetics of UK-343,664: a P-gp and CYP3A4 substrate","volume":"9","author":"Abuasal","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2017.01.026_b0055","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40203-014-0002-x","article-title":"In silico evaluation of gadofosveset pharmacokinetics in different population groups using the Simcyp\u00ae simulator platform","volume":"2","author":"Spanakis","year":"2014","journal-title":"Silico Pharmacol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0060","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1021\/mp300482w","article-title":"Predicting pharmacokinetic profiles using in silico derived parameters","volume":"10","author":"Hosea","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2017.01.026_b0065","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1080\/10837450902891360","article-title":"Physiologically based pharmacokinetics (PBPK)","volume":"41","author":"Espie","year":"2009","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.ejpb.2017.01.026_b0070","series-title":"Pharmacokinetics","author":"Gibaldi","year":"1982"},{"key":"10.1016\/j.ejpb.2017.01.026_b0075","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.ejps.2005.12.003","article-title":"Transporters as a determinant of drug clearance and tissue distribution","volume":"27","author":"Shitara","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0080","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev-pharmtox-010510-100540","article-title":"Physiologically-based pharmacokinetics in drug development and regulatory science","volume":"51","author":"Rowland","year":"2011","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0085","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1021\/jm970530e","article-title":"Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes","volume":"41","author":"Kansy","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejpb.2017.01.026_b0090","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1002\/jps.20075","article-title":"Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery","volume":"93","author":"Kerns","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0095","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10822-006-9101-z","article-title":"Comparative QSAR studies on PAMPA\/modified PAMPA for high throughput profiling of drug absorption potential with respect to Caco-2 cells and human intestinal absorption","volume":"21","author":"Verma","year":"2007","journal-title":"J. Comput. \u2013 Aided Mol. Des."},{"key":"10.1016\/j.ejpb.2017.01.026_b0100","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s10822-009-9261-8","article-title":"QSAR application for the prediction of compound permeability with in silico descriptors in practical use","volume":"23","author":"Nakao","year":"2009","journal-title":"J. Comput. \u2013 Aided Mol. Des."},{"key":"10.1016\/j.ejpb.2017.01.026_b0105","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/BF02353860","article-title":"Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125","volume":"22","author":"Kawai","year":"1994","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1016\/j.ejpb.2017.01.026_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(25)07246-1","article-title":"The theory and applications of the exchange of inert gas at the lungs and tissues","volume":"3","author":"Kety","year":"1951","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejpb.2017.01.026_b0115","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1023\/A:1018959415963","article-title":"Effect of plasma protein binding on kinetics of capillary uptake and efflux","volume":"10","author":"Morgan","year":"1993","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2017.01.026_b0120","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s10928-011-9200-x","article-title":"Development of appropriate equations for physiologically based pharmacokinetic modeling of permeability-limited and flow-limited transport","volume":"38","author":"Thompson","year":"2011","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"10.1016\/j.ejpb.2017.01.026_b0125","doi-asserted-by":"publisher","first-page":"4586","DOI":"10.1002\/jps.21317","article-title":"Validation of a rapid equilibrium dialysis approach for the measurement of plasma protein binding","volume":"97","author":"Waters","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0130","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1124\/jpet.105.088328","article-title":"In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C] verapamil","volume":"316","author":"Lee","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejpb.2017.01.026_b0135","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s11419-012-0133-x","article-title":"A rapid and simultaneous analysis of theophylline and its metabolites in human whole blood by ultra-performance liquid chromatography-tandem mass spectrometry","volume":"30","author":"Ogawa","year":"2012","journal-title":"Forensic Toxicol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0140","series-title":"Guidance for Industry: Bioanalytical Method Validation. US Department of Health and Human Services","author":"FDA","year":"2001"},{"key":"10.1016\/j.ejpb.2017.01.026_b0145","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1080\/00016480152583683","article-title":"Homozygous disruption of the mdr1a P-glycoprotein