{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:49:49Z","timestamp":1780656589779,"version":"3.54.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.ejpb.2021.07.008","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T05:44:28Z","timestamp":1627364668000},"page":"127-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Cyclodextrin based bone regenerative inclusion complex for resveratrol in postmenopausal osteoporosis"],"prefix":"10.1016","volume":"167","author":[{"given":"Aarti Abhishek","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaila","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Ghate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Saklani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Narayana Kalkura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Baby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogendra","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish K.","family":"Chourasia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2021.07.008_b0005","first-page":"217","article-title":"Significance of wine and resveratrol in cardiovascular disease: French paradox revisited","volume":"11","author":"Vidavalur","year":"2006","journal-title":"Exp. Clin. Cardiol."},{"key":"10.1016\/j.ejpb.2021.07.008_b0010","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jconrel.2011.09.083","article-title":"Administration of resveratrol: what formulation solutions to bioavailability limitations?","volume":"158","author":"Amri","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2021.07.008_b0015","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/nyas.12145","article-title":"Osteogenic effects of resveratrol in vitro: potential for the prevention and treatment of osteoporosis","volume":"1290","author":"Mobasheri","year":"2013","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.ejpb.2021.07.008_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom9030094","article-title":"Advance on resveratrol application in bone regeneration: progress and perspectives for use in oral and maxillofacial surgery","volume":"9","author":"Murgia","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejpb.2021.07.008_b0025","first-page":"76","article-title":"Effects of resveratrol on bone mineral density in ovarectomized rats","volume":"22","author":"Lin","year":"2005","journal-title":"Int. J. Biomed. Science"},{"key":"10.1016\/j.ejpb.2021.07.008_b0030","first-page":"5032","article-title":"Protective effects of resveratrol on osteoporosis via activation of the SIRT1-NF-\u03baB signaling pathway in rats","volume":"14","author":"Wang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejpb.2021.07.008_b0035","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1089\/jmf.2005.8.14","article-title":"Effects of trans -resveratrol from polygonum cuspidatum on bone loss using the ovariectomized rat model","volume":"8","author":"Liu","year":"2005","journal-title":"J. Med. Food"},{"key":"10.1016\/j.ejpb.2021.07.008_b0040","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1055\/s-2008-1074550","article-title":"Comparison of the phytohormones genistein, resveratrol and 8-prenylnaringenin as agents for preventing osteoporosis","volume":"74","author":"Sehmisch","year":"2008","journal-title":"Planta Med."},{"key":"10.1016\/j.ejpb.2021.07.008_b0045","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.bbadis.2014.10.003","article-title":"Resveratrol supplementation affects bone acquisition and osteoporosis: pre-clinical evidence toward translational diet therapy","volume":"1852","author":"Tou","year":"2014","journal-title":"Biochim. Biophys. Acta \u2013 Mol. Basis Dis."},{"key":"10.1016\/j.ejpb.2021.07.008_b0050","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijpharm.2015.01.003","article-title":"Resveratrol nanoformulations: challenges and opportunities","volume":"479","author":"Summerlin","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2021.07.008_b0055","unstructured":"Center for Drug Evaluation and Research, Advisory Committee Calendar - Updated Agenda and Public Participation: November 20-21, 2017: Meeting of the Pharmacy Compounding Advisory Committee Meeting Announcement, 2017."},{"key":"10.1016\/j.ejpb.2021.07.008_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules23051161","article-title":"Solubility of cyclodextrins and drug\/cyclodextrin complexes","volume":"23","author":"Saokham","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ejpb.2021.07.008_b0065","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.xphs.2020.10.026","article-title":"Cyclodextrins in parenteral formulations","volume":"110","author":"Loftsson","year":"2021","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2021.07.008_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119396","article-title":"Sulfobutylether-\u03b2-cyclodextrin","volume":"583","author":"Stella","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2021.07.008_b0075","first-page":"8","article-title":"Formulation and evaluation of meloxicam orally dispersible capsules","volume":"4","author":"El-Mahrouk","year":"2009","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2021.07.008_b0080","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.foodchem.2006.10.068","article-title":"Cyclodextrins as resveratrol carrier system","volume":"104","author":"Lucas-Abell\u00e1n","year":"2007","journal-title":"Food Chem."},{"key":"10.1016\/j.ejpb.2021.07.008_b0085","doi-asserted-by":"crossref","first-page":"14114","DOI":"10.1039\/C4RA14737E","article-title":"Theoretical study of complexation of resveratrol with cyclodextrins and cucurbiturils: structure and antioxidative activity","volume":"5","author":"Lu","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejpb.2021.07.008_b0090","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.colsurfb.2013.11.025","article-title":"A characterization study of resveratrol\/sulfobutyl ether-\u03b2-cyclodextrin inclusion complex and in vitro anticancer activity","volume":"115","author":"Venuti","year":"2014","journal-title":"Colloids Surf., B Biointerfaces"},{"key":"10.1016\/j.ejpb.2021.07.008_b0095","doi-asserted-by":"crossref","first-page":"7279","DOI":"10.1021\/jf048794e","article-title":"Structural basis for antioxidant activity of trans-resveratrol: ab initio calculations and crystal and molecular structure","volume":"52","author":"Caruso","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejpb.2021.07.008_b0100","doi-asserted-by":"crossref","first-page":"9782","DOI":"10.1021\/ma202055a","article-title":"Aggregation and host-guest interactions in dansyl-substituted poly(acrylate)s in the presence of \u03b2-cyclodextrin and a \u03b2-cyclodextrin dimer in aqueous solution: a UV-vis, fluorescence, 1H NMR, and rheological study","volume":"44","author":"Wang","year":"2011","journal-title":"Macromolecules"},{"key":"10.1016\/j.ejpb.2021.07.008_b0105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10847-018-0797-x","article-title":"In silico prediction coupled with in vitro experiments and absorption modeling to study the inclusion complex of telmisartan with modified beta-cyclodextrin","volume":"91","author":"Chandra","year":"2018","journal-title":"J. Incl. Phenom. Macrocycl. Chem."