{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:51:40Z","timestamp":1792759900140,"version":"4.5.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005668","name":"Foundation for Research Support of the Federal District","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021828","name":"DAAD Regional Office New York","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005878","name":"Research Council for Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination of Higher Education Personnel Improvement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ejpb.2024.114535","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T23:03:39Z","timestamp":1729292619000},"page":"114535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Development of transferosomes for topical ocular drug delivery of curcumin"],"prefix":"10.1016","volume":"205","author":[{"given":"Geisa Nascimento","family":"Barbalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Brugger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Raab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jara-Sophie","family":"Lechner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6481-2364","authenticated-orcid":false,"given":"Ta\u00eds","family":"Gratieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8888-2340","authenticated-orcid":false,"given":"Cornelia M.","family":"Keck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5997-5994","authenticated-orcid":false,"given":"Ilva D.","family":"Rupenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-3833","authenticated-orcid":false,"given":"Priyanka","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ejpb.2024.114535_b0005","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/17425247.2021.1872542","article-title":"Liposomes as vehicles for topical ophthalmic drug delivery and ocular surface protection","volume":"18","author":"L\u00f3pez-Cano","year":"2021","journal-title":"Expert Opin. Drug Deliv."},{"issue":"4","key":"10.1016\/j.ejpb.2024.114535_b0010","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3109\/10717544.2014.943336","article-title":"Liposomes in topical ophthalmic drug delivery: an update","volume":"23","author":"Agarwal","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejpb.2024.114535_b0015","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ijpharm.2019.04.001","article-title":"Comparative study of liposomes, ethosomes and transfersomes as carriers for enhancing the transdermal delivery of diflunisal: In vitro and in vivo evaluation","volume":"563","author":"Abd El-Alim","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"12","key":"10.1016\/j.ejpb.2024.114535_b0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0290224","article-title":"Liposomes and transferosomes in the delivery of papain for the treatment of keloids and hypertrophic scars","volume":"18","author":"Sapkota","year":"2023","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ejpb.2024.114535_b0025","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0005-2736(01)00369-8","article-title":"New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers","volume":"1514","author":"Cevc","year":"2001","journal-title":"Transfersomes. Biochim. Biophys. Acta (BBA) \u2013 Biomemb."},{"key":"10.1016\/j.ejpb.2024.114535_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118817","article-title":"Transferosomes as nanocarriers for drugs across the skin: Quality by design from lab to industrial scale","volume":"573","author":"Fern\u00e1ndez-Garc\u00eda","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ejpb.2024.114535_b0035","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ijpharm.2010.06.034","article-title":"Role of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin delivery","volume":"397","author":"El Zaafarany","year":"2010","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.ejpb.2024.114535_b0040","first-page":"243","article-title":"Transfersomes: ultra deformable vesicular carrier systems in transdermal drug delivery system","volume":"4","author":"Sivannarayana","year":"2012","journal-title":"Res. J. Pharm. Dosage Forms Technol."},{"issue":"2","key":"10.1016\/j.ejpb.2024.114535_b0045","first-page":"309","article-title":"Drug carrier transfersomes: A novel tool for transdermal drug delivery system","volume":"2","author":"Sachan","year":"2013","journal-title":"Int. J. Res. Develop. Pharmacy Life Sci."},{"issue":"1","key":"10.1016\/j.ejpb.2024.114535_b0050","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0005-2736(92)90154-E","article-title":"Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force","volume":"1104","author":"Cevc","year":"1992","journal-title":"Biochim. Biophys. Acta Biomembr."},{"issue":"1","key":"10.1016\/j.ejpb.2024.114535_b0055","doi-asserted-by":"crossref","first-page":"e1918","DOI":"10.1002\/wnan.1918","article-title":"Transferosomes as a transdermal drug delivery system: Dermal kinetics and recent developments","volume":"16","author":"Matharoo","year":"2024","journal-title":"WIREs Nanomed. Nanobiotechnol."