{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:06:16Z","timestamp":1790021176181,"version":"4.0.1"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["2015\/01268-2"],"award-info":[{"award-number":["2015\/01268-2"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.ejpb.2017.11.012","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T04:33:29Z","timestamp":1511498009000},"page":"84-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"special_numbering":"C","title":["Retrograded starch\/pectin coated gellan gum-microparticles for oral administration of insulin: A technological platform for protection against enzymatic degradation and improvement of intestinal permeability"],"prefix":"10.1016","volume":"123","author":[{"given":"Andr\u00e9ia B.","family":"Meneguin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Beyssac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislain","family":"Garrait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassana","family":"Hsein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz S.F.","family":"Cury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2017.11.012_b0005","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jconrel.2015.11.023","article-title":"pH responsive and enzymatically-responsive hydrogel microparticles for the oral delivery of therapeutic proteins: Effects of protein size, crosslinking density, and hydrogel degradation on protein delivery","volume":"221","author":"Koetting","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2017.11.012_b0010","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.yexcr.2011.02.013","article-title":"Introduction to current and future protein therapeutics: a protein engineering perspective","volume":"317","author":"Carter","year":"2011","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.ejpb.2017.11.012_b0015","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.drudis.2014.09.003","article-title":"An overview of FDA-approved biologics medicines","volume":"20","author":"Kinch","year":"2015","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejpb.2017.11.012_b0020","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/B978-0-12-391860-4.00014-8","article-title":"Nanotechnology as a promising strategy for alternative routes of insulin delivery","author":"Reis","year":"2012"},{"key":"10.1016\/j.ejpb.2017.11.012_b0025","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/adc.2010.183731","article-title":"Lipoatrophy with insulin analogues in type I diabetes","volume":"96","author":"Babiker","year":"2010","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ejpb.2017.11.012_b0030","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.carbpol.2011.01.057","article-title":"\u03b2-Cyclodextrin grafting hyperbranched polyglycerols as carriers for nasal insulin delivery","volume":"84","author":"Zhang","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2017.11.012_b0035","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0378-5173(99)00471-8","article-title":"In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption","volume":"198","author":"Onuki","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0040","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jconrel.2009.03.019","article-title":"Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery","volume":"137","author":"Chono","year":"2009","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2017.11.012_b0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijpharm.2010.07.029","article-title":"Effect of different enhancers on the transdermal permeation of insulin analog","volume":"398","author":"Yerramsetty","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0050","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ejps.2006.04.014","article-title":"Nanoscale analysis of protein and peptide absorption: insulin absorption using complexation and pH-sensitive hydrogels as delivery vehicles","volume":"29","author":"Peppas","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.11.012_b0055","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S1359-6446(01)01962-6","article-title":"Insulin therapies \u2013 past, present and future","volume":"6","author":"Pillai","year":"2001","journal-title":"Drug Discov. Today."},{"key":"10.1016\/j.ejpb.2017.11.012_b0060","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ijpharm.2006.05.050","article-title":"Development of PEGDMA: MAA based hydrogel microparticles for oral insulin delivery","volume":"323","author":"Kumar","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0065","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ijpharm.2012.03.056","article-title":"Oral delivery of therapeutic protein\/peptide for diabetes \u2013 future perspectives","volume":"440","author":"Rekha","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0070","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.addr.2007.08.019","article-title":"Current challenges in noninvasive insulin delivery systems: a comparative review","volume":"59","author":"Khafagy","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2017.11.012_b0075","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijpharm.2003.03.001","article-title":"Devices based on intelligent biopolymers for oral protein delivery","volume":"277","author":"Peppas","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0080","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.carbpol.2014.07.021","article-title":"Mucoadhesive beads of gellan gum\/pectin intended to controlled delivery of drugs","volume":"113","author":"Prezotti","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2017.11.012_b0085","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.carbpol.2011.02.010","article-title":"Al+3 ion cross-linked and acetalated gellan hydrogel network beads for prolonged release of glipizide","volume":"85","author":"Maiti","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2017.11.012_b0090","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.colsurfb.2015.10.016","article-title":"Whey protein mucoadhesive properties for oral drug delivery: mucin\u2013whey protein interaction and mucoadhesive bond strength","volume":"136","author":"Hsein","year":"2015","journal-title":"Colloid. Surface B"},{"key":"10.1016\/j.ejpb.2017.11.012_b0095","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1208\/s12249-010-9384-1","article-title":"Stomach-specific controlled release gellan beads of acid-soluble drug prepared by ionotropic gelation method","volume":"11","author":"Narkar","year":"2010","journal-title":"AAPS PharmSciTech."