gene affects blood-nerve barrier function in mice administered with neurotoxic drugs","volume":"121","author":"Saito","year":"2001","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0150","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/BF01059275","article-title":"A physiologically based pharmacokinetic model for theophylline disposition in the pregnant and nonpregnant rat","volume":"12","author":"Gabrielsson","year":"1984","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1016\/j.ejpb.2017.01.026_b0155","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1177\/074823379701300401","article-title":"Physiological parameter values for physiologically based pharmacokinetic models","volume":"13407","author":"Brown","year":"1997","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.ejpb.2017.01.026_b0160","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1517\/17425250802691074","article-title":"The Simcyp\u00ae population-based ADME simulator","volume":"5","author":"Jamei","year":"2009","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0165","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1191\/096228099673819272","article-title":"Measuring agreement in method comparison studies","volume":"8","author":"Bland","year":"1999","journal-title":"Stat. Methods Med. Res."},{"key":"10.1016\/j.ejpb.2017.01.026_b0170","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1208\/s12248-013-9470-x","article-title":"Drug\u2013drug interaction studies: regulatory guidance and an industry perspective","volume":"15","author":"Prueksaritanont","year":"2013","journal-title":"AAPS J."},{"key":"10.1016\/j.ejpb.2017.01.026_b0175","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3109\/00498258509045346","article-title":"Dose-dependent elimination of theophylline in rats","volume":"15","author":"Teunissen","year":"1985","journal-title":"Xenobiotica"},{"key":"10.1016\/j.ejpb.2017.01.026_b0180","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/bdd.2510080406","article-title":"Theophylline tissue partitioning and volume of distribution in normal and dietary-induced obese rats","volume":"8","author":"Shum","year":"1987","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.ejpb.2017.01.026_b0185","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1007\/s11095-006-9210-3","article-title":"Mechanistic approaches to volume of distribution predictions: understanding the processes","volume":"24","author":"Rodgers","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2017.01.026_b0190","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0022-3565(24)36999-X","article-title":"The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data","volume":"283","author":"Obach","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejpb.2017.01.026_b0195","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/BF03190588","article-title":"Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1\/2 be predicted from in-vivo rat data?","volume":"29","author":"Caldwell","year":"2004","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.ejpb.2017.01.026_b0200","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0022-3565(24)37815-2","article-title":"Physiologically based pharmacokinetics of cyclosporine A: extension to tissue distribution kinetics in rats and scale-up to human","volume":"287","author":"Kawai","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejpb.2017.01.026_b0205","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0090-9556(25)07045-X","article-title":"Cyclosporine pharmacokinetics in rats and interspecies comparison in dogs, rabbits, rats, and humans","volume":"16","author":"Sangalli","year":"1988","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejpb.2017.01.026_b0210","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0165-3806(90)90163-S","article-title":"A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat","volume":"56","author":"Keep","year":"1990","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.ejpb.2017.01.026_b0215","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1007\/s11095-007-9517-8","article-title":"A novel design of artificial membrane for improving the PAMPA model","volume":"25","author":"Chen","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2017.01.026_b0220","doi-asserted-by":"publisher","first-page":"4721","DOI":"10.1016\/j.bmc.2005.04.076","article-title":"Relationships between structure and high-throughput screening permeability of diverse drugs with artificial membranes: application to prediction of Caco-2 cell permeability","volume":"13","author":"Fujikawa","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejpb.2017.01.026_b0225","doi-asserted-by":"publisher","DOI":"10.1002\/9783906390468","author":"Testa","year":"2006","journal-title":"Pharmacokinetics profiling in drug research"},{"key":"10.1016\/j.ejpb.2017.01.026_b0230","doi-asserted-by":"publisher","first-page":"F867","DOI":"10.1152\/ajprenal.00528.2007","article-title":"Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics","volume":"294","author":"Vallon","year":"2008","journal-title":"Am. J. Physiol. Renal"},{"key":"10.1016\/j.ejpb.2017.01.026_b0235","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1211\/jpp.59.9.0011","article-title":"Role of intestinal efflux transporters in the intestinal absorption of methotrexate in