{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:20:35Z","timestamp":1790230835578,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.ejpb.2018.09.028","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T01:48:15Z","timestamp":1538012895000},"page":"180-191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Conformational polymorphic changes in the crystal structure of the chiral antiparasitic drug praziquantel and interactions with calcium carbonate"],"prefix":"10.1016","volume":"132","author":[{"given":"Ana","family":"Borrego-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Carazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Albertini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Passerini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5766-4014","authenticated-orcid":false,"given":"Beatrice","family":"Perissutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Cerezo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Viseras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hern\u00e1ndez-Laguna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Aguzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Ignacio","family":"Sainz-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2018.09.028_b0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0001-706X(00)00122-4","article-title":"The global status of schistosomiasis and its control","volume":"7","author":"Chitsulo","year":"2000","journal-title":"Acta Trop."},{"key":"10.1016\/j.ejpb.2018.09.028_b0010","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk","volume":"6","author":"Steinmann","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejpb.2018.09.028_b0015","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ijpharm.2015.09.019","article-title":"Development of flexible and dispersible oral formulations containing praziquantel for potential schistosomiasis treatment of pre-school age children","volume":"495","author":"Trastullo","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2018.09.028_b0020","unstructured":"WHO, WHO Schistosomiasis, World Health Organization, http:\/\/www.who.int\/es\/news-room\/fact-sheets\/detail\/schistosomiasis, 2018 (accessed 29 June 2018)."},{"key":"10.1016\/j.ejpb.2018.09.028_b0025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0163-7258(95)00026-7","article-title":"Antischistomal drugs: past, present\u2026and future?","volume":"68","author":"Cioli","year":"1995","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejpb.2018.09.028_b0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00436-002-0751-z","article-title":"Praziquantel","volume":"90","author":"Cioli","year":"2003","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ejpb.2018.09.028_b0035","unstructured":"EP 7.0. European Pharmacopoeia Seventh Edition. Directorate for the Quality of Medicines of the Council of Europe, Strasbourg, France, 2011."},{"key":"10.1016\/j.ejpb.2018.09.028_b0040","unstructured":"USP 36-NF31. United States Pharmacopoeia 36 and National Formulary 31. US Pharmacopoeial Convention, Rockville, MD USA, 2013."},{"key":"10.1016\/j.ejpb.2018.09.028_b0045","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0163-7258(85)90020-8","article-title":"Praziquantel: mechanisms of anti-schistosomal activity","volume":"29","author":"Andrews","year":"1985","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejpb.2018.09.028_b0050","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF00507974","article-title":"A benzodiazepine derivative and praziquantel: effects on musculature of Schistosoma mansoni and Schistosoma japonicum","volume":"304","author":"Pax","year":"1978","journal-title":"Naanyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.ejpb.2018.09.028_b0055","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1002\/jps.20211","article-title":"Structural characterization and enantioseparation of the chiral compound praziquantel","volume":"93","author":"Liu","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2018.09.028_b0060","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/chir.530070205","article-title":"Solubility phase-diagram of praziquantel enantiomeric system","volume":"7","author":"Lim","year":"1995","journal-title":"Chirality"},{"key":"10.1016\/j.ejpb.2018.09.028_b0065","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3109\/10837459809028638","article-title":"Solubility properties of racemic praziquantel and its enantiomers","volume":"3","author":"El-Arini","year":"1998","journal-title":"Pharm. Dev. Techn."},{"key":"10.1016\/j.ejpb.2018.09.028_b0070","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/chir.20251","article-title":"Investigation of the phase diagrams of chiral praziquantel","volume":"18","author":"Liu","year":"2006","journal-title":"Chirality"},{"key":"10.1016\/j.ejpb.2018.09.028_b0075","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1021\/cg301314w","article-title":"Cocrystals of active pharmaceuticals ingredients-praziquantel in combination with oxalic, malonic, succinic, maleic, fumaric, glutaric, adipic and pimelic acids","volume":"13","author":"Espinosa-Lara","year":"2013","journal-title":"Cryst. Growth. Des."},{"key":"10.1016\/j.ejpb.2018.09.028_b0080","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ejpb.2004.03.001","article-title":"Classification of orally administered drugs on the World Health Organization Model list of essential medicines according to the biopharmaceutics classification system","volume":"58","author":"Lindenberg","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2018.09.028_b0085","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijpharm.2005.01.033","article-title":"In vitro characterization of some biopharmaceutical properties of praziquantel","volume":"295","author":"Gonz\u00e1lez-Esquivel","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2018.09.028_b0090","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijpharm.2006.03.028","article-title":"Evaluation of melt granulation and ultrasonic spray congealing as techniques to enhance the dissolution of praziquantel","volume":"318","author":"Passerini","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2018.09.028_b0095","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.clay.2017.12.024","article-title":"Biopharmaceutical improvement of praziquantel by interaction with montmorillonite and sepiolite","volume":"160","author":"Borrego-S\u00e1nchez","year":"2018","journal-title":"Appl. Clay. Sci."},{"key":"10.1016\/j.ejpb.2018.09.028_b0100","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejpb.2018.01.018","article-title":"A new soluble and bioactive polymorph of praziquantel","volume":"127","author":"Zanolla","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2018.09.028_b0105","series-title":"Handbook of Pharmaceutical Excipients","author":"Rowe","year":"2009"},{"key":"10.1016\/j.ejpb.2018.09.028_b0110","unstructured":"J.D. Mart\u00edn-Ramos, XPowder software, http:\/\/www.xpowder.com, 2005 (accessed 29 June 2018)."