{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:06:46Z","timestamp":1770332806793,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501536"],"award-info":[{"award-number":["81501536"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473120"],"award-info":[{"award-number":["81473120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Project of Medical and Health Technology Development Program in Shandong Province","award":["2013WS0354"],"award-info":[{"award-number":["2013WS0354"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.ejpb.2017.04.006","type":"journal-article","created":{"date-parts":[[2017,4,14]],"date-time":"2017-04-14T02:00:33Z","timestamp":1492135233000},"page":"151-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Radioiodinated hypericin disulfonic acid sodium salts as a DNA-binding probe for early imaging of necrotic myocardium"],"prefix":"10.1016","volume":"117","author":[{"given":"Xinghua","family":"Duan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuihua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaomei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongjian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wencai","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejpb.2017.04.006_b0005","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1161\/CIR.0000000000000152","article-title":"Heart disease and stroke statistics\u20132015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.ejpb.2017.04.006_b0010","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.jacc.2008.01.003","article-title":"Revascularization of the infarct-related artery: never too late to do well","volume":"51","author":"Sabate","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.ejpb.2017.04.006_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/CIRCIMAGING.114.003099","article-title":"Patient selection for elective revascularization to reduce myocardial infarction and mortality: new lessons from randomized trials, coronary physiology, and statistics","volume":"8","author":"Gould","year":"2015","journal-title":"Circ. Cardiovasc. Imaging"},{"issue":"7","key":"10.1016\/j.ejpb.2017.04.006_b0020","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0735-1097(02)01726-6","article-title":"Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis","volume":"39","author":"Allman","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/j.ejpb.2017.04.006_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12410-014-9270-4","article-title":"SPECT and PET protocols for imaging myocardial viability","volume":"7","author":"Sciagr\u00e0","year":"2014","journal-title":"Curr. Cardiovasc. Imaging Rep."},{"issue":"5","key":"10.1016\/j.ejpb.2017.04.006_b0030","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF02984480","article-title":"Clinical usefulness of ECG-gated 18F-FDG PET combined with 99mTC-MIBI gated SPECT for evaluating myocardial viability and function","volume":"18","author":"Yamakawa","year":"2004","journal-title":"Ann. Nucl. Med."},{"issue":"5","key":"10.1016\/j.ejpb.2017.04.006_b0035","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00259-003-1407-7","article-title":"Long-term prognostic value of exercise 99mTc-MIBI SPET myocardial perfusion imaging in patients after percutaneous coronary intervention","volume":"31","author":"Zhang","year":"2004","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.ejpb.2017.04.006_b0040","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/S1071-3581(05)80297-1","article-title":"111In-antimyosin and 99mTc-MIBI to detect myocardium at risk after acute myocardial infarction","volume":"2","author":"Cas\u00e1ns","year":"1995","journal-title":"J. Nucl. Cardiol."},{"issue":"4","key":"10.1016\/j.ejpb.2017.04.006_b0045","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00259-003-1136-y","article-title":"Non-invasive in vivo imaging of myocardial apoptosis and necrosis","volume":"30","author":"Flotats","year":"2003","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"issue":"2","key":"10.1016\/j.ejpb.2017.04.006_b0050","first-page":"234","article-title":"Rapid infarct imaging with a technetium-99m-labeled antimyosin recombinant single-chain Fv: evaluation in a canine model of acute myocardial infarction","volume":"34","author":"Nedelman","year":"1993","journal-title":"J. Nucl. Med.: Off. Publ. Soc. Nucl. Med."},{"issue":"3","key":"10.1016\/j.ejpb.2017.04.006_b0055","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0001-2998(99)80014-2","article-title":"The current role of infarct avid imaging","volume":"29","author":"Khaw","year":"1999","journal-title":"Semin. Nucl. Med."