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Soc. Rev."},{"issue":"4","key":"10.1016\/j.ejpb.2021.05.029_b0510","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1021\/acs.nanolett.8b00040","article-title":"Smart nanoreactors for pH-responsive tumor homing, mitochondria-targeting, and enhanced photodynamic-immunotherapy of cancer","volume":"18","author":"Yang","year":"2018","journal-title":"Nano Lett."},{"issue":"13","key":"10.1016\/j.ejpb.2021.05.029_b0515","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1016\/j.biomaterials.2010.01.065","article-title":"Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles","volume":"31","author":"He","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2021.05.029_b0520","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jconrel.2018.03.012","article-title":"Size shrinkable drug delivery nanosystems and priming the tumor microenvironment for deep intratumoral penetration of nanoparticles","volume":"277","author":"Niu","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2021.05.029_b0525","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.biomaterials.2017.09.013","article-title":"pH multistage responsive micellar system with charge-switch and PEG layer detachment for co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells","volume":"147","author":"Yang","year":"2017","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.ejpb.2021.05.029_b0530","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1021\/acs.nanolett.7b02031","article-title":"Acidity-triggered ligand-presenting nanoparticles to overcome sequential drug delivery barriers to tumors","volume":"17","author":"Wang","year":"2017","journal-title":"Nano Lett."},{"issue":"4","key":"10.1016\/j.ejpb.2021.05.029_b0535","doi-asserted-by":"crossref","first-page":"622","DOI":"10.2967\/jnumed.114.152132","article-title":"Comparative studies of three 68Ga-labeled [Des-Arg10]kallidin derivatives for imaging bradykinin B1 receptor expression with PET","volume":"56","author":"Lin","year":"2015","journal-title":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine."},{"issue":"3","key":"10.1016\/j.ejpb.2021.05.029_b0540","doi-asserted-by":"crossref","first-page":"1602494","DOI":"10.1002\/smll.201602494","article-title":"ATP\/pH Dual Responsive Nanoparticle with d-[des-Arg10] Kallidin Mediated Efficient In Vivo Targeting Drug Delivery","volume":"13","author":"Zhang","year":"2017","journal-title":"Small"},{"issue":"5","key":"10.1016\/j.ejpb.2021.05.029_b0545","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1452","article-title":"Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles","volume":"9","author":"Selby","year":"2017","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"issue":"3","key":"10.1016\/j.ejpb.2021.05.029_b0550","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ejpb.2012.09.001","article-title":"pH-Dependent doxorubicin release from terpolymer of starch, polymethacrylic acid and polysorbate 80 nanoparticles for overcoming multi-drug resistance in human breast cancer cells","volume":"82","author":"Shalviri","year":"2012","journal-title":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV."},{"issue":"101","key":"10.1016\/j.ejpb.2021.05.029_b0555","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.colsurfb.2012.07.015","article-title":"Design of pH-responsive nanoparticles of terpolymer of poly(methacrylic acid), polysorbate 80 and starch for delivery of doxorubicin","volume":"1","author":"Shalviri","year":"2013","journal-title":"Colloids Surf., B"},{"issue":"4","key":"10.1016\/j.ejpb.2021.05.029_b0560","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/s41565-019-0381-6","article-title":"Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer","volume":"14","author":"Xu","year":"2019","journal-title":"Nat. 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