{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:44:54Z","timestamp":1790837094037,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"European Regional Development Fund in the Framework of the Polish Innovation Economy Operational Program","award":["POIG.02.01.00-12-023\/08"],"award-info":[{"award-number":["POIG.02.01.00-12-023\/08"]}]},{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre","doi-asserted-by":"crossref","award":["2011\/03\/B\/ST5\/01557"],"award-info":[{"award-number":["2011\/03\/B\/ST5\/01557"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre","doi-asserted-by":"crossref","award":["2017\/01\/X\/NZ7\/01148"],"award-info":[{"award-number":["2017\/01\/X\/NZ7\/01148"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.ejpb.2018.04.016","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T13:03:12Z","timestamp":1523970192000},"page":"69-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Polymeric micelle-mediated delivery of half-sandwich ruthenium(II) complexes with phosphanes derived from fluoroloquinolones for lung adenocarcinoma treatment"],"prefix":"10.1016","volume":"128","author":[{"given":"Przemys\u0142aw","family":"Ko\u0142oczek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Sk\u00f3rska-Stania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Cierniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Sebastian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula K.","family":"Komarnicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"P\u0142otek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Kyzio\u0142","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2018.04.016_b0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jorganchem.2017.03.038","article-title":"Advances in the design of organometallic anticancer complexes","volume":"839","author":"Zhang","year":"2017","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0010","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jinorgbio.2017.08.034","article-title":"Anticancer Ru(\u03b76-p-cymene) complexes of 2-pyridinecarbothioamides: a structure\u2013activity relationship study","volume":"177","author":"Arshad","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep43005","article-title":"Combination of ruthenium(II)-arene complex [Ru(\u03b76-p-cymene)Cl2(pta)] (RAPTA-C) and the epidermal growth factor receptor inhibitor erlotinib results in efficient angiostatic and antitumor activity","volume":"7","author":"Berndsen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejpb.2018.04.016_b0020","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ejmech.2017.11.059","article-title":"Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells","volume":"143","author":"Teixeira","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0025","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ejmech.2012.08.001","article-title":"Organometallic ruthenium(II) complexes: Synthesis, structure and influence of substitution at azomethine carbon towards DNA\/BSA binding, radical scavenging and cytotoxicity","volume":"55","author":"Sathyadevi","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0030","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jinorgbio.2016.04.008","article-title":"How half sandwich ruthenium compounds interact with DNA while not being hydrolyzed; a comparative study","volume":"160","author":"Tsolis","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0035","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1039\/C7CS00195A","article-title":"The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials","volume":"46","author":"Zeng","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejpb.2018.04.016_b0040","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jinorgbio.2017.12.011","article-title":"Delivery of [Ru(\u03b76-p-cymene)Cl2{Ph2P(CH2)3SPh-\u03baP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study","volume":"180","author":"Edeler","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0045","first-page":"1747","article-title":"HERG K+ channel related chemosensitivity to sparfloxacin in colon cancer cells","volume":"23","author":"Gong","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejpb.2018.04.016_b0050","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jinorgbio.2017.02.017","article-title":"Ruthenium(II) piano stool coordination compounds with aminomethylphosphanes: synthesis, characterisation and preliminary biological study in vitro","volume":"170","author":"P\u0142otek","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0055","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1039\/C5DT04011F","article-title":"Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode","volume":"45","author":"Komarnicka","year":"2016","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejpb.2018.04.016_b0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jinorgbio.2016.09.015","article-title":"New copper(I) complexes bearing lomefloxacin motif: spectroscopic properties, in vitro cytotoxicity and interactions with DNA and human serum albumin","volume":"165","author":"Komarnicka","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0065","doi-asserted-by":"crossref","DOI":"10.1039\/C7DT03917D","article-title":"Copper(I) complexes with phosphine derived from sparfloxacin. Part III: multifaceted cell death and preliminary study of liposomal formulation of selected copper(I) complex","author":"Kyzio\u0142","year":"2018","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejpb.2018.04.016_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2018.01.008","article-title":"CuI and CuII complexes with phosphine derivatives of fluoroquinolone antibiotics \u2013 a