{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:21:54Z","timestamp":1791433314773,"version":"4.3.3"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100019503","name":"Kaohsiung Municipal United Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019503","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.ejpb.2024.114477","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T20:45:44Z","timestamp":1725050744000},"page":"114477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Targeted colorectal cancer treatment: In vitro anti-cancer effects of carnosine nanoparticles supported by agar and magnetic iron oxide"],"prefix":"10.1016","volume":"203","author":[{"given":"Lan-Chi","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4892-8372","authenticated-orcid":false,"given":"Thai-Khuong","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Ci","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5358-0836","authenticated-orcid":false,"given":"Shuchen","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6518-5312","authenticated-orcid":false,"given":"Chih-Chung","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6552-4157","authenticated-orcid":false,"given":"Shu-Ling","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2024.114477_b0005","first-page":"89","article-title":"Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors","volume":"14","author":"Rawla","year":"2019","journal-title":"Gastroenterology Review\/przegl\u0105d Gastroenterologiczny"},{"key":"10.1016\/j.ejpb.2024.114477_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13578-019-0361-4","article-title":"Signaling pathways involved in colorectal cancer progression","volume":"9","author":"Koveitypour","year":"2019","journal-title":"Cell Biosci."},{"key":"10.1016\/j.ejpb.2024.114477_b0015","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000347166","article-title":"Molecular pathways and cellular metabolism in colorectal cancer","volume":"30","author":"Hagland","year":"2013","journal-title":"Dig. Surg."},{"key":"10.1016\/j.ejpb.2024.114477_b0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrc.2016.138","article-title":"Cell cycle proteins as promising targets in cancer therapy","volume":"17","author":"Otto","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejpb.2024.114477_b0025","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s00018-019-03351-7","article-title":"Tumor angiogenesis: causes, consequences, challenges and opportunities","volume":"77","author":"Lugano","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejpb.2024.114477_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctarc.2021.100422","article-title":"Tumor angiogenesis: Current challenges and therapeutic opportunities","volume":"28","author":"Al-Ostoot","year":"2021","journal-title":"Cancer Treatment and Research Communications"},{"key":"10.1016\/j.ejpb.2024.114477_b0035","first-page":"39","article-title":"Multiple cell death modalities and their key features","volume":"2","author":"Yan","year":"2020","journal-title":"World Academy of Sciences Journal"},{"key":"10.1016\/j.ejpb.2024.114477_b0040","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2184.2012.00845.x","article-title":"Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis","volume":"45","author":"Ouyang","year":"2012","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ejpb.2024.114477_b0045","doi-asserted-by":"crossref","unstructured":"L.Q. Zepka, T.C. Do Nascimento, E. Jacob-Lopes, Bioactive Compounds: Biosynthesis, Characterization and Applications, BoD\u2013Books on Demand2021, https:\/\/doi.org\/10.5772\/intechopen.91131.","DOI":"10.5772\/intechopen.91131"},{"key":"10.1016\/j.ejpb.2024.114477_b0050","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.3390\/cancers12113308","article-title":"Recurrence risk after radical colorectal cancer surgery\u2014less than before, but how high is it?","volume":"12","author":"Osterman","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.ejpb.2024.114477_b0055","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/aps.2015.80","article-title":"Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway","volume":"36","author":"Su","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejpb.2024.114477_b0060","doi-asserted-by":"crossref","unstructured":"M. Karami Fath, K. Babakhaniyan, M. Zokaei, A. Yaghoubian, S. Akbari, M. Khorsandi, A. Soofi, M. Nabi-Afjadi, H. Zalpoor, F. Jalalifar, Anti-cancer peptide-based therapeutic strategies in solid tumors, Cellular & Molecular Biology Letters 27 (2022) 33, https:\/\/doi.org\/10.1186\/s11658-022-00332-w.","DOI":"10.1186\/s11658-022-00332-w"},{"key":"10.1016\/j.ejpb.2024.114477_b0065","first-page":"5","article-title":"Bioactive peptides for anticancer therapies","volume":"4","author":"Zhang","year":"2023","journal-title":"Biomaterials Translational"},{"key":"10.1016\/j.ejpb.2024.114477_b0070","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.3390\/molecules27103303","article-title":"Unveiling