{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:23:43Z","timestamp":1778757823021,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.ejpb.2017.07.013","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T20:00:27Z","timestamp":1501012827000},"page":"426-436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["A comparison of three Peyer\u2019s patch \u201cM-like\u201d cell culture models: particle uptake, bacterial interaction, and epithelial histology"],"prefix":"10.1016","volume":"119","author":[{"given":"Tauseef","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Gogarty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin G.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Brayden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2017.07.013_b0005","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/imr.12400","article-title":"Peyer\u2019s patches: Organizing B-cell responses at the intestinal frontier","volume":"271","author":"Reboldi","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ejpb.2017.07.013_b0010","doi-asserted-by":"crossref","first-page":"6110","DOI":"10.1073\/pnas.0400969101","article-title":"Intestinal villous M cells: an antigen entry site in the mucosal epithelium","volume":"101","author":"Jang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejpb.2017.07.013_b0015","unstructured":"N.A. Mabbott, D.S. Donaldson, H. Ohno, I.R. Williams, Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium, 6 (2013) 666\u2013677."},{"key":"10.1016\/j.ejpb.2017.07.013_b0020","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0264-410X(02)00613-8","article-title":"Oral immunization of adult volunteers with microencapsulated enterotoxigenic Escherichia coli (ETEC) CS6 antigen","volume":"21","author":"Katz","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.ejpb.2017.07.013_b0025","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1021\/acs.molpharmaceut.5b00265","article-title":"Combinatorial approach of antigen delivery using M cell-homing peptide and mucoadhesive vehicle to enhance the efficacy of oral vaccine","volume":"12","author":"Singh","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2017.07.013_b0030","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S1359-6446(05)03536-1","article-title":"Keynote review: intestinal Peyer\u2019s patch M cells and oral vaccine targeting","volume":"10","author":"Brayden","year":"2005","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejpb.2017.07.013_b0035","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-2559.1994.tb00550.x","article-title":"M-cells are damaged and increased in number in inflamed human ileal mucosa","volume":"24","author":"Cuvelier","year":"1994","journal-title":"Histopathology."},{"key":"10.1016\/j.ejpb.2017.07.013_b0040","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1128\/IAI.67.2.946-953.1999","article-title":"Human intestinal M cells display the sialyl Lewis A antigen","volume":"67","author":"Giannasca","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejpb.2017.07.013_b0045","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.277.5328.949","article-title":"Conversion by Peyer\u2019s Patch lymphocytes of human enterocytes into M Cells that transport bacteria","volume":"277","author":"Kern\u00e9is","year":"1997","journal-title":"Science (80-)"},{"key":"10.1016\/j.ejpb.2017.07.013_b0050","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S1286-4579(00)01266-1","article-title":"Molecular studies of the intestinal mucosal barrier physiopathology using cocultures of epithelial and immune cells: a technical update","volume":"2","author":"Kern\u00e9is","year":"2000","journal-title":"Microbes Infect."},{"key":"10.1016\/j.ejpb.2017.07.013_b0055","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1006\/bbrc.2000.4038","article-title":"Expression of specific markers and particle transport in a new human intestinal M-cell model","volume":"279","author":"Gullberg","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejpb.2017.07.013_b0060","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ejps.2005.04.015","article-title":"Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium","volume":"25","author":"des Rieux","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.07.013_b0065","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/intimm\/dxh011","article-title":"Cell culture modeling of specialized tissue: identification of genes expressed specifically by follicle-associated epithelium of Peyer\u2019s patch by expression profiling of Caco-2\/Raji co-cultures","volume":"16","author":"Lo","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1016\/j.ejpb.2017.07.013_b0070","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ejps.2006.12.006","article-title":"An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells","volume":"30","author":"des Rieux","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.07.013_b0075","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1038\/nprot.2007.303","article-title":"Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers","volume":"2","author":"Hubatsch","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejpb.2017.07.013_b0080","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejpb.2015.05.013","article-title":"Sodium caprate-induced increases in intestinal permeability and epithelial damage are prevented by misoprostol","volume":"94","author":"Brayden","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2017.07.013_b0085","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nprot.2017.041","article-title":"A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation","volume":"12","author":"Beloqui","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejpb.2017.07.013_b0090","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.addr.2004.07.014","article-title":"Use of fluorescence imaging to investigate the structure and function of intestinal M cells","volume":"57","author":"Buda","year":"2005","journal-title":"Adv Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2017.07.013_b0095","doi-asserted-by":"crossref","DOI":"10.1099\/mic.0.2008\/021162-0","article-title":"Salmonella translocates across an in vitro M cell model independently of SPI-1 and SPI-2","volume":"154","author":"Martinez-Argudo","year":"2008","journal-title":"Microbiology"},{"key":"10.1016\/j.ejpb.2017.07.013_b0100","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/1574-6968.12323","article-title":"Translocation of Vibrio parahaemolyticus across an in vitro M cell model","volume":"350","author":"Finn","year":"2014","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ejpb.2017.07.013_b0105","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.xphs.2016.03.043","article-title":"The pro-inflammatory cytokine interleukin-6 regulates nanoparticle transport across model follicle-associated epithelium cells","volume":"105","author":"Miyake","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.07.013_b0110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejps.2017.05.054","article-title":"A new cell-to-cell interaction model for epithelial microfold cell formation and the enhancing effect of epidermal growth factor","volume":"106","author":"Chaikhumwang","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2015","key":"10.1016\/j.ejpb.2017.07.013_b0115","first-page":"782","article-title":"In vitro M-like cells genesis through a tissue-engineered triple-culture intestinal model","volume":"104","author":"Araujo","year":"2015","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.ejpb.2017.07.013_b0120","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1021\/mp400507g","article-title":"Development of an advanced intestinal in vitro triple culture permeability model to study transport of nanoparticles","volume":"11","author":"Schimpel","year":"2014","journal-title":"Mol. Pharm."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641117303405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641117303405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T10:24:39Z","timestamp":1602584679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641117303405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":24,"alternative-id":["S0939641117303405"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2017.07.013","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comparison of three Peyer\u2019s patch \u201cM-like\u201d cell culture models: particle uptake, bacterial interaction, and epithelial histology","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2017.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}