},{"key":"10.1016\/j.ejpb.2021.07.008_b0110","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.5012\/bkcs.2013.34.4.1051","article-title":"Facile docking and scoring studies of carborane ligands with estrogen receptor","volume":"34","author":"Ok","year":"2013","journal-title":"Bull. Korean Chem. Soc."},{"key":"10.1016\/j.ejpb.2021.07.008_b0115","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1039\/c4ce00316k","article-title":"Knowledge-based approaches to co-crystal design","volume":"16","author":"Wood","year":"2014","journal-title":"CrystEngComm"},{"key":"10.1016\/j.ejpb.2021.07.008_b0120","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1107\/S0108768110003988","article-title":"Universal prediction of intramolecular hydrogen bonds in organic crystals","volume":"66","author":"Galek","year":"2010","journal-title":"Acta Crystallogr. Sect. B Struct. Sci."},{"key":"10.1016\/j.ejpb.2021.07.008_b0125","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1021\/acs.jcim.5b00337","article-title":"Blind pose prediction, scoring, and affinity ranking of the CSAR 2014 dataset","volume":"56","author":"Martiny","year":"2015","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ejpb.2021.07.008_b0130","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1172\/JCI116483","article-title":"Loss of cancellous bone mass and connectivity in ovariectomized rats can be restored by combined treatment with parathyroid hormone and estradiol","volume":"91","author":"Shen","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejpb.2021.07.008_b0135","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s00223-013-9755-1","article-title":"Effects of different dosages of parathyroid hormone-related protein 1\u201334 on the bone metabolism of the ovariectomized rat model of osteoporosis","volume":"93","author":"Xu","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.ejpb.2021.07.008_b0140","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.foodchem.2014.05.094","article-title":"NMR (1H, ROESY) spectroscopic and molecular modelling investigations of supramolecular complex of \u03b2-cyclodextrin and curcumin","volume":"165","author":"Jahed","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.ejpb.2021.07.008_b0145","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/0192623307310945","article-title":"Cyclodextrins","volume":"36","author":"Quanren","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.ejpb.2021.07.008_b0150","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijpharm.2012.06.055","article-title":"Cyclodextrins","volume":"453","author":"Kurkov","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2021.07.008_b0155","series-title":"Osteoporosis Research Animal Models","author":"Duque","year":"2011"},{"key":"10.1016\/j.ejpb.2021.07.008_b0160","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1017\/S0007114513003115","article-title":"Long-term resveratrol treatment prevents ovariectomy-induced osteopenia in rats without hyperplastic effects on the uterus","volume":"111","author":"Zhao","year":"2014","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ejpb.2021.07.008_b0165","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1021\/cr970019t","article-title":"NMR studies of cyclodextrins and cyclodextrin complexes","volume":"98","author":"Schneider","year":"1998","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejpb.2021.07.008_b0170","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10847-012-0214-9","article-title":"Structural characterization and diffusional analysis of the inclusion complexes of fluoroadamantane with \u03b2-cyclodextrin and its derivatives studied via 1H, 13C and 19F NMR spectroscopy","volume":"76","author":"Gu","year":"2013","journal-title":"J. Incl. Phenom. Macrocycl. Chem."},{"key":"10.1016\/j.ejpb.2021.07.008_b0175","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ijpharm.2018.05.016","article-title":"Elucidation of the orientation of selected drugs with 2-hydroxylpropyl-\u03b2-cyclodextrin using 2D-NMR spectroscopy and molecular modeling","volume":"545","author":"Adhikari","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2021.07.008_b0180","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4103\/pm.pm_619_18","article-title":"Osteogenic activity of resveratrol in human fetal osteoblast cells","volume":"15","author":"Aarti Abhishek Shah","year":"2019","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.ejpb.2021.07.008_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics13020136","article-title":"Cyclodextrin-based supramolecular complexes of osteoinductive agents for dental tissue regeneration","volume":"13","author":"Terauchi","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2021.07.008_b0190","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.ijbiomac.2016.01.114","article-title":"Supramolecular inclusion complexation of simvastatin with methylated \u03b2-cyclodextrins for promoting osteogenic differentiation","volume":"93","author":"Terauchi","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2021.07.008_b0195","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijpharm.2018.05.063","article-title":"Enhanced cellular uptake and osteogenic differentiation efficiency of melatonin by inclusion complexation with 2-hydroxypropyl \u03b2-cyclodextrin","volume":"547","author":"Terauchi","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2021.07.008_b0200","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.biomaterials.2007.12.023","article-title":"Osteotropic \u03b2-cyclodextrin for local bone regeneration","volume":"29","author":"Liu","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2021.07.008_b0205","first-page":"1543","article-title":"Hormone-replacement therapy in the million women study","volume":"30","author":"Collaborators","year":"2005","journal-title":"The Lancet"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641121001892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641121001892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:44:39Z","timestamp":1760546679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641121001892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":41,"alternative-id":["S0939641121001892"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2021.07.008","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclodextrin based bone regenerative inclusion complex for resveratrol in postmenopausal osteoporosis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2021.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}