},{"issue":"9","key":"10.1016\/j.ejpb.2024.114535_b0060","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12090855","article-title":"A promising nanoencapsulation technique for transdermal drug delivery","volume":"12","author":"Opatha","year":"2020","journal-title":"Pharmaceutics."},{"issue":"8","key":"10.1016\/j.ejpb.2024.114535_b0065","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.3390\/pharmaceutics14081695","article-title":"Linoleic acid-based transferosomes for topical ocular delivery of cyclosporine A","volume":"14","author":"Uwaezuoke","year":"2022","journal-title":"Pharmaceutics."},{"issue":"2","key":"10.1016\/j.ejpb.2024.114535_b0070","first-page":"161","article-title":"Design and characterization of fluconazole loaded elastic liposome based gel for treatment of keratomycosis","volume":"47","author":"Nanda","year":"2022","journal-title":"Fabad J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.ejpb.2024.114535_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12050465","article-title":"Fabrication of transgelosomes for enhancing the ocular delivery of acetazolamide: statistical optimization, in vitro characterization, and in vivo study","volume":"12","author":"Mazyed","year":"2020","journal-title":"Pharmaceutics."},{"issue":"3","key":"10.1016\/j.ejpb.2024.114535_b0080","first-page":"627","article-title":"Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera","volume":"38","author":"H\u00e4m\u00e4l\u00e4inen","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejpb.2024.114535_b0085","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejps.2018.03.034","article-title":"Corneal and conjunctival drug permeability: Systematic comparison and pharmacokinetic impact in the eye","volume":"119","author":"Ramsay","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.ejpb.2024.114535_b0090","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejpb.2005.01.009","article-title":"Cell culture models of the ocular barriers","volume":"60","author":"Hornof","year":"2005","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"6","key":"10.1016\/j.ejpb.2024.114535_b0095","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s13346-015-0275-6","article-title":"In vitro and ex vivo corneal penetration and absorption models","volume":"6","author":"Agarwal","year":"2016","journal-title":"Drug Deliv. Transl. Res."},{"issue":"1","key":"10.1016\/j.ejpb.2024.114535_b0100","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0169-409X(01)00193-4","article-title":"Transscleral drug delivery for posterior segment disease","volume":"52","author":"Geroski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.ejpb.2024.114535_b0105","first-page":"627","article-title":"Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera","volume":"38","author":"Hamalainen","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.ejpb.2024.114535_b0110","doi-asserted-by":"crossref","first-page":"e29009","DOI":"10.1016\/j.heliyon.2024.e29009","article-title":"Evaluation of curcumin-based ophthalmic nano-emulsion on atropine-induced dry eye in mice","volume":"10","author":"Hadipour Jahromy","year":"2024","journal-title":"Heliyon."},{"key":"10.1016\/j.ejpb.2024.114535_b0115","first-page":"1966","article-title":"Curcumin suppresses ovalbumin-induced allergic conjunctivitis","volume":"18","author":"Chung","year":"2012","journal-title":"Mol. Vis."},{"issue":"10","key":"10.1016\/j.ejpb.2024.114535_b0120","article-title":"Topically applied standardized aqueous extract of Curcuma longa Linn. suppresses endotoxin-induced uveal inflammation in rats","volume":"51","author":"Agarwal","year":"2013","journal-title":"Indian J. Exp. Biol."},{"issue":"9","key":"10.1016\/j.ejpb.2024.114535_b0125","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1167\/iovs.07-1186","article-title":"The anti-inflammatory effects of Curcuma longa and Berberis aristata in endotoxin-induced uveitis in rabbits","volume":"49","author":"Gupta","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.ejpb.2024.114535_b0130","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1167\/iovs.04-1304","article-title":"Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats","volume":"46","author":"Suryanarayana","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.ejpb.2024.114535_b0135","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.bbrc.2007.07.059","article-title":"Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina","volume":"361","author":"Mrudula","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejpb.2024.114535_b0140","first-page":"5337","article-title":"Effect of curcumin on aging retinal pigment epithelial cells","author":"Zhu","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"issue":"12","key":"10.1016\/j.ejpb.2024.114535_b0145","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1002\/fsn3.1930","article-title":"Highly bioavailable curcumin preparation with a co-grinding and solvent-free process","volume":"8","author":"Lu","year":"2020","journal-title":"Food Sci. Nutr."