{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:45:50Z","timestamp":1790189150057,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001537","name":"University of Auckland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001794","name":"University of Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ejpb.2019.01.014","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T02:02:23Z","timestamp":1547690543000},"page":"102-107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Ultrasound-responsive nanobubbles for enhanced intravitreal drug migration: An ex vivo evaluation"],"prefix":"10.1016","volume":"136","author":[{"given":"Sachin S.","family":"Thakur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Shan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary H.","family":"Houston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel L.","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristofer J.","family":"Thurecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilva D.","family":"Rupenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harendra S.","family":"Parekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2019.01.014_b0005","series-title":"Global Data on Visual Impairments 2010","author":"Mariotti","year":"2012"},{"issue":"11","key":"10.1016\/j.ejpb.2019.01.014_b0010","doi-asserted-by":"crossref","first-page":"e003471","DOI":"10.1136\/bmjopen-2013-003471","article-title":"The economic burden of visual impairment and blindness: a systematic review","volume":"3","author":"K\u00f6berlein","year":"2013","journal-title":"BMJ Open"},{"key":"10.1016\/j.ejpb.2019.01.014_b0015","series-title":"Priority Eye Diseases","first-page":"29","article-title":"Prevention of Blindness and Visual Impairment","author":"World Health Organization","year":"2015"},{"key":"10.1016\/j.ejpb.2019.01.014_b0020","series-title":"Age-Related Macular Degeneration: Guidelines for Management","author":"Royal College of Ophthalmologists","year":"2009"},{"key":"10.1016\/j.ejpb.2019.01.014_b0025","series-title":"Diabetic Retinopathy Guidelines","author":"Royal College of Ophthalmologists","year":"2012"},{"issue":"3","key":"10.1016\/j.ejpb.2019.01.014_b0030","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ajo.2011.05.029","article-title":"Intraocular pressure: modulation as treatment for glaucoma","volume":"152","author":"Caprioli","year":"2011","journal-title":"Am J Ophthalmol"},{"issue":"10","key":"10.1016\/j.ejpb.2019.01.014_b0035","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1167\/iovs.08-3148","article-title":"Pharmacokinetics of bevacizumab after topical, subconjunctival, and intravitreal administration in rabbits","volume":"50","author":"Nomoto","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"10.1016\/j.ejpb.2019.01.014_b0040","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1517\/17425247.2014.927864","article-title":"Intravitreal drug delivery in retinal disease: are we out of our depth?","volume":"11","author":"Thakur","year":"2014","journal-title":"Expert Opin Drug Deliv"},{"issue":"2","key":"10.1016\/j.ejpb.2019.01.014_b0045","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/IAE.0b013e3181e586b2","article-title":"Posterior vitreous detachment with microplasmin alters the retinal penetration of intravitreal bevacizumab (Avastin) in rabbit eyes","volume":"31","author":"Goldenberg","year":"2011","journal-title":"Retina"},{"issue":"11","key":"10.1016\/j.ejpb.2019.01.014_b0050","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1023\/A:1020940927675","article-title":"Hydraulic flow and vascular clearance influences on intravitreal drug delivery","volume":"19","author":"Missel","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2019.01.014_b0055","series-title":"Drug Product Development for the Back of the Eye","first-page":"125","article-title":"Principles of Retinal Drug Delivery from Within the Vitreous","author":"Wilson","year":"2011"},{"issue":"2","key":"10.1016\/j.ejpb.2019.01.014_b0060","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1167\/iovs.10-5813","article-title":"Effects of vitreous liquefaction on the intravitreal distribution of sodium fluorescein, fluorescein dextran, and fluorescent microparticles","volume":"52","author":"Tan","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.ejpb.2019.01.014_b0065","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s11095-010-0356-7","article-title":"Contribution of saccadic motion to intravitreal drug transport: theoretical analysis","volume":"28","author":"Balachandran","year":"2011","journal-title":"Pharm. Res."