{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:08:14Z","timestamp":1790856494976,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"am","delay-in-days":299,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Irish Department of Agriculture Food Institutional Research Measure","award":["11F042"],"award-info":[{"award-number":["11F042"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.ejpb.2017.03.007","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T06:31:38Z","timestamp":1489473098000},"page":"276-284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Evaluation of PepT1 transport of food-derived antihypertensive peptides, Ile-Pro-Pro and Leu-Lys-Pro using in vitro, ex vivo and in vivo transport models"],"prefix":"10.1016","volume":"115","author":[{"given":"John P.","family":"Gleeson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Brayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin\u00e9ad M.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2017.03.007_b0005","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.peptides.2015.08.009","article-title":"Bioactive properties of milk proteins in humans: a review","volume":"73","author":"Nongonierma","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.ejpb.2017.03.007_b0010","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/ajh\/hps044","article-title":"Do the lactotripeptides isoleucine-proline-proline and valine-proline-proline reduce systolic blood pressure in European subjects? A meta-analysis of randomized controlled trials","volume":"26","author":"Cicero","year":"2013","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ejpb.2017.03.007_b0015","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3109\/07853890.2012.663926","article-title":"Antihypertensive effects of bioactive tripeptides \u2013 a random effects meta-analysis","volume":"45","author":"Turpeinen","year":"2013","journal-title":"Ann. Med."},{"key":"10.1016\/j.ejpb.2017.03.007_b0020","doi-asserted-by":"crossref","first-page":"966","DOI":"10.3945\/ajcn.2009.28406","article-title":"Effect of premeal consumption of whey protein and its hydrolysate on food intake and postmeal glycemia and insulin responses in young adults","volume":"91","author":"Akhavan","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ejpb.2017.03.007_b0025","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.idairyj.2013.06.006","article-title":"Influence of whey protein and its hydrolysate on prehypertension and postprandial hyperglycaemia in adult men","volume":"33","author":"Goudarzi","year":"2013","journal-title":"Int. Dairy J."},{"key":"10.1016\/j.ejpb.2017.03.007_b0030","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3168\/jds.S0022-0302(95)76689-9","article-title":"Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk","volume":"78","author":"Nakamura","year":"1995","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ejpb.2017.03.007_b0035","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0162-3109(99)00118-6","article-title":"LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein","volume":"44","author":"Fujita","year":"1999","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.ejpb.2017.03.007_b0040","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1365-2621.2000.tb16049.x","article-title":"Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins","volume":"65","author":"Fujita","year":"2000","journal-title":"J. Food Sci."},{"key":"10.1016\/j.ejpb.2017.03.007_b0045","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3168\/jds.S0022-0302(95)76745-5","article-title":"Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme","volume":"78","author":"Nakamura","year":"1995","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ejpb.2017.03.007_b0050","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.addr.2016.01.010","article-title":"Oral delivery of macromolecular drugs: where we are after almost 100 years of attempts","volume":"101","author":"Moroz","year":"2016","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.ejpb.2017.03.007_b0055","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4155\/ppa.14.15","article-title":"Formulation strategies to improve oral peptide delivery","volume":"3","author":"Maher","year":"2014","journal-title":"Pharmaceut. Patent Anal."},{"key":"10.1016\/j.ejpb.2017.03.007_b0060","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1021\/jf072671n","article-title":"Producibility and digestibility of antihypertensive beta-casein tripeptides, Val-Pro-Pro and Ile-Pro-Pro, in the gastrointestinal tract: analyses using an in vitro model of mammalian gastrointestinal digestion","volume":"56","author":"Ohsawa","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejpb.2017.03.007_b0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/10409239309082572","article-title":"Proline-dependent structural and biological properties of peptides and proteins","volume":"28","author":"Yaron","year":"1993","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.ejpb.2017.03.007_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2015.05.009","article-title":"Stability, toxicity and intestinal permeation enhancement of two food-derived antihypertensive tripeptides, Ile-Pro-Pro and Leu-Lys-Pro","volume":"71","author":"Gleeson","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.ejpb.2017.03.007_b0075","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1208\/s12248-010-9195-z","article-title":"A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1)","volume":"12","author":"Omkvist","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.ejpb.2017.03.007_b0080","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1271\/bbb.66.378","article-title":"Transepithelial