{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:57:19Z","timestamp":1792000639995,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SA700\/20"],"award-info":[{"award-number":["SA700\/20"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.ejpb.2019.10.012","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T20:23:42Z","timestamp":1572726222000},"page":"113-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Solubility of pharmaceutical ingredients in triglycerides"],"prefix":"10.1016","volume":"145","author":[{"given":"Joscha","family":"Brinkmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Huxoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Luebbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Sadowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2019.10.012_b0005","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.apsb.2015.07.003","article-title":"Insoluble drug delivery strategies: review of recent advances and business prospects","volume":"5","author":"Kalepu","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejpb.2019.10.012_b0010","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1016\/j.ddtec.2012.03.002","article-title":"Lipid-based formulations for oral delivery of lipophilic drugs","volume":"9","author":"Kuentz","year":"2012","journal-title":"Drug Discov. Today. Technol."},{"issue":"Suppl 2","key":"10.1016\/j.ejpb.2019.10.012_b0015","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1016\/S0928-0987(00)00167-6","article-title":"Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems","volume":"11","author":"Pouton","year":"2000","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2019.10.012_b0020","series-title":"Vegetable Oils in Food Technology: Composition, Properties and Uses","author":"Gunstone","year":"2011"},{"key":"10.1016\/j.ejpb.2019.10.012_b0025","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1021\/acs.molpharmaceut.5b00704","article-title":"Tools for early prediction of drug loading in lipid-based formulations","volume":"13","author":"Alsk\u00e4r","year":"2016","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2019.10.012_b0030","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ejps.2006.04.016","article-title":"Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system","volume":"29","author":"Pouton","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2019.10.012_b0035","first-page":"1","article-title":"Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches - a PEARRL review","volume":"71","author":"Ditzinger","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2019.10.012_b0040","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ejps.2009.09.012","article-title":"Formulate-ability of ten compounds with different physicochemical profiles in SMEDDS","volume":"38","author":"Thi","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2019.10.012_b0045","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1007\/s11095-013-1083-7","article-title":"Computational prediction of drug solubility in lipid based formulation excipients","volume":"30","author":"Persson","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2019.10.012_b0050","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ijpharm.2016.09.015","article-title":"Rapid determination of drug solubilization versus supersaturation in natural and digested lipids","volume":"513","author":"Gautschi","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2019.10.012_b0055","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijpharm.2017.04.063","article-title":"Montmorillonite-lipid hybrid carriers for ionizable and neutral poorly water-soluble drugs: formulation, characterization and in vitro lipolysis studies","volume":"526","author":"Dening","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2019.10.012_b0060","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1021\/je900342a","article-title":"Solid\u2212liquid\u2212gas equilibrium of the ternaries ibuprofen + myristic acid + CO 2 and ibuprofen + tripalmitin + CO 2","volume":"55","author":"Hong","year":"2010","journal-title":"J. Chem. Eng. Data"},{"key":"10.1016\/j.ejpb.2019.10.012_b0065","first-page":"11","article-title":"Chemical and related factors controlling lipid solubility","volume":"92","author":"Anderson","year":"1999","journal-title":"Bull. Tech. Gattefosse"},{"key":"10.1016\/j.ejpb.2019.10.012_b0070","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3390\/molecules22020296","article-title":"Amorphous-amorphous phase separation in API\/polymer formulations","volume":"22","author":"Luebbert","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.ejpb.2019.10.012_b0075","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11095-017-2316-y","article-title":"Influence of low-molecular-weight excipients on the phase behavior of PVPVA64 amorphous solid dispersions","volume":"35","author":"Lehmkemper","year":"2018","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2019.10.012_b0080","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1021\/acs.jced.8b01046","article-title":"Thermodynamic modeling of triglycerides using PC-SAFT","volume":"64","author":"Brinkmann","year":"2019","journal-title":"J. Chem. Eng. Data"},{"key":"10.1016\/j.ejpb.2019.10.012_b0085","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1021\/mp400729x","article-title":"Thermodynamic phase behavior of API\/polymer solid dispersions","volume":"11","author":"Prudic","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2019.10.012_b0090","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ijpharm.2017.11.014","article-title":"Investigating phase separation in amorphous solid dispersions via Raman mapping","volume":"535","author":"Luebbert","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2019.10.012_b0095","series-title":"Molecular Thermodynamics of Fluid-Phase Equilibria","author":"Prausnitz","year":"1999"},{"key":"10.1016\/j.ejpb.2019.10.012_b0100","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1021\/ie0003887","article-title":"Perturbed-chain SAFT: an equation of state based on a perturbation theory for chain molecules","volume":"40","author":"Gross","year":"2001","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.ejpb.2019.10.012_b0105","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/BF02643296","article-title":"Thermal properties of fats and oils","volume":"24","author":"Charbonnet","year":"1947","journal-title":"J. Am. Oil Chem. Soc."},{"key":"10.1016\/j.ejpb.2019.10.012_b0110","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/03639040701580606","article-title":"Increasing the dissolution rate of a low-solubility drug through a crystalline-amorphous transition: a case study with indomethacin correction of indomethicin","volume":"34","author":"Pan","year":"2008","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejpb.2019.10.012_b0115","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1021\/ie010954d","article-title":"Application of the perturbed-chain SAFT equation of state to associating systems","volume":"41","author":"Gross","year":"2002","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.ejpb.2019.10.012_b0120","doi-asserted-by":"crossref","first-page":"15544","DOI":"10.1021\/jp072640v","article-title":"Modeling of polar systems using PCP-SAFT: an approach to account for induced-association interactions","volume":"111","author":"Kleiner","year":"2007","journal-title":"J. Phys. Chem. C."},{"key":"10.1016\/j.ejpb.2019.10.012_b0125","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1021\/acs.jced.7b00005","article-title":"Phase behavior of binary mixtures containing succinic acid or its esters","volume":"62","author":"Altuntepe","year":"2017","journal-title":"J. Chem. Eng. Data"},{"key":"10.1016\/j.ejpb.2019.10.012_b0130","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.fluid.2014.01.029","article-title":"Thermodynamics of fenofibrate and solubility in pure organic solvents","volume":"367","author":"Watterson","year":"2014","journal-title":"Fluid Phase Equilib."},{"key":"10.1016\/j.ejpb.2019.10.012_b0135","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1002\/jps.21725","article-title":"Modeling the solubility of pharmaceuticals in pure solvents and solvent mixtures for drug process design","volume":"98","author":"Ruether","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2019.10.012_b0140","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1021\/acs.molpharmaceut.8b00840","article-title":"Understanding dissolution and crystallization with imaging: a surface point of view","volume":"15","author":"Novakovic","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2019.10.012_b0145","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1021\/mp400299a","article-title":"Indomethacin: new polymorphs of an old drug","volume":"10","author":"Surwase","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2019.10.012_b0150","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1021\/acs.cgd.6b00554","article-title":"Polymorphs, hydrates, cocrystals, and cocrystal hydrates: thermodynamic modeling of theophylline systems","volume":"16","author":"Lange","year":"2016","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.ejpb.2019.10.012_b0155","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1002\/jps.23205","article-title":"Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a range of representative formulations","volume":"101","author":"Williams","year":"2012","journal-title":"J. Pharm. Sci."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641119312913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641119312913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:41:29Z","timestamp":1777592489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641119312913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":31,"alternative-id":["S0939641119312913"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2019.10.012","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Solubility of pharmaceutical ingredients in triglycerides","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2019.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}