{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:48:26Z","timestamp":1790596106640,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY21H160030"],"award-info":[{"award-number":["LY21H160030"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFE0107800"],"award-info":[{"award-number":["2022YFE0107800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.ejpb.2023.09.003","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T11:27:02Z","timestamp":1693999622000},"page":"205-218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Double layer spherical nanoparticles with hyaluronic acid coating to enhance oral delivery of exenatide in T2DM rats"],"prefix":"10.1016","volume":"191","author":[{"given":"Yiying","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2596-2903","authenticated-orcid":false,"given":"Linjie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-8217","authenticated-orcid":false,"given":"Xiaoyan","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6055-3163","authenticated-orcid":false,"given":"Qi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjiang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenHong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DongHang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ejpb.2023.09.003_b0005","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.biotechadv.2015.02.010","article-title":"Polymer-based nanoparticles for oral insulin delivery: Revisited approaches","volume":"33","author":"Fonte","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ejpb.2023.09.003_b0010","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41573-019-0053-0","article-title":"Advances in oral peptide therapeutics","volume":"19","author":"Drucker","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejpb.2023.09.003_b0015","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2337\/dc17-1519","article-title":"Clinical Impact of ITCA 650, a Novel Drug-Device GLP-1 Receptor Agonist, in Uncontrolled Type 2 Diabetes and Very High Baseline HbA(1c): The FREEDOM-1 HBL (High Baseline) Study","volume":"41","author":"Henry","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ejpb.2023.09.003_b0020","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1016\/j.clinthera.2012.09.007","article-title":"Safety of exenatide once weekly in patients with type 2 diabetes mellitus treated with a thiazolidinedione alone or in combination with metformin for 2 years","volume":"34","author":"Norwood","year":"2012","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ejpb.2023.09.003_b0025","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.ijbiomac.2019.07.168","article-title":"Cellular uptake and transport characteristics of chitosan modified nanoparticles in Caco-2 cell monolayers","volume":"138","author":"Dou","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.ejpb.2023.09.003_b0030","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jconrel.2007.05.019","article-title":"Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles","volume":"122","author":"Chalasani","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2023.09.003_b0035","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.addr.2015.08.001","article-title":"Stabilization challenges and formulation strategies associated with oral biologic drug delivery systems","volume":"93","author":"Truong-Le","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2023.09.003_b0040","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1517\/17425247.2015.1068287","article-title":"Self-emulsifying drug delivery systems in oral (poly)peptide drug delivery","volume":"12","author":"Leonaviciute","year":"2015","journal-title":"Expert Opin. Drug Del."},{"key":"10.1016\/j.ejpb.2023.09.003_b0045","article-title":"Fc-modified exenatide-loaded nanoparticles for oral delivery to improve hypoglycemic effects in mice","volume":"8","author":"Shi","year":"2018","journal-title":"Sci. Rep.-Uk"},{"key":"10.1016\/j.ejpb.2023.09.003_b0050","doi-asserted-by":"crossref","unstructured":"A. Abramson, E. Caffarel-Salvador, M. Khang, D. Dellal, D. Silverstein, Y. Gao, M.R. Frederiksen, A. Vegge, F. Hub\u00e1lek, J.J. Water, A.V. Friderichsen, J. Fels, R.K. Kirk, C. Cleveland, J. Collins, S. Tamang, A. Hayward, T. Landh, S.T. Buckley, N. Roxhed, U. Rahbek, R. Langer, G. Traverso, An ingestible self-orienting system for oral delivery of macromolecules, Science (New York, N.Y.), 363 (2019) 611-615.","DOI":"10.1126\/science.aau2277"},{"issue":"1","key":"10.1016\/j.ejpb.2023.09.003_b0055","doi-asserted-by":"crossref","DOI":"10.1186\/s12877-017-0658-2","article-title":"Prevalence and treatment of diabetes mellitus and hypertension among older adults with intellectual disability in comparison with the general population","volume":"17","author":"Axmon","year":"2017","journal-title":"BMC Geriatr."