{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T21:31:59Z","timestamp":1771968719835,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013944","name":"Institut de Canc\u00e9rologie de Lorraine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013944","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.ejpb.2023.01.010","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T18:07:08Z","timestamp":1674151628000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Phototoxicity of temoporfin-loaded cyclodextrin nanosponges in stroma-rich three-dimensional models of head and neck cancer"],"prefix":"10.1016","volume":"184","author":[{"given":"Laureline","family":"Lamy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon","family":"Fran\u00e7ois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Bezdetnaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilya","family":"Yakavets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2023.01.010_b0005","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.3390\/cancers13174447","article-title":"Photodynamic therapy: a compendium of latest reviews","volume":"13","author":"Algorri","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ejpb.2023.01.010_b0010","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.686303","article-title":"Photodynamic therapy for the treatment and diagnosis of cancer \u2013 a review of the current clinical status","volume":"9","author":"Gunaydin","year":"2021","journal-title":"Front. Chem."},{"key":"10.1016\/j.ejpb.2023.01.010_b0015","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3322\/caac.20114","article-title":"Photodynamic therapy of cancer: an update","volume":"61","author":"Agostinis","year":"2011","journal-title":"CA-Can. J. Clin."},{"key":"10.1016\/j.ejpb.2023.01.010_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpap.2021.100042","article-title":"The photophysics of photosensitization: a brief overview","volume":"7","author":"Quina","year":"2021","journal-title":"J. Photochem. Photobiol."},{"key":"10.1016\/j.ejpb.2023.01.010_b0025","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1572-1000(05)00007-4","article-title":"Mechanisms in photodynamic therapy: part one-photosensitizers, photochemistry and cellular localization","volume":"1","author":"Castano","year":"2004","journal-title":"Photodiagnosis Photodyn Ther."},{"key":"10.1016\/j.ejpb.2023.01.010_b0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1572-1000(05)00060-8","article-title":"Mechanisms in photodynamic therapy: part three-photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction","volume":"2","author":"Castano","year":"2005","journal-title":"Photodiagnosis. Photodyn. Ther."},{"key":"10.1016\/j.ejpb.2023.01.010_b0035","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/j.1751-1097.2011.00986.x","article-title":"Temoporfin (Foscan\u00ae, 5,10,15,20-tetra(m-hydroxyphenyl)chlorin) \u2013 a second-generation photosensitizer","volume":"87","author":"Senge","year":"2011","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ejpb.2023.01.010_b0040","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pdpdt.2011.10.001","article-title":"mTHPC \u2013 A drug on its way from second to third generation photosensitizer?","volume":"9","author":"Senge","year":"2012","journal-title":"Photodiagn. Photodyn."},{"key":"10.1016\/j.ejpb.2023.01.010_b0045","doi-asserted-by":"crossref","unstructured":"A. Wiehe, M.O. Senge, The photosensitizer temoporfin (mTHPC) \u2013 chemical, pre-clinical and clinical developments in the last decade, Photochem. Photobiol. n\/a (n.d.). https:\/\/doi.org\/10.1111\/php.13730.","DOI":"10.1111\/php.13730"},{"key":"10.1016\/j.ejpb.2023.01.010_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.102800","article-title":"Quality of life following photodynamic therapy for head and neck pathologies: an exploratory study","volume":"38","author":"Jerjes","year":"2022","journal-title":"Photodiagnosis Photodyn Ther."},{"key":"10.1016\/j.ejpb.2023.01.010_b0055","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.bbagen.2005.06.014","article-title":"Investigation of Foscan interactions with plasma proteins","volume":"1725","author":"Sasnouski","year":"2005","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.ejpb.2023.01.010_b0060","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jconrel.2019.05.035","article-title":"Current state of the nanoscale delivery systems for temoporfin-based photodynamic therapy: advanced delivery strategies","volume":"304","author":"Yakavets","year":"2019","journal-title":"J. Control. Release."},{"key":"10.1016\/j.ejpb.2023.01.010_b0065","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jconrel.2019.06.029","article-title":"Advanced in silico modeling explains pharmacokinetics and biodistribution of temoporfin nanocrystals in humans","volume":"308","author":"Jablonka","year":"2019","journal-title":"J. Control. Release"},{"issue":"8","key":"10.1016\/j.ejpb.2023.01.010_b0070","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.3390\/molecules23081936","article-title":"Use of cyclodextrins in anticancer photodynamic therapy treatment","volume":"23","author":"Ben Mihoub","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ejpb.2023.01.010_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119595","article-title":"Host-guest complexes \u2013 boosting the performance of photosensitizers","volume":"586","author":"Sowa","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2023.01.010_b0080","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejpb.2020.06.022","article-title":"Cyclodextrin nanosponge as a temoporfin nanocarrier: Balancing between accumulation and penetration in 3D tumor