{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:32:43Z","timestamp":1793039563868,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2020-116067RB-100\/AEI\/10"],"award-info":[{"award-number":["PID2020-116067RB-100\/AEI\/10"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["13039\/50110001103"],"award-info":[{"award-number":["13039\/50110001103"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020-116067RB-100\/AEI\/10.13039\/50110001103"],"award-info":[{"award-number":["PID2020-116067RB-100\/AEI\/10.13039\/50110001103"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["FPU 14\/01412"],"award-info":[{"award-number":["FPU 14\/01412"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["FPU 13\/01693"],"award-info":[{"award-number":["FPU 13\/01693"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ejpb.2025.114737","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T21:18:39Z","timestamp":1746739119000},"page":"114737","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Metallomic evaluation of selenium nanoparticles and selenomethionine for the attenuation of cisplatin-induced nephrotoxicity"],"prefix":"10.1016","volume":"212","author":[{"given":"Alejandro","family":"Iglesias-Jim\u00e9nez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Artiaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Moreno-Gordaliza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Milagros G\u00f3mez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2025.114737_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.102925","article-title":"Cisplatin: The first metal based anticancer drug","volume":"88","author":"Ghosh","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114737_b0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1039\/B911438F","article-title":"Analytical methodologies for metallomics studies of antitumor Pt-containing drugs","volume":"2","author":"Esteban-Fern\u00e1ndez","year":"2010","journal-title":"Metallomics"},{"key":"10.1016\/j.ejpb.2025.114737_b0015","doi-asserted-by":"crossref","DOI":"10.1177\/1758835920923430","article-title":"Cisplatin-induced renal toxicity in elderly people","volume":"12","author":"Duan","year":"2020","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.ejpb.2025.114737_b0020","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: Molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114737_b0025","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1124\/jpet.110.165779","article-title":"Cilastatin attenuates cisplatin-induced proximal tubular cell damage","volume":"334","author":"Camano","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejpb.2025.114737_b0030","doi-asserted-by":"crossref","first-page":"7933","DOI":"10.1021\/ac201933x","article-title":"Elemental bioimaging in kidney by LA-ICP-MS as a tool to study nephrotoxicity and renal protective strategies in cisplatin therapies","volume":"83","author":"Moreno-Gordaliza","year":"2011","journal-title":"Anal. Chem"},{"key":"10.1016\/j.ejpb.2025.114737_b0035","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejps.2019.03.002","article-title":"Differences in binding kinetics, bond strength and adduct formation between Pt-based drugs and S- or N-donor groups: A comparative study using mass spectrometry techniques","volume":"132","author":"Artiaga","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"issue":"9","key":"10.1016\/j.ejpb.2025.114737_b0040","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/sj.ki.5002786","article-title":"Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies","volume":"73","author":"Pabla","year":"2008","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.ejpb.2025.114737_b0045","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00204-012-0821-7","article-title":"Cisplatin-induced nephrotoxicity and targets of nephroprotection: An update","volume":"86","author":"Dos Santos","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ejpb.2025.114737_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.804685","article-title":"Protective effect of mannitol on cisplatin-induced nephrotoxicity: a systematic review and meta-analysis","volume":"11","author":"Li","year":"2021","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114737_b0055","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.2042-7158.1998.tb06906.x","article-title":"Protective effects of selenomethionine against cisplatin-induced renal toxicity in mice and rats","volume":"50","author":"Rao","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2025.114737_b0060","doi-asserted-by":"crossref","unstructured":"D. Garc\u00eda Sar, M. Montes-Bay\u00f3n, E. Blanco Gonz\u00e1lez, L.M. Sierra Zapico, A. Sanz-Medel, Reduction of cisplatin-induced nephrotoxicity in vivo by selenomethionine: The effect on Cisplatin - DNA adducts, Chem. Res. Toxicol. 24 (6) (2011) 896\u2013904, doi: 10.1021\/tx200085n.","DOI":"10.1021\/tx200085n"},{"key":"10.1016\/j.ejpb.2025.114737_b0065","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.biopha.2018.12.146","article-title":"Therapeutic applications of selenium nanoparticles","volume":"111","author":"Khurana","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114737_b0070","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3390\/ijms20010075","article-title":"Selenium species: Current status and potentials in cancer prevention and therapy","volume":"20","author":"Tan","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"16","key":"10.1016\/j.ejpb.2025.114737_b0075","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202100598","article-title":"Selenium nanoparticles for biomedical applications: from development and characterization to therapeutics","volume":"10","author":"Ferro","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.ejpb.2025.114737_b0080","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.colsurfb.2