transport of the bioactive tripeptide, Val-Pro-Pro, in human intestinal Caco-2 cell monolayers","volume":"66","author":"Satake","year":"2002","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.ejpb.2017.03.007_b0085","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1017\/S0954422414000225","article-title":"Are intact peptides absorbed from the healthy gut in the adult human?","volume":"27","author":"Miner-Williams","year":"2014","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.ejpb.2017.03.007_b0090","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1006\/bbrc.1993.2545","article-title":"Evidence for predominantly paracellular transport of thyrotropin-releasing hormone across Caco-2 cell monolayers","volume":"197","author":"Gan","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejpb.2017.03.007_b0095","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.peptides.2008.03.021","article-title":"The angiotensin converting enzyme inhibitory tripeptides Ile-Pro-Pro and Val-Pro-Pro show increasing permeabilities with increasing physiological relevance of absorption models","volume":"29","author":"Foltz","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.ejpb.2017.03.007_b0100","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0005-2736(93)90108-C","article-title":"H(+)-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayers display distinctive characteristics","volume":"1151","author":"Thwaites","year":"1993","journal-title":"Biochem. Biophys. Acta."},{"key":"10.1016\/j.ejpb.2017.03.007_b0105","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1021\/acs.jafc.6b00279","article-title":"Structural design of oligopeptides for intestinal transport model","volume":"64","author":"Hong","year":"2016","journal-title":"J. Agricult. Food Chem."},{"key":"10.1016\/j.ejpb.2017.03.007_b0110","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.bbagen.2012.07.007","article-title":"The PepT1-transportable soy tripeptide VPY reduces intestinal inflammation","volume":"1820","author":"Kovacs-Nolan","year":"2012","journal-title":"Biochim. et Biophys. Acta (BBA) \u2013 Gener. Subjects"},{"key":"10.1016\/j.ejpb.2017.03.007_b0115","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.idairyj.2013.05.009","article-title":"Bioavailability of antihypertensive lactoferricin B-derived peptides: transepithelial transport and resistance to intestinal and plasma peptidases","volume":"32","author":"Fern\u00e1ndez-Musoles","year":"2013","journal-title":"Int. Dairy J."},{"key":"10.1016\/j.ejpb.2017.03.007_b0120","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1172\/JCI7192","article-title":"H(+)\/solute-induced intracellular acidification leads to selective activation of apical Na(+)\/H(+) exchange in human intestinal epithelial cells","volume":"104","author":"Thwaites","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejpb.2017.03.007_b0125","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1039\/c3ib40126j","article-title":"Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation","volume":"5","author":"Kim","year":"2013","journal-title":"Integrat. Biol.: Quantitat. Biosci. Nano Macro"},{"key":"10.1016\/j.ejpb.2017.03.007_b0130","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejps.2005.02.009","article-title":"PH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers","volume":"25","author":"Neuhoff","year":"2005","journal-title":"Europ. J. Pharmaceut. Sci.: Off. J. Europ. Federat. Pharmaceut. Sci."},{"key":"10.1016\/j.ejpb.2017.03.007_b0135","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/gut.24.8.734","article-title":"Determination of acid surface pH in vivo in rat proximal jejunum","volume":"24","author":"Lucas","year":"1983","journal-title":"Gut"},{"key":"10.1016\/j.ejpb.2017.03.007_b0140","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1038\/nprot.2007.303","article-title":"Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers","volume":"2","author":"Hubatsch","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejpb.2017.03.007_b0145","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ejps.2012.08.010","article-title":"Evaluation of alkylmaltosides as intestinal permeation enhancers: comparison between rat intestinal mucosal sheets and Caco-2 monolayers","volume":"47","author":"Petersen","year":"2012","journal-title":"Europ. J. Pharmaceut. Sci.: Off. J. Europ. Federat. Pharmaceut. Sci."},{"key":"10.1016\/j.ejpb.2017.03.007_b0150","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ijpharm.2016.03.063","article-title":"Excised segments of rat small intestine in Ussing chamber studies: a comparison of native and stripped tissue viability and permeability to drugs","volume":"505","author":"Sjogren","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.03.007_b0155","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1476-5381.1982.tb09178.x","article-title":"Kinins stimulate net chloride secretion by the rat colon","volume":"75","author":"Cuthbert","year":"1982","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejpb.2017.03.007_b0160","first-page":"2516","article-title":"PH dependent but not P-gp dependent bidirectional transport study of S-propranolol: the importance of passive diffusion","volume":"32","author":"Zheng","year":"2015","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2017.03.007_b0165","doi-asserted-by":"crossref","unstructured":"S.W. Mateer, J. Cardona, E. Marks, B.J. Goggin, et al., Ex vivo intestinal sacs to assess mucosal permeability in models of gastrointestinal disease, J. Visual. Exper., JoVE (2016) e53250.","DOI":"10.3791\/53250-v"},{"key":"10.1016\/j.ejpb.2017.03.007_b0170","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.ejpb.2014.10.013","article-title":"Investigation of coco-glucoside as a novel intestinal permeation enhancer in rat models","volume":"88","author":"Aguirre","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2017.03.007_b0175","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1124\/dmd.112.044990","article-title":"Role of the intestinal peptide transporter PEPT1 in Oseltamivir absorption: In vitro and in vivo studies","volume":"40","author":"Poirier","year":"2012","journal-title":"Drug Metab. Disposit."