the hidden therapeutic potential of carnosine, a molecule with a multimodal mechanism of action: A position paper","volume":"27","author":"Caruso","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ejpb.2024.114477_b0075","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3233\/JAD-2007-11210","article-title":"Could carnosine or related structures suppress Alzheimer's disease?","volume":"11","author":"Hipkiss","year":"2007","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ejpb.2024.114477_b0080","doi-asserted-by":"crossref","first-page":"128","DOI":"10.14336\/AD.2017.0120","article-title":"Depression, diabetes and dementia: Formaldehyde may be a common causal agent; could carnosine, a pluripotent peptide, be protective?","volume":"8","author":"Hipkiss","year":"2017","journal-title":"Aging Dis."},{"key":"10.1016\/j.ejpb.2024.114477_b0085","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s12640-018-9867-5","article-title":"Glycotoxins: Dietary and metabolic origins; possible amelioration of neurotoxicity by carnosine, with special reference to Parkinson\u2019s disease","volume":"34","author":"Hipkiss","year":"2018","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ejpb.2024.114477_b0090","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/s41401-018-0182-8","article-title":"Profiling and targeting of cellular mitochondrial bioenergetics: inhibition of human gastric cancer cell growth by carnosine","volume":"40","author":"Cheng","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejpb.2024.114477_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2019.108230","article-title":"Carnosine exerts antitumor activity against bladder cancers in vitro and in vivo via suppression of angiogenesis","volume":"74","author":"Hwang","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ejpb.2024.114477_b0100","first-page":"665","article-title":"L-carnosine prevents the pro-cancerogenic activity of senescent peritoneal mesothelium towards ovarian cancer cells","volume":"36","author":"Miku\u0142a-Pietrasik","year":"2016","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ejpb.2024.114477_b0105","doi-asserted-by":"crossref","first-page":"e0218972","DOI":"10.1371\/journal.pone.0218972","article-title":"Carnosine inhibits glioblastoma growth independent from PI3K\/Akt\/mTOR signaling","volume":"14","author":"Oppermann","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.ejpb.2024.114477_b0110","doi-asserted-by":"crossref","first-page":"e96755","DOI":"10.1371\/journal.pone.0096755","article-title":"The anti-proliferative effect of L-carnosine correlates with a decreased expression of hypoxia inducible factor 1 alpha in human colon cancer cells","volume":"9","author":"Iovine","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejpb.2024.114477_b0115","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s11626-018-0264-4","article-title":"L-carnosine induces apoptosis\/cell cycle arrest via suppression of NF-\u03baB\/STAT1 pathway in HCT116 colorectal cancer cells","volume":"54","author":"Lee","year":"2018","journal-title":"In Vitro Cellular & Developmental Biology-Animal"},{"key":"10.1016\/j.ejpb.2024.114477_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-018-0392-8","article-title":"Nano based drug delivery systems: recent developments and future prospects","volume":"16","author":"Patra","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ejpb.2024.114477_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40824-019-0166-x","article-title":"Therapeutic efficacy of nanoparticles and routes of administration","volume":"23","author":"Chenthamara","year":"2019","journal-title":"Biomaterials Research"},{"key":"10.1016\/j.ejpb.2024.114477_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120666","article-title":"Pegylated liquisomes: a novel combined passive targeting nanoplatform of L-carnosine for breast cancer","volume":"602","author":"Gaafar","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2024.114477_b0135","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1258387","article-title":"Evaluation of anti-cancer effects of carnosine and melittin-loaded niosomes in MCF-7 and MDA-MB-231 breast cancer cells","volume":"14","author":"Hussein","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejpb.2024.114477_b0140","doi-asserted-by":"crossref","first-page":"891","DOI":"10.2217\/nnm-2019-0428","article-title":"Chemotherapeutic potential of L-carnosine from stimuli-responsive magnetic nanoparticles against breast cancer model","volume":"15","author":"Farid","year":"2020","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ejpb.2024.114477_b0145","doi-asserted-by":"crossref","unstructured":"V.V. Ranade, M.A. Hollinger, J.B. Cannon, Drug delivery systems, CRC press2003, https:\/\/doi.org\/10.1201\/9781420040142.","DOI":"10.1201\/9781420040142"},{"key":"10.1016\/j.ejpb.2024.114477_b0150","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.3390\/polym13162729","article-title":"Applications of biopolymers for drugs and probiotics delivery","volume":"13","author":"Gheorghita","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.ejpb.2024.114477_b0155","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jconrel.2020.07.028","article-title":"Agarose-based biomaterials for advanced drug delivery","volume":"326","author":"Yazdi","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2024.114477_b0160","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/elsc.201500116","article-title":"Agarose bioplastic-based drug delivery system for surgical and wound dressings","volume":"17","author":"Awadhiya","year":"2017","journal-title":"Eng. Life Sci."