{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:26:27Z","timestamp":1785795987765,"version":"3.56.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.ejpb.2023.04.001","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T11:24:06Z","timestamp":1680866646000},"page":"12-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Cocrystallization of 5-fluorouracil with gallic acid: A novel 5-fluorouracil cocrystal displaying synergistic anti-tumor activity both in oral and intraperitoneal injection administration"],"prefix":"10.1016","volume":"187","author":[{"given":"Han","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiqin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3499-8337","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2023.04.001_b0005","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.3390\/nu11092147","article-title":"Dietary curcumin: correlation between bioavailability and health potential","volume":"11","author":"Dei Cas","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.ejpb.2023.04.001_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131485","article-title":"Apigenin-oxymatrine binary co-amorphous mixture: enhanced solubility, bioavailability, and anti-inflammatory effect","volume":"373","author":"Li","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.ejpb.2023.04.001_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119731","article-title":"Self-assembled lecithin-chitosan nanoparticles improve the oral bioavailability and alter the pharmacokinetics of raloxifene","volume":"588","author":"Murthy","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2023.04.001_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.matlet.2021.129763","article-title":"Development of water-soluble curcumin grafted magnetic nanoparticles for enhancing bioavailability, fluorescence, and magnetic resonance imaging activity","volume":"294","author":"Periyathambi","year":"2021","journal-title":"Mater. Lett."},{"key":"10.1016\/j.ejpb.2023.04.001_b0025","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1039\/D0CE00713G","article-title":"Cocrystallization of 5-fluorouracil and l-phenylalanine: the first zwitterionic cocrystal of 5-fluorouracil with amino acid exhibiting perfect in vitro\/vivo pharmaceutical properties","volume":"22","author":"Wang","year":"2020","journal-title":"CrystEngComm"},{"key":"10.1016\/j.ejpb.2023.04.001_b0030","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1021\/acs.cgd.0c01716","article-title":"Extremely bioavailable cocrystal of pterostilbene","volume":"21","author":"Bofill","year":"2021","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.ejpb.2023.04.001_b0035","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.3390\/pharmaceutics13111817","article-title":"Improved bioavailability of poorly soluble drugs through gastrointestinal muco-adhesion of lipid nanoparticles","volume":"13","author":"Tan","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2023.04.001_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119307","article-title":"The solubility, permeability and the dose as key factors in formulation development for oral lipophilic drugs: Maximizing the bioavailability of carbamazepine with a cosolvent-based formulation","volume":"582","author":"Fine-Shamir","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2023.04.001_b0045","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/ddr.21832","article-title":"Challenges of peptide and protein drug delivery by oral route: current strategies to improve the bioavailability","volume":"82","author":"Verma","year":"2021","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.ejpb.2023.04.001_b0050","doi-asserted-by":"crossref","first-page":"09","DOI":"10.13005\/msri\/140103","article-title":"Cocrystals: a review of recent trends in pharmaceutical and material science applications","volume":"14","author":"Javoor","year":"2017","journal-title":"Mater. Sci. Res. India"},{"key":"10.1016\/j.ejpb.2023.04.001_b0055","doi-asserted-by":"crossref","first-page":"8127","DOI":"10.1039\/D0CE01289K","article-title":"A 5-fluorouracil\u2013kaempferol drug\u2013drug cocrystal: a ternary phase diagram, characterization and property evaluation","volume":"22","author":"Lv","year":"2020","journal-title":"CrystEngComm"},{"key":"10.1016\/j.ejpb.2023.04.001_b0060","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1021\/cg500502j","article-title":"Controlled synthesis of new 5-fluorocytosine Cocrystals Based on the pKa rule","volume":"14","author":"da Silva","year":"2014","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.ejpb.2023.04.001_b0065","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.2042-7158.2010.01246.x","article-title":"Enhanced dissolution and stability of adefovir dipivoxil by cocrystal formation","volume":"63","author":"Gao","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2023.04.001_b0070","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1021\/acs.cgd.1c01051","article-title":"Enhanced solubility, dissolution, and permeability of abacavir by salt and cocrystal