},{"key":"10.1016\/j.ejpb.2017.11.012_b0100","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.biotechadv.2014.07.006","article-title":"A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules","volume":"32","author":"Choonara","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ejpb.2017.11.012_b0105","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejpb.2016.08.002","article-title":"In vitro and in vivo evaluation of an oral multiple-unit formulation for colonic delivery of insulin","volume":"108","author":"Maroni","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0110","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.phrs.2016.05.016","article-title":"Oral delivery of insulin via polyethylene imine-based nanoparticles for colonic release allows glycemic control in diabetic rats","volume":"110","author":"Salvioni","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejpb.2017.11.012_b0115","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jconrel.2010.04.024","article-title":"Novel pectin\u20134-aminothiophenole conjugate microparticles for colon-specific drug delivery","volume":"145","author":"Perera","year":"2010","journal-title":"J. Control. Release."},{"key":"10.1016\/j.ejpb.2017.11.012_b0120","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.carbpol.2013.07.077","article-title":"Films from resistant starch-pectin dispersions intended for colonic drug delivery","volume":"99","author":"Meneguin","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2017.11.012_b0125","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.carbpol.2016.10.062","article-title":"Resistant starch\/pectin free-standing films reinforced with nanocellulose intended for colonic methotrexate release","volume":"157","author":"Meneguin","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2017.11.012_b0130","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.1016\/j.biomaterials.2012.05.013","article-title":"Elucidating the signaling mechanism of an epithelial tight-junction opening induced by chitosan","volume":"33","author":"Hsu","year":"2012","journal-title":"Biomaterial"},{"key":"10.1016\/j.ejpb.2017.11.012_b0135","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijpharm.2013.06.016","article-title":"Whey protein and alginate hydrogel microparticles for insulin intestinal absorption: evaluation of permeability enhancement properties on Caco-2 cells","volume":"453","author":"D\u00e9at-Lain\u00e9","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0140","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1002\/marc.201400267","article-title":"Natural anionic polymer acts as highly efficient trypsin inhibitor based on an electrostatic interaction mechanism","volume":"35","author":"Lv","year":"2014","journal-title":"Macromol. Rapid Commun."},{"key":"10.1016\/j.ejpb.2017.11.012_b0145","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1085\/jgp.110.6.727","article-title":"Calcium site specificity. Early Ca2+-related tight junction events","volume":"110","author":"Lacaz-Vieira","year":"1997","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejpb.2017.11.012_b0150","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jconrel.2010.08.007","article-title":"Cyclodextrin complexed insulin encapsulated hydrogel microparticles: an oral delivery system for insulin","volume":"147","author":"Sajeesh","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2017.11.012_b0155","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0168-3659(00)00274-1","article-title":"Optimization of an in vitro procedure for the determination of the enzymatic inhibition potency of multifunctional polymers","volume":"68","author":"Ameye","year":"2000","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2017.11.012_b0160","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.carbpol.2015.04.007","article-title":"Preparation and characterization of a bacterial cellulose\/silk fibroin sponge scaffold for tissue regeneration","volume":"128","author":"Barud","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2017.11.012_b0165","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijpharm.2014.12.058","article-title":"In-vitro evaluation of the effect of polymer structure on uptake of novel polymer-insulin polyelectrolyte complexes by human epithelial cells","volume":"479","author":"Ibie","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0170","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ijbiomac.2014.06.046","article-title":"gum microspheres containing a novel -amylase from marine Nocardiopsis sp. strain B2 for immobilization","volume":"70","author":"Chakrabortya","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2017.11.012_b0175","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1021\/bm030072t","article-title":"Binding effect of Cu2+ as a trigger on the sol-to-gel and the coil-to-helix transition processes of polysaccharide gellan gum","volume":"5","author":"Kanesaka","year":"2004","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ejpb.2017.11.012_b0180","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0378-5173(98)00351-2","article-title":"Effect of the formulation on the in vitro release of propranolol from gellan beads","volume":"178","author":"Kedzierewicz","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0185","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jcis.2009.05.027","article-title":"Prediction models for shape and size of ca-alginate macrobeads produced through extrusion\u2013dripping method","volume":"338","author":"Chan","year":"2009","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ejpb.2017.11.012_b0190","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ijbiomac.2013.03.065","article-title":"A RP-HPLC method for quantification of diclofenac sodium released from biological macromolecules","volume":"58","author":"Bhattacharya","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2017.11.012_b0195","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2174\/156720110790396445","article-title":"Formulation of controlled release gellan gum macro beads of amoxicillin","volume":"7","author":"Babu","year":"2010","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.ejpb.2017.11.012_b0200","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0031-6865(97)00040-X","article-title":"Effect of coating of aluminium carboxymethylcellulose beads on the release and bioavailability of diclofenac sodium","volume":"72","author":"Hosny","year":"1998","journal-title":"Pharm. Acta Helvetiae"},{"key":"10.1016\/j.ejpb.2017.11.012_b0205","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.ijbiomac.2012.08.021","article-title":"Calcium alginate\/gum arabic beads containing glibenclamide: development and in vitro