},{"issue":"10","key":"10.1016\/j.ejpb.2024.114535_b0150","first-page":"4285","article-title":"Development and pharmacokinetic evaluation of a curcumin co-solvent formulation","volume":"33","author":"John","year":"2013","journal-title":"Anticancer Res"},{"issue":"5","key":"10.1016\/j.ejpb.2024.114535_b0155","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1386-1425(03)00342-1","article-title":"Determination of acidity constants of curcumin in aqueous solution and apparent rate constant of its decomposition","volume":"60","author":"Bernab\u00e9-Pineda","year":"2004","journal-title":"Spectrochim. Acta - Part A: Mol. Biomol. Spectros."},{"issue":"2","key":"10.1016\/j.ejpb.2024.114535_b0160","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ejpb.2010.12.006","article-title":"Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model","volume":"77","author":"Wahlang","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"8","key":"10.1016\/j.ejpb.2024.114535_b0165","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1080\/10837450.2017.1330345","article-title":"Formulation and characterization of Phospholipon 90 G and tween 80 based transfersomes for transdermal delivery of eprosartan mesylate","volume":"23","author":"Ahad","year":"2018","journal-title":"Pharm. Dev. Technol."},{"issue":"5","key":"10.1016\/j.ejpb.2024.114535_b0170","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3109\/03639045.2014.900075","article-title":"Nanovesicular carrier-mediated transdermal delivery of tadalafil: i- formulation and physicsochemical characterization","volume":"41","author":"Mehanna","year":"2015","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"4","key":"10.1016\/j.ejpb.2024.114535_b0175","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/00914037.2018.1434651","article-title":"Influence of probe-sonication process on drug entrapment efficiency of liposomes loaded with a hydrophobic drug","volume":"68","author":"He","year":"2019","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"issue":"7","key":"10.1016\/j.ejpb.2024.114535_b0180","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/jbm.b.34324","article-title":"Effects of solvent used for fabrication on drug loading and release kinetics of electrosprayed temozolomide-loaded PLGA microparticles for the treatment of glioblastoma","volume":"107","author":"Rodriguez de Anda","year":"2019","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.ejpb.2024.114535_b0185","unstructured":"R.H. M\u00fcller, R. Nitzsche, B.-R. Paulke, editors. Zetapotential und Partikelladung in der Laborpraxis: Einf\u00fchrung in die Theorie, praktische Messdurchf\u00fchrung, Dateninterpretation. Colloidal drug carriers 1st expert meeting; 1995; Berlin: Wissenschaftliche Verlagssgesellschaft; 1996."},{"key":"10.1016\/j.ejpb.2024.114535_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2024.114372","article-title":"Design and evaluation of curcumin-loaded poloxamer hydrogels as injectable depot formulations","volume":"201","author":"Jose","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2024.114535_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.xphs.2024.06.011","article-title":"Mechanism of ocular penetration of lipophilic drugs from lipophilic vehicles","author":"Liu","year":"2024","journal-title":"J. Pharm. Sci."},{"issue":"6","key":"10.1016\/j.ejpb.2024.114535_b0200","doi-asserted-by":"crossref","first-page":"10866","DOI":"10.1021\/acsomega.9b00825","article-title":"Liposomal nanovesicles for efficient encapsulation of staphylococcal antibiotics","volume":"4","author":"Gonzalez Gomez","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejpb.2024.114535_b0205","doi-asserted-by":"crossref","DOI":"10.3897\/pharmacia.71.e127997","article-title":"Development and evaluation of curcumin-loaded vesicular carriers: impact of formulation variables","volume":"71","author":"Momekova","year":"2024","journal-title":"Pharmacia."},{"key":"10.1016\/j.ejpb.2024.114535_b0210","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/978-1-60761-609-2_14","article-title":"Preparation and characterization of doxorubicin liposomes","author":"Niu","year":"2010","journal-title":"Cancer Nanotechnol.: Methods Protocols."},{"key":"10.1016\/j.ejpb.2024.114535_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2023.123623","article-title":"Curcumin quantification in skin and mucosa: Optimization of extraction and chromatographic method validation","volume":"1217","author":"Tolentino","year":"2023","journal-title":"J. Chromatogr. B"},{"issue":"3","key":"10.1016\/j.ejpb.2024.114535_b0220","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1021\/js960307p","article-title":"Application of binary polymer system in drug release rate modulation. 