},{"key":"10.1016\/j.ejpb.2017.03.007_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10735-007-9093-6","article-title":"Microwave oven-based technique for immunofluorescent staining of paraffin-embedded tissues","volume":"39","author":"Long","year":"2008","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.ejpb.2017.03.007_b0185","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/jps.20062","article-title":"Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin","volume":"93","author":"Behrens","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.03.007_b0190","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.nbt.2013.05.008","article-title":"The Caco-2 cell culture model enables sensitive detection of enhanced protein permeability in the presence of N-decyl-\u03b2-d-maltopyranoside","volume":"30","author":"Maru\u0161i\u0107","year":"2013","journal-title":"New Biotechnol."},{"key":"10.1016\/j.ejpb.2017.03.007_b0195","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.fct.2014.02.003","article-title":"Transport characteristics of isorhamnetin across intestinal Caco-2 cell monolayers and the effects of transporters on it","volume":"66","author":"Duan","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejpb.2017.03.007_b0200","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF00588693","article-title":"The influence of buffer pH, glucose and sodium ion concentration on the acid microclimate in rat proximal jejunum in vitro","volume":"385","author":"Lucas","year":"1980","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.ejpb.2017.03.007_b0205","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.ejps.2008.08.004","article-title":"Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories","volume":"35","author":"Hayeshi","year":"2008","journal-title":"Europ. J. Pharmaceut. Sci.: Off. J. Europ. Federat. Pharmaceut. Sci."},{"key":"10.1016\/j.ejpb.2017.03.007_b0210","doi-asserted-by":"crossref","first-page":"H243","DOI":"10.1111\/j.1750-3841.2009.01301.x","article-title":"Modeling of the relationship between dipeptide structure and dipeptide stability, permeability, and ACE inhibitory activity","volume":"74","author":"Foltz","year":"2009","journal-title":"J. Food Sci."},{"key":"10.1016\/j.ejpb.2017.03.007_b0215","first-page":"E7","article-title":"Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip","volume":"113","author":"Kim","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejpb.2017.03.007_b0220","first-page":"364","article-title":"Hijacking solute carriers for proton-coupled drug transport","volume":"25","author":"Anderson","year":"2010","journal-title":"Physiology (Bethesda, Md.)"},{"key":"10.1016\/j.ejpb.2017.03.007_b0225","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.coph.2013.08.004","article-title":"Drug transport via the intestinal peptide transporter PepT1","volume":"13","author":"Brandsch","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.ejpb.2017.03.007_b0230","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s003600050247","article-title":"Characteristics of dipeptide transport in pig jejunum in vitro","volume":"169","author":"Winckler","year":"1999","journal-title":"J. Comp. Physiol. B"},{"key":"10.1016\/j.ejpb.2017.03.007_b0235","doi-asserted-by":"crossref","first-page":"G128","DOI":"10.1152\/ajpgi.00017.2011","article-title":"Amino acid absorption and homeostasis in mice lacking the intestinal peptide transporter PEPT1","volume":"301","author":"N\u00e4ssl","year":"2011","journal-title":"Am. J. Physiol. \u2013 Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejpb.2017.03.007_b0240","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/bdd.366","article-title":"Comparison of ceftibuten transport across Caco-2 cells and rat jejunum mounted on modified Ussing chambers","volume":"24","author":"Menon","year":"2003","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.ejpb.2017.03.007_b0245","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1113\/expphysiol.2005.029959","article-title":"H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine","volume":"92","author":"Thwaites","year":"2007","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.ejpb.2017.03.007_b0250","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1248\/bpb.26.886","article-title":"Factors affecting the microclimate pH of the rat jejunum in ringer bicarbonate buffer","volume":"26","author":"Legen","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejpb.2017.03.007_b0255","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1136\/gut.28.6.707","article-title":"Mucosal surface pH of the large intestine of the rat and of normal and inflamed large intestine in man","volume":"28","author":"McNeil","year":"1987","journal-title":"Gut"},{"key":"10.1016\/j.ejpb.2017.03.007_b0260","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/jps.2600751209","article-title":"Effects of potential damaging agents on the microclimate-pH in the rat jejunum","volume":"75","author":"Iwatsubo","year":"1986","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.03.007_b0265","doi-asserted-by":"crossref","first-page":"G678","DOI":"10.1152\/ajpgi.00098.2013","article-title":"Glucose-dependent