{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:01:05Z","timestamp":1791165665938,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020707","name":"Janssen Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020707","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ejpb.2023.10.011","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T21:04:33Z","timestamp":1697490273000},"page":"144-157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["A toolbox for mimicking gastrointestinal conditions in children: Design and evaluation of biorelevant dissolution media for mimicking paediatric gastric- and small intestinal conditions"],"prefix":"10.1016","volume":"193","author":[{"given":"Lisa","family":"Freerks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1191-3772","authenticated-orcid":false,"given":"Tina","family":"Arien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Mackie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Inghelbrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7356-5780","authenticated-orcid":false,"given":"Sandra","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2023.10.011_b0005","unstructured":"European Medicines Agency, ICH guideline E8 (R1) on general considerations for clinical studies. EMA\/CHMP\/ICH\/544570\/1998, 2021."},{"key":"10.1016\/j.ejpb.2023.10.011_b0010","unstructured":"European Medicines Agency, Reflection paper on the use of extrapolation in the development of medicines for paediatrics - Final. EMA\/189724\/2018, 2018."},{"key":"10.1016\/j.ejpb.2023.10.011_b0015","doi-asserted-by":"crossref","first-page":"e1242","DOI":"10.1542\/peds.2010-3487","article-title":"Extrapolation of adult data and other data in pediatric drug-development programs","volume":"128","author":"Dunne","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.ejpb.2023.10.011_b0020","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1177\/0962280216631359","article-title":"Extrapolation of efficacy and other data to support the development of new medicines for children: A systematic review of methods","volume":"27","author":"Wadsworth","year":"2018","journal-title":"Stat. Methods Med. Res."},{"key":"10.1016\/j.ejpb.2023.10.011_b0025","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/bcp.13883","article-title":"Commentary on the EMA Reflection Paper on the use of extrapolation in the development of medicines for paediatrics","volume":"85","author":"Ollivier","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejpb.2023.10.011_b0030","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s11095-014-1348-9","article-title":"Biorelevant in vitro performance testing of orally administered dosage forms-workshop report","volume":"31","author":"Reppas","year":"2014","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2023.10.011_b0035","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1023\/A:1011910801212","article-title":"Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs","volume":"15","author":"Galia","year":"1998","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2023.10.011_b0040","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1517\/17425247.2010.527943","article-title":"A biorelevant dissolution stress test device - background and experiences","volume":"7","author":"Garbacz","year":"2010","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejpb.2023.10.011_b0045","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s11095-008-9569-4","article-title":"Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update","volume":"25","author":"Jantratid","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2023.10.011_b0050","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/jphp.12777","article-title":"Assessing the influence of media composition and ionic strength on drug release from commercial immediate-release and enteric-coated aspirin tablets","volume":"69","author":"Karkossa","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2023.10.011_b0055","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.xphs.2018.02.016","article-title":"A Biopredictive In Vitro Comparison of Oral Locally Acting Mesalazine Formulations by a Novel Dissolution Model for Assessing Intraluminal Drug Release in Individual Subjects","volume":"107","author":"Karkossa","year":"2018","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2023.10.011_b0060","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1211\/0022357023367","article-title":"Media to simulate the postprandial stomach I. Matching the Physicochemical Characteristics of Standard Breakfasts","volume":"56","author":"Klein","year":"2004","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2023.10.011_b0065","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jconrel.2008.06.014","article-title":"Use of the BioDis to generate a physiologically relevant IVIVC","volume":"130","author":"Klein","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2023.10.011_b0070","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1211\/0022357056172","article-title":"Site-specific delivery of anti-inflammatory drugs in the gastrointestinal tract: an in-vitro release model","volume":"57","author":"Klein","year":"2005","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2023.10.011_b0075","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ejps.2013.08.024","article-title":"In vitro models for the prediction of in vivo performance of oral dosage forms","volume":"57","author":"Kostewicz","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2023.10.011_b0080","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejps.2015.11.012","article-title":"An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation","volume":"82","author":"Kourentas","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2023.10.011_b0085","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ejps.2013.09.004","article-title":"Development of a bio-relevant dissolution test device simulating mechanical aspects present in the fed stomach","volume":"57","author":"Koziolek","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2023.10.011_b0090","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1021\/acs.molpharmaceut.9b00799","article-title":"Application of the GastroDuo as an in Vitro Dissolution Tool To Simulate the Gastric Emptying of the Postprandial