},{"key":"10.1016\/j.ejpb.2017.04.006_b0060","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijcard.2016.02.035","article-title":"The role of anti-myosin antibodies in perpetuating cardiac damage following myocardial infarction","volume":"209","author":"O'Donohoe","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"4","key":"10.1016\/j.ejpb.2017.04.006_b0065","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1016\/j.ijcard.2013.07.108","article-title":"Detection and quantification of acute reperfused myocardial infarction in rabbits using DISA-SPECT\/CT and 3.0T cardiac MRI","volume":"168","author":"Feng","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejpb.2017.04.006_b0070","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/eurheartj\/ehm588","article-title":"Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT","volume":"29","author":"Fonge","year":"2008","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.ejpb.2017.04.006_b0075","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.nucmedbio.2003.07.003","article-title":"Pharmacokinetics and tumor retention of 125I-labeled RGD peptide are improved by PEGylation","volume":"31","author":"Chen","year":"2004","journal-title":"Nucl. Med. Biol."},{"issue":"1","key":"10.1016\/j.ejpb.2017.04.006_b0080","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejmech.2007.03.022","article-title":"Synthesis, characterization and biological activity of Schiff base analogues of indole-3-carboxaldehyde","volume":"43","author":"Sinha","year":"2008","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"10.1016\/j.ejpb.2017.04.006_b0085","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1021\/bc500309r","article-title":"Impact of multiple negative charges on blood clearance and biodistribution characteristics of 99mTc-labeled dimeric cyclic RGD peptides","volume":"25","author":"Yang","year":"2014","journal-title":"Bioconjug. Chem."},{"issue":"2","key":"10.1016\/j.ejpb.2017.04.006_b0090","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1562\/0031-8655(2002)076<0208:PPOADO>2.0.CO;2","article-title":"Photodynamic properties of amphiphilic derivatives of aluminum tetrasulfophthalocyanine","volume":"76","author":"Allen","year":"2002","journal-title":"Photochem. Photobiol."},{"issue":"17","key":"10.1016\/j.ejpb.2017.04.006_b0095","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1021\/jm030136i","article-title":"Water soluble, core-modified porphyrins. 3. Synthesis, photophysical properties, and in vitro studies of photosensitization, uptake, and localization with carboxylic acid-substituted derivatives","volume":"46","author":"You","year":"2003","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.ejpb.2017.04.006_b0100","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijbiomac.2006.06.021","article-title":"Sulfated chitin and chitosan as novel biomaterials","volume":"40","author":"Jayakumar","year":"2007","journal-title":"Int. J. Biol. Macromol."},{"issue":"15","key":"10.1016\/j.ejpb.2017.04.006_b0105","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1021\/ol100923d","article-title":"Hoechst-IR: an imaging agent that detects necrotic tissue in vivo by binding extracellular DNA","volume":"12","author":"Dasari","year":"2010","journal-title":"Org. Lett."},{"issue":"10","key":"10.1016\/j.ejpb.2017.04.006_b0110","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1021\/bc3003309","article-title":"Biomarkers and molecular probes for cell death imaging and targeted therapeutics","volume":"23","author":"Smith","year":"2012","journal-title":"Bioconjug. Chem."},{"issue":"1","key":"10.1016\/j.ejpb.2017.04.006_b0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mrfmmm.2007.03.008","article-title":"Noncovalent interactions with DNA: an overview","volume":"623","author":"Strekowski","year":"2007","journal-title":"Mutat. Res.\/Fundament. Mol. Mech. Mutagen."},{"key":"10.1016\/j.ejpb.2017.04.006_b0120","unstructured":"Preparation of hypericin. 0 432 496 A2, 1992."},{"key":"10.1016\/j.ejpb.2017.04.006_b0125","first-page":"1","article-title":"Synthesis of hypericin via emodin anthrone derived from a two-fold Diels-Alder reaction of 1,4-benzoquinone","author":"Jiro","year":"2006","journal-title":"Nat. Prod. Commun."},{"issue":"4","key":"10.1016\/j.ejpb.2017.04.006_b0130","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3109\/1061186X.2013.867962","article-title":"Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis","volume":"22","author":"Ji","year":"2014","journal-title":"J. Drug Target."},{"issue":"11","key":"10.1016\/j.ejpb.2017.04.006_b0135","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1021\/mp500216g","article-title":"Highly efficient one-pot labeling of new phosphonium cations with fluorine-18 as potential PET agents for myocardial perfusion imaging","volume":"11","author":"Zhao","year":"2014","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.ejpb.2017.04.006_b0140","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1021\/acs.molpharmaceut.5b00630","article-title":"Synthesis and evaluation of 131I-Skyrin as a necrosis avid agent for potential targeted radionuclide therapy of solid tumors","volume":"13","author":"Wang","year":"2015","journal-title":"Mol. Pharm."