formation","volume":"22","author":"Ji","year":"2022","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.ejpb.2023.04.001_b0075","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1021\/acs.cgd.6b00552","article-title":"Improving the membrane permeability of 5-fluorouracil via cocrystallization","volume":"16","author":"Dai","year":"2016","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.ejpb.2023.04.001_b0080","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1208\/s12249-019-1360-9","article-title":"Cocrystal of 5-fluorouracil: characterization and evaluation of biopharmaceutical parameters","volume":"20","author":"Gautam","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2023.04.001_b0085","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1021\/acs.cgd.0c01519","article-title":"Cocrystals of propylthiouracil and nutraceuticals toward sustained-release: design, structure analysis, and solid-state characterization","volume":"21","author":"Xiao","year":"2021","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.ejpb.2023.04.001_b0090","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.3390\/molecules26092414","article-title":"New cocrystals of antipsychotic drug aripiprazole: decreasing the dissolution through cocrystallization","volume":"26","author":"Liu","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejpb.2023.04.001_b0095","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.xphs.2017.01.033","article-title":"Pharmaceutical co-crystal of flufenamic acid: synthesis and characterization of two novel drug-drug co-crystal","volume":"106","author":"Nechipadappu","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2023.04.001_b0100","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1038\/sj.onc.1208552","article-title":"Oncogenic Ras increases sensitivity of colon cancer cells to 5-FU-induced apoptosis","volume":"24","author":"Klampfer","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.ejpb.2023.04.001_b0105","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1039\/D0CE00409J","article-title":"Modulating the solubility and pharmacokinetic properties of 5-fluorouracil via cocrystallization","volume":"22","author":"Dai","year":"2020","journal-title":"CrystEngComm"},{"key":"10.1016\/j.ejpb.2023.04.001_b0110","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejps.2017.03.042","article-title":"Fast dissolving drug-drug eutectics with improved compressibility and synergistic effects","volume":"104","author":"Thipparaboina","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2023.04.001_b0115","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejpb.2020.08.024","article-title":"The mechanism of binding with the \u03b1-glucosidase in vitro and the evaluation on hypoglycemic effect in vivo: cocrystals involving synergism of gallic acid and conformer","volume":"156","author":"Xue","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2023.04.001_b0120","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3390\/molecules25051163","article-title":"Characterizations and assays of \u03b1-glucosidase inhibition activity on gallic acid cocrystals: can the cocrystals be defined as a new chemical entity during binding with the \u03b1-glucosidase?","volume":"25","author":"Xue","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ejpb.2023.04.001_b0125","doi-asserted-by":"crossref","first-page":"7992","DOI":"10.1039\/D0CE01297A","article-title":"The supramolecular self-assembly of 5-fluorouracil and caffeic acid through cocrystallization strategy opens up a new way for the development of synergistic antitumor pharmaceutical cocrystal","volume":"22","author":"Yu","year":"2020","journal-title":"CrystEngComm"},{"key":"10.1016\/j.ejpb.2023.04.001_b0130","doi-asserted-by":"crossref","first-page":"15068","DOI":"10.1039\/C8NJ01576G","article-title":"Structural and computational insights into the enhanced solubility of dipfluzine by complexation: salt and salt-cocrystal","volume":"42","author":"Guo","year":"2018","journal-title":"New J. Chem."},{"key":"10.1016\/j.ejpb.2023.04.001_b0135","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.powtec.2015.11.068","article-title":"Powder grinding preparation of co-amorphous \u03b2-azelnidipine and maleic acid combination: molecular interactions and physicochemical properties","volume":"291","author":"Han","year":"2016","journal-title":"Powder Technol."},{"key":"10.1016\/j.ejpb.2023.04.001_b0140","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1039\/c3ce26967a","article-title":"Crystal engineering approach to produce complex of azelnidipine with maleic acid","volume":"15","author":"Lian","year":"2013","journal-title":"CrystEngComm"},{"key":"10.1016\/j.ejpb.2023.04.001_b0145","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s11095-013-1181-6","article-title":"Preparation, characterization, and evaluation of dipfluzine\u2013benzoic acid co-crystals with improved physicochemical properties","volume":"31","author":"Lin","year":"2014","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2023.04.001_b0150","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jpba.2017.02.005","article-title":"Solid state characterization of azelnidipine\u2013oxalic acid co-crystal and co-amorphous complexes: the effect of different azelnidipine polymorphs","volume":"138","author":"Pan","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejpb.2023.04.001_b0155","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1021\/acs.molpharmaceut.7b00217","article-title":"Preparation of curcumin\u2013piperazine coamorphous phase and fluorescence spectroscopic and density functional theory simulation studies on the interaction with bovine serum albumin","volume":"14","author":"Pang","year":"2017","journal-title":"Mol. Pharmaceut."