rats","volume":"59","author":"Yokooji","year":"2007","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0240","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1124\/jpet.106.110379","article-title":"Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP)2\/ABCC2-and MRP4\/ABCC4-mediated methotrexate transport","volume":"320","author":"El-Sheikh","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejpb.2017.01.026_b0245","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/bjc.1997.145","article-title":"Indomethacin-mediated reversal of multidrug resistance and drug efflux in human and murine cell lines overexpressing MRP, but not P-glycoprotein","volume":"75","author":"Draper","year":"1997","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejpb.2017.01.026_b0250","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1124\/dmd.107.019125","article-title":"Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of \u03b2-lactam antibiotics","volume":"36","author":"Kato","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejpb.2017.01.026_b0255","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1128\/AAC.50.1.80-87.2006","article-title":"Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport","volume":"50","author":"Yamaguchi","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejpb.2017.01.026_b0260","doi-asserted-by":"publisher","first-page":"3557","DOI":"10.1097\/00001756-200111160-00037","article-title":"P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain","volume":"12","author":"Potschka","year":"2001","journal-title":"NeuroReport"},{"key":"10.1016\/j.ejpb.2017.01.026_b0265","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/clpt.2010.142","article-title":"Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers","volume":"88","author":"Frymoyer","year":"2010","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejpb.2017.01.026_b0270","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1002\/jps.21618","article-title":"Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol","volume":"98","author":"Kato","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0275","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1124\/jpet.102.037580","article-title":"Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs","volume":"303","author":"Khamdang","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejpb.2017.01.026_b0280","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1124\/dmd.30.4.457","volume":"30","author":"Guo","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejpb.2017.01.026_b0285","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1002\/jps.1111","article-title":"HT29-MTX and Caco-2\/TC7 monolayers as predictive models for human intestinal absorption: Role of the mucus layer","volume":"90","author":"Pontier","year":"2001","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0290","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1002\/bdd.721","article-title":"Effects of lovastatin on the pharmacokinetics of nicardipine in rats","volume":"31","author":"Chung","year":"2010","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.ejpb.2017.01.026_b0295","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1124\/dmd.111.040766","article-title":"Species differences in distribution and prediction of human V(ss) from preclinical data","volume":"39","author":"Berry","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejpb.2017.01.026_b0300","series-title":"LOGKOW Databank","author":"Sangster","year":"1994"},{"key":"10.1016\/j.ejpb.2017.01.026_b0305","series-title":"LOGKOW\u2013A Databank of Evaluated Octanolwater Partition Coefficients","author":"Sangster","year":"1993"},{"key":"10.1016\/j.ejpb.2017.01.026_b0310","series-title":"Exploring QSAR: Fundamentals and Applications in Chemistry and Biology","author":"Hansch","year":"1995"},{"key":"10.1016\/j.ejpb.2017.01.026_b0315","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1002\/jps.10494","article-title":"Fast gradient HPLC method to determine compounds binding to human serum albumin. Relationships with octanol\/water and immobilized artificial membrane lipophilicity","volume":"92","author":"Valko","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0320","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1039\/C39950002241","article-title":"Rapid estimation of octanol\u2013water partition coefficients using deoxycholate micelles in capillary electrophoresis","author":"Adlard","year":"1995","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"10.1016\/j.ejpb.2017.01.026_b0325","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1023\/B:JOPA.0000042737.14033.c6","article-title":"Development of a whole body physiologically based model to characterise the pharmacokinetics of benzodiazepines. 