{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:10:58Z","timestamp":1789495858502,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"am","delay-in-days":341,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17 K08481"],"award-info":[{"award-number":["17 K08481"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.ejpb.2021.11.011","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T12:21:40Z","timestamp":1638447700000},"page":"43-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Bioinspired carbon monoxide delivery using artificial blood attenuates the progression of obliterative bronchiolitis via suppression of macrophage activation by IL-17A"],"prefix":"10.1016","volume":"170","author":[{"given":"Yuki","family":"Watabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Enoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Otagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsutomo","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ejpb.2021.11.011_b0005","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.healun.2014.08.004","article-title":"Focus theme: Retransplantation","volume":"33","author":"Yusen","year":"2014","journal-title":"J. Hear. Lung Transplant."},{"key":"10.1016\/j.ejpb.2021.11.011_b0010","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1183\/09031936.00107514","article-title":"An international ISHLT\/ATS\/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome","volume":"44","author":"Meyer","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejpb.2021.11.011_b0015","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrd3228","article-title":"The therapeutic potential of carbon monoxide","volume":"9","author":"Motterlini","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejpb.2021.11.011_b0020","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1582-4934.2006.tb00426.x","article-title":"Protective effect of carbon monoxide in transplantation","volume":"10","author":"Nakao","year":"2006","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ejpb.2021.11.011_b0025","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/tri.12314","article-title":"Carbon monoxide-releasing molecule attenuates allograft airway rejection","volume":"27","author":"Ohtsuka","year":"2014","journal-title":"Transpl. Int."},{"key":"10.1016\/j.ejpb.2021.11.011_b0030","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.2174\/0929867325666181113122340","article-title":"Use of Hemoglobin for Delivering Exogenous Carbon Monoxide in Medicinal Applications","volume":"27","author":"Taguchi","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejpb.2021.11.011_b0035","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/jfb8010010","article-title":"Overview of Potential Clinical Applications of Hemoglobin Vesicles (HbV) as Artificial Red Cells, Evidenced by Preclinical Studies of the Academic Research Consortium","volume":"8","author":"Sakai","year":"2017","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.ejpb.2021.11.011_b0040","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3109\/03602532.2011.558094","article-title":"Pharmacokinetic properties of hemoglobin vesicles as a substitute for red blood cells","volume":"43","author":"Taguchi","year":"2011","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.ejpb.2021.11.011_b0045","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1016\/j.xphs.2017.04.006","article-title":"The Use of Hemoglobin Vesicles for Delivering Medicinal Gas for the Treatment of Intractable Disorders","volume":"106","author":"Taguchi","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2021.11.011_b0050","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/SHK.0b013e318188f83d","article-title":"Hemoglobin vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model","volume":"31","author":"Sakai","year":"2009","journal-title":"Shock."},{"key":"10.1016\/j.ejpb.2021.11.011_b0055","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1021\/acsbiomaterials.1c00424","article-title":"Preparation of Artificial Red Blood Cells (Hemoglobin Vesicles) Using the Rotation-Revolution Mixer for High Encapsulation Efficiency","volume":"7","author":"Kure","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.ejpb.2021.11.011_b0060","doi-asserted-by":"crossref","first-page":"6553","DOI":"10.1016\/j.biomaterials.2014.04.049","article-title":"Carbon monoxide-bound hemoglobin-vesicles for the treatment of bleomycin-induced pulmonary fibrosis","volume":"35","author":"Nagao","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2021.11.011_b0065","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jconrel.2021.07.015","article-title":"Liposome-encapsulated methemoglobin as an antidote against cyanide poisoning","volume":"337","author":"Suzuki","year":"2021","journal-title":"J. Control. Release."},{"key":"10.1016\/j.ejpb.2021.11.011_b0070","article-title":"Cell uptake and anti-tumor effect of liposomes containing encapsulated paclitaxel-bound albumin against breast cancer cells in 2D and 3D cultured models","volume":"55","author":"Okamoto","year":"2020","journal-title":"J. Drug Deliv Sci. Technol."},{"key":"10.1016\/j.ejpb.2021.11.011_b0075","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.2147\/IJN.S118185","article-title":"Carbon monoxide-bound hemoglobin vesicles ameliorate multiorgan injuries induced by severe acute pancreatitis in mice by their anti-inflammatory and antioxidant properties","volume":"11","author":"Nagao","year":"2016","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.ejpb.2021.11.011_b0080","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1021\/bc800431d","article-title":"Artificial Oxygen Carriers, Hemoglobin Vesicles and Albumin\u2212Hemes, Based on Bioconjugate Chemistry","volume":"20","author":"Nakagawa","year":"2009","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejpb.2021.11.011_b0085","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1124\/dmd.109.027094","article-title":"Pharmacokinetic study of enclosed hemoglobin and outer lipid component after the administration of hemoglobin vesicles as an artificial oxygen carrier","volume":"37","author":"Taguchi","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejpb.2021.11.011_b0090","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/TP.0000000000000892","article-title":"Obliterative Bronchiolitis","volume":"100","author":"Aguilar","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.ejpb.2021.11.011_b0095","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.intimp.2015.02.003","article-title":"IL-25 regulates the polarization of macrophages and attenuates obliterative bronchiolitis in murine trachea transplantation models","volume":"25","author":"Liu","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejpb.2021.11.011_b0100","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1080\/10717544.2018.1477860","article-title":"Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity","volume":"25","author":"Taguchi","year":"2018","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejpb.2021.11.011_b0105","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jconrel.2021.01.025","article-title":"Nano-designed carbon monoxide donor SMA\/CORM2 exhibits protective effect against acetaminophen induced liver injury through macrophage reprograming and promoting liver regeneration","volume":"331","author":"Song","year":"2021","journal-title":"J. Control. Release."