},{"key":"10.1016\/j.ejpb.2018.09.028_b0115","doi-asserted-by":"crossref","first-page":"7338","DOI":"10.1021\/jp980939v","article-title":"COMPASS: an ab initio force-field optimized for condensed-phase applications-overview with details on alkane and benzene compounds","volume":"102","author":"Sun","year":"1998","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ejpb.2018.09.028_b0120","unstructured":"Accelrys Materials Studio, version v 6.0. Accelrys Inc., San Diego, USA, 2012."},{"key":"10.1016\/j.ejpb.2018.09.028_b0125","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ejps.2016.04.023","article-title":"Molecular and crystal structure of praziquantel. Spectroscopic properties and crystal polymorphism","volume":"92","author":"Borrego-S\u00e1nchez","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2018.09.028_b0130","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1088\/0953-8984\/14\/11\/302","article-title":"The Siesta method for ab initio order-N materials simulation","volume":"14","author":"Soler","year":"2002","journal-title":"J. Phys. Condens. Matter."},{"key":"10.1016\/j.ejpb.2018.09.028_b0135","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1103\/PhysRevLett.77.3865","article-title":"Generalized gradient approximation made simple","volume":"77","author":"Perdew","year":"1996","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.ejpb.2018.09.028_b0140","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1103\/PhysRevB.43.1993","article-title":"Efficient pseudopotentials for plane-wave calculations","volume":"43","author":"Troullier","year":"1991","journal-title":"Phys. Rev. B"},{"key":"10.1016\/j.ejpb.2018.09.028_b0145","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.2138\/am.2005.1819","article-title":"Quantum mechanical calculations of trans-vacant and cis-vacant polymorphism in dioctahedral 2:1 phyllosilicates","volume":"90","author":"Sainz-D\u00edaz","year":"2005","journal-title":"Am. Miner."},{"key":"10.1016\/j.ejpb.2018.09.028_b0150","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jmgm.2013.06.006","article-title":"Crystal structure, stability and spectroscopic properties of methane and CO2 hydrates","volume":"44","author":"Martos-Villa","year":"2013","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.ejpb.2018.09.028_b0155","series-title":"Analytical Profiles of Drug Substances and Excipients","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0099-5428(08)60760-1","article-title":"Praziquantel","author":"El-Subbagh","year":"1998"},{"key":"10.1016\/j.ejpb.2018.09.028_b0160","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1248\/cpb.47.1629","article-title":"Preparation, dissolution and characterization of praziquantel solid dispersions","volume":"47","author":"De la Torre","year":"1999","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejpb.2018.09.028_b0165","first-page":"163","article-title":"Development and evaluation of praziquantel solid dispersions in sodium starch glycolate","volume":"12","author":"Chaud","year":"2013","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.ejpb.2018.09.028_b0170","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10847-010-9852-y","article-title":"Computational analysis and physico-chemical characterization of an inclusion compound between praziquantel and methyl-\u03b2-cyclodextrin for use as an alternative in the treatment of schistosomiasis","volume":"70","author":"Rodrigues","year":"2010","journal-title":"J. Incl. Phenom. Macrocycl. Chem."},{"key":"10.1016\/j.ejpb.2018.09.028_b0175","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0039-9140(02)00372-7","article-title":"FTIR quantitative analysis of calcium carbonate (calcite) and silica (quartz) mixtures using the constant ratio method. Application to geological samples","volume":"58","author":"Reig","year":"2002","journal-title":"Talanta"},{"key":"10.1016\/j.ejpb.2018.09.028_b0180","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0039-9140(02)00638-0","article-title":"Quantitative analysis of synthetic calcium carbonate polymorphs using FT-IR spectroscopy","volume":"59","author":"Vagenas","year":"2003","journal-title":"Talanta"},{"key":"10.1016\/j.ejpb.2018.09.028_b0185","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00894-017-3266-3","article-title":"Molecular modeling and infrared and Raman spectroscopy of the crystal structure of the chiral anti-parasitic drug praziquantel","volume":"23","author":"Borrego-S\u00e1nchez","year":"2017","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.ejpb.2018.09.028_b0190","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/j.saa.2005.02.026","article-title":"FT\u2013Raman spectroscopic study of calcium-rich and magnesium-rich carbonate minerals","volume":"61","author":"Edwards","year":"2005","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.ejpb.2018.09.028_b0195","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.micron.2010.06.014","article-title":"Confocal Raman and electronic microscopy studies on the topotactic conversion of calcium carbonate from Pomacea lineate shells into hydroxyapatite bioceramic materials in phosphate media","volume":"41","author":"De Paula","year":"2010","journal-title":"Micron"},{"key":"10.1016\/j.ejpb.2018.09.028_b0200","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.vibspec.2013.04.005","article-title":"Raman spectroscopic quantification of calcium carbonate in spiked milk powder samples","volume":"67","author":"Smith","year":"2013","journal-title":"Vib. Spectrosc."},{"key":"10.1016\/j.ejpb.2018.09.028_b0205","first-page":"8","article-title":"Racemic drugs: racemic mixture, racemic compound, or pseudoracemate?","volume":"1","author":"Mitchell","year":"1998","journal-title":"J. Pharm. Pharm. Sci."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641118308245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641118308245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T04:48:47Z","timestamp":1605070127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641118308245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":41,"alternative-id":["S0939641118308245"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2018.09.028","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conformational polymorphic changes in the crystal structure of the chiral antiparasitic drug praziquantel and interactions with calcium carbonate","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2018.09.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}