{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:11:04Z","timestamp":1789477864986,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000980","name":"Arthritis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000980","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.ejpb.2018.05.001","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T05:42:05Z","timestamp":1525326125000},"page":"327-336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Sustained intra-articular release of celecoxib in an equine repeated LPS synovitis model"],"prefix":"10.1016","volume":"128","author":[{"given":"Stefan M.","family":"Cokelaere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia G.M.","family":"Plomp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"de Boef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"de Leeuw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Bool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris H.A.","family":"van de Lest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Ren\u00e9","family":"van Weeren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoline M.","family":"Korthagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2018.05.001_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/157339708785133523","article-title":"Animal models of osteoarthritis","volume":"4","author":"Little","year":"2008","journal-title":"Curr. Rheumatol. Rev."},{"key":"10.1016\/j.ejpb.2018.05.001_b0010","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nrrheum.2016.93","article-title":"The brain-joint axis in osteoarthritis: nerves, circadian clocks and beyond","volume":"12","author":"Berenbaum","year":"2016","journal-title":"Nat. Rev. Rheum."},{"key":"10.1016\/j.ejpb.2018.05.001_b0015","series-title":"Joint Disease in the horse","first-page":"33","article-title":"Traumatic arthritis and posttraumatic osteoarthritis in the horse","author":"McIlwraith","year":"2016"},{"key":"10.1016\/j.ejpb.2018.05.001_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/joca.2001.0488","article-title":"Osteoarthritis or osteoarthrosis: the definition of inflammation becomes a semantic issue in the genomic era of molecular medicine","volume":"10","author":"Attur","year":"2002","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejpb.2018.05.001_b0025","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nrrheum.2016.136","article-title":"Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis","volume":"12","author":"Robinson","year":"2016","journal-title":"Nat. Rev. Rheum."},{"key":"10.1016\/j.ejpb.2018.05.001_b0030","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nrrheum.2015.95","article-title":"Cartilage damage in osteoarthritis and rheumatoid arthritis \u2013 two unequal siblings","volume":"11","author":"Pap","year":"2015","journal-title":"Nat. Rev. Rheum."},{"key":"10.1016\/j.ejpb.2018.05.001_b0035","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.joca.2015.02.009","article-title":"Inflammatory biomarkers in osteoarthritis","volume":"23","author":"Daghestani","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejpb.2018.05.001_b0040","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2165\/00003495-200059040-00017","article-title":"Celecoxib: a review of its use in osteoarthritis, rheumatoid arthritis and acute pain","volume":"59","author":"Clemett","year":"2000","journal-title":"Drugs"},{"key":"10.1016\/j.ejpb.2018.05.001_b0045","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/rheumatology\/kei187","article-title":"Inhibition of COX-2 by celecoxib in the canine groove model of osteoarthritis","volume":"45","author":"Mastbergen","year":"2006","journal-title":"Rheumatology"},{"key":"10.1016\/j.ejpb.2018.05.001_b0050","first-page":"A5","article-title":"Validated bicianalytical method development for determination of etorocoxib in human plasma and its application to pharmacokinetic studies in rats","volume":"58","author":"Vadnerkar","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2018.05.001_b0055","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijpharm.2012.11.031","article-title":"Intra-articular delivery of liposomal celecoxib-hyaluronate combination for the treatment of osteoarthritis in rabbit model","volume":"441","author":"Dong","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2018.05.001_b0060","unstructured":"M. Subhahar, Pharmacokinetics and Pharmacodynamics of Some NSAIDs in Horses: A Pharmacological, Biochemical and Forensic Study, PhD thesis, Preston, United Kingdom, 2013."},{"key":"10.1016\/j.ejpb.2018.05.001_b0065","doi-asserted-by":"crossref","first-page":"551","DOI":"10.2217\/ijr.14.45","article-title":"Efficacy and tolerability of celecoxib in osteoarthritis patients who previously failed naproxen and ibuprofen","volume":"9","author":"Asmus","year":"2014","journal-title":"Int. J. Clin. Rheumatol."},{"key":"10.1016\/j.ejpb.2018.05.001_b0070","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1056\/NEJMoa050405","article-title":"Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention","volume":"352","author":"Solomon","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejpb.2018.05.001_b0075","first-page":"945","article-title":"Cardiovascular issues of COX-2 inhibitors and NSAIDs","volume":"34","author":"Wong","year":"2005","journal-title":"Aust. Fam. Physician"},{"key":"10.1016\/j.ejpb.2018.05.001_b0080","unstructured":"C. Larsen, J. \u2205stergaard, S.W. Larsen, H. Jensen, S. Jacobsen, C. Lindegaard, P.H. Andersen. Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders, J. Pharm Sci 97 (2008) 4622\u20134654."