{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:20:13Z","timestamp":1773246013778,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81573365"],"award-info":[{"award-number":["81573365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Basic Public Welfare Research Project of Zhejiang Province, China","award":["LGF18H300004"],"award-info":[{"award-number":["LGF18H300004"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.ejpb.2020.01.015","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T11:34:03Z","timestamp":1580384043000},"page":"135-144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The study of intestinal absorption and biodistribution in vivo of proton pump inhibitors"],"prefix":"10.1016","volume":"149","author":[{"given":"Tianxiang","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xindong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaolei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuzhi","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingpo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxin","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weigen","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejpb.2020.01.015_b0005","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0163-7258(03)00015-9","article-title":"Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and future","volume":"98","author":"Aihara","year":"2003","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.ejpb.2020.01.015_b0010","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.bpg.2009.10.004","article-title":"Acid-related disorders in the elderly","volume":"23","author":"Franceschi","year":"2009","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"issue":"4","key":"10.1016\/j.ejpb.2020.01.015_b0015","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1043-6618(03)00009-4","article-title":"Histamine in the control of gastric acid secretion: a topic review","volume":"47","author":"Barocelli","year":"2003","journal-title":"Pharmacol. Res."},{"issue":"12","key":"10.1016\/j.ejpb.2020.01.015_b0020","first-page":"772","article-title":"Mast cells in gastrointestinal disease","volume":"6","author":"Ramsay","year":"2010","journal-title":"Gastroenterol. Hepatol. (N Y)"},{"issue":"6","key":"10.1016\/j.ejpb.2020.01.015_b0025","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/gut.32.6.698","article-title":"Gastrin-histamine sequence in the regulation of gastric acid secretion","volume":"32","author":"Waldum","year":"1991","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.ejpb.2020.01.015_b0030","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.bmc.2006.07.068","article-title":"Recent advances in proton pump inhibitors and management of acid-peptic disorders","volume":"15","author":"Jain","year":"2007","journal-title":"Bioorg. Med. Chem."},{"issue":"Suppl 2","key":"10.1016\/j.ejpb.2020.01.015_b0035","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2036.2006.02943.x","article-title":"Review article: the clinical pharmacology of proton pump inhibitors","volume":"23","author":"Sachs","year":"2006","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.ejpb.2020.01.015_b0040","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1586\/17474124.2.4.509","article-title":"Rabeprazole: a second-generation proton pump inhibitor in the treatment of acid-related disease","volume":"2","author":"Pallotta","year":"2008","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"issue":"Suppl 1","key":"10.1016\/j.ejpb.2020.01.015_b0045","first-page":"S29","article-title":"Shortcomings of the first-generation proton pump inhibitors","volume":"13","author":"Tytgat","year":"2001","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.ejpb.2020.01.015_b0050","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0149-2918(00)80032-6","article-title":"The proton-pump inhibitors: similarities and differences","volume":"22","author":"Horn","year":"2000","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ejpb.2020.01.015_b0055","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-2125.1991.tb05530.x","article-title":"Influence of acid secretory status on absorption of omeprazole from enteric coated granules","volume":"31","author":"Andersson","year":"1991","journal-title":"Br. J. Clin. Pharmac."},{"issue":"9","key":"10.1016\/j.ejpb.2020.01.015_b0060","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1152\/ajpgi.00458.2014","article-title":"Suppression of contractile activity in the small intestine by indomethacin and omeprazole","volume":"308","author":"Lichtenberger","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejpb.2020.01.015_b0065","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2174\/157341310793348713","article-title":"Evaluation of in vitro dissolution and in vivo oral absorption of drug nanopowders prepared by novel wet-milling equipment","volume":"6","author":"Yusuke","year":"2010","journal-title":"Curr. Nanosci."},{"issue":"9","key":"10.1016\/j.ejpb.2020.01.015_b0070","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1081\/DDC-100102270","article-title":"Effect of various salts on the stability of lansoprazole, omeprazole, and pantoprazole as determined by high-performance liquid chromatography","volume":"25","author":"Ekpe","year":"1999","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"1","key":"10.1016\/j.ejpb.2020.01.015_b0075","first-page":"1","article-title":"Validated Stability-indicating assay method for determination of Ilaprazole in bulk drug and tablets by high performance liquid chromatography","volume":"10","author":"Shelke","year":"2015","journal-title":"Eurasian J. Anal. Chem."},{"key":"10.1016\/j.ejpb.2020.01.015_b0080","first-page":"S386","article-title":"HPLC method development and validation for simultaneous analysis of diclofenac sodium and rabeprazole sodium","volume":"7","author":"Heda","year":"2010","journal-title":"E-J. Chem."},{"issue":"3","key":"10.1016\/j.ejpb.2020.01.015_b0085","first-page":"368","article-title":"Predicting human intestinal permeability using single-pass intestinal perfusion in rat","volume":"10","author":"Zakeri-Milani","year":"2007","journal-title":"J. Pharm. Pharm. Sci."},{"issue":"8","key":"10.1016\/j.ejpb.2020.01.015_b0090","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/aps.2012.64","article-title":"Pharmacokinetic interactions between ilaprazole and clarithromycin following ilaprazole, clarithromycin and amoxicillin triple therapy","volume":"33","author":"Cao","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"issue":"11","key":"10.1016\/j.ejpb.2020.01.015_b0095","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/bmc.2932","article-title":"The chiral bioconversion and preclinical pharmacokinetic analysis of (R)-(+)-rabeprazole in beagle dogs by HPLC and HPLC-MS\/MS","volume":"27","author":"Gao","year":"2013","journal-title":"Biomed. Chromatogr."},{"issue":"2","key":"10.1016\/j.ejpb.2020.01.015_b0100","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jpba.2007.09.019","article-title":"Simultaneous determination of hydrazinocurcumin and phenol red in samples from rat intestinal permeability studies: HPLC method development and validation","volume":"46","author":"Rathore","year":"2008","journal-title":"J. Pharmaceut. Biomed."},{"issue":"2","key":"10.1016\/j.ejpb.2020.01.015_b0105","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1472-8206.1999.tb00334.x","article-title":"Gastrointestinal absorption of drugs: methods and studies","volume":"13","author":"Barthe","year":"1999","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.ejpb.2020.01.015_b0110","unstructured":"https:\/\/www.drugbank.ca\/drugs\/DB01129."},{"key":"10.1016\/j.ejpb.2020.01.015_b0115","first-page":"132","article-title":"Physicochemical properties of ilaprazole sodium","volume":"23","author":"Hou","year":"2013","journal-title":"Pharm. Today"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641120300278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641120300278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:36:57Z","timestamp":1760546217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641120300278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":23,"alternative-id":["S0939641120300278"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2020.01.015","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The study of intestinal absorption and biodistribution in vivo of proton pump inhibitors","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2020.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}