},{"key":"10.1016\/j.ejpb.2024.114477_b0165","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10924-021-02212-4","article-title":"Application of poly (Agar-co-glycerol-co-sweet almond oil) based organo-hydrogels as a drug delivery material","volume":"30","author":"Ersen Dudu","year":"2022","journal-title":"J. Polym. Environ."},{"key":"10.1016\/j.ejpb.2024.114477_b0170","article-title":"Review on the biomedical and sensing applications of nanomaterial-incorporated hydrogels","volume":"23","author":"Kailasa","year":"2022","journal-title":"Mater. Today Chem."},{"key":"10.1016\/j.ejpb.2024.114477_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2023.09.011","article-title":"Inorganic nanoparticles in dermopharmaceutical and cosmetic products: properties, formulation development, toxicity, and regulatory issues","author":"Mascarenhas-Melo","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2024.114477_b0180","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejpb.2016.01.017","article-title":"Pharmaceutical formulation of HSA hybrid coated iron oxide nanoparticles for magnetic drug targeting","volume":"101","author":"Zaloga","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2024.114477_b0185","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1021\/acsami.8b14559","article-title":"Zingerone nanotetramer strengthened the polypharmacological efficacy of zingerone on human hepatoma cell lines","volume":"11","author":"Kung","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejpb.2024.114477_b0190","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.3390\/ma14081824","article-title":"Utilizing edible agar as a carrier for dual functional doxorubicin-Fe3O4 nanotherapy drugs","volume":"14","author":"Wang","year":"2021","journal-title":"Materials"},{"key":"10.1016\/j.ejpb.2024.114477_b0195","doi-asserted-by":"crossref","unstructured":"Z. Darzynkiewicz, G. Juan, E. Bedner, Determining cell cycle stages by flow cytometry, Current protocols in cell biology 1 (1999) 8.4. 1-8.4. 18, https:\/\/doi.org\/10.1002\/0471143030.cb0804s01.","DOI":"10.1002\/0471143030.cb0804s01"},{"key":"10.1016\/j.ejpb.2024.114477_b0200","doi-asserted-by":"crossref","unstructured":"K.J. Livak, T.D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method, methods 25 (2001) 402-408, https:\/\/doi.org\/10.1006\/meth.2001.1262.","DOI":"10.1006\/meth.2001.1262"},{"key":"10.1016\/j.ejpb.2024.114477_b0205","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1016\/j.ijhydene.2015.12.174","article-title":"Synthesis, Characterization and Hydrogen Storage Characteristics of Ambient Pressure Dried Carbon Aerogel","volume":"41","author":"Singh","year":"2016","journal-title":"Int. J. Hydrogen Energy"},{"key":"10.1016\/j.ejpb.2024.114477_b0210","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/21\/44\/445601","article-title":"Green fabrication of agar-conjugated Fe3O4 magnetic nanoparticles","volume":"21","author":"Hsieh","year":"2010","journal-title":"Nanotechnology"},{"key":"10.1016\/j.ejpb.2024.114477_b0215","first-page":"219","article-title":"Magnetite (Fe3O4) nanoparticles for chromium removal, Bangladesh","volume":"53","author":"Hossain","year":"2018","journal-title":"J. Sci. Ind. Res."},{"key":"10.1016\/j.ejpb.2024.114477_b0220","doi-asserted-by":"crossref","first-page":"603","DOI":"10.18632\/aging.100934","article-title":"Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies","volume":"8","author":"Pistritto","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ejpb.2024.114477_b0225","doi-asserted-by":"crossref","unstructured":"P.B. Bhosale, A. Abusaliya, H.H. Kim, S.E. Ha, M.Y. Park, S.H. Jeong, P. Vetrivel, J.D. Heo, J.