},{"issue":"467","key":"10.1016\/j.ejpb.2023.09.003_b0060","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aar7047","article-title":"Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist","volume":"10","author":"Buckley","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejpb.2023.09.003_b0065","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jconrel.2018.03.018","article-title":"In vivo evaluation of an oral self-emulsifying drug delivery system (SEDDS) for exenatide","volume":"277","author":"Menzel","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2023.09.003_b0070","article-title":"Amphiphiles Self-Assembly: Basic Concepts and Future Perspectives of Supramolecular Approaches","volume":"2015","author":"Lombardo","year":"2015","journal-title":"Adv. Cond. Matter Phys."},{"key":"10.1016\/j.ejpb.2023.09.003_b0075","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1021\/cr200254q","article-title":"Nonaqueous polar solvents in reverse micelle systems","volume":"112","author":"Correa","year":"2012","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejpb.2023.09.003_b0080","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ijpharm.2014.10.054","article-title":"Nanocarrier improves the bioavailability, stability and antitumor activity of camptothecin","volume":"477","author":"Tang","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2023.09.003_b0085","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s11095-010-0130-x","article-title":"Phospholipids and lipid-based formulations in oral drug delivery","volume":"27","author":"Fricker","year":"2010","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2023.09.003_b0090","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jconrel.2017.04.038","article-title":"Lipophilic peptide character - What oral barriers fear the most","volume":"255","author":"Zupan\u010di\u010d","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2023.09.003_b0095","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.addr.2018.07.001","article-title":"SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs","volume":"142","author":"Mahmood","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2023.09.003_b0100","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ijpharm.2017.03.027","article-title":"Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione","volume":"523","author":"Het\u00e9nyi","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2023.09.003_b0105","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.actbio.2018.03.013","article-title":"Targeting tumor hypoxia with stimulus-responsive nanocarriers in overcoming drug resistance and monitoring anticancer efficacy","volume":"71","author":"Xie","year":"2018","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.ejpb.2023.09.003_b0110","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1039\/C9BM01546A","article-title":"AIE\/FRET-based versatile PEG-Pep-TPE\/DOX nanoparticles for cancer therapy and real-time drug release monitoring","volume":"8","author":"Wang","year":"2020","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.ejpb.2023.09.003_b0115","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ijpharm.2018.12.062","article-title":"Hyaluronic acid enhances cell survival of encapsulated insulin-producing cells in alginate-based microcapsules","volume":"557","author":"Canibano-Hernandez","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"25","key":"10.1016\/j.ejpb.2023.09.003_b0120","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1039\/C4TB00273C","article-title":"Improving the oral delivery efficiency of anticancer drugs by chitosan coated polycaprolactone-grafted hyaluronic acid nanoparticles","volume":"2","author":"Huang","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ejpb.2023.09.003_b0125","article-title":"Rapid gelation of oxidized hyaluronic acid and succinyl chitosan for integration with insulin-loaded micelles and epidermal growth factor on diabetic wound healing, Materials science & engineering","volume":"117","author":"Zhu","year":"2020","journal-title":"C, Mater. Biol. Appl."},{"issue":"2","key":"10.1016\/j.ejpb.2023.09.003_b0130","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1208\/s12248-013-9546-7","article-title":"Hyaluronidase-Sensitive Nanoparticle Templates for Triggered Release of HIV\/AIDS Microbicide In Vitro","volume":"16","author":"Agrahari","year":"2014","journal-title":"AAPS J."