insulinotropic polypeptide regulates dipeptide absorption in mouse jejunum","volume":"305","author":"Coon","year":"2013","journal-title":"Amer. J. Physiol. \u2013 Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejpb.2017.03.007_b0270","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF00580717","article-title":"PH-microclimate at the luminal surface of the intestinal mucosa of guinea pig and rat","volume":"407","author":"Rechkemmer","year":"1986","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.ejpb.2017.03.007_b0275","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1136\/gut.19.8.735","article-title":"Acid microclimate in coeliac and Crohn's disease: a model for folate malabsorption","volume":"19","author":"Lucas","year":"1978","journal-title":"Gut"},{"key":"10.1016\/j.ejpb.2017.03.007_b0280","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijpharm.2006.11.058","article-title":"Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats","volume":"336","author":"Jain","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.03.007_b0285","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2009.03.081","article-title":"PEPT1 involved in the uptake and transepithelial transport of cefditoren in vivo and in vitro","volume":"612","author":"Zhang","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejpb.2017.03.007_b0290","doi-asserted-by":"crossref","first-page":"500","DOI":"10.2133\/dmpk.DMPK-10-RG-045","article-title":"Pharmacokinetics and mechanism of intestinal absorption of JBP485 in rats","volume":"25","author":"Cang","year":"2010","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.ejpb.2017.03.007_b0295","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1021\/bi0026371","article-title":"A novel inhibitor of the mammalian peptide transporter PepT1","volume":"40","author":"Kn\u00fctter","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejpb.2017.03.007_b0300","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1124\/dmd.112.049239","article-title":"Significance of peptide transporter 1 in the intestinal permeability of Valacyclovir in wild-type and PepT1 knockout mice","volume":"41","author":"Yang","year":"2013","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejpb.2017.03.007_b0305","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/j.lfs.2006.08.013","article-title":"Combined administration of captopril with an antihypertensive Val-Tyr di-peptide to spontaneously hypertensive rats attenuates the blood pressure lowering effect","volume":"79","author":"Matsui","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.ejpb.2017.03.007_b0310","doi-asserted-by":"crossref","first-page":"e0130638","DOI":"10.1371\/journal.pone.0130638","article-title":"Enhanced lactotripeptide bioavailability by co-ingestion of macronutrients","volume":"10","author":"Ten Have","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ejpb.2017.03.007_b0315","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.peptides.2007.11.006","article-title":"Identification of ACE-inhibitory peptides in salt-free soy sauce that are transportable across caco-2 cell monolayers","volume":"29","author":"Zhu","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.ejpb.2017.03.007_b0320","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1016\/j.bmc.2007.04.042","article-title":"Caco-2 cell permeability and stability of two d-glucopyranuronamide conjugates of thyrotropin-releasing hormone","volume":"15","author":"Wessling","year":"2007","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.ejpb.2017.03.007_b0325","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1021\/jf405639w","article-title":"Transport of Egg White ACE-Inhibitory Peptide, Gln-Ile-Gly-Leu-Phe, in Human Intestinal Caco-2 Cell Monolayers with Cytoprotective Effect","volume":"62","author":"Ding","year":"2014","journal-title":"J. Agric. Food Chem."},{"issue":"39","key":"10.1016\/j.ejpb.2017.03.007_b0330","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1021\/acs.jafc.6b02719","article-title":"Impact of in vitro gastrointestinal digestion and transepithelial transport on antioxidant and ACE-inhibitory activies of Brewers spent yeast autolysate","volume":"64","author":"Vieira","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejpb.2017.03.007_b0335","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejps.2012.10.007","article-title":"Comprehensive study on regional human intestinal permeability and prediction of fraction absorbed of drugs using the Ussing chamber technique","volume":"48","author":"Sj\u00f6berg","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.03.007_b0340","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0939-6411(02)00116-9","article-title":"In vitro and in situ evidence for the contribution of Labrasol\u00ae and Gelucire 44\/14 on transport of cephalexin and cefoperazone by rat intestine","volume":"54","author":"Koga","year":"2002","journal-title":"Eur. J. Pharm. Biopharm."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641116308980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641116308980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:30:41Z","timestamp":1760545841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641116308980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":68,"alternative-id":["S0939641116308980"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2017.03.007","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of PepT1 transport of food-derived antihypertensive peptides, Ile-Pro-Pro and Leu-Lys-Pro using in vitro, ex vivo and in vivo transport models","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2017.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}