},{"key":"10.1016\/j.ejpb.2023.04.001_b0160","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jpba.2018.03.006","article-title":"Experimental and DFT simulation study of a novel felodipine cocrystal: characterization, dissolving properties and thermal decomposition kinetics","volume":"154","author":"Yang","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejpb.2023.04.001_b0165","first-page":"127","article-title":"Synthesis, characterization and antitumor activity of 5-fluorouracil-nicotinamide cocrystal","volume":"46","author":"Min","year":"2017","journal-title":"J. Zhejiang Univ. (Med. Sci.)"},{"key":"10.1016\/j.ejpb.2023.04.001_b0170","doi-asserted-by":"crossref","first-page":"27540","DOI":"10.1039\/C5RA01911G","article-title":"Gallic acid: a versatile antioxidant with promising therapeutic and industrial applications","volume":"5","author":"Badhani","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejpb.2023.04.001_b0175","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3390\/molecules23030695","article-title":"Gallic acid content and an antioxidant mechanism are responsible for the antiproliferative activity of 'Ataulfo' mango peel on LS180 cells","volume":"23","author":"Velderrain-Rodriguez","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ejpb.2023.04.001_b0180","series-title":"Handbook on Gallic Acid: Natural Occurrences, Antioxidant Properties and Health Implications","first-page":"1","article-title":"Antioxidant, antitumoral and anti-inflammatory activities of gallic acid","author":"Locatelli","year":"2013"},{"key":"10.1016\/j.ejpb.2023.04.001_b0185","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3390\/v8060157","article-title":"Antiviral effects of black raspberry (Rubus coreanus) seed and its gallic acid against influenza virus infection","volume":"8","author":"Lee","year":"2016","journal-title":"Viruses"},{"key":"10.1016\/j.ejpb.2023.04.001_b0190","doi-asserted-by":"crossref","first-page":"35608","DOI":"10.1039\/C5RA02727F","article-title":"Gallic acid: prospects and molecular mechanisms of its anticancer activity","volume":"5","author":"Subramanian","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejpb.2023.04.001_b0195","article-title":"Improving hygroscopic stability of palmatine chloride by forming a pharmaceutical salt cocrystal of palmatine chloride-gallic acid with neutral molecule","volume":"66","author":"Zhang","year":"2021","journal-title":"J. Drug Deliv. Sci. Tec."},{"key":"10.1016\/j.ejpb.2023.04.001_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112576","article-title":"Gallic acid for cancer therapy: Molecular mechanisms and boosting efficacy by nanoscopical delivery","volume":"157","author":"Ashrafizadeh","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejpb.2023.04.001_b0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-019-0868-0","article-title":"Effect of Gallic acid in potentiating chemotherapeutic effect of Paclitaxel in HeLa cervical cancer cells","volume":"19","author":"Aborehab","year":"2019","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.ejpb.2023.04.001_b0210","first-page":"1779","article-title":"Gallic acid has anticancer activity and enhances the anticancer effects of cisplatin in non-small cell lung cancer A549 cells via the JAK\/STAT3 signaling pathway","volume":"41","author":"Zhang","year":"2019","journal-title":"Oncology reports"},{"key":"10.1016\/j.ejpb.2023.04.001_b0215","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22638","article-title":"Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line","volume":"35","author":"Aborehab","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ejpb.2023.04.001_b0220","first-page":"1","article-title":"Cocrystal of 5-fluorouracil: characterization and evaluation of biopharmaceutical parameters","volume":"3","author":"Gautam","year":"2019","journal-title":"Aaps Pharmscitech,"},{"key":"10.1016\/j.ejpb.2023.04.001_b0225","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jep.2017.08.038","article-title":"Artemisinin permeability via Caco-2 cells increases after simulated digestion of Artemisia annua leaves","volume":"210","author":"Desrosiers","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejpb.2023.04.001_b0230","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.3390\/biom12121739","article-title":"Increasing cellular uptake and permeation of curcumin using a novel polymer-surfactant formulation","volume":"12","author":"Liu","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejpb.2023.04.001_b0235","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11243-004-2854-0","article-title":"Synthesis, spectral, fluorescence, thermal and biological studies on ionic hafnocene pyrimidine complexes","volume":"30","author":"Malhotra","year":"2005","journal-title":"Transition Met. Chem."