},{"key":"10.1016\/j.ejpb.2018.05.001_b0085","doi-asserted-by":"crossref","unstructured":"S.W. Larsen, A.B. Frost, J. \u2205stergaard, M.H. Thomsen, S. Jacobsen, C. Skonberg, S.H. Hansen, H.E. Jensen, C. Larsen, In vitro and in vivo characteristics of celecoxib in situ formed suspensions for intra-articular administration, J. Pharm. Sci. 100 (2011) 4330\u20134337.","DOI":"10.1002\/jps.22630"},{"key":"10.1016\/j.ejpb.2018.05.001_b0090","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrrheum.2013.159","article-title":"Progress in intra-articular delivery","volume":"10","author":"Evans","year":"2014","journal-title":"Nat. Rev. Rheum."},{"key":"10.1016\/j.ejpb.2018.05.001_b0095","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ejpb.2009.06.009","article-title":"Intra-articular drug delivery systems for the treatment of rheumatic diseases: a review of the factors influencing their performance","volume":"73","author":"Butoescu","year":"2009","journal-title":"Eur. J. Pharm. Biopharmac."},{"key":"10.1016\/j.ejpb.2018.05.001_b0100","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tvjl.2010.09.019","article-title":"Intra-articular drug delivery: the challenge to extend drug residence time within the joint","volume":"190","author":"Edwards","year":"2011","journal-title":"Vet. J."},{"key":"10.1016\/j.ejpb.2018.05.001_b0105","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3390\/polym6030799","article-title":"Review: Drugs and polymers for delivery systems in OA joints: clinical needs and opportunities","volume":"6","author":"Janssen","year":"2014","journal-title":"Polymers"},{"key":"10.1016\/j.ejpb.2018.05.001_b0110","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.ijpharm.2016.11.002","article-title":"Encapsulation of NSAIDs for inflammation management: overview, progress, challenges and prospects","volume":"515","author":"Badri","year":"2016","journal-title":"Int. J. Pharmac."},{"issue":"27","key":"10.1016\/j.ejpb.2018.05.001_b0115","doi-asserted-by":"crossref","first-page":"7919","DOI":"10.1016\/j.biomaterials.2014.05.064","article-title":"Release behavior and intra-articular biocompatibility of celecoxib-loaded acetyl-capped PCLA-PEG-PCLA thermogels","volume":"35","author":"Petit","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2018.05.001_b0120","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejpb.2012.01.009","article-title":"Influence of PEG in PEG-PLGA microspheres on particle properties and protein release","volume":"81","author":"Buske","year":"2012","journal-title":"Eur. J. Pharmac. Biopharmac."},{"key":"10.1016\/j.ejpb.2018.05.001_b0125","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jconrel.2014.03.052","article-title":"Hydrogels in a historical perspective: from simple networks to smart materials","volume":"190","author":"Buwalda","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2018.05.001_b0130","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ijpharm.2014.06.029","article-title":"Thermoresponsive polymers: Insights into decisive hydrogel characteristics, mechanisms of gelation, and promising biomedical applications","volume":"472","author":"Matanovi\u0107","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2018.05.001_b0135","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.joca.2012.08.008","article-title":"Evaluation of the inflammatory response in experimentally induced synovitis in the horse: a comparison of recombinant equine interleukin 1 beta and lipopolysaccharide","volume":"20","author":"Ross","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejpb.2018.05.001_b0140","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1177\/0300985815588611","article-title":"Animal models of osteoarthritis: comparisons and key considerations","volume":"52","author":"McCoy","year":"2015","journal-title":"Vet. Pathol."},{"issue":"2016","key":"10.1016\/j.ejpb.2018.05.001_b0145","first-page":"49","article-title":"Osteoarthritis year in review 2015: imaging","volume":"24","author":"Wang","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejpb.2018.05.001_b0150","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.1016\/j.biomaterials.2013.07.046","article-title":"In situ forming acyl-capped PCLA\u2013PEG\u2013PCLA triblock copolymer based hydrogels","volume":"34","author":"Sandker","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2018.05.001_b0155","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.biomaterials.2015.02.109","article-title":"Sustained intra-articular release of celecoxib from in situ forming gels made of acetyl-capped PCLA-PEG-PCLA triblock copolymers in horses","volume":"53","author":"Petit","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2018.05.001_b0160","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1021\/bm400804w","article-title":"Effect of polymer composition on rheological and degradation properties of temperature-responsive gelling systems composed of acyl-capped PCLA-PEG-PCLA","volume":"14","author":"Petit","year":"2013","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ejpb.2018.05.001_b0165","doi-asserted-by":"crossref","first-page":"R35","DOI":"10.1186\/ar2640","article-title":"Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: a longitudinal experimental study","volume":"11","author":"De Grauw","year":"2009","journal-title":"Arth. Res. Ther."},{"key":"10.1016\/j.ejpb.2018.05.001_b0170","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2746\/042516409X436286","article-title":"In vivo effects of meloxicam on inflammatory mediators, MMP activity and cartilage biomarkers in equine joints with acute synovitis","volume":"41","author":"De Grauw","year":"2009","journal-title":"Eq. Vet. J."},{"key":"10.1016\/j.ejpb.2018.05.001_b0175","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2746\/042516406777749236","article-title":"Arthrogenic lameness of the fetlock: synovial fluid markers of inflammation and cartilage turnover in relation to clinical joint pain","volume":"38","author":"De Grauw","year":"2006","journal-title":"Eq. Vet J."