{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:36:46Z","timestamp":1762609006574,"version":"build-2065373602"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ejpb.2022.11.002","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T06:16:17Z","timestamp":1668147377000},"page":"113-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Antigen stabilizing hydrogels based on cyclodextrins and polyethylene glycol act as type-2 adjuvants with suppressed local irritation"],"prefix":"10.1016","volume":"181","author":[{"given":"Tomoya","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumika","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honatsu","family":"Ishiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risako","family":"Onodera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taishi","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Shimamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Itou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Iwase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Arima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Motoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2022.11.002_b0005","doi-asserted-by":"crossref","DOI":"10.17653\/2374-9105.SSe0001","article-title":"Vaccination for disease prevention and control: the necessity of renewed emphasis and new approaches","volume":"1","author":"Chang","year":"2014","journal-title":"J. Immunol. Immunotech."},{"key":"10.1016\/j.ejpb.2022.11.002_b0010","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1590\/S0100-879X2012007500142","article-title":"Recombinant vaccines and the development of new vaccine strategies","volume":"45","author":"Nascimento","year":"2012","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.ejpb.2022.11.002_b0015","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ijpharm.2008.04.036","article-title":"Vaccine adjuvant systems: enhancing the efficacy of sub-unit protein antigens","volume":"364","author":"Perrie","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2022.11.002_b0020","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1099\/jmm.0.038943-0","article-title":"Alum adjuvant: some of the tricks of the oldest adjuvant","volume":"61","author":"Kool","year":"2012","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.ejpb.2022.11.002_b0025","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s40264-015-0350-4","article-title":"Comparative safety of vaccine adjuvants: a summary of current evidence and future needs","volume":"38","author":"Petrovsky","year":"2015","journal-title":"Drug Saf."},{"key":"10.1016\/j.ejpb.2022.11.002_b0030","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.0818-9641.2004.01272.x","article-title":"Vaccine adjuvants: current state and future trends","volume":"82","author":"Petrovsky","year":"2004","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.ejpb.2022.11.002_b0035","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1586\/erv.09.20","article-title":"Opportunities and challenges of developing thermostable vaccines","volume":"8","author":"Chen","year":"2009","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.ejpb.2022.11.002_b0040","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/jps.10294","article-title":"Stabilization of alum-adjuvanted vaccine dry powder formulations: mechanism and application","volume":"92","author":"Maa","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2022.11.002_b0045","doi-asserted-by":"crossref","first-page":"13520","DOI":"10.1038\/ncomms13520","article-title":"Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months","volume":"7","author":"Pelliccia","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejpb.2022.11.002_b0050","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/jps.10296","article-title":"Thermal stability of vaccines","volume":"92","author":"Brandau","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2022.11.002_b0055","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1248\/cpb.c18-00735","article-title":"Cyclodextrin-based molecular accessories for drug discovery and drug delivery","volume":"67","author":"Higashi","year":"2019","journal-title":"Chem. Pharm. Bull (Tokyo)"},{"key":"10.1016\/j.ejpb.2022.11.002_b0060","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1021\/cr970025p","article-title":"Cyclodextrin drug carrier systems","volume":"98","author":"Uekama","year":"1998","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejpb.2022.11.002_b0065","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1021\/cr9000622","article-title":"Polymeric rotaxanes","volume":"109","author":"Harada","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejpb.2022.11.002_b0070","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1021\/ma00212a039","article-title":"Complex formation between poly(ethylene glycol) and \u03b1-cyclodextrin","volume":"23","author":"Harada","year":"1990","journal-title":"Macromolecules"},{"key":"10.1016\/j.ejpb.2022.11.002_b0075","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/370126a0","article-title":"Double-stranded inclusion complexes of cyclodextrin threaded on poly(ethylene glycol)","volume":"370","author":"Harada","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.ejpb.2022.11.002_b0080","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1021\/cr970027+","article-title":"Cyclodextrin rotaxanes and polyrotaxanes","volume":"106","author":"Wenz","year":"2006","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejpb.2022.11.002_b0085","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/asiamat.2010.84","article-title":"Cyclodextrin-based supramolecular architectures: syntheses, structures, and applications for drug and gene delivery","volume":"2","author":"Li","year":"2010","journal-title":"NPG Asia Mater."},{"key":"10.1016\/j.ejpb.2022.11.002_b0090","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1295\/polymj.26.1019","article-title":"Sol-gel transition during inclusion complex formation between \u03b1-cyclodextrin and high molecular weight poly(ethylene glycol)s in aqueous solution","volume":"26","author":"Li","year":"1994","journal-title":"Polym. J."