Stomach","volume":"16","author":"Schick","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2023.10.011_b0095","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0928-0987(01)00169-5","article-title":"A dynamic in vitro lipolysis model. I. Controlling the rate of lipolysis by continuous addition of calcium","volume":"14","author":"Zangenberg","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2023.10.011_b0100","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0928-0987(01)00182-8","article-title":"A dynamic in vitro lipolysis model. II: Evaluation of the model","volume":"14","author":"Zangenberg","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2023.10.011_b0105","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejpb.2022.09.015","article-title":"Patient-specific in vitro drug release testing coupled with in silico PBPK modeling to forecast the in vivo performance of oral extended-release levodopa formulations in Parkinson\u2019s disease patients","volume":"180","author":"Wollmer","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2023.10.011_b0110","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejpb.2020.08.014","article-title":"Safe, swallowable and palatable paediatric mini-tablet formulations for a WHO model list of essential medicines for children compound - A promising starting point for future PUMA applications","volume":"156","author":"Freerks","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2023.10.011_b0115","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1208\/s12249-016-0671-3","article-title":"Simulating Different Dosing Scenarios for a Child-Appropriate Valproate ER Formulation in a New Pediatric Two-Stage Dissolution Model","volume":"18","author":"Karkossa","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2023.10.011_b0120","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s11095-015-1762-7","article-title":"Assessment of Age-Related Changes in Pediatric Gastrointestinal Solubility","volume":"33","author":"Maharaj","year":"2016","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2023.10.011_b0125","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1208\/s12249-020-01825-7","article-title":"In Vivo Predictive Dissolution Testing of Montelukast Sodium Formulations Administered with Drinks and Soft Foods to Infants","volume":"21","author":"Martir","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2023.10.011_b0130","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1111\/bcp.13956","article-title":"Potential prediction of formulation performance in paediatric patients using biopharmaceutical tools and simulation of clinically relevant administration scenarios of nifedipine and lorazepam","volume":"85","author":"der Vossen","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejpb.2023.10.011_b0135","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11095-020-02912-x","article-title":"A Biopredictive In Vitro Approach for Assessing Compatibility of a Novel Pediatric Hydrocortisone Drug Product within Common Pediatric Dosing Vehicles","volume":"37","author":"Wollmer","year":"2020","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2023.10.011_b0140","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1208\/s12248-010-9203-3","article-title":"The use of biorelevant dissolution media to forecast the in vivo performance of a drug","volume":"12","author":"Klein","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.ejpb.2023.10.011_b0145","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ejps.2018.07.022","article-title":"Gastric fluid composition in a paediatric population: Age-dependent changes relevant for gastrointestinal drug disposition","volume":"123","author":"van den Abeele","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2023.10.011_b0150","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejpb.2020.11.010","article-title":"Characterisation of fasted state gastric and intestinal fluids collected from children","volume":"158","author":"Pawar","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2023.10.011_b0155","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1021\/acs.molpharmaceut.9b00510","article-title":"Magnetic Resonance Imaging Quantification of Gastrointestinal Liquid Volumes and Distribution in the Gastrointestinal Tract of Children","volume":"16","author":"Papadatou-Soulou","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2023.10.011_b0160","article-title":"A Toolbox for Mimicking Gastrointestinal Conditions in Children: Simulated Paediatric Breakfast Media (SPBM) for Addressing the Variability of Gastric Contents After Typical Paediatric Breakfasts","author":"Freerks","year":"2021","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2023.10.011_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.114084","article-title":"Review of paediatric gastrointestinal physiology relevant to the absorption of orally administered medicines","volume":"181","author":"Wollmer","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2023.10.011_b0170","unstructured":"European Medicines Agency, Reflection paper: Formulations of choice for the paediatric population. EMEA\/CHMP\/PEG\/194810\/2005, 2006."},{"key":"10.1016\/j.ejpb.2023.10.011_b0175","first-page":"122","article-title":"Physicochemical characterisation of fluids and soft foods frequently mixed with oral drug formulations prior to administration to children","volume":"71","author":"Kersten","year":"2016","journal-title":"Pharmazie"},{"key":"10.1016\/j.ejpb.2023.10.011_b0180","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s11095-022-03208-y","article-title":"Vehicles for Drug Administration to Children: Results and Learnings from an In-Depth Screening of FDA-Recommended Liquids and Soft Foods for Product Quality Assessment","volume":"39","author":"Freerks","year":"2022","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2023.10.011_b0185","first-page":"6","article-title":"The Mini Paddle Apparatus\u2013a Useful Tool in the Early Developmental Stage? Experiences with Immediate-Release Dosage Forms","volume":"13","author":"Klein","year":"2006","journal-title":"Dissol. Technol."},{"key":"10.1016\/j.ejpb.2023.10.011_b0190","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1208\/s12249-008-9161-6","article-title":"A standardized mini paddle apparatus as an alternative to the standard paddle","volume":"9","author":"Klein","year":"2008","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2023.10.011_b0195","unstructured":"European Medicines Agency, ICH Topic Q 2 (R1), Validation of Analytical Procedures: Text and Methodology: Note for guidance on validation of analytical procedures: text and methodology. CPMP\/ICH\/381\/95, 1995."