{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:28:12Z","timestamp":1783337292060,"version":"3.54.6"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.ejpb.2023.01.020","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T02:06:29Z","timestamp":1675044389000},"page":"159-169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Polymer micelles for the protection and delivery of specialized pro-resolving mediators"],"prefix":"10.1016","volume":"184","author":[{"given":"Mitchell","family":"de Prinse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghui","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9011-433X","authenticated-orcid":false,"given":"Brian G.","family":"Amsden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2023.01.020_b0005","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.smim.2015.03.004","article-title":"The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution","volume":"27","author":"Serhan","year":"2015","journal-title":"Seminars in immunology"},{"key":"10.1016\/j.ejpb.2023.01.020_b0010","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nri.2015.4","article-title":"Specialized pro-resolving mediators: endogenous regulators of infection and inflammation","volume":"16","author":"Basil","year":"2016","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.ejpb.2023.01.020_b0015","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.21037\/jtd.2017.10.116","article-title":"Are specialized pro-resolving mediators promising therapeutic agents for severe bronchial asthma","volume":"9","author":"Hisada","year":"2017","journal-title":"Journal of Thoracic Disease"},{"key":"10.1016\/j.ejpb.2023.01.020_b0020","doi-asserted-by":"crossref","first-page":"e0143141","DOI":"10.1371\/journal.pone.0143141","article-title":"In vivo availability of pro-resolving lipid mediators in oxazolone induced dermal inflammation in the mouse","volume":"10","author":"Homann","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejpb.2023.01.020_b0025","doi-asserted-by":"crossref","unstructured":"C. Di Tommaso, J.-L. Bourges, F. Valamanesh, G. Trubitsyn, A. Torriglia, J.-C. Jeanny, F. Behar-Cohen, R. Gurny, M. M\u221a\u2202ller, Novel micelle carriers for cyclosporin A topical ocular delivery: in vivo cornea penetration, ocular distribution and efficacy studies. European Journal of Pharmaceutics and Biopharmaceutics 81 (2012) 257-264.","DOI":"10.1016\/j.ejpb.2012.02.014"},{"key":"10.1016\/j.ejpb.2023.01.020_b0030","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1021\/bm4018879","article-title":"Dithiol-PEG-PDLLA micelles: preparation and evaluation as potential topical ocular delivery vehicle","volume":"15","author":"Yang","year":"2014","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ejpb.2023.01.020_b0035","doi-asserted-by":"crossref","first-page":"18651","DOI":"10.1039\/C5NR04770F","article-title":"Self-assembled polymeric nanocarriers for the targeted delivery of retinoic acid to the hair follicle","volume":"7","author":"Lapteva","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.ejpb.2023.01.020_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120736","article-title":"Polymeric micelle formulations for the cutaneous delivery of sirolimus: A new approach for the treatment of facial angiofibromas in tuberous sclerosis complex","volume":"604","author":"Quartier","year":"2021","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.ejpb.2023.01.020_b0045","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/10717540050120179","article-title":"PCL-b-PEO micelles as a delivery vehicle for FK506: assessment of a functional recovery of crushed peripheral nerve","volume":"7","author":"Allen","year":"2000","journal-title":"Drug Delivery"},{"key":"10.1016\/j.ejpb.2023.01.020_b0050","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.7150\/thno.18962","article-title":"Rapid fluorescence imaging of spinal cord following epidural administration of a nerve-highlighting fluorophore","volume":"7","author":"Liu","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.ejpb.2023.01.020_b0055","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/jps.2600540619","article-title":"Auto-oxidation of linoleic acid in micellar solution","volume":"54","author":"Swarbrick","year":"1965","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.ejpb.2023.01.020_b0060","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/ejlt.201400114","article-title":"Paradox of omega-3 PUFA oxidation","volume":"116","author":"Miyashita","year":"2014","journal-title":"European Journal of Lipid Science and Technology"},{"key":"10.1016\/j.ejpb.2023.01.020_b0065","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1021\/ma00008a008","article-title":"Synthesis, properties, and biodegradation of poly (1, 3-trimethylene carbonate)","volume":"24","author":"Zhu","year":"1991","journal-title":"Macromolecules"},{"key":"10.1016\/j.ejpb.2023.01.020_b0070","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1023\/A:1025084304766","article-title":"Physical properties of high molecular weight 1,3-trimethylene carbonate and D, L-lactide copolymers","volume":"14","author":"Pego","year":"2003","journal-title":"Journal Of Materials Science-Materials In Medicine"},{"key":"10.1016\/j.ejpb.2023.01.020_b0075","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/mabi.200800318","article-title":"Low viscosity poly (trimethylene carbonate) for localized drug delivery: rheological properties and in vivo degradation","volume":"9","author":"Timbart","year":"2009","journal-title":"Macromolecular Bioscience"},{"key":"10.1016\/j.ejpb.2023.01.020_b0080","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1002\/jps.22074","article-title":"Drug\u2013polymer solubility and miscibility: stability consideration and practical challenges in amorphous solid dispersion development","volume":"99","author":"Qian","year":"2010","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.ejpb.2023.01.020_b0085","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ijpharm.2014.06.038","article-title":"Solubility of crystalline organic compounds in high and low molecular weight amorphous matrices above and below the glass transition by zero enthalpy extrapolation","volume":"472","author":"Amharar","year":"2014","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.ejpb.2023.01.020_b0090","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/pat.3524","article-title":"Tuning loading and release by modification of micelle core crystallinity and preparation","volume":"26","author":"Glavas","year":"2015","journal-title":"Polymers for Advanced Technologies"},{"key":"10.1016\/j.ejpb.2023.01.020_b0095","unstructured":"J.