spheroids","volume":"154","author":"Yakavets","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2023.01.010_b0085","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.3390\/jcm8101686","article-title":"Stroma-rich co-culture multicellular tumor spheroids as a tool for photoactive drugs screening","volume":"8","author":"Yakavets","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ejpb.2023.01.010_b0090","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.3390\/cancers12123727","article-title":"NIR imaging of the integrin-rich head and neck squamous cell carcinoma using ternary copper indium selenide\/zinc sulfide-based quantum dots","volume":"12","author":"Yakavets","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.ejpb.2023.01.010_b0095","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.oraloncology.2007.07.001","article-title":"Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation","volume":"44","author":"Kellermann","year":"2008","journal-title":"Oral Oncol."},{"key":"10.1016\/j.ejpb.2023.01.010_b0100","first-page":"240","article-title":"Comparison of the influence of photodynamic reaction on the Me45 and MEWO cell lines in vitro","volume":"16","author":"Choroma\u0144ska","year":"2012","journal-title":"Contemp. Oncol. (Pozn)"},{"key":"10.1016\/j.ejpb.2023.01.010_b0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12951-020-00743-x","article-title":"Effect of stroma on the behavior of temoporfin-loaded lipid nanovesicles inside the stroma-rich head and neck carcinoma spheroids","volume":"19","author":"Yakavets","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ejpb.2023.01.010_b0110","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1124\/pr.55.4.4","volume":"55","author":"Neubig","year":"2003","journal-title":"Pharmacol. Rev."},{"issue":"10","key":"10.1016\/j.ejpb.2023.01.010_b0115","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1093\/bioinformatics\/btaa826","article-title":"synergy: a Python library for calculating, analyzing and visualizing drug combination synergy","volume":"37","author":"Wooten","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ejpb.2023.01.010_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.progpolymsci.2021.101408","article-title":"Cyclodextrin polymers: structure, synthesis, and use as drug carriers","volume":"118","author":"Liu","year":"2021","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.ejpb.2023.01.010_b0125","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/17425247.2019.1591365","article-title":"Cyclodextrin-based nanosponges as promising carriers for active agents","volume":"16","author":"Allahyari","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejpb.2023.01.010_b0130","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s10856-022-06652-9","article-title":"The ascension of nanosponges as a drug delivery carrier: preparation, characterization, and applications","volume":"33","author":"Tiwari","year":"2022","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.ejpb.2023.01.010_b0135","first-page":"e262731","article-title":"Cyclodextrin-Containing polymers: versatile platforms of drug delivery materials","volume":"2012","author":"Heidel","year":"2012","journal-title":"J. Drug Del."},{"key":"10.1016\/j.ejpb.2023.01.010_b0140","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejps.2016.06.012","article-title":"Inclusion complexation with \u03b2-cyclodextrin derivatives alters photodynamic activity and biodistribution of meta-tetra(hydroxyphenyl)chlorin","volume":"91","author":"Yankovsky","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2023.01.010_b0145","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijpharm.2017.07.037","article-title":"The alteration of temoporfin distribution in multicellular tumor spheroids by \u03b2-cyclodextrins","volume":"529","author":"Yakavets","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2023.01.010_b0150","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3390\/cancers11091366","article-title":"Matryoshka-type liposomes offer the improved delivery of temoporfin to tumor spheroids","volume":"11","author":"Yakavets","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.ejpb.2023.01.010_b0155","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrc.2016.108","article-title":"Cancer nanomedicine: progress, challenges and opportunities","volume":"17","author":"Shi","year":"2017","journal-title":"Nat. Rev. Can."},{"key":"10.1016\/j.ejpb.2023.01.010_b0160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.oraloncology.2010.10.013","article-title":"Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer","volume":"47","author":"Bello","year":"2011","journal-title":"Oral Oncol."},{"key":"10.1016\/j.ejpb.2023.01.010_b0165","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/jop.12623","article-title":"Prognostic value of the immunohistochemical detection of cancer-associated fibroblasts in oral cancer: a systematic review and meta-analysis","volume":"47","author":"Dourado","year":"2018","journal-title":"J. Oral Pathol. Med."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641123000097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641123000097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:49:22Z","timestamp":1760546962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641123000097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":33,"alternative-id":["S0939641123000097"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2023.01.010","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phototoxicity of temoporfin-loaded cyclodextrin nanosponges in stroma-rich three-dimensional models of head and neck cancer","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2023.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}