},{"key":"10.1016\/j.ejpb.2023.04.001_b0240","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.saa.2018.05.002","article-title":"Investigation into structure and dehydration dynamic of gallic acid monohydrate: a Raman spectroscopic study","volume":"201","author":"Cai","year":"2018","journal-title":"Spectrochim. Acta, Part A"},{"key":"10.1016\/j.ejpb.2023.04.001_b0245","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/1097-4555(200007)31:7<595::AID-JRS582>3.0.CO;2-9","article-title":"Fourier transform Raman spectrum and ab initio and density functional computations of the vibrational spectrum, molecular geometry, atomic charges and some molecular properties of the anticarcinogenic drug 5-fluorouracil","volume":"31","author":"Rastogi","year":"2000","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.ejpb.2023.04.001_b0250","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.trac.2017.09.009","article-title":"Overview of experimental and computational methods for the determination of the pKa values of 5-fluorouracil, cyclophosphamide, ifosfamide, imatinib and methotrexate, TrAC","volume":"97","author":"Mioduszewska","year":"2017","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.ejpb.2023.04.001_b0255","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/jrs.4752","article-title":"Monitoring deprotonation of gallic acid by Raman spectroscopy","volume":"46","author":"Huguenin","year":"2015","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.ejpb.2023.04.001_b0260","article-title":"Organic salt versus salt cocrystal: thermal behavior, structural and photoluminescence investigations","volume":"1\u201311","author":"Crisan","year":"2021","journal-title":"J. Therm. Anal. Calorim."},{"key":"10.1016\/j.ejpb.2023.04.001_b0265","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.3390\/molecules24203683","article-title":"5-fluorouracil\u2014complete insight into its neutral and ionised forms","volume":"24","author":"Wieli\u0144ska","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ejpb.2023.04.001_b0270","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10787-021-00917-5","article-title":"Curcumin and n-acetylcysteine cocrystal produced with supercritical solvent: characterization, solubility, and preclinical evaluation of antinociceptive and anti-inflammatory activities","volume":"30","author":"Paulazzi","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.ejpb.2023.04.001_b0275","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ejpb.2021.09.009","article-title":"The effect of buffer species on biorelevant dissolution and precipitation assays\u2013comparison of phosphate and bicarbonate buffer","volume":"171","author":"Krollik","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2023.04.001_b0280","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1021\/acs.cgd.2c00007","article-title":"Cocrystals of nitrofurantoin: how coformers can modify its solubility and permeability across intestinal cell monolayers","volume":"22","author":"Segalina","year":"2022","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.ejpb.2023.04.001_b0285","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1021\/mp500826y","article-title":"Indomethacin co-crystals and their parent mixtures: does the intestinal barrier recognize them differently?","volume":"12","author":"Ferretti","year":"2015","journal-title":"Mol Pharm"},{"key":"10.1016\/j.ejpb.2023.04.001_b0290","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3109\/00498254.2014.973470","article-title":"Time-dependent inhibition of CYP3A4 by gallic acid in human liver microsomes and recombinant systems","volume":"45","author":"Pu","year":"2015","journal-title":"Xenobiotica"},{"key":"10.1016\/j.ejpb.2023.04.001_b0295","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1208\/s12248-012-9413-y","article-title":"Renal organic anion transporters (SLC22 family): expression, regulation, roles in toxicity, and impact on injury and disease","volume":"15","author":"Wang","year":"2013","journal-title":"AAPS J"},{"key":"10.1016\/j.ejpb.2023.04.001_b0300","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1124\/dmd.32.5.479","article-title":"Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3","volume":"32","author":"Kobayashi","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejpb.2023.04.001_b0305","doi-asserted-by":"crossref","first-page":"15777","DOI":"10.1021\/acsomega.9b03574","article-title":"Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide","volume":"5","author":"Zhang","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejpb.2023.04.001_b0310","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1039\/D1AN00171J","article-title":"Supramolecular self-assembly and perfected in vitro\/vivo property of 5-fluorouracil and ferulic acid on the strength of double optimized strategy: the first 5-fluorouracial-phenolic acid nutraceutical cocrystal with synergistic antitumor efficacy","volume":"146","author":"Yu","year":"2021","journal-title":"Analyst"},{"key":"10.1016\/j.ejpb.2023.04.001_b0315","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/tera.1420480409","article-title":"Effects of developmental stage and tissue type on embryo\/fetal DNA distributions and 5-fluorouracil-induced cell\u2013cycle perturbations","volume":"48","author":"Elstein","year":"1993","journal-title":"Teratology"},{"key":"10.1016\/j.ejpb.2023.04.001_b0320","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s13273-021-00118-9","article-title":"Dehydroabietic acid inhibits the gastric cancer cell growth via induced apoptosis and cell cycle arrest","volume":"17","author":"Kim","year":"2021","journal-title":"Mol. Cell. Toxicol."