},{"issue":"2","key":"10.1016\/j.ejpb.2023.09.003_b0135","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.apsb.2018.01.013","article-title":"Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery","volume":"8","author":"Wagner","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejpb.2023.09.003_b0140","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.colsurfb.2018.06.024","article-title":"Paclitaxel delivered by CD44 receptor-targeting and endosomal pH sensitive dual functionalized hyaluronic acid micelles for multidrug resistance reversion, Colloids and surfaces","volume":"170","author":"Liu","year":"2018","journal-title":"B, Biointerfaces"},{"key":"10.1016\/j.ejpb.2023.09.003_b0145","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1211\/0022357044085","article-title":"Mucoadhesive and penetration enhancement properties of three grades of hyaluronic acid using porcine buccal and vaginal tissue, Caco-2 cell lines, and rat jejunum","volume":"56","author":"Sandri","year":"2004","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2023.09.003_b0150","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.canlet.2012.07.002","article-title":"Hyaluronic acid-coated nanostructured lipid carriers for targeting paclitaxel to cancer","volume":"334","author":"Yang","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejpb.2023.09.003_b0155","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1208\/s12249-012-9807-2","article-title":"Insulin-loaded pH-sensitive hyaluronic acid nanoparticles enhance transcellular delivery","volume":"13","author":"Han","year":"2012","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2023.09.003_b0160","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1021\/acs.molpharmaceut.7b00236","article-title":"Hyaluronic Acid Molecular Weight-Dependent Modulation of Mucin Nanostructure for Potential Mucosal Therapeutic Applications","volume":"14","author":"Hansen","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2023.09.003_b0165","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1111\/jcmm.13110","article-title":"Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles","volume":"21","author":"Salatin","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejpb.2023.09.003_b0170","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1539-6924.2010.01446.x","article-title":"Exposure assessment approaches for engineered nanomaterials, Risk analysis : an official publication of the Society for","volume":"30","author":"Abbott","year":"2010","journal-title":"Risk Anal."},{"key":"10.1016\/j.ejpb.2023.09.003_b0175","article-title":"Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2)","author":"Honary","year":"2013","journal-title":"Trop. J. Pharm. Res."},{"issue":"2","key":"10.1016\/j.ejpb.2023.09.003_b0180","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cis.2011.02.005","article-title":"Influence of process and formulation parameters on the formation of submicron particles by solvent displacement and emulsification-diffusion methods critical comparison","volume":"163","author":"Mora-Huertas","year":"2011","journal-title":"Adv. Colloid Interface Sci."},{"issue":"42","key":"10.1016\/j.ejpb.2023.09.003_b0185","doi-asserted-by":"crossref","first-page":"17745","DOI":"10.1039\/C5NR04831A","article-title":"Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy","volume":"7","author":"Xiao","year":"2015","journal-title":"Nanoscale"},{"issue":"1-2","key":"10.1016\/j.ejpb.2023.09.003_b0190","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ijpharm.2014.05.047","article-title":"In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin","volume":"472","author":"Hintzen","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2023.09.003_b0195","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.2147\/IJN.S105419","article-title":"Improved oral bioavailability of poorly water-soluble glimepiride by utilizing microemulsion technique","volume":"11","author":"Li","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejpb.2023.09.003_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.120884","article-title":"Hyaluronic acid modified oral drug delivery system with mucoadhesiveness and macrophage-targeting for colitis treatment","volume":"313","author":"Zhang","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2023.09.003_b0205","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12951-023-02015-w","article-title":"Hyaluronic acid-graphene oxide quantum dots nanoconjugate as dual purpose drug delivery and therapeutic agent in meta-inflammation","volume":"21","author":"Sarkar","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ejpb.2023.09.003_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.116506","article-title":"Hyaluronic acid-functionalized lipoplexes and polyplexes as emerging nanocarriers for receptor-targeted cancer therapy","volume":"233","author":"Chandra","year":"2023","journal-title":"Environ. Res."