},{"key":"10.1016\/j.ejpb.2022.11.002_b0095","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.addr.2008.02.011","article-title":"Cyclodextrin-based supramolecular architectures: syntheses, structures, and applications for drug and gene delivery","volume":"60","author":"Li","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2022.11.002_b0100","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/jbm.a.10444","article-title":"Injectable drug-delivery systems based on supramolecular hydrogels formed by poly(ethylene oxide)s and \u03b1-cyclodextrin","volume":"65","author":"Li","year":"2003","journal-title":"J. Biomed. Mater. Res. A."},{"key":"10.1016\/j.ejpb.2022.11.002_b0105","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.xphs.2017.01.002","article-title":"Stabilizing effects for antibody formulations and safety profiles of cyclodextrin polypseudorotaxane hydrogels","volume":"106","author":"Higashi","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2022.11.002_b0110","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1208\/s12249-015-0309-x","article-title":"Design and evaluation of the highly concentrated human IgG formulation using cyclodextrin polypseudorotaxane hydrogels","volume":"16","author":"Higashi","year":"2015","journal-title":"AAPS PharmSciTech."},{"key":"10.1016\/j.ejpb.2022.11.002_b0115","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.3389\/fimmu.2018.02619","article-title":"DAMP-inducing adjuvant and PAMP adjuvants parallelly enhance protective type-2 and type-1 immune responses to influenza split vaccination","volume":"9","author":"Hayashi","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejpb.2022.11.002_b0120","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1016\/j.vaccine.2016.04.001","article-title":"Intranasal hydroxypropyl-\u03b2-cyclodextrin-adjuvanted influenza vaccine protects against sub-heterologous virus infection","volume":"34","author":"Kusakabe","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.ejpb.2022.11.002_b0125","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.4049\/jimmunol.1402027","article-title":"Hydroxypropyl-\u03b2-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen","volume":"194","author":"Onishi","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejpb.2022.11.002_b0130","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1248\/bpb1978.5.741","article-title":"Cyclodextrin-induced hemolysis and shape changes of human erythrocytes in vitro","volume":"5","author":"Irie","year":"1982","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.ejpb.2022.11.002_b0135","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ejps.2010.04.014","article-title":"Evaluation of the cytotoxicity of \u03b2-cyclodextrin derivatives: evidence for the role of cholesterol extraction","volume":"40","author":"Kiss","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2022.11.002_b0140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1432-1033.1989.tb15171.x","article-title":"Differential effects of \u03b1-, \u03b2- and \u03b3-cyclodextrins on human erythrocytes","volume":"186","author":"Ohtani","year":"1989","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ejpb.2022.11.002_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117419","article-title":"Polypseudorotaxane-based supramolecular hydrogels consisting of cyclodextrins and Pluronics as stabilizing agents for antibody drugs","volume":"256","author":"Ohshita","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2022.11.002_b0150","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1023\/A:1018523029030","article-title":"Synergistic gelation of xanthan gum with locust bean gum: a rheological investigation","volume":"14","author":"Copetti","year":"1997","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.ejpb.2022.11.002_b0155","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ijbiomac.2018.03.105","article-title":"Rheological characterizations of concentrated binary gum mixtures with xanthan gum and galactomannans","volume":"114","author":"Jo","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2022.11.002_b0160","first-page":"1170","article-title":"Complexes of starchy materials with organic compounds part III. X-ray Ssudies on amylose and cyclodextrin complexes","volume":"33","author":"Takeo","year":"1969","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.ejpb.2022.11.002_b0165","first-page":"568","article-title":"Complexes of starchy materials with organic compound part IV. X-ray diffraction of \u03b3-cyclodextrin complexes","volume":"34","author":"Takeo","year":"1970","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.ejpb.2022.11.002_b0170","doi-asserted-by":"crossref","first-page":"9036","DOI":"10.1021\/la048970d","article-title":"Two-phase channel structures based on \u03b1-cyclodextrin-polyethylene glycol inclusion complexes","volume":"20","author":"Topchieva","year":"2004","journal-title":"Langmuir"},{"key":"10.1016\/j.ejpb.2022.11.002_b0175","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1007\/s11095-006-9227-7","article-title":"Crystal structure changes of \u03b3-cyclodextrin after the SEDS process in supercritical carbon dioxide affect the dissolution rate of complexed budesonide","volume":"24","author":"Toropainen","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2022.11.002_b0180","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1002\/jps.23232","article-title":"Cyclodextrin\/poly(ethylene glycol) polypseudorotaxane hydrogels as a promising sustained-release system for lysozyme","volume":"101","author":"Higashi","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2022.11.002_b0185","doi-asserted-by":"crossref","first-page":"18252","DOI":"10.1039\/C7RA00861A","article-title":"Cytotoxicity study of polyethylene glycol derivatives","volume":"7","author":"Liu","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejpb.2022.11.002_b0190","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4103\/0975-7406.99013","article-title":"Locust bean gum: exploring its potential for biopharmaceutical applications","volume":"4","author":"Dionisio","year":"2012","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.ejpb.2022.11.002_b0195","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.carbpol.2017.01.074","article-title":"Cyclodextrin-based