},{"key":"10.1016\/j.ejpb.2023.04.001_b0325","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/bjc.1995.519","article-title":"Differences in resistance to 5-fluorouracil as a function of cell cycle delay and not apoptosis","volume":"72","author":"Pickard","year":"1995","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejpb.2023.04.001_b0330","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0006-2952(94)00444-Q","article-title":"Aberrant cell cycle inhibition pattern in human colon carcinoma cell lines after exposure to 5-fluorouracil","volume":"49","author":"Pizzorno","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejpb.2023.04.001_b0335","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/15548627.2017.1378838","article-title":"Autophagy pathway: cellular and molecular mechanisms","volume":"14","author":"Yu","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.ejpb.2023.04.001_b0340","doi-asserted-by":"crossref","first-page":"18678","DOI":"10.1074\/jbc.M801855200","article-title":"A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells","volume":"283","author":"Wang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejpb.2023.04.001_b0345","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1242\/jcs.195057","article-title":"Ratiometric analysis of Acridine Orange staining in the study of acidic organelles and autophagy","volume":"129","author":"Thome","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejpb.2023.04.001_b0350","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12249-020-01803-z","article-title":"Autophagy-inducing inhalable co-crystal formulation of Niclosamide-Nicotinamide for lung cancer therapy","volume":"21","author":"Ray","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2023.04.001_b0355","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/cdd.2014.143","article-title":"Autosis and autophagic cell death: the dark side of autophagy","volume":"22","author":"Liu","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejpb.2023.04.001_b0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/17588359211009001","article-title":"Oral drugs in the treatment of metastatic colorectal cancer","volume":"13","author":"Garcia-Alfonso","year":"2021","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.ejpb.2023.04.001_b0365","first-page":"2289","article-title":"The oral fluoropyrimidines in cancer chemotherapy","volume":"5","author":"Lamont","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejpb.2023.04.001_b0370","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/00001813-200310000-00003","article-title":"Dihydropyrimidine dehydrogenase inhibition as a strategy for the oral administration of 5-fluorouracil: utility in the treatment of advanced colorectal cancer","volume":"14","author":"Schmoll","year":"2003","journal-title":"Anti-cancer Drugs"},{"key":"10.1016\/j.ejpb.2023.04.001_b0375","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00280-019-03936-w","article-title":"Dihydropyrimidine dehydrogenase in the metabolism of the anticancer drugs","volume":"84","author":"Sharma","year":"2019","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.ejpb.2023.04.001_b0380","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1248\/bpb.21.871","article-title":"First-pass metabolism of 5-fluorouracil in the perfused rat small intestine","volume":"21","author":"Gu","year":"1998","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejpb.2023.04.001_b0385","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/j.2042-7158.1998.tb06917.x","article-title":"First-pass metabolism of 5-fluorouracil in rats","volume":"50","author":"Yuasa","year":"1998","journal-title":"J. Pharm. Pharmacol."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641123000814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641123000814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:51:01Z","timestamp":1760547061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641123000814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":77,"alternative-id":["S0939641123000814"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2023.04.001","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cocrystallization of 5-fluorouracil with gallic acid: A novel 5-fluorouracil cocrystal displaying synergistic anti-tumor activity both in oral and intraperitoneal injection administration","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2023.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}