},{"issue":"2","key":"10.1016\/j.ejpb.2019.01.014_b0070","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10237-012-0398-3","article-title":"Saccade movements effect on the intravitreal drug delivery in vitreous substitutes: a numerical study","volume":"12","author":"Modareszadeh","year":"2013","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"7","key":"10.1016\/j.ejpb.2019.01.014_b0075","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1076\/ceyr.16.7.663.5061","article-title":"Drug distribution in the vitreous humor of the human eye: the effects of intravitreal injection position and volume","volume":"16","author":"Friedrich","year":"1997","journal-title":"Curr. Eye Res."},{"issue":"3","key":"10.1016\/j.ejpb.2019.01.014_b0080","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrd1662","article-title":"Healing sound: the use of ultrasound in drug delivery and other therapeutic applications","volume":"4","author":"Mitragotri","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"issue":"4","key":"10.1016\/j.ejpb.2019.01.014_b0085","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.ultrasmedbio.2012.11.010","article-title":"Ultrasound-enhanced delivery of antibiotics and anti-inflammatory drugs into the eye","volume":"39","author":"Nabili","year":"2013","journal-title":"Ultrasound Med. Biol."},{"issue":"6","key":"10.1016\/j.ejpb.2019.01.014_b0090","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1167\/iovs.13-11978","article-title":"Ultrasound-mediated transscleral delivery of macromolecules to the posterior segment of rabbit eye in vivo","volume":"54","author":"Suen","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.ejpb.2019.01.014_b0095","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/gt.2009.84","article-title":"Ultrasound-targeted microbubble destruction enhances AAV-mediated gene transfection in human RPE cells in vitro and rat retina in vivo","volume":"16","author":"Li","year":"2009","journal-title":"Gene Ther."},{"issue":"22","key":"10.1016\/j.ejpb.2019.01.014_b0100","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.3760\/cma.j.issn.0366-6999.2009.22.007","article-title":"Ultrasound-mediated microbubble delivery of pigment epithelium-derived factor gene into retina inhibits choroidal neovascularization","volume":"122","author":"Zhou","year":"2009","journal-title":"Chin Med. J. (Engl.)"},{"issue":"1","key":"10.1016\/j.ejpb.2019.01.014_b0105","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1001\/archopht.1970.00990040004002","article-title":"Clinical test for evaluating donor corneas","volume":"84","author":"Stocker","year":"1970","journal-title":"Arch. Ophthalmol."},{"issue":"5","key":"10.1016\/j.ejpb.2019.01.014_b0110","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1159\/000265211","article-title":"The mechanical properties of the vitreous of pig and human donor eyes","volume":"14","author":"Weber","year":"1982","journal-title":"Ophthalmic Res."},{"issue":"9","key":"10.1016\/j.ejpb.2019.01.014_b0115","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.jbiomech.2008.04.015","article-title":"Rheological properties of the vitreous and the role of hyaluronic acid","volume":"41","author":"Nickerson","year":"2008","journal-title":"J. Biomech."},{"issue":"4","key":"10.1016\/j.ejpb.2019.01.014_b0120","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.exer.2008.01.011","article-title":"Maintenance of adult porcine retina and retinal pigment epithelium in perfusion culture: characterisation of an organotypic in vitro model","volume":"86","author":"Kobuch","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejpb.2019.01.014_b0125","series-title":"IP Australia","article-title":"Method for preparing a lipid bubble","author":"Thakur","year":"2015"},{"issue":"5","key":"10.1016\/j.ejpb.2019.01.014_b0130","doi-asserted-by":"crossref","first-page":"e0178305","DOI":"10.1371\/journal.pone.0178305","article-title":"Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina","volume":"12","author":"Thakur","year":"2017","journal-title":"PloS one"},{"issue":"3","key":"10.1016\/j.ejpb.2019.01.014_b0135","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0886-3350(03)00666-7","article-title":"Revised Miyake-Apple technique for postmortem eye preparation","volume":"30","author":"Davis","year":"2004","journal-title":"J. Cataract. Refract. Surg."},{"issue":"3","key":"10.1016\/j.ejpb.2019.01.014_b0140","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.exer.2004.09.015","article-title":"Alterations in human vitreous humour following cataract extraction","volume":"80","author":"Neal","year":"2005","journal-title":"Exp. Eye Res."},{"issue":"5","key":"10.1016\/j.ejpb.2019.01.014_b0145","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.exer.2004.07.011","article-title":"Regional mapping of molecular components of human liquid vitreous by dynamic light scattering","volume":"79","author":"Bettelheim","year":"2004","journal-title":"Exp. Eye Res."