{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:46:42Z","timestamp":1782452802603,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","award":["NCKUH-11308010"],"award-info":[{"award-number":["NCKUH-11308010"]}],"id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111\\u20132635-E-143\\u2013001"],"award-info":[{"award-number":["111\\u20132635-E-143\\u2013001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 112\\u20132635-E-143\\u2013001"],"award-info":[{"award-number":["NSTC 112\\u20132635-E-143\\u2013001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ejpb.2025.114676","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T11:25:13Z","timestamp":1740396313000},"page":"114676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Hydrophobic interactions enhance doxorubicin delivery from hyaluronic acid nanogels"],"prefix":"10.1016","volume":"210","author":[{"given":"Yu-Chu","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hsuan","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Hsiang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Fon","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejpb.2025.114676_b0005","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA: A Cancer J. Clinicians"},{"key":"10.1016\/j.ejpb.2025.114676_b0010","article-title":"Study on knowledge of chemotherapy's adverse effects and their self-care ability to manage - the cancer survivors impact","volume":"11","author":"Arunachalam","year":"2021","journal-title":"Clin. Epidemiol. Glob"},{"issue":"4","key":"10.1016\/j.ejpb.2025.114676_b0015","article-title":"The incidence and severity of patient-reported side effects of chemotherapy in routine clinical care: a prospective observational study","volume":"15","author":"Katta","year":"2023","journal-title":"Cureus J Med Science"},{"key":"10.1016\/j.ejpb.2025.114676_b0020","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejpb.2015.03.018","article-title":"Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy","volume":"93","author":"P\u00e9rez-Herrero","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2025.114676_b0025","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.2147\/IJN.S406415","article-title":"Lipid nanocarrier-based drug delivery systems: therapeutic advances in the treatment of lung cancer","volume":"18","author":"Kim","year":"2023","journal-title":"Int. J. Nanomed."},{"issue":"12","key":"10.1016\/j.ejpb.2025.114676_b0030","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.3390\/nano11123432","article-title":"A comprehensive updated review on magnetic nanoparticles in diagnostics","volume":"11","author":"Farinha","year":"2021","journal-title":"Nanomaterials (Basel)."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114676_b0035","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s11671-023-03943-0","article-title":"Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review","volume":"18","author":"Unnikrishnan","year":"2023","journal-title":"Discov. Nano"},{"issue":"9","key":"10.1016\/j.ejpb.2025.114676_b0040","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/acs.chemrev.3c00705","article-title":"Polymeric nanoparticles for drug delivery","volume":"124","author":"Beach","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejpb.2025.114676_b0045","article-title":"Theranostic polymeric nanoparticles as a new approach in cancer therapy and diagnosis: a review","volume":"29","author":"Hosseini","year":"2023","journal-title":"Mater. Today Chem."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114676_b0050","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.3390\/polym12061397","article-title":"Stimuli-responsive polymeric nanocarriers for drug delivery, imaging, and theragnosis","volume":"12","author":"Das","year":"2020","journal-title":"Polymers-Basel"},{"key":"10.1016\/j.ejpb.2025.114676_b0055","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.707319","article-title":"Stimuli-responsive polymeric nanoplatforms for cancer therapy","volume":"9","author":"Chang","year":"2021","journal-title":"Front Bioeng. Biotech."},{"issue":"11","key":"10.1016\/j.ejpb.2025.114676_b0060","doi-asserted-by":"crossref","first-page":"910","DOI":"10.2174\/1381612827666211208150210","article-title":"Stimuli-responsive polymeric nanosystems for therapeutic applications","volume":"28","author":"Handa","year":"2022","journal-title":"Curr. Pharm Design"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114676_b0065","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.ejpb.2025.114676_b0070","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3390\/pharmaceutics16050674","article-title":"Novel drug delivery systems: an important direction for drug innovation research and development","volume":"16","author":"Chen","year":"2024","journal-title":"Pharmaceutics"},{"issue":"24","key":"10.1016\/j.ejpb.2025.114676_b0075","doi-asserted-by":"crossref","first-page":"7970","DOI":"10.1111\/febs.16179","article-title":"The state of CD44 activation in cancer progression and therapeutic targeting","volume":"289","author":"Guo","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.ejpb.2025.114676_b0080","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.2147\/IJN.S165359","article-title":"Reduction-sensitive CD44 receptor-targeted hyaluronic acid derivative micelles for doxorubicin delivery","volume":"13","author":"Yang","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejpb.2025.114676_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.120884","article-title":"Hyaluronic acid modified oral drug delivery system with mucoadhesiveness and macrophage-targeting for colitis treatment","volume":"313","author":"Zhang","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2025.114676_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113655","article-title":"Targeting CD44-positive ovarian cancers via engineered paclitaxel prodrug nanoparticles for enhanced chemotherapeutic efficacy","volume":"154","author":"Sun","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejpb.2025.114676_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122145","article-title":"Chemical modification of hyaluronic acid as a strategy for the development of advanced drug delivery systems","volume":"337","author":"Bokatyi","year":"2024","journal-title":"Carbohyd. Polym."