{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:15:26Z","timestamp":1792091726424,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.ejpb.2020.05.011","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T22:24:50Z","timestamp":1589581490000},"page":"257-269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Fatty acid chain length impacts nanonizing capacity of albumin-fatty acid nanomicelles: Enhanced physicochemical property and cellular delivery of poorly water-soluble drug"],"prefix":"10.1016","volume":"152","author":[{"given":"Chulhun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nileshkumar","family":"Meghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimar","family":"Loebenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Hao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Ri","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom-Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2020.05.011_b0005","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.apsb.2015.07.003","article-title":"Insoluble drug delivery strategies: review of recent advances and business prospects","volume":"5","author":"Kalepu","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejpb.2020.05.011_b0010","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1208\/s12248-015-9814-9","article-title":"Drug delivery approaches in addressing clinical pharmacology-related issues: opportunities and challenges","volume":"17","author":"Wen","year":"2015","journal-title":"AAPS J."},{"key":"10.1016\/j.ejpb.2020.05.011_b0015","doi-asserted-by":"crossref","first-page":"775","DOI":"10.4155\/tde-2017-0039","article-title":"Patient-centered drug delivery and its potential applications for unmet medical needs","volume":"8","author":"Park","year":"2017","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.ejpb.2020.05.011_b0020","doi-asserted-by":"crossref","unstructured":"B. Chatterjee, S. Hamed Almurisi, A. Ahmed Mahdi Dukhan, U.K. Mandal, P. Sengupta, Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view, Drug Deliv. 23 (2016) 3639\u20133652.","DOI":"10.1080\/10717544.2016.1214990"},{"key":"10.1016\/j.ejpb.2020.05.011_b0025","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ejpb.2017.02.003","article-title":"A comparison between pure active pharmaceutical ingredients and therapeutic deep eutectic solvents: Solubility and permeability studies","volume":"114","author":"Duarte","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2020.05.011_b0030","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ijpharm.2017.07.025","article-title":"Drug solubility in lipid nanocarriers: influence of lipid matrix and available interfacial area","volume":"529","author":"Goke","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2020.05.011_b0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.apsb.2013.12.003","article-title":"Can formulation and drug delivery reduce attrition during drug discovery and development\u2014review of feasibility, benefits and challenges","volume":"4","author":"Basavaraj","year":"2014","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejpb.2020.05.011_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2019.01.009","article-title":"Bridging the gaps between academic research and industrial product developments of lipid-based formulations","author":"Holm","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2020.05.011_b0045","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.addr.2019.01.008","article-title":"Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs","volume":"142","author":"Vithani","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2020.05.011_b0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1208\/s12249-019-1335-x","article-title":"Self-emulsifying oral lipid drug delivery systems: advances and challenges","volume":"20","author":"Rani","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2020.05.011_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2017.11.003","article-title":"Measuring the emulsification dynamics and stability of self-emulsifying drug delivery systems","volume":"123","author":"Vasconcelos","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2020.05.011_b0060","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijpharm.2009.04.033","article-title":"Synthesis, characterization, drug-loading capacity and safety of novel octyl modified serum albumin micelles","volume":"376","author":"Gong","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2020.05.011_b0065","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3109\/03639045.2014.935390","article-title":"Co-delivery of paclitaxel and \u03b1-tocopherol succinate by novel chitosan-based polymeric micelles for improving micellar stability and efficacious combination therapy","volume":"41","author":"Emami","year":"2015","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejpb.2020.05.011_b0070","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.1039\/C8TB01384E","article-title":"Improving the carrier stability and drug loading of unimolecular micelle-based nanotherapeutics for acid-activated drug delivery and enhanced antitumor therapy","volume":"6","author":"Shi","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ejpb.2020.05.011_b0075","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejpb.2018.04.023","article-title":"Self-assembled amphiphilic zein-lactoferrin micelles for tumor targeted co-delivery of rapamycin and wogonin to breast cancer","volume":"128","author":"Sabra","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2020.05.011_b0080","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.msec.2018.03.030","article-title":"Self-assembled