2. Influence of formulation variables and hydrodynamic conditions on release kinetics","volume":"86","author":"Kim","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2024.114535_b0437","doi-asserted-by":"crossref","first-page":"105026","DOI":"10.1016\/j.ejps.2019.105026","article-title":"Interpreting non-linear drug diffusion data: Utilizing Korsmeyer-Peppas model to study drug release from liposomes","volume":"138","author":"Wu","year":"2019","journal-title":"European Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.ejpb.2024.114535_b0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ymeth.2024.05.005","article-title":"OphthalMimic: A new alternative apparatus without animal tissue for the evaluation of topical ophthalmic drug products","volume":"228","author":"Barbalho","year":"2024","journal-title":"Methods."},{"issue":"2","key":"10.1016\/j.ejpb.2024.114535_b0230","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0378-5173(89)90305-0","article-title":"Gelrite\u00ae: A novel, ion-activated, in-situ gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol","volume":"57","author":"Rozier","year":"1989","journal-title":"Int. J. Pharm."},{"issue":"5\u20136","key":"10.1016\/j.ejpb.2024.114535_b0235","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/BF02269781","article-title":"Interconversion of cyclosporin molecular form inducing peak broadening, tailing and splitting during reversed-phase liquid chromatography","volume":"38","author":"Nishikawa","year":"1994","journal-title":"Chromatographia"},{"issue":"C","key":"10.1016\/j.ejpb.2024.114535_b0240","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0021-9673(01)87348-9","article-title":"Investigation of the mechanism of peak broadening observed in the high-performance liquid chromatographic analysis of cyclosporine","volume":"333","author":"Bowers","year":"1985","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.ejpb.2024.114535_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2012.04.063","article-title":"Conjunctival and corneal tolerability assessment of ocular naltrexone niosomes and their ingredients on the hen's egg chorioallantoic membrane and excised bovine cornea models","volume":"432","author":"Abdelkader","year":"2012","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ejpb.2024.114535_b0250","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0272-0590(91)90246-Z","article-title":"Evaluation of seven in vitro alternatives for ocular safety testing","volume":"17","author":"Bruner","year":"1991","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.ejpb.2024.114535_b0255","unstructured":"P. Weterings, Y.H.M. Vanerp, editors. Validation of the BECAM assay - An eye irritancy screening test. Pharmaceutisch weekblad-scientific edition; 1987: Royal Dutch Assoc Advancement Pharmacy 11 Alexanderstraat, PO BOX 30460, 2514 The Hague, Netherlands."},{"issue":"5","key":"10.1016\/j.ejpb.2024.114535_b0260","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1208\/s12249-021-02050-6","article-title":"Ocular Distribution of Papaverine Using Non-aqueous Vehicles","volume":"22","author":"Agarwal","year":"2021","journal-title":"AAPS PharmSciTech"},{"issue":"1","key":"10.1016\/j.ejpb.2024.114535_b0265","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijpharm.2018.01.019","article-title":"Semifluorinated alkane based systems for enhanced corneal penetration of poorly soluble drugs","volume":"538","author":"Agarwal","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2024.114535_b0270","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejpb.2019.06.008","article-title":"Topical semifluorinated alkane-based azithromycin suspension for the management of ocular infections","volume":"142","author":"Agarwal","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"5","key":"10.1016\/j.ejpb.2024.114535_b0275","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000514498","article-title":"Dermal penetration analysis of curcumin in an ex vivo porcine ear model using epifluorescence microscopy and digital image processing","volume":"34","author":"Pelikh","year":"2021","journal-title":"Skin Pharmacol. Physiol."},{"issue":"10","key":"10.1016\/j.ejpb.2024.114535_b0280","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.3390\/pharmaceutics16101302","article-title":"Utilizing an ex vivo skin penetration analysis model for predicting ocular drug penetration: A feasibility study with curcumin formulations","volume":"16","author":"Raab","year":"2024","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.ejpb.2024.114535_b0285","unstructured":"W. Rasband, ImageJ - Image Processing and Analysis in Java. Astrophysics Source Code Library. 2012;1:06013."