1: estimation of rat tissue-plasma partition ratios","volume":"31","author":"Gueorguieva","year":"2004","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"10.1016\/j.ejpb.2017.01.026_b0330","article-title":"Measuring log P using liposomes; a possible tool to study drug-membrane interactions","volume":"49","author":"Avdeef","year":"1997","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0335","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1211\/jpp.61.01.0007","article-title":"Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism","volume":"61","author":"Yang","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0340","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1021\/js960244a","article-title":"Comparison of plasma and free tissue levels of ceftriaxone in rats by microdialysis","volume":"86","author":"Kovar","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0345","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1128\/AAC.01210-07","article-title":"Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A","volume":"52","author":"Lee","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejpb.2017.01.026_b0350","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0090-9556(25)08158-9","article-title":"Disposition of sumatriptan in laboratory animals and humans","volume":"21","author":"Dixon","year":"1993","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejpb.2017.01.026_b0355","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/(SICI)1520-6017(200001)89:1<16::AID-JPS3>3.0.CO;2-E","article-title":"A priori prediction of tissue: plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery","volume":"89","author":"Poulin","year":"2000","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0360","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1002\/jps.21130","article-title":"Prediction of drug tissue to plasma concentration ratios using a measured volume of distribution in combination with lipophilicity","volume":"97","author":"Jansson","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0365","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1124\/dmd.109.029629","article-title":"Prediction of V(ss) from in vitro tissue-binding studies","volume":"38","author":"Berry","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejpb.2017.01.026_b0370","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.ejps.2009.12.007","article-title":"Prediction of the in vitro intrinsic clearance determined in suspensions of human hepatocytes by using artificial neural networks","volume":"39","author":"Paixao","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0375","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1128\/AAC.21.5.804","article-title":"Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans","volume":"21","author":"Laskin","year":"1982","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejpb.2017.01.026_b0380","first-page":"608","article-title":"Evaluation of partitioning and solubility data for some guanine derivatives in terms of mutual miscibility of octanol and water phase","volume":"48","author":"Kristl","year":"1993","journal-title":"Pharmazie"},{"key":"10.1016\/j.ejpb.2017.01.026_b0385","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1128\/CMR.00092-12","article-title":"Importance of relating efficacy measures to unbound drug concentrations for anti-infective agents","volume":"26","author":"Gonzalez","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ejpb.2017.01.026_b0390","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/00498250802668863","article-title":"Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: impact of plasma and microsomal binding","volume":"39","author":"Emoto","year":"2009","journal-title":"Xenobiotica"},{"key":"10.1016\/j.ejpb.2017.01.026_b0395","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/BF01062191","article-title":"Physiologic modeling of cyclosporin kinetics in rat and man","volume":"19","author":"Bernareggi","year":"1991","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1016\/j.ejpb.2017.01.026_b0400","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/BF01046701","article-title":"Cyclosporin: pharmacokinetics and detailed studies of plasma and erythrocyte binding during intravenous and oral administration","volume":"34","author":"Legg","year":"1988","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0405","doi-asserted-by":"publisher","first-page":"4518","DOI":"10.1002\/jps.22635","article-title":"Toward an integrated human clearance prediction strategy that minimizes animal use","volume":"100","author":"Beaumont","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0410","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1002\/jps.20059","article-title":"Computational prediction of the plasma protein-binding percent of diverse pharmaceutical compounds","volume":"93","author":"Yamazaki","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0415","first-page":"323","article-title":"Assessment of macrolide transport using PAMPA, Caco-2 and MDCKII-hMDR1 assays","volume":"83","author":"No\u017eini\u0107","year":"2010","journal-title":"Croat. Chem. Acta"},{"key":"10.1016\/j.ejpb.2017.01.026_b0420","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1023\/B:PHAM.0000026423.48583.e2","article-title":"Correction of permeability with pore radius of tight junctions in Caco-2 monolayers improves the prediction of the dose fraction of hydrophilic drugs absorbed by humans","volume":"21","author":"Saitoh","year":"2004","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2017.01.026_b0425","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.ijpharm.2008.07.008","article-title":"Pharmacokinetic evaluation of indomethacin ethyl ester-loaded nanoencapsules","volume":"363","author":"Cattani","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.01.026_b0430","doi-asserted-by":"publisher","first-page":"B222","DOI":"10.1093\/geronj\/46.6.B222","article-title":"Age-and dose-dependent naproxen disposition in Fischer 344 