comparative study on the cytotoxic mode of action","author":"Bykowska","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0075","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejpb.2016.12.019","article-title":"Polymeric mixed micelles as nanomedicines: achievements and perspectives","volume":"113","author":"Cagel","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2018.04.016_b0080","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jorganchem.2015.05.011","article-title":"Arene ruthenium dithiolatoecarborane complexes for boron neutron capture therapy (BCNT)","volume":"796","author":"Romero-Canelon","year":"2015","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0085","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1002\/smll.201500288","article-title":"Polymeric micelle-mediated delivery of DNA-targeting organometallic complexes for resistant ovarian cancer treatment","volume":"11","author":"Duan","year":"2015","journal-title":"Small"},{"key":"10.1016\/j.ejpb.2018.04.016_b0090","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1021\/ma402078d","article-title":"Superior Chemotherapeutic benefits from the ruthenium-based anti-metastatic drug NAMI-A through conjugation to polymeric micelles","volume":"47","author":"Blunden","year":"2014","journal-title":"Macromolecules"},{"key":"10.1016\/j.ejpb.2018.04.016_b0095","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/adhm.201500827","article-title":"Ruthenium-containing block copolymer assemblies: red-light-responsive metallopolymers with tunable nanostructures for enhanced cellular uptake and anticancer phototherapy","volume":"5","author":"Sun","year":"2016","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.ejpb.2018.04.016_b0100","doi-asserted-by":"crossref","first-page":"1603702","DOI":"10.1002\/adma.201603702","article-title":"An amphiphilic ruthenium polymetallodrug for combined photodynamic therapy and photochemotherapy in vivo","volume":"29","author":"Sun","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejpb.2018.04.016_b0105","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1039\/C7DT03390G","article-title":"Photoresponsive ruthenium-containing polymers: potential polymeric metallodrugs for anticancer phototherapy","volume":"47","author":"Sun","year":"2018","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejpb.2018.04.016_b0110","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.molstruc.2015.04.044","article-title":"Phosphine derivatives of sparfloxacin \u2013 Synthesis, structures and in vitro activity","volume":"1096","author":"Komarnicka","year":"2015","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ejpb.2018.04.016_b0115","unstructured":"Agilent, CrysAlis PRO, Agilent Technologies Ltd., Yarnton, Oxfordshire, England, 2015."},{"key":"10.1016\/j.ejpb.2018.04.016_b0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","article-title":"Crystal structure refinement with SHELXL","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr. C"},{"key":"10.1016\/j.ejpb.2018.04.016_b0125","unstructured":"Mercury 3.9."},{"key":"10.1016\/j.ejpb.2018.04.016_b0130","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.poly.2016.10.003","article-title":"Synthesis and structural characterization of new heteroleptic copper(I) complexes based on mixed phosphine\/thiocarbamoyl-pyrazoline ligands","volume":"121","author":"Favarin","year":"2017","journal-title":"Polyhedron"},{"key":"10.1016\/j.ejpb.2018.04.016_b0135","doi-asserted-by":"crossref","first-page":"13969","DOI":"10.1039\/C5DT01119A","article-title":"New ruthenium(II) coordination compounds possessing bidentate aminomethylphosphane ligands: synthesis, characterisation and biological study in vitro","volume":"44","author":"P\u0142otek","year":"2015","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejpb.2018.04.016_b0140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0022-328X(02)01926-5","article-title":"Synthesis and characterisation of some water soluble ruthenium(II)-arene complexes and an investigation of their antibiotic and antiviral properties","volume":"668","author":"Allardyce","year":"2003","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0145","article-title":"DNA interactions mediated by cyclopentadienidoruthenium(II) complexes containing water-soluble phosphanes","volume":"2803\u20132812","author":"Romerosa","year":"2007","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0150","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jinorgbio.2015.07.016","article-title":"Cytotoxicity of Ru(II) piano\u2013stool complexes with chloroquine and chelating ligands against breast and lung tumor cells: Interactions with DNA and BSA","volume":"153","author":"Colina-Vegas","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0155","doi-asserted-by":"crossref","first-page":"12865","DOI":"10.1039\/C7DT01801K","article-title":"Half sandwich Ru(II)-acylthioureas complexes: DNA\/HSA-binding, antimigration and cell death properties in a breast tumor cell line","volume":"46","author":"Colina-Vegasa","year":"2017","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejpb.2018.04.016_b0160","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.freeradbiomed.2016.04.198","article-title":"Mitochondrial ROS regulation of proliferating cells","volume":"100","author":"Diebold","year":"2016","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.ejpb.2018.04.016_b0165","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.poly.2007.08.037","article-title":"Half-sandwich para-cymene ruthenium(II) naphthylazophenolato complexes: Synthesis, molecular structure, light emission, redox behavior and catalytic oxidation