},{"issue":"6","key":"10.1016\/j.ejpb.2017.04.006_b0145","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1182\/blood-2002-10-3312","article-title":"Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells","volume":"102","author":"Jiang","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ejpb.2017.04.006_b0150","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jphotobiol.2014.11.008","article-title":"DNA binding and cytotoxicity activity of a chiral iron (III) triangle complex based on a natural rosin product","volume":"142","author":"Fei","year":"2015","journal-title":"J. Photochem. Photobiol. B"},{"issue":"7","key":"10.1016\/j.ejpb.2017.04.006_b0155","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.2967\/jnumed.108.061739","article-title":"Small-animal PET of tumors with 64Cu-labeled RGD-bombesin heterodimer","volume":"50","author":"Liu","year":"2009","journal-title":"J. Nucl. Med."},{"issue":"3","key":"10.1016\/j.ejpb.2017.04.006_b0160","first-page":"309","article-title":"Synthesis and properties of hypericins substituted with acidic and basic residues: hypericin tetrasulfonic acid-A water soluble hypericin derivative","volume":"129","author":"Falk","year":"1998","journal-title":"Monatshefte fu \u00c8r Chemie"},{"key":"10.1016\/j.ejpb.2017.04.006_b0165","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jphotobiol.2016.04.005","article-title":"Characterization of the binding of an anticancer drug, lapatinib to human serum albumin","volume":"160","author":"Kabir","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"issue":"2\u20133","key":"10.1016\/j.ejpb.2017.04.006_b0170","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF02668093","article-title":"P792: a rapid clearance blood pool agent for magnetic resonance imaging: preliminary results","volume":"12","author":"Port","year":"2001","journal-title":"Magn. Reson. Mater. Phys., Biol. Med."},{"issue":"1","key":"10.1016\/j.ejpb.2017.04.006_b0175","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0005-2736(01)00421-7","article-title":"Interaction of enkephalin peptides with anionic model membranes","volume":"1558","author":"Romanowski","year":"2002","journal-title":"Biochem. Biophys. Acta."},{"issue":"3","key":"10.1016\/j.ejpb.2017.04.006_b0180","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/ph6030320","article-title":"Cell penetration properties of a highly efficient mini maurocalcine Peptide","volume":"6","author":"Tisseyre","year":"2013","journal-title":"Pharmaceuticals"},{"issue":"12","key":"10.1016\/j.ejpb.2017.04.006_b0185","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.1038\/cddis.2011.130","article-title":"Cardiomyocyte death: mechanisms and translational implications","volume":"2","author":"Chiong","year":"2011","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.ejpb.2017.04.006_b0190","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.2967\/jnumed.106.037754","article-title":"Imaging acute cardiac cell death: temporal and spatial distribution of 99mTc-labeled C2A in the area at risk after myocardial ischemia and reperfusion","volume":"48","author":"Zhu","year":"2007","journal-title":"J. Nucl. Med."},{"issue":"6","key":"10.1016\/j.ejpb.2017.04.006_b0195","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1161\/CIRCIMAGING.111.966374","article-title":"Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium","volume":"4","author":"Huang","year":"2011","journal-title":"Circ. Cardiovasc. Imaging"},{"issue":"16","key":"10.1016\/j.ejpb.2017.04.006_b0200","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1093\/nar\/25.16.3290","article-title":"In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells","volume":"25","author":"Bijsterbosch","year":"1997","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.ejpb.2017.04.006_b0205","first-page":"1315","article-title":"Minimizing liver, bowel, and gastric activity in myocardial perfusion SPECT","volume":"41","author":"van Dongen","year":"2000","journal-title":"J. Nucl. Med."},{"issue":"7","key":"10.1016\/j.ejpb.2017.04.006_b0210","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/00006231-199907000-00005","article-title":"Metoclopramide has no effect on abdominal activity of sestamibi in myocardial SPET","volume":"20","author":"Weinmann","year":"1999","journal-title":"Nucl. Med. Commun."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641116304167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641116304167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T20:13:21Z","timestamp":1589746401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641116304167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":42,"alternative-id":["S0939641116304167"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2017.04.006","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radioiodinated hypericin disulfonic acid sodium salts as a DNA-binding probe for early imaging of necrotic myocardium","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2017.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}