},{"issue":"7","key":"10.1016\/j.ejpb.2019.01.014_b0150","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1021\/mz3002534","article-title":"Confinement of acoustic cavitation for the synthesis of protein-shelled nanobubbles for diagnostics and nucleic acid delivery","volume":"1","author":"Zhou","year":"2012","journal-title":"ACS Macro Lett."},{"issue":"4","key":"10.1016\/j.ejpb.2019.01.014_b0155","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00417-011-1617-9","article-title":"The parameters of the porcine eyeball","volume":"249","author":"Sanchez","year":"2011","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"2","key":"10.1016\/j.ejpb.2019.01.014_b0160","first-page":"14","article-title":"Liposome: methods of preparation and applications","volume":"3","author":"Dua","year":"2012","journal-title":"Int. J. Pharm. Stud. Res."},{"key":"10.1016\/j.ejpb.2019.01.014_b0165","series-title":"Encyclopedia of Microbluidics and Nanofluidics","first-page":"25","article-title":"Acoustic Streaming","author":"Suh","year":"2008"},{"key":"10.1016\/j.ejpb.2019.01.014_b0170","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.addr.2014.01.007","article-title":"Ultrasound mediated transdermal drug delivery","volume":"72","author":"Azagury","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2019.01.014_b0175","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejpb.2017.06.009","article-title":"Ultrasound-mediated nanoparticle delivery across ex vivo bovine retina after intravitreal injection","volume":"119","author":"Huang","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"3","key":"10.1016\/j.ejpb.2019.01.014_b0180","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1109\/TUFFC.2005.1417264","article-title":"Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: in vitro verification","volume":"52","author":"Rychak","year":"2005","journal-title":"IEEE Trans. Ultrason. Ferroelectr. Freq. Control"},{"issue":"7","key":"10.1016\/j.ejpb.2019.01.014_b0185","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1109\/TUFFC.2004.1320741","article-title":"A method for radiation-force localized drug delivery using gas-filled lipospheres","volume":"51","author":"Shortencarier","year":"2004","journal-title":"IEEE Trans. Ultrason. Ferroelectr. Freq. Control"},{"issue":"10","key":"10.1016\/j.ejpb.2019.01.014_b0190","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.addr.2008.03.002","article-title":"Driving delivery vehicles with ultrasound","volume":"60","author":"Ferrara","year":"2008","journal-title":"Adv. Drug. Deliv. Rev."},{"issue":"7","key":"10.1016\/j.ejpb.2019.01.014_b0195","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1097\/ICO.0000000000000142","article-title":"Modified Miyake-Apple camera: illustration of deep anterior lamellar keratoplasty pearls learned from simultaneous anterior and posterior corneal imaging","volume":"33","author":"Moloney","year":"2014","journal-title":"Cornea"},{"issue":"3","key":"10.1016\/j.ejpb.2019.01.014_b0200","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/ICO.0000000000000060","article-title":"Modification of the Miyake-Apple technique for simultaneous anterior and posterior video imaging of wet laboratory-based corneal surgery","volume":"33","author":"Tan","year":"2014","journal-title":"Cornea"},{"issue":"10","key":"10.1016\/j.ejpb.2019.01.014_b0205","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1118\/1.4929553","article-title":"Thermal safety of ultrasound-enhanced ocular drug delivery: a modeling study","volume":"42","author":"Nabili","year":"2015","journal-title":"Med. Phys."},{"key":"10.1016\/j.ejpb.2019.01.014_b0210","series-title":"European Committee for Medical Ultrasound Safety Bylaw, Newsletter 12","author":"Federation","year":"1998"},{"issue":"4","key":"10.1016\/j.ejpb.2019.01.014_b0215","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0014-4835(76)90172-X","article-title":"Dynamic viscoelastic properties of bovine vitreous","volume":"23","author":"Bettelheim","year":"1976","journal-title":"Exp. Eye Res."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641118314127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641118314127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:33:16Z","timestamp":1760545996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641118314127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":43,"alternative-id":["S0939641118314127"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2019.01.014","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultrasound-responsive nanobubbles for enhanced intravitreal drug migration: An ex vivo evaluation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2019.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}