rats","volume":"46","author":"Satterwhite","year":"1991","journal-title":"J. Gerontol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0435","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/BF01061845","article-title":"The effect of hepatic uptake on the disappearance of warfarin from the plasma of rats: a kinetic analysis","volume":"11","author":"Covell","year":"1983","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1016\/j.ejpb.2017.01.026_b0440","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1002\/jps.2600721103","article-title":"Physiologically based pharmacokinetic model for \u03b2-lactam antibiotics I: tissue distribution and elimination in rats","volume":"72","author":"Tsuji","year":"1983","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0445","first-page":"1411","article-title":"Effects of quercetin on the pharmacokinetics of etoposide after oral or intravenous administration of etoposide in rats","volume":"29","author":"Li","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejpb.2017.01.026_b0450","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/bdd.565","article-title":"Pharmacokinetics of intravenous methotrexate in mutant Nagase analbuminemic rats","volume":"28","author":"Choi","year":"2007","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.ejpb.2017.01.026_b0455","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1211\/0022357055533","article-title":"Effects of non-steroidal anti-inflammatory drugs on the pharmacokinetics and elimination of aciclovir in rats","volume":"57","author":"Gwak","year":"2005","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0460","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1002\/(SICI)1520-636X(1997)9:4<354::AID-CHIR7>3.0.CO;2-D","article-title":"Stereoselective pharmacokinetics of ibuprofen in rats: effect of enantiomer-enantiomer interaction in plasma protein binding","volume":"9","author":"Itoh","year":"1997","journal-title":"Chirality"},{"key":"10.1016\/j.ejpb.2017.01.026_b0465","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0022-3565(25)12609-8","article-title":"Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat","volume":"254","author":"Belpaire","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejpb.2017.01.026_b0470","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3109\/00498254.2011.633177","article-title":"Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes","volume":"42","author":"Choi","year":"2012","journal-title":"Xenobiotica"},{"key":"10.1016\/j.ejpb.2017.01.026_b0475","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0022-3565(25)32025-2","article-title":"Phenytoin pharmacokinetics in burned rats and plasma protein binding of phenytoin in burned patients","volume":"213","author":"Bowdle","year":"1980","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejpb.2017.01.026_b0480","first-page":"49","article-title":"Effect of resveratrol on the pharmacokinetics of oral and intravenous nicardipine in rats: possible role of P-glycoprotein inhibition by resveratrol","volume":"64","author":"Choi","year":"2009","journal-title":"Pharmazie"},{"key":"10.1016\/j.ejpb.2017.01.026_b0485","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1124\/jpet.102.035972","article-title":"In vitro, pharmacokinetic, and pharmacodynamic interactions of ketoconazole and midazolam in the rat","volume":"302","author":"Kotegawa","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejpb.2017.01.026_b0490","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1211\/0022357991776840","article-title":"Effects of cyclosporin on the pharmacokinetics of propranolol after intravenous and oral administration to control rats and to rats with uranyl nitrate-induced acute renal failure","volume":"51","author":"Lee","year":"1999","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0495","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1002\/jps.10128","article-title":"Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition","volume":"91","author":"Poulin","year":"2002","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.01.026_b0500","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1111\/j.2042-7158.2010.01127.x","article-title":"Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats","volume":"62","author":"Wang","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2017.01.026_b0505","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/bdd.2510140702","article-title":"Intravenous verapamil kinetics in rats: marked arteriovenous concentration difference and comparison with humans","volume":"14","author":"Manitpisitkul","year":"1993","journal-title":"Biopharm. Drug Dispos."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641116306415?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641116306415?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T05:07:40Z","timestamp":1749964060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641116306415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":101,"alternative-id":["S0939641116306415"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2017.01.026","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Estimation of the minimum permeability coefficient in rats for perfusion-limited tissue distribution in whole-body physiologically-based pharmacokinetics","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2017.01.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}