},{"key":"10.1016\/j.ejpb.2025.114676_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111025","article-title":"Naturally derived DNA nanogels as pH- and glutathione-triggered anticancer drug carriers","volume":"114","author":"Chen","year":"2020","journal-title":"Mater Sci. Eng. C Mater Biol. Appl."},{"key":"10.1016\/j.ejpb.2025.114676_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2023.104643","article-title":"Organic disulfide crosslinked nucleic acid-based nanocarriers for anticancer drug applications","volume":"86","author":"Cr Huang","year":"2023","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ejpb.2025.114676_b0110","article-title":"Crosslinking kiwifruit-derived DNA with natural aromatic aldehydes generates membranolytic antibacterial nanogels","volume":"255","author":"Chung","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2025.114676_b0115","article-title":"Antibacterial activities of functional groups on the benzene rings in nucleic acid nanocarriers","volume":"38","author":"Jing-Qin Yang","year":"2024","journal-title":"Mater. Today Chem."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114676_b0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF02898201","article-title":"Glutaraldehyde exposure and its occupational impact in the health care environment","volume":"11","author":"Smith","year":"2006","journal-title":"Environ. Health Prev. Med."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114676_b0125","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3390\/polym12020291","article-title":"the effect of cross-linking with citric acid on the properties of agar\/fish gelatin films","volume":"12","author":"Uranga","year":"2020","journal-title":"Polymers (Basel)"},{"issue":"5","key":"10.1016\/j.ejpb.2025.114676_b0130","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1039\/D0BM01403F","article-title":"Genipin-cross-linked hydrogels based on biomaterials for drug delivery: a review","volume":"9","author":"Yu","year":"2021","journal-title":"Biomater Sci-Uk"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114676_b0135","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s10965-021-02859-6","article-title":"Effect of oil-water interface and payload-DNA interactions on payload-encapsulated DNA nanogels","volume":"29","author":"Chen","year":"2022","journal-title":"J. Polym. Res."},{"key":"10.1016\/j.ejpb.2025.114676_b0140","article-title":"Natural nanogels crosslinked with S-benzyl-L-cysteine exhibit potent antibacterial activity","volume":"153","author":"Chung","year":"2023","journal-title":"Biomater Adv."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114676_b0145","first-page":"42","article-title":"Helical structure and circular dichroism spectra of DNA: a theoretical study","volume":"117","author":"Miyahara","year":"2013","journal-title":"Chem. A Eur. J."},{"issue":"4","key":"10.1016\/j.ejpb.2025.114676_b0150","first-page":"5627","article-title":"CD44 promotes cell proliferation in non-small cell lung cancer","volume":"15","author":"Hu","year":"2018","journal-title":"Oncol. Lett."},{"issue":"49","key":"10.1016\/j.ejpb.2025.114676_b0155","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202206688","article-title":"Disruption of iron homeostasis to induce ferroptosis with albumin-encapsulated Pt(IV) nanodrug for the treatment of non-small cell lung cancer","volume":"19","author":"Tian","year":"2023","journal-title":"Small"},{"issue":"5","key":"10.1016\/j.ejpb.2025.114676_b0160","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3390\/cells8050470","article-title":"Application of cancer organoid model for drug screening and personalized therapy","volume":"8","author":"Kondo","year":"2019","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.ejpb.2025.114676_b0165","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3390\/cells12040659","article-title":"Doxorubicin-An agent with multiple mechanisms of anticancer activity","volume":"12","author":"Kciuk","year":"2023","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.ejpb.2025.114676_b0170","article-title":"Organoids: the current status and biomedical applications","volume":"4","author":"Yang","year":"2023","journal-title":"MedComm (2020)."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114676_b0175","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.7150\/thno.91362","article-title":"Construction of tumor organoids and their application to cancer research and therapy","volume":"14","author":"Lv","year":"2024","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.ejpb.2025.114676_b0180","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1016\/j.bmc.2008.12.049","article-title":"Interaction of genistein benzyl derivatives with lipid bilayers\u2013fluorescence spectroscopic and calorimetric study","volume":"17","author":"Maniewska","year":"2009","journal-title":"Bioorg. Med. Chem."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114676_b0185","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3390\/membranes12030331","article-title":"In silico drug design of benzothiadiazine derivatives interacting with phospholipid cell membranes","volume":"12","author":"Hu","year":"2022","journal-title":"Membranes (Basel)"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125000529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125000529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T22:49:57Z","timestamp":1753742997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641125000529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":37,"alternative-id":["S0939641125000529"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114676","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrophobic interactions enhance doxorubicin delivery from hyaluronic acid nanogels","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114676","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114676"}}