-A. Kim, C.k. Won, Apigetrin promotes TNF\u03b1-induced apoptosis, necroptosis, G2\/M phase cell cycle arrest, and ROS generation through inhibition of NF-\u03baB pathway in Hep3B liver cancer cells, Cells 11 (2022) 2734, https:\/\/doi.org\/ 10.3390\/cells11172734.","DOI":"10.3390\/cells11172734"},{"key":"10.1016\/j.ejpb.2024.114477_b0230","doi-asserted-by":"crossref","first-page":"5095","DOI":"10.2147\/IJN.S412835","article-title":"Lignin\/Puerarin Nanoparticle-Incorporated Hydrogel Improves Angiogenesis through Puerarin-Induced Autophagy Activation","author":"Pan","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejpb.2024.114477_b0235","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9912436","article-title":"Reactive oxygen species (ROS) regulates different types of cell death by acting as a rheostat","volume":"2021","author":"Villalpando-Rodriguez","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejpb.2024.114477_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2022.112479","article-title":"Towards in vivo photomediated delivery of anticancer peptides: Insights from pharmacokinetic and-dynamic data","volume":"233","author":"Komarov","year":"2022","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.ejpb.2024.114477_b0245","article-title":"Anti-cancer actions of carnosine and the restoration of normal cellular homeostasis, Biochimica et Biophysica Acta (BBA)-Molecular","volume":"1868","author":"Turner","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.ejpb.2024.114477_b0250","first-page":"1","article-title":"Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis","volume":"23","author":"Hsieh","year":"2022","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ejpb.2024.114477_b0255","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41392-022-01110-y","article-title":"Regulated cell death (RCD) in cancer: key pathways and targeted therapies","volume":"7","author":"Peng","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ejpb.2024.114477_b0260","first-page":"2977","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species, Biochimica et Biophysica Acta (BBA)-Molecular","volume":"1863","author":"Redza-Dutordoir","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.ejpb.2024.114477_b0265","doi-asserted-by":"crossref","first-page":"382","DOI":"10.7150\/jca.8024","article-title":"Carnosine inhibits the proliferation of human gastric carcinoma cells by retarding Akt\/mTOR\/p70S6K signaling","volume":"5","author":"Zhang","year":"2014","journal-title":"J. Cancer"},{"key":"10.1016\/j.ejpb.2024.114477_b0270","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/EBC20170035","article-title":"Regulation of selective autophagy: the p62\/SQSTM1 paradigm","volume":"61","author":"Lamark","year":"2017","journal-title":"Essays Biochem."},{"key":"10.1016\/j.ejpb.2024.114477_b0275","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5653\/cerm.2013.40.1.33","article-title":"Autophagy-related protein LC3 and Beclin-1 in the first trimester of pregnancy","volume":"40","author":"Chifenti","year":"2013","journal-title":"Clin. Exp. Reprod. Med."},{"key":"10.1016\/j.ejpb.2024.114477_b0280","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.trecan.2021.09.003","article-title":"Necroptosis and tumor progression","volume":"8","author":"Yan","year":"2022","journal-title":"Trends in Cancer"},{"key":"10.1016\/j.ejpb.2024.114477_b0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-019-1029-8","article-title":"The role of necroptosis in cancer biology and therapy","volume":"18","author":"Gong","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ejpb.2024.114477_b0290","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jare.2017.06.006","article-title":"Anti-angiogenic agents for the treatment of solid tumors: potential pathways, therapy and current strategies\u2013a review","volume":"8","author":"Al-Abd","year":"2017","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ejpb.2024.114477_b0295","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s11481-014-9531-7","article-title":"Vascular endothelial growth factor signaling in hypoxia and inflammation","volume":"9","author":"Ramakrishnan","year":"2014","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.ejpb.2024.114477_b0300","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1158\/1541-7786.MCR-06-0404","article-title":"The role of VEGF and EGFR inhibition: implications for combining anti\u2013VEGF and anti\u2013EGFR agents","volume":"5","author":"Tabernero","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.ejpb.2024.114477_b0305","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3390\/brainsci10060330","article-title":"VEGF Upregulates EGFR Expression to Stimulate Chemotactic Behaviors in the rMC-1 Model of M\u00fcller Glia","volume":"10","author":"Pe\u00f1a","year":"2020","journal-title":"Brain Sci."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641124003035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641124003035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T05:20:53Z","timestamp":1730092853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641124003035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":61,"alternative-id":["S0939641124003035"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2024.114477","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted colorectal cancer treatment: In vitro anti-cancer effects of carnosine nanoparticles supported by agar and magnetic iron oxide","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2024.114477","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114477"}}