nanomicelles of amphiphilic clotrimazole glycyl-glycine analogue augmented drug delivery, apoptosis and restrained melanoma tumour progression","volume":"89","author":"Kaur","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.ejpb.2020.05.011_b0085","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1021\/acs.bioconjchem.7b00505","article-title":"Synthesis and characterization of fatty acid grafted chitosan polymer and their nanomicelles for nonviral gene delivery applications","volume":"28","author":"Sharma","year":"2017","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejpb.2020.05.011_b0090","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201704324","article-title":"Advancements and challenges in multidomain multicargo delivery vehicles","volume":"30","author":"Pugliese","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejpb.2020.05.011_b0095","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.lfs.2005.12.007","article-title":"Multiple biological activities of curcumin: a short review","volume":"78","author":"Maheshwari","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.ejpb.2020.05.011_b0100","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3109\/1061186X.2016.1157883","article-title":"Oral bioavailability of curcumin: problems and advancements","volume":"24","author":"Liu","year":"2016","journal-title":"J. Drug Target."},{"key":"10.1016\/j.ejpb.2020.05.011_b0105","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.msec.2017.12.007","article-title":"Rational design of curcumin loaded multifunctional mesoporous silica nanoparticles to enhance the cytotoxicity for targeted and controlled drug release","volume":"85","author":"Chen","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.ejpb.2020.05.011_b0110","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1021\/acs.molpharmaceut.8b00655","article-title":"Self-assembled nanomicelles as curcumin drug delivery vehicles: impact on solitary fibrous tumor cell protein expression and viability","volume":"15","author":"Dagrada","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2020.05.011_b0115","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1208\/s12249-017-0906-y","article-title":"Development of chitosan-based pH-sensitive polymeric micelles containing curcumin for colon-targeted drug delivery","volume":"19","author":"Woraphatphadung","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2020.05.011_b0120","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jddst.2017.07.013","article-title":"A conjugation of stearic acid to apotransferrin, fattigation-platform, as a core to form self-assembled nanoparticles: Encapsulation of a hydrophobic paclitaxel and receptor-driven cancer targeting","volume":"41","author":"Amin","year":"2017","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejpb.2020.05.011_b0125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijpharm.2018.04.047","article-title":"Design and evaluation of clickable gelatin-oleic nanoparticles using fattigation-platform for cancer therapy","volume":"545","author":"Meghani","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2020.05.011_b0130","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.colsurfb.2018.05.060","article-title":"Modulation of serum albumin protein corona for exploring cellular behaviors of fattigation-platform nanoparticles","volume":"170","author":"Nguyen","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ejpb.2020.05.011_b0135","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijpharm.2019.04.038","article-title":"The roles of short and long chain fatty acids on physicochemical properties and improved cancer targeting of albumin-based fattigation-platform nanoparticles containing doxorubicin","volume":"564","author":"Park","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2020.05.011_b0140","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.msec.2017.05.029","article-title":"Biodistribution and in vivo performance of fattigation-platform theranostic nanoparticles","volume":"79","author":"Tran","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.ejpb.2020.05.011_b0145","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.msec.2017.03.012","article-title":"Fattigation-platform theranostic nanoparticles for cancer therapy","volume":"75","author":"Tran","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.ejpb.2020.05.011_b0150","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.colsurfb.2017.08.014","article-title":"Fattigation-platform nanoparticles using apo-transferrin stearic acid as a core for receptor-oriented cancer targeting","volume":"159","author":"Amin","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ejpb.2020.05.011_b0155","doi-asserted-by":"crossref","first-page":"18039","DOI":"10.1038\/srep18039","article-title":"Variant fatty acid-like molecules conjugation, novel approaches for extending the stability of therapeutic peptides","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejpb.2020.05.011_b0160","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bcp.2016.04.016","article-title":"Site-specific fatty chain-modified exenatide analogs with balanced glucoregulatory activity and prolonged in vivo activity","volume":"110","author":"Sun","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejpb.2020.05.011_b0165","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.xphs.2016.10.021","article-title":"Challenges in translational development of pharmaceutical cocrystals","volume":"106","author":"Kale","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2020.05.011_b0170","first-page":"219","article-title":"A novel paclitaxel-loaded polymeric micelle