},{"key":"10.1016\/j.ejpb.2023.10.011_b0200","first-page":"211","article-title":"Measurement of gastrointestinal pH and regional transit times in normal children","volume":"11","author":"Fallingborg","year":"1990","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.ejpb.2023.10.011_b0205","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1021\/acs.molpharmaceut.7b00426","article-title":"Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs","volume":"14","author":"Hens","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2023.10.011_b0210","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11095-019-2731-3","article-title":"Measuring pH and Buffer Capacity in Fluids Aspirated from the Fasted Upper Gastrointestinal Tract of Healthy Adults","volume":"37","author":"Litou","year":"2020","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2023.10.011_b0215","series-title":"Oral Drug Absorption: Prediction and Assessment","year":"2010"},{"key":"10.1016\/j.ejpb.2023.10.011_b0220","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1208\/s12249-016-0649-1","article-title":"In Vitro Model Simulating Gastro-Intestinal Digestion in the Pediatric Population (Neonates and Young Infants)","volume":"18","author":"Kamstrup","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2023.10.011_b0225","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF00441923","article-title":"Viscosity and electrolyte concentrations in gastric juice from cystic fibrosis children compared to healthy children","volume":"136","author":"Schmidt","year":"1981","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.ejpb.2023.10.011_b0230","doi-asserted-by":"crossref","first-page":"33","DOI":"10.20344\/amp.4010","article-title":"Biochemical and biophysical investigation of surfactant in neonatal gastric aspirate at birth","volume":"26","author":"Bangyozova","year":"2013","journal-title":"Acta Med. Port."},{"key":"10.1016\/j.ejpb.2023.10.011_b0235","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11095-004-9004-4","article-title":"Predicting drug disposition via application of BCS: transport\/absorption\/ elimination interplay and development of a biopharmaceutics drug disposition classification system","volume":"22","author":"Wu","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2023.10.011_b0240","doi-asserted-by":"crossref","unstructured":"J.C. Ruela Corr\u00eaa, D.M. D\u2019Arcy, dos Reis Serra, Cristina Helena, H.R. Nunes Salgado, Darunavir: a critical review of its properties, use and drug interactions, Pharmacology 90 (2012) 102\u2013109.","DOI":"10.1159\/000339862"},{"key":"10.1016\/j.ejpb.2023.10.011_b0245","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4103\/2230-973X.143116","article-title":"Formulation and evaluation of fast dissolving tablet containing domperidone ternary solid dispersion","volume":"4","author":"Patel","year":"2014","journal-title":"Int. J. Pharm. Invest."},{"key":"10.1016\/j.ejpb.2023.10.011_b0250","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1002\/jps.20878","article-title":"Pharmacokinetics of itraconazole after intravenous and oral dosing of itraconazole-cyclodextrin formulations","volume":"96","author":"Buchanan","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2023.10.011_b0255","first-page":"378","article-title":"Cyclodextrin-water soluble polymer ternary complexes enhance the solubility and dissolution behaviour of poorly soluble drugs","volume":"83","author":"Taupitz","year":"2013","journal-title":"Case Example: Itraconazole, European Journal of Pharmaceutics and Biopharmaceutics"},{"key":"10.1016\/j.ejpb.2023.10.011_b0260","unstructured":"Drugbank, Itraconazole, https:\/\/go.drugbank.com\/drugs\/DB01167, accessed 16 February 2022."},{"key":"10.1016\/j.ejpb.2023.10.011_b0265","unstructured":"Drugbank, Domperidone, https:\/\/go.drugbank.com\/drugs\/DB01184, accessed 16 February 2022."},{"key":"10.1016\/j.ejpb.2023.10.011_b0270","unstructured":"Drugbank, Acetaminophen, https:\/\/go.drugbank.com\/drugs\/DB00316, accessed 4 January 2023."},{"key":"10.1016\/j.ejpb.2023.10.011_b0275","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejpb.2022.05.010","article-title":"Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids","volume":"176","author":"Abuhassan","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2023.10.011_b0280","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ejpb.2023.03.005","article-title":"Fed intestinal solubility limits and distributions applied to the Developability classification system","volume":"186","author":"Silva","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2023.10.011_b0285","unstructured":"Drugbank, Darunavir ethanolate, https:\/\/go.drugbank.com\/salts\/DBSALT001338, accessed 16 February 2022."},{"key":"10.1016\/j.ejpb.2023.10.011_b0290","unstructured":"Drugbank, Mebendazole, https:\/\/go.drugbank.com\/drugs\/DB00643, accessed 4 January 2023."},{"key":"10.1016\/j.ejpb.2023.10.011_b0295","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1365-2036.2005.02683.x","article-title":"Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging","volume":"22","author":"Schiller","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.ejpb.2023.10.011_b0300","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejpb.2019.02.001","article-title":"A review of GI conditions critical to oral drug absorption in malnourished children","volume":"137","author":"Freerks","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641123002710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641123002710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:54:16Z","timestamp":1760547256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641123002710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":60,"alternative-id":["S0939641123002710"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2023.10.011","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A toolbox for mimicking gastrointestinal conditions in children: Design and evaluation of biorelevant dissolution media for mimicking paediatric gastric- and small intestinal conditions","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2023.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}