},{"issue":"1","key":"10.1016\/j.ejpb.2024.114535_b0290","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1186\/s12859-017-1934-z","article-title":"Image J2: ImageJ for the next generation of scientific image data","volume":"18","author":"Rueden","year":"2017","journal-title":"BMC Bioinf."},{"issue":"Special Issue 1","key":"10.1016\/j.ejpb.2024.114535_b0295","doi-asserted-by":"crossref","first-page":"245","DOI":"10.22159\/ijap.2020.v12s1.FF053","article-title":"Effects of sonication on size distribution and entrapment of lynestrenol transferosome","volume":"12","author":"Iskandarsyah","year":"2020","journal-title":"Int. J. Appl. Pharm."},{"issue":"3","key":"10.1016\/j.ejpb.2024.114535_b0300","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jconrel.2011.04.019","article-title":"A method for enhancing the ocular penetration of eye drops using nanoparticles of hydrolyzable dye","volume":"153","author":"Baba","year":"2011","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.ejpb.2024.114535_b0305","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijpharm.2006.12.037","article-title":"Effect of mean diameter and polydispersity of PLG microspheres on drug release: Experiment and theory","volume":"337","author":"Berchane","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2024.114535_b0310","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.2147\/IJN.S423251","article-title":"Curcumin transferosome-loaded thermosensitive intranasal in situ gel as prospective antiviral therapy for SARS-Cov-2","volume":"18","author":"Eleraky","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejpb.2024.114535_b0315","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.colsurfb.2018.08.027","article-title":"Assessing the potential of liposomes loaded with curcumin as a therapeutic intervention in asthma","volume":"172","author":"Ng","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"7","key":"10.1016\/j.ejpb.2024.114535_b0320","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.3390\/nano9071028","article-title":"Preparation and characterization of self nano-emulsifying drug delivery system loaded with citraland its antiproliferative effect on colorectal cells in vitro","volume":"9","author":"Mohd Izham","year":"2019","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ejpb.2024.114535_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.rinphs.2014.09.001","article-title":"Effect of the excipient concentration on the pharmacokinetics of PM181104, a novel antimicrobial thiazolyl cyclic peptide antibiotic, following intravenous administration to mice","volume":"4","author":"Yemparala","year":"2014","journal-title":"Results Pharma Sci."},{"issue":"3","key":"10.1016\/j.ejpb.2024.114535_b0330","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/08982104.2013.788025","article-title":"Design and optimization of surfactant-based nanovesicles for ocular delivery of Clotrimazole","volume":"23","author":"Basha","year":"2013","journal-title":"J. Liposome Res."},{"issue":"12","key":"10.1016\/j.ejpb.2024.114535_b0335","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/S0731-7085(96)02024-9","article-title":"Stability of curcumin in buffer solutions and characterization of its degradation products","volume":"15","author":"Wang","year":"1997","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.ejpb.2024.114535_b0340","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijpharm.2011.05.049","article-title":"The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems\u2014A review","volume":"415","author":"Fredenberg","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2024.114535_b0345","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jconrel.2018.12.029","article-title":"Probing the mechanism of bupivacaine drug release from multivesicular liposomes","volume":"294","author":"Manna","year":"2019","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.ejpb.2024.114535_b0350","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0378-5173(83)90064-9","article-title":"Mechanisms of solute release from porous hydrophilic polymers","volume":"15","author":"Korsmeyer","year":"1983","journal-title":"Int. J. Pharmaceut."},{"issue":"2","key":"10.1016\/j.ejpb.2024.114535_b0355","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0168-3659(02)00137-2","article-title":"Characterization of the initial burst release of a model peptide from poly(d, l-lactide-co-glycolide) microspheres","volume":"82","author":"Wang","year":"2002","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.ejpb.2024.114535_b0360","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0939-6411(00)00127-2","article-title":"Effect of pH, ionic strength and oxygen burden on the chemical stability of EPC\/cholesterol liposomes under accelerated conditions: Part 1: Lipid hydrolysis","volume":"50","author":"J-aA","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"9","key":"10.1016\/j.ejpb.2024.114535_b0365","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/jps.2600840915","article-title":"Chemical Hydrolysis of Phospholipids","volume":"84","author":"Zuidam","year":"1995","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2024.114535_b0370","unstructured":"OECD. Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants. Paris: OECD Publishing; 2009."},{"key":"10.1016\/j.ejpb.2024.114535_b0375","unstructured":"OECD. Test No. 438: Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants. Paris: OECD Publishing; 2009."},{"issue":"2","key":"10.1016\/j.ejpb.2024.114535_b0380","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.vascn.2010.01.001","article-title":"Validating and troubleshooting ocular in vitro toxicology tests","volume":"61","author":"Barile","year":"2010","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"1","key":"10.1016\/j.ejpb.2024.114535_b0385","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0278-6915(93)90182-X","article-title":"Justification of the enucleated eye test with eyes of slaughterhouse animals as an alternative to the draize eye irritation test with rabbits","volume":"31","author":"Prinsen","year":"1993","journal-title":"Food Chem. Toxicol."},{"issue":"12","key":"10.1016\/j.ejpb.2024.114535_b0390","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1021\/js9802594","article-title":"Permeability of cornea, sciera, and conjunctiva: A literature analysis for drug delivery to the eye","volume":"87","author":"Prausnitz","year":"1998","journal-title":"J Pharma Sci."},{"key":"10.1016\/j.ejpb.2024.114535_b0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114867","article-title":"Non-aqueous formulations in topical ocular drug delivery \u2013 A paradigm shift?","volume":"198","author":"Agarwal","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2024.114535_b0400","doi-asserted-by":"crossref","unstructured":"C.S. Foster, M.S. De La Maza, Structural Considerations of the Sclera. In: The Sclera. Springer New York; 1994. p. 1-32.","DOI":"10.1007\/978-1-4757-2343-4_1"},{"issue":"8","key":"10.1016\/j.ejpb.2024.114535_b0405","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/jps.2600760802","article-title":"Physicochemical determinants of drug diffusion across the conjunctiva, sclera, and cornea","volume":"76","author":"Ahmed","year":"1987","journal-title":"J. Pharm. Sci."},{"issue":"11","key":"10.1016\/j.ejpb.2024.114535_b0410","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.addr.2006.07.027","article-title":"Challenges and obstacles of ocular pharmacokinetics and drug delivery","volume":"58","author":"Urtti","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.ejpb.2024.114535_b0415","doi-asserted-by":"crossref","DOI":"10.1097\/00003226-199705000-00013","article-title":"Histopathology of the ocular surface after eye rubbing","volume":"16","author":"Greiner","year":"1997","journal-title":"Cornea"},{"issue":"11","key":"10.1016\/j.ejpb.2024.114535_b0420","doi-asserted-by":"crossref","DOI":"10.1097\/OPX.0b013e3181bc652e","article-title":"In vivo confocal microscopy of the palpebral conjunctiva and tarsal plate","volume":"86","author":"Efron","year":"2009","journal-title":"Optomet. Vis. Sci."},{"issue":"5","key":"10.1016\/j.ejpb.2024.114535_b0425","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/tvst.10.5.3","article-title":"Collagen structural changes in rat tarsus after crosslinking","volume":"10","author":"Akella","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"issue":"1","key":"10.1016\/j.ejpb.2024.114535_b0430","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/bjo.2007.126144","article-title":"Differences in meibomian fatty acid composition in patients with meibomian gland dysfunction and aqueous-deficient dry eye","volume":"92","author":"Joffre","year":"2008","journal-title":"Br. J. Ophthalmol."},{"issue":"7","key":"10.1016\/j.ejpb.2024.114535_b0435","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1124\/dmd.117.075473","article-title":"Penetration route of the selective glucocorticoid receptor agonist SA22465 and betamethasone into rabbit meibomian gland based on pharmacokinetics and autoradiography","volume":"45","author":"Asano","year":"2017","journal-title":"Drug Metab. Dispos."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641124003618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641124003618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T23:33:09Z","timestamp":1733009589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641124003618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":88,"alternative-id":["S0939641124003618"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2024.114535","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of transferosomes for topical ocular drug delivery of curcumin","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2024.114535","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114535"}}