system with favorable biocompatibility and superior antitumor activity","volume":"38","author":"Deng","year":"2018","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejpb.2020.05.011_b0175","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jddst.2017.11.006","article-title":"Reprecipitation of poorly water-soluble cilostazol crystals using adsorbing carriers for enhanced dissolution and physicochemical modification","volume":"43","author":"Baek","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejpb.2020.05.011_b0180","doi-asserted-by":"crossref","DOI":"10.2174\/1381612825666190618102717","article-title":"Modulation of drug crystallization and molecular interactions by additives in solid dispersions for improving drug bioavailability","author":"Tran","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejpb.2020.05.011_b0185","article-title":"Simulated, biorelevant, clinically relevant or physiologically relevant dissolution media: the hidden role of bicarbonate buffer","author":"Silva","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2020.05.011_b0190","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1208\/s12248-017-0085-5","article-title":"Evolution of choice of solubility and dissolution media after two decades of biopharmaceutical classification system","volume":"19","author":"Bou-Chacra","year":"2017","journal-title":"AAPS J."},{"key":"10.1016\/j.ejpb.2020.05.011_b0195","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijpharm.2013.09.021","article-title":"Encapsulation of paclitaxel into lauric acid-O-carboxymethyl chitosan-transferrin micelles for hydrophobic drug delivery and site-specific targeted delivery","volume":"457","author":"Nam","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2020.05.011_b0200","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.carbpol.2018.10.086","article-title":"Linolenic acid-modified methoxy poly (ethylene glycol)-oligochitosan conjugate micelles for encapsulation of amphotericin B","volume":"205","author":"Song","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2020.05.011_b0205","doi-asserted-by":"crossref","unstructured":"S. Gorinstein, M. Weisz, A. Caspi, I. Libman, H.T. Lerner, S. Trakhtenberg, A. Rosen, I. Goshev, M. Zemser, M.C. A\u00f1on, Structure characterization of human serum proteins in solution and dry state, J. Pept. Res. 59 (2002) 71\u201378.","DOI":"10.1046\/j.1397-002x.2001.jpp10948.doc.x"},{"key":"10.1016\/j.ejpb.2020.05.011_b0210","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jcis.2018.10.078","article-title":"Caffeoyl maleic fatty alcohol monoesters: Synthesis, characterization and antioxidant assessment","volume":"536","author":"Anankanbil","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ejpb.2020.05.011_b0215","doi-asserted-by":"crossref","first-page":"0063","DOI":"10.1038\/s41570-017-0063","article-title":"Evolution of macromolecular complexity in drug delivery systems","volume":"1","author":"Kakkar","year":"2017","journal-title":"Nat. Rev. Chem."},{"key":"10.1016\/j.ejpb.2020.05.011_b0220","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1021\/acs.molpharmaceut.5b00157","article-title":"PEGylated Fmoc-amino acid conjugates as effective nanocarriers for improved drug delivery","volume":"12","author":"Zhang","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2020.05.011_b0225","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.drudis.2010.02.009","article-title":"Nanonization strategies for poorly water-soluble drugs","volume":"16","author":"Chen","year":"2011","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.ejpb.2020.05.011_b0230","article-title":"Drug solubility: importance and enhancement techniques","volume":"2012","author":"Savjani","year":"2012","journal-title":"ISRN Pharm."},{"key":"10.1016\/j.ejpb.2020.05.011_b0235","article-title":"Solubility enhancement and application of cyclodextrins in local drug delivery","author":"Kim","year":"2019","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.ejpb.2020.05.011_b0240","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s40005-017-0357-1","article-title":"Enhancing solubility of poorly aqueous soluble drugs: critical appraisal of techniques","volume":"48","author":"Singh","year":"2018","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.ejpb.2020.05.011_b0245","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s40005-016-0299-z","article-title":"Analysis and optimization of drug solubility to improve pharmacokinetics","volume":"47","author":"Thapa","year":"2017","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.ejpb.2020.05.011_b0250","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.ijbiomac.2016.07.101","article-title":"Development of surface curcumin nanoparticles modified with biological macromolecules for anti-tumor effects","volume":"92","author":"Choi","year":"2016","journal-title":"Int. J. Biol. Macromol."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641120301387?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641120301387?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:39:10Z","timestamp":1760546350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641120301387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":50,"alternative-id":["S0939641120301387"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2020.05.011","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fatty acid chain length impacts nanonizing capacity of albumin-fatty acid nanomicelles: Enhanced physicochemical property and cellular delivery of poorly water-soluble drug","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2020.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}