sustained and controllable release system of insulin utilizing the combination system of self-assembly PEGylation and polypseudorotaxane formation","volume":"164","author":"Hirotsu","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2022.11.002_b0200","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.coi.2012.03.008","article-title":"Adjuvants for human vaccines","volume":"24","author":"Alving","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ejpb.2022.11.002_b0205","doi-asserted-by":"crossref","first-page":"455","DOI":"10.15585\/mmwr.mm6715a5","article-title":"Recommendations of the advisory committee on immunization practices for use of a hepatitis B vaccine with a novel adjuvant","volume":"67","author":"Schillie","year":"2018","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"key":"10.1016\/j.ejpb.2022.11.002_b0210","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nri3247","article-title":"Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination","volume":"12","author":"Desmet","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejpb.2022.11.002_b0215","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.immuni.2016.11.010","article-title":"Inhaled fine particles induce alveolar macrophage death and interleukin-1\u03b1 release to promote inducible bronchus-associated lymphoid tissue formation","volume":"45","author":"Kuroda","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.ejpb.2022.11.002_b0220","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nm.2403","article-title":"DNA released from dying host cells mediates aluminum adjuvant activity","volume":"17","author":"Marichal","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejpb.2022.11.002_b0225","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1021\/js960213f","article-title":"Pharmaceutical applications of cyclodextrins. III. Toxicological issues and safety evaluation","volume":"86","author":"Irie","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2022.11.002_b0230","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0169-409X(98)00057-X","article-title":"Cyclodextrins in peptide and protein delivery","volume":"36","author":"Irie","year":"1999","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2022.11.002_b0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084856","article-title":"Fluorescently labeled methyl-\u03b2-cyclodextrin enters intestinal epithelial Caco2 cells by fluid-phase endocytosis","volume":"9","author":"Fenyvesi","year":"2014","journal-title":"PLoS ONE."},{"key":"10.1016\/j.ejpb.2022.11.002_b0240","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1073\/pnas.0914309107","article-title":"Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells","volume":"107","author":"Rosenbaum","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejpb.2022.11.002_b0245","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/jphp.12405","article-title":"Effects of cyclodextrins on GM1-gangliosides in fibroblasts from GM1-gangliosidosis patients","volume":"67","author":"Maeda","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2022.11.002_b0250","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10847-018-0835-8","article-title":"Lowering effect of dimethyl-\u03b1-cyclodextrin on GM1-ganglioside accumulation in GM1-gangliosidosis model cells and in brain of \u03b2-galactosidase-knockout mice","volume":"93","author":"Maeda","year":"2019","journal-title":"J. Incl. Phenom. Macrocycl. Chem."},{"key":"10.1016\/j.ejpb.2022.11.002_b0255","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijpharm.2010.03.026","article-title":"Potential use of \u03b3-cyclodextrin polypseudorotaxane hydrogels as an injectable sustained release system for insulin","volume":"392","author":"Abu","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2022.11.002_b0260","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1295\/koron.2014-0036","article-title":"The network structure and the drug release characteristics of agar gel and xanthan gum-locust bean gum complex gel","volume":"72","author":"Hishikawa","year":"2015","journal-title":"Kobunshi Ronbunshu."},{"key":"10.1016\/j.ejpb.2022.11.002_b0265","doi-asserted-by":"crossref","first-page":"19ra12","DOI":"10.1126\/scitranslmed.3000490","article-title":"Long-term thermostabilization of live poxviral and adenoviral vaccine vectors at supraphysiological temperatures in carbohydrate glass","volume":"2","author":"Alcock","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejpb.2022.11.002_b0270","doi-asserted-by":"crossref","first-page":"eaau4819","DOI":"10.1126\/sciadv.aau4819","article-title":"Novel technology for storage and distribution of live vaccines and other biological medicines at ambient temperature","volume":"6","author":"Bajrovic","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejpb.2022.11.002_b0271","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0378-5173(94)90080-9","article-title":"Evaluation of the cytotoxicity of cyclodextrins and hydroxypropylated derivatives","volume":"101","author":"Leroy-Lechat","year":"1994","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2022.11.002_b0272","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.cell.2019.04.012","article-title":"Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance","volume":"177","author":"Cirelli","year":"2019","journal-title":"Cell"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641122002533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641122002533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:50:04Z","timestamp":1760547004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641122002533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":56,"alternative-id":["S0939641122002533"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2022.11.002","relation":{},"ISSN":["0939-6411"],"issn-type":[{"type":"print","value":"0939-6411"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antigen stabilizing hydrogels based on cyclodextrins and polyethylene glycol act as type-2 adjuvants with suppressed local irritation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2022.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}