characterization","volume":"51","author":"Nayak","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2017.11.012_b0210","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/02652040110081389","article-title":"Gastric resistant microbeads of metal ion cross-linked carboxymethyl guar gum for oral drug delivery","volume":"19","author":"Reddy","year":"2002","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.ejpb.2017.11.012_b0215","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejpb.2010.09.016","article-title":"Preparation and evaluation of alginate\u2013chitosan microspheres for oral delivery of insulin","volume":"77","author":"Zhang","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0220","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijbiomac.2013.03.064","article-title":"Oral delivery of insulin from alginate\/chitosan crosslinked by glutaraldehyde","volume":"58","author":"Tahtat","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2017.11.012_b0225","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3109\/10717544.2010.528067","article-title":"Mucoadhesive hydrogel microparticles based on poly (methacrylic acid-vinyl pyrrolidone)-chitosan for oral drug delivery","volume":"18","author":"Sajeesh","year":"2011","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejpb.2017.11.012_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-3659(97)00204-6","article-title":"The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins","volume":"52","author":"Bernkop-Schnurch","year":"1998","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2017.11.012_b0235","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ijpharm.2012.10.003","article-title":"Development and in vitro characterization of insulin loaded whey protein and alginate microparticles","volume":"439","author":"D\u00e9at-Lain\u00e9","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0240","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jconrel.2004.02.013","article-title":"Controlling the mechanism of trypsin inhibition by the numbers of \u03b1-cyclodextrins and carboxyl groups in carboxyethylester-polyrotaxanes","volume":"96","author":"Eguchi","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2017.11.012_b0245","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.carbpol.2012.08.044","article-title":"Development and in vitro evaluation of coated pellets containing chitosan to potential colonic drug delivery","volume":"91","author":"Ferrari","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2017.11.012_b0250","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ijpharm.2004.03.008","article-title":"Cross-linked high amylose starch derivatives for drug release: II. swelling properties and mechanistic study","volume":"278","author":"Mulhbacher","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0255","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.carbpol.2014.02.022","article-title":"Ispaghula mucilage-gellan mucoadhesive beads of metformin HCl: development by response surface methodology","volume":"107","author":"Nayak","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2017.11.012_b0260","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0268-005X(03)00039-0","article-title":"Surface characterization and dissolution properties of high amylose corn starch\u2013pectin coatings","volume":"18","author":"Dimantov","year":"2004","journal-title":"Food Hydrocolloid"},{"key":"10.1016\/j.ejpb.2017.11.012_b0265","series-title":"Pectin: Chemical Properties, Uses and Health Benefits","first-page":"65","article-title":"Oral drug release systems based on pectin","author":"Cury","year":"2014"},{"key":"10.1016\/j.ejpb.2017.11.012_b0270","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0378-5173(83)90064-9","article-title":"Mechanisms of solute release from porous hydrophilic polymers","volume":"15","author":"Korsmeyer","year":"1983","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0275","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejpb.2004.03.023","article-title":"Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs","volume":"58","author":"Van der Merwe","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0280","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/(SICI)1520-6017(200001)89:1<63::AID-JPS7>3.0.CO;2-6","article-title":"Caco-2 versus caco-2\/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport","volume":"89","author":"Hilgendorf","year":"2000","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2017.11.012_b0285","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1208\/s12249-010-9390-3","article-title":"Insulin loaded nanoparticles based on N-trimethyl chitosan: in vitro (caco-2 model) and ex vivo (excised rat jejunum, duodenum, and ileum) evaluation of penetration enhancement properties","volume":"11","author":"Sandri","year":"2010","journal-title":"AAPS Pharm. Sci. Tech."},{"key":"10.1016\/j.ejpb.2017.11.012_b0290","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.carbpol.2010.08.005","article-title":"Structure\u2013activity relationships of methylated N-aryl chitosan derivatives for enhancing paracellular permeability across Caco-2 cells","volume":"83","author":"Kowapradit","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2017.11.012_b0295","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijpharm.2005.01.022","article-title":"Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium","volume":"294","author":"Salamat-Miller","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2017.11.012_b0300","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.ijbiomac.2017.05.138","article-title":"Can natural polymers assist in delivering insulin orally?","volume":"103","author":"Nur","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2017.11.012_b0305","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ejpb.2008.09.028","article-title":"Mucoadhesive polymeric platforms for controlled drug delivery","volume":"71","author":"Andrews","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641117306732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641117306732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T16:52:38Z","timestamp":1535215958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641117306732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":61,"alternative-id":["S0939641117306732"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2017.11.012","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retrograded starch\/pectin coated gellan gum-microparticles for oral administration of insulin: A technological platform for protection against enzymatic degradation and improvement of intestinal permeability","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2017.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}