properties","volume":"27","author":"Kumar","year":"2008","journal-title":"Polyhedron"},{"key":"10.1016\/j.ejpb.2018.04.016_b0170","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1021\/om101146q","article-title":"Coordination Chemistry of the (\u03b76-p-Cymene)ruthenium(II) fragment with Bis-, Tris-, and Tetrakis(pyrazol-1-yl)borate ligands: synthesis, structural, electrochemical, and catalytic diastereoselective nitroaldol reaction studies","volume":"30","author":"Pettinari","year":"2011","journal-title":"Organometallics"},{"key":"10.1016\/j.ejpb.2018.04.016_b0175","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ccr.2008.04.014","article-title":"Functionalised \u03b76-arene ruthenium complexes","volume":"253","author":"Therrien","year":"2009","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.ejpb.2018.04.016_b0180","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1089\/ars.2010.3663","article-title":"Anticancer activity of metal complexes: involvement of redox processes","volume":"15","author":"Jungwirth","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.ejpb.2018.04.016_b0185","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jinorgbio.2016.01.005","article-title":"Synthesis, characterization and biological evaluation of novel Ru(II)\u2013arene complexes containing intercalating ligands","volume":"160","author":"Nikolic","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ma9050386","article-title":"Microwave-assisted synthesis of arene Ru(II) complexes induce tumor cell apoptosis through selectively binding and stabilizing bcl-2 G-quadruplex DNA","volume":"9","author":"Chen","year":"2016","journal-title":"Materials"},{"key":"10.1016\/j.ejpb.2018.04.016_b0195","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ijpharm.2017.09.005","article-title":"Polymeric micelles: basic research to clinical practice","volume":"532","author":"Deshmukh","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2018.04.016_b0200","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1039\/C2CS35312A","article-title":"Multicompartmentalized polymeric systems: towards biomimetic cellular structure and function","volume":"42","author":"Marguet","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejpb.2018.04.016_b0205","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.colsurfb.2015.09.034","article-title":"Design of liposomal formulations for cell targeting","volume":"136","author":"Nogueira","year":"2015","journal-title":"Colloids Surf. B: Biointerf."},{"key":"10.1016\/j.ejpb.2018.04.016_b0210","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejpb.2015.03.018","article-title":"Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy","volume":"93","author":"P\u00e9rez-Herrero","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2018.04.016_b0215","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jconrel.2016.11.015","article-title":"To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?","volume":"244","author":"Danhier","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2018.04.016_b0220","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1021\/acs.bioconjchem.6b00437","article-title":"Nanodrug delivery: is the enhanced permeability and retention effect sufficient for curing cancer?","volume":"27","author":"Nakamura","year":"2016","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.ejpb.2018.04.016_b0225","article-title":"Overcoming obstacles in the tumor microenvironment: recent advancements in nanoparticle delivery for cancer theranostics","author":"Overchuk","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2018.04.016_b0230","doi-asserted-by":"crossref","first-page":"14768","DOI":"10.1002\/chem.201303341","article-title":"DMSO-mediated ligand dissociation: renaissance for biological activity of N-heterocyclic-[Ru(\u03b76-arene)Cl2] drug candidates","volume":"19","author":"Patra","year":"2013","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.ejpb.2018.04.016_b0235","doi-asserted-by":"crossref","first-page":"22039","DOI":"10.1021\/acsami.6b07031","article-title":"Design of pluronic-based formulation for enhanced redaporfin-photodynamic therapy against pigmented melanoma","volume":"8","author":"Pucelik","year":"2016","journal-title":"ACS Appl. Mater. Interf."},{"key":"10.1016\/j.ejpb.2018.04.016_b0240","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.1016\/j.biomaterials.2011.04.075","article-title":"The potential of pluronic polymeric micelles encapsulated with paclitaxel for the treatment of melanoma using subcutaneous and pulmonary metastatic mice models","volume":"32","author":"Zhang","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2018.04.016_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ica.2016.01.006","article-title":"Current and future potential of metallo drugs: Revisiting DNA-binding of metal containing molecules and their diverse mechanism of action","volume":"444","author":"Zaki","year":"2016","journal-title":"Inorganica Chimica Acta"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641118301061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641118301061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T06:46:34Z","timestamp":1561704394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641118301061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":49,"alternative-id":["S0939641118301061"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2018.04.016","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polymeric micelle-mediated delivery of half-sandwich ruthenium(II) complexes with phosphanes derived from fluoroloquinolones for lung adenocarcinoma treatment","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2018.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}