},{"issue":"7","key":"10.1016\/j.ejpb.2023.09.003_b0215","doi-asserted-by":"crossref","first-page":"7081","DOI":"10.1016\/j.actbio.2013.03.005","article-title":"Applications and emerging trends of hyaluronic acid in tissue engineering, as a dermal filler and in osteoarthritis treatment","volume":"9","author":"Fakhari","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejpb.2023.09.003_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124484","article-title":"Comprehensive review on biosynthesis of hyaluronic acid with different molecular weights and its biomedical applications","volume":"240","author":"Jabbari","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2023.09.003_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125657","article-title":"Hypoxia and CD44 receptors dual-targeted nano-micelles with AGT-inhibitory activity for the targeting delivery of carmustine","volume":"246","author":"Li","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2023.09.003_b0230","doi-asserted-by":"crossref","DOI":"10.3390\/ph15010103","article-title":"CD44-Targeted Carriers: The Role of Molecular Weight of Hyaluronic Acid in the Uptake of Hyaluronic Acid-Based Nanoparticles","volume":"15","author":"Chiesa","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.ejpb.2023.09.003_b0235","article-title":"pH-Responsive and Mucoadhesive Nanoparticles for Enhanced Oral Insulin Delivery: The Effect of Hyaluronic Acid with Different Molecular Weights","volume":"15","author":"Wang","year":"2023","journal-title":"Pharmaceutics"},{"issue":"5","key":"10.1016\/j.ejpb.2023.09.003_b0240","first-page":"477","article-title":"Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells, European journal of pharmaceutical sciences : official journal of the European Federation for","volume":"24","author":"Sha","year":"2005","journal-title":"Pharm. Sci."},{"key":"10.1016\/j.ejpb.2023.09.003_b0245","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jconrel.2019.08.008","article-title":"Labrasol\u00ae is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies","volume":"310","author":"McCartney","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2023.09.003_b0250","doi-asserted-by":"crossref","first-page":"5544","DOI":"10.1021\/acs.jafc.9b00397","article-title":"Transepithelial Transport Route and Liposome Encapsulation of Milk-Derived ACE-Inhibitory Peptide Arg-Leu-Ser-Phe-Asn-Pro","volume":"67","author":"Zhang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejpb.2023.09.003_b0255","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/jcp.28959","article-title":"Elucidation of the mechanism underlying CD44v6-induced transformation of IEC-6 normal intestinal epithelial cells","volume":"235","author":"Chung","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejpb.2023.09.003_b0260","doi-asserted-by":"crossref","unstructured":"M. Uhl\u00e9n, L. Fagerberg, M. Hallstr\u00f6m Bj\u00f6rn, C. Lindskog, P. Oksvold, A. Mardinoglu, \u00c5. Sivertsson, C. Kampf, E. Sj\u00f6stedt, A. Asplund, I. Olsson, K. Edlund, E. Lundberg, S. Navani, A.-K. Szigyarto Cristina, J. Odeberg, D. Djureinovic, O. Takanen Jenny, S. Hober, T. Alm, P.-H. Edqvist, H. Berling, H. Tegel, J. Mulder, J. Rockberg, P. Nilsson, M. Schwenk Jochen, M. Hamsten, K. von Feilitzen, M. Forsberg, L. Persson, F. Johansson, M. Zwahlen, G. von Heijne, J. Nielsen, F. Pont\u00e9n, Tissue-based map of the human proteome, Science (New York, N.Y.), 347 (2015) 1260419.","DOI":"10.1126\/science.1260419"},{"key":"10.1016\/j.ejpb.2023.09.003_b0265","doi-asserted-by":"crossref","first-page":"2158964","DOI":"10.1080\/10717544.2022.2158964","article-title":"Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery","volume":"30","author":"Chen","year":"2023","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejpb.2023.09.003_b0270","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ijpharm.2011.08.031","article-title":"Evaluation of the physical and biological properties of hyaluronan and hyaluronan fragments","volume":"420","author":"Ferguson","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2023.09.003_b0275","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.biomaterials.2005.08.020","article-title":"The effect of hyaluronic acid on insulin secretion in HIT-T15 cells through the enhancement of gap-junctional intercellular communications","volume":"27","author":"Li","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2023.09.003_b0280","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jdiacomp.2013.06.003","article-title":"Effects of the GLP-1 receptor agonist lixisenatide on postprandial glucose and gastric emptying \u2013 preclinical evidence","volume":"28","author":"Werner","year":"2014","journal-title":"J. Diabetes Complications"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641123002369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641123002369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:53:49Z","timestamp":1760547229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641123002369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":56,"alternative-id":["S0939641123002369"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2023.09.003","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Double layer spherical nanoparticles with hyaluronic acid coating to enhance oral delivery of exenatide in T2DM rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2023.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}