{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T20:31:03Z","timestamp":1768768263179,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ejpb.2025.114701","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T16:52:47Z","timestamp":1742748767000},"page":"114701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Self-dispersible eutectic mixtures with fenofibrate and ibuprofen: Processability and API particle size"],"prefix":"10.1016","volume":"211","author":[{"given":"Peter","family":"Schlosser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Bunjes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2025.114701_b0005","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1056-8719(00)00107-6","article-title":"Drug like properties and the causes of poor solubility and poor permeability","volume":"44","author":"Lipinski","year":"2000","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.ejpb.2025.114701_b0010","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1023\/A:1016212804288","article-title":"A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability","volume":"12","author":"Amidon","year":"1995","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2025.114701_b0015","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1515\/zpch-1904-4704","article-title":"Theorie der Reaktionsgeschwindigkeit in heterogenen Systemen","volume":"47U","author":"Nernst","year":"1904","journal-title":"Z. Phys. Chem."},{"key":"10.1016\/j.ejpb.2025.114701_b0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1515\/zpch-1904-4705","article-title":"Reaktionsgeschwindigkeit in heterogenen Systemen","volume":"47U","author":"Brunner","year":"1904","journal-title":"Z. Phys. Chem."},{"key":"10.1016\/j.ejpb.2025.114701_b0025","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1248\/cpb.9.866","article-title":"Studies on absorption of eutectic mixture. I. A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man","volume":"9","author":"Sekiguchi","year":"1961","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejpb.2025.114701_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119741","article-title":"Eutectic mixtures as an approach to enhance solubility, dissolution rate and oral bioavailability of poorly water-soluble drugs","volume":"588","author":"Bazzo","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114701_b0035","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1023\/A:1014499119549","article-title":"Prediction of poly(ethylene) glycol-drug eutectic compositions using an index based on the van't Hoff equation","volume":"19","author":"Law","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2025.114701_b0040","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jps.10324","article-title":"Properties of rapidly dissolving eutectic mixtures of poly(ethylene glycol) and fenofibrate: the eutectic microstructure","volume":"92","author":"Law","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114701_b0045","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/jps.20754","article-title":"Factors affecting the formation of eutectic solid dispersions and their dissolution behavior","volume":"96","author":"Vippagunta","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114701_b0050","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1111\/jphp.12277","article-title":"Eutectic, monotectic and immiscibility systems of nimesulide with water-soluble carriers: phase equilibria, solid-state characterisation and in-vivo\/pharmacodynamic evaluation","volume":"66","author":"Abdelkader","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2025.114701_b0055","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1080\/03639040701744095","article-title":"Enhanced dissolution of ibuprofen using solid dispersion with polyethylene glycol 20000","volume":"34","author":"Newa","year":"2008","journal-title":"Drug. Dev. Ind. Pharm."},{"key":"10.1016\/j.ejpb.2025.114701_b0060","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1248\/cpb.56.569","article-title":"Enhancement of solubility, dissolution and bioavailability of ibuprofen in solid dispersion systems","volume":"56","author":"Newa","year":"2008","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejpb.2025.114701_b0065","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3109\/10837450903584936","article-title":"Evaluation and modeling of the eutectic composition of various drug-polyethylene glycol solid dispersions","volume":"16","author":"Baird","year":"2011","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.ejpb.2025.114701_b0070","doi-asserted-by":"crossref","first-page":"9690","DOI":"10.1021\/acsomega.9b03886","article-title":"Contribution of crystal lattice energy on the dissolution behavior of eutectic solid dispersions","volume":"5","author":"Chaturvedi","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejpb.2025.114701_b0075","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1023\/B:JTAN.0000042156.21899.de","article-title":"Evaluation of an index based on van't Hoff equation to predict PEG-drug eutectic composition","volume":"78","author":"Oberoi","year":"2004","journal-title":"J. Therm. Anal. Calorim."