},{"key":"10.1016\/j.ejpb.2021.11.011_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2015.00602","article-title":"Macrophages during the fibrotic process: M2 as friend and foe","volume":"6","author":"Braga","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejpb.2021.11.011_b0115","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.molmed.2016.02.004","article-title":"Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?","volume":"22","author":"Byrne","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejpb.2021.11.011_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-77828-y","article-title":"Loading Imatinib inside targeted nanoparticles to prevent Bronchiolitis Obliterans Syndrome","volume":"10","author":"Pandolfi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejpb.2021.11.011_b0125","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1600-6143.2009.02558.x","article-title":"Posttransplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition","volume":"9","author":"Hodge","year":"2009","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.ejpb.2021.11.011_b0130","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/ajt.12065","article-title":"TNF\u03b1 from classically activated macrophages accentuates epithelial to mesenchymal transition in obliterative bronchiolitis","volume":"13","author":"Borthwick","year":"2013","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.ejpb.2021.11.011_b0135","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1111\/j.1600-6143.2008.02321.x","article-title":"The role of the IL23\/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation","volume":"8","author":"Vanaudenaerde","year":"2008","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.ejpb.2021.11.011_b0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.intimp.2017.08.022","article-title":"IL-17 contributes to the pathogenesis of obliterative bronchiolitis via regulation of M1 macrophages polarization in murine heterotopic trachea transplantation models","volume":"52","author":"Meng","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejpb.2021.11.011_b0145","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1165\/rcmb.2016-0154OC","article-title":"IL-17A Blockade attenuates obliterative bronchiolitis and IFN-g cellular immune response in lung allografts","volume":"56","author":"Gupta","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejpb.2021.11.011_b0150","doi-asserted-by":"crossref","first-page":"L401","DOI":"10.1152\/ajplung.00080.2012","article-title":"IL-17 induces type V collagen overexpression and EMT via TGF-\u03b2-dependent pathways in obliterative bronchiolitis","volume":"304","author":"Vittal","year":"2013","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"10.1016\/j.ejpb.2021.11.011_b0155","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.ejpb.2021.11.011_b0160","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nrd3794","article-title":"Targeting IL-17 and T H 17 cells in chronic inflammation","volume":"11","author":"Miossec","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejpb.2021.11.011_b0165","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/sji.12189","article-title":"Carbon Monoxide-Releasing Molecule-A1 Inhibits Th1\/Th17 and Stimulates Th2 Differentiation In vitro","volume":"80","author":"Nikolic","year":"2014","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.ejpb.2021.11.011_b0170","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1007\/s00125-014-3170-7","article-title":"Pharmacological application of carbon monoxide ameliorates islet-directed autoimmunity in mice via anti-inflammatory and anti-apoptotic effects","volume":"57","author":"Nikolic","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejpb.2021.11.011_b0175","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1111\/ajt.13215","article-title":"CD4 T cells but not Th17 cells are required for mouse lung transplant obliterative bronchiolitis","volume":"15","author":"Wu","year":"2015","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.ejpb.2021.11.011_b0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039750","article-title":"Marking and quantifying IL-17A-producing cells in vivo","volume":"7","author":"Price","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ejpb.2021.11.011_b0185","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nm.3423","article-title":"Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity","volume":"20","author":"Kim","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejpb.2021.11.011_b0190","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jconrel.2016.05.016","article-title":"Evaluation of a new type of nano-sized carbon monoxide donor on treating mice with experimentally induced colitis","volume":"234","author":"Nagao","year":"2016","journal-title":"J. Control. Release."},{"key":"10.1016\/j.ejpb.2021.11.011_b0195","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1021\/bc990173h","article-title":"Poly(ethylene glycol)-conjugation and deoxygenation enable long-term preservation of hemoglobin-vesicles as oxygen carriers in a liquid state","volume":"11","author":"Sakai","year":"2000","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejpb.2021.11.011_b0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165557","article-title":"Long-term stored hemoglobin-vesicles, a cellular type of hemoglobin-based oxygen carrier, has resuscitative effects comparable to that for fresh red blood cells in a rat model with massive hemorrhage without post-transfusion lung injury","volume":"11","author":"Tokuno","year":"2016","journal-title":"PLoS ONE"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641121003416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641121003416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:44:58Z","timestamp":1760546698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641121003416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":40,"alternative-id":["S0939641121003416"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2021.11.011","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioinspired carbon monoxide delivery using artificial blood attenuates the progression of obliterative bronchiolitis via suppression of macrophage activation by IL-17A","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2021.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}