-P. Latere Dwan\u2019Isa, L. Rouxhet, V. Pr\u00e9at, M. E. Brewster, A. Arien, Prediction of drug solubility in amphiphilic di-block copolymer micelles: the role of polymer-drug compatibility. Die Pharmazie-An International Journal of Pharmaceutical Sciences 62 (2007) 499-504."},{"key":"10.1016\/j.ejpb.2023.01.020_b0100","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1021\/acs.biomac.9b00618","article-title":"Like Dissolves Like? A Comprehensive Evaluation of Partial Solubility Parameters to Predict Polymer-Drug Compatibility in Ultrahigh Drug-Loaded Polymer Micelles","volume":"20","author":"Luebtow","year":"2019","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ejpb.2023.01.020_b0105","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02633110","article-title":"Solubility of linoleic acid in aqueous solutions and its reaction with water","volume":"38","author":"Mabrouk","year":"1961","journal-title":"Journal of the American Oil Chemists\u2019 Society"},{"key":"10.1016\/j.ejpb.2023.01.020_b0110","doi-asserted-by":"crossref","first-page":"15495","DOI":"10.1021\/acs.langmuir.8b03576","article-title":"effect of formulation and processing parameters on the size of mPEG-b-p (HPMA-Bz) polymeric micelles","volume":"34","author":"Bagheri","year":"2018","journal-title":"Langmuir"},{"key":"10.1016\/j.ejpb.2023.01.020_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2014.04.057","article-title":"Statistical comparison of the slopes of two regression lines: A tutorial","volume":"838","author":"Andrade","year":"2014","journal-title":"Analytica Chimica Acta"},{"key":"10.1016\/j.ejpb.2023.01.020_b0120","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.biomaterials.2005.09.017","article-title":"The in vivo and in vitro degradation behavior of poly(trimethylene carbonate)","volume":"27","author":"Zhang","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2023.01.020_b0125","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ejpb.2006.09.008","article-title":"In vitro release of a water-soluble agent from low viscosity biodegradable, injectable oligomers","volume":"65","author":"Sharifpoor","year":"2007","journal-title":"European Journal Of Pharmaceutics And Biopharmaceutics"},{"key":"10.1016\/j.ejpb.2023.01.020_b0130","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/marc.200300085","article-title":"Synthesis and Characterization of Novel Biodegradable Copolymers of 5-Benzyloxy-1,3-dioxan-2-one and Glycolide","volume":"24","author":"Cheng","year":"2003","journal-title":"Macromolecular Rapid Communications"},{"key":"10.1016\/j.ejpb.2023.01.020_b0135","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1021\/ma070190z","article-title":"Reverse thermal gelling PEG-PTMC diblock copolymer aqueous solution","volume":"40","author":"Kim","year":"2007","journal-title":"Macromolecules"},{"key":"10.1016\/j.ejpb.2023.01.020_b0140","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.polymdegradstab.2018.10.022","article-title":"Degradation of poly(5-hydroxy-trimethylene carbonate) in aqueous environments","volume":"158","author":"Chen","year":"2018","journal-title":"Polymer Degradation and Stability"},{"key":"10.1016\/j.ejpb.2023.01.020_b0145","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1021\/acs.molpharmaceut.0c00064","article-title":"Liquid degradable poly (trimethylene-carbonate-co-5-hydroxy-trimethylene carbonate): an injectable drug delivery vehicle for acid-sensitive drugs","volume":"17","author":"Mohajeri","year":"2020","journal-title":"Molecular Pharmaceutics"},{"key":"10.1016\/j.ejpb.2023.01.020_b0150","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1021\/bm049836a","article-title":"Synthesis and Characterization of Biodegradable Poly(ethylene glycol)- block-poly(5-benzyloxy-trimethylene carbonate) Copolymers for Drug Delivery","volume":"5","author":"Zeng","year":"2004","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ejpb.2023.01.020_b0155","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.colsurfa.2007.05.078","article-title":"Polymeric nano-micelles using poly (ethylene glycol) and poly (trimethylene carbonate) diblock copolymers as a drug carrier","volume":"313","author":"Hyun","year":"2008","journal-title":"Colloids and Surfaces A: Physicochemical and Engineering Aspects"},{"key":"10.1016\/j.ejpb.2023.01.020_b0160","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1021\/ma00005a010","article-title":"Poly (styrene-ethylene oxide) block copolymer micelle formation in water: a fluorescence probe study","volume":"24","author":"Wilhelm","year":"1991","journal-title":"Macromolecules"},{"key":"10.1016\/j.ejpb.2023.01.020_b0165","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1002\/anie.202010934","article-title":"The Trojan Horse Goes Wild: The Effect of Drug Loading on the Behavior of Nanoparticles","volume":"60","author":"Stenzel","year":"2021","journal-title":"Angewandte Chemie International Edition"},{"key":"10.1016\/j.ejpb.2023.01.020_b0170","doi-asserted-by":"crossref","first-page":"24531","DOI":"10.1021\/acsami.9b22495","article-title":"Think beyond the core: impact of the hydrophilic corona on drug solubilization using polymer micelles","volume":"12","author":"Haider","year":"2020","journal-title":"ACS Applied Materials & Interfaces"},{"key":"10.1016\/j.ejpb.2023.01.020_b0175","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/j.1460-2075.1991.tb07651.x","article-title":"The inhibition of the GTPase activating protein-Ha-ras interaction by acidic lipids is due to physical association of the C-terminal domain of the GTPase activating protein with micellar structures","volume":"10","author":"Serth","year":"1991","journal-title":"The EMBO Journal"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641123000267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641123000267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:51:40Z","timestamp":1760547100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641123000267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":35,"alternative-id":["S0939641123000267"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2023.01.020","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polymer micelles for the protection and delivery of specialized pro-resolving mediators","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2023.01.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}