},{"issue":"Suppl 2","key":"10.1016\/j.ejpb.2025.114701_b0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0928-0987(00)00167-6","article-title":"Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems","volume":"11","author":"Pouton","year":"2000","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114701_b0085","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ejps.2006.04.016","article-title":"Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system","volume":"29","author":"Pouton","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114701_b0090","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.addr.2007.10.010","article-title":"Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies","volume":"60","author":"Pouton","year":"2008","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.ejpb.2025.114701_b0095","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrd2197","article-title":"Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs","volume":"6","author":"Porter","year":"2007","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.ejpb.2025.114701_b0100","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ijpharm.2015.09.009","article-title":"Development of self emulsifying lipid formulations of BCS class II drugs with low to medium lipophilicity","volume":"495","author":"Jannin","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114701_b0105","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.addr.2007.09.006","article-title":"Approaches for the development of solid and semi-solid lipid-based formulations","volume":"60","author":"Jannin","year":"2008","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.ejpb.2025.114701_b0110","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/jps.2600691122","article-title":"Comparison of polyethylene glycol and polyoxyethylene stearate as excipients for solid dispersion systems of griseofulvin and tolbutamide II: dissolution and solubility studies","volume":"69","author":"Kaur","year":"1980","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114701_b0115","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/jps.2600691121","article-title":"Comparison of polyethylene glycol and polyoxyethylene stearate as excipients for solid dispersion systems of griseofulvin and tolbutamide I: phase equilibria","volume":"69","author":"Kaur","year":"1980","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114701_b0120","unstructured":"Royal Society of Chemistry, (R)-(-)-Ibuprofen | C13H18O2 | ChemSpider, 2024, http:\/\/www.chemspider.com\/Chemical-Structure.102822.html, accessed 26 July 2024."},{"key":"10.1016\/j.ejpb.2025.114701_b0125","unstructured":"Royal Society of Chemistry, Fenofibrate | C20H21ClO4 | ChemSpider, 2024, http:\/\/www.chemspider.com\/Chemical-Structure.3222.html, accessed 26 July 2024."},{"key":"10.1016\/j.ejpb.2025.114701_b0130","doi-asserted-by":"crossref","first-page":"13513","DOI":"10.1039\/C8RA01182F","article-title":"Towards controlling the crystallisation behaviour of fenofibrate melt: triggers of crystallisation and polymorphic transformation","volume":"8","author":"Tipduangta","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejpb.2025.114701_b0135","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1021\/js970443+","article-title":"An investigation of FB interactions with poly(ethylene glycol) 6000, poly(ethylene glycol) 4000, and poly-\u03b5-caprolactone by thermoanalytical and spectroscopic methods and modeling","volume":"87","author":"Lacoulonche","year":"1998","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114701_b0140","first-page":"843","article-title":"Binary eutectic solidification","volume":"236","author":"Hunt","year":"1966","journal-title":"Trans. Metall. Soc. AIME"},{"key":"10.1016\/j.ejpb.2025.114701_b0145","first-page":"1043","article-title":"The structure of faceteted\/nonfaceteted crystals","volume":"242","author":"Hunt","year":"1968","journal-title":"Trans. Metall. Soc. AIME"},{"key":"10.1016\/j.ejpb.2025.114701_b0150","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0022-0248(81)90173-1","article-title":"Influence on the adsorption on structure formation in eutectic systems","volume":"52","author":"Podolinsky","year":"1981","journal-title":"J. Cryst. Growth"},{"key":"10.1016\/j.ejpb.2025.114701_b0155","doi-asserted-by":"crossref","first-page":"17721","DOI":"10.1021\/jp047989m","article-title":"Structural and thermal characterization of mono- and diacyl polyoxyethylene glycol by infrared spectroscopy and x-ray diffraction coupled to differential calorimetry","volume":"108","author":"Brubach","year":"2004","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ejpb.2025.114701_b0160","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/zaac.19261570104","article-title":"\u00dcber die Kristallisationsgeschwindigkeit in bin\u00e4ren und tern\u00e4ren Mischungen, aus denen die reinen Komponenten kristallisieren","volume":"157","author":"Tammann","year":"1926","journal-title":"Z. Anorg. Allg. Chem."},{"key":"10.1016\/j.ejpb.2025.114701_b0165","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/zaac.19342200313","article-title":"\u00dcber den Mechanismus der eutektischen Kristallisation","volume":"220","author":"Botschwar","year":"1934","journal-title":"Z. Anorg. Allg. Chem."},{"key":"10.1016\/j.ejpb.2025.114701_b0170","series-title":"Kinetic processes: Crystal growth, diffusion, and phase transitions in materials","author":"Jackson","year":"2004"},{"key":"10.1016\/j.ejpb.2025.114701_b0175","first-page":"132","article-title":"Precipitation anomalies during isothermal crystallization from undercooled, binary eutectic melts","volume":"10","author":"Kofler","year":"1965","journal-title":"J. Aust. Inst. Metals"},{"key":"10.1016\/j.ejpb.2025.114701_b0180","first-page":"864","article-title":"The dentritic-eutectic transition","volume":"239","author":"Hunt","year":"1967","journal-title":"Trans. Metall. Soc. AIME"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125000785?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125000785?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T06:16:13Z","timestamp":1748326573000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641125000785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":36,"alternative-id":["S0939641125000785"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114701","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Self-dispersible eutectic mixtures with fenofibrate and ibuprofen: Processability and API particle size","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114701","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114701"}}