},{"key":"10.1016\/j.ejpb.2018.05.001_b0180","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jpba.2008.12.006","article-title":"Determination of two COX-2 inhibitors in serum and synovial fluid of patients with inflammatory arthritis by ultra performance liquid chromatography-inductively coupled plasma mass spectroscopy and quadrupole time-of-flight mass spectrometry","volume":"49","author":"Gika","year":"2009","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejpb.2018.05.001_b0185","article-title":"Celecoxib for osteoarthritis","volume":"5","author":"Puljak","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejpb.2018.05.001_b0190","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.2527\/jas.2012-5981","article-title":"Influence of an intra-articular lipopolysaccharide challenge on markers of inflammation and cartilage metabolism in young horses","volume":"91","author":"Lucia","year":"2013","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.ejpb.2018.05.001_b0195","first-page":"107","article-title":"An induced synovitis model in ponies","volume":"77","author":"Firth","year":"1987","journal-title":"Cornell Vet."},{"key":"10.1016\/j.ejpb.2018.05.001_b0200","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.2042-3306.1994.tb04056.x","article-title":"Experimentally-induced synovitis as a model of acute synovitis in the horse","volume":"26","author":"Palmer","year":"1994","journal-title":"Eq. Vet. J."},{"key":"10.1016\/j.ejpb.2018.05.001_b0205","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1063-4584(05)80321-8","article-title":"Biochemical and biomechanical alterations in equine articular cartilage following an experimentally-induced synovitis","volume":"4","author":"Palmer","year":"1996","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejpb.2018.05.001_b0210","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.2042-3306.2010.00077.x","article-title":"J.J. L'ami, W. Back, P.R. van Weeren, Intra-articular opioid analgesia is effective in reducing pain and inflammation in an equine LPS induced synovitis model","volume":"42","author":"van Loon","year":"2010","journal-title":"Eq. Vet. J."},{"key":"10.1016\/j.ejpb.2018.05.001_b0215","article-title":"The preventive effects of two nutraceuticals on experimentally induced acute synovitis","volume":"24","author":"Van de Water","year":"2016","journal-title":"Eq. Vet. J."},{"key":"10.1016\/j.ejpb.2018.05.001_b0220","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.2460\/ajvr.69.12.1646","article-title":"Anti-inflammatory and analgesic effects of intra-articular injection of triamcinolone acetonide, mepivacaine hydrochloride, or both on lipopolysaccharide-induced lameness in horses","volume":"69","author":"Kay","year":"2008","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.ejpb.2018.05.001_b0225","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tvjl.2004.09.004","article-title":"Compensatory load redistribution of horses with induced weight-bearing forelimb lameness trotting on a treadmill","volume":"171","author":"Weishaupt","year":"2006","journal-title":"Vet. J."},{"key":"10.1016\/j.ejpb.2018.05.001_b0230","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.vetimm.2016.03.016","article-title":"Duration of in vivo endotoxin tolerance in horses","volume":"173","author":"Holcombe","year":"2016","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.ejpb.2018.05.001_b0235","unstructured":"R.J. Todhunter, Anatomy and physiology of synovial joints, in: C.W. McIlwraith, G.W. Trotter (Eds.), Joint disease in the horse, 1st ed., Philadelphia, PA: Saunders, 1996, pp. 1\u201328."},{"key":"10.1016\/j.ejpb.2018.05.001_b0240","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jconrel.2016.11.003","article-title":"Celecoxib-loaded PEA microspheres as an auto regulatory drug-delivery system after intra-articular injection","volume":"244","author":"Janssen","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2018.05.001_b0245","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.joca.2005.02.004","article-title":"Selective COX-2 inhibition is favorable to human early and late-stage osteoarthritic cartilage: a human in vitro study","volume":"13","author":"Mastbergen","year":"2005","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejpb.2018.05.001_b0250","unstructured":"M.C. Zweers, T.N. de Boer, J. van Roon, J.W.J. Bijlsma, F.P.J.G Lafeber, S.C. Mastbergen, Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis, Arthr. Res. Ther. 13 (2011) 239 <http:\/\/arthritis-research.com\/content\/13\/5\/239>."},{"key":"10.1016\/j.ejpb.2018.05.001_b0255","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.joca.2014.03.011","article-title":"Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress","volume":"22","author":"Su","year":"2014","journal-title":"Osteoarth. Cartil."},{"key":"10.1016\/j.ejpb.2018.05.001_b0260","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.3390\/ijms11104106","article-title":"Efficacy of intra-articular injection of celecoxib in a rabbit model of osteoarthritis","volume":"11","author":"Jiang","year":"2010","journal-title":"Int. J. Mol. Sci."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641117309888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641117309888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T13:38:50Z","timestamp":1569245930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641117309888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":52,"alternative-id":["S0939641117309888"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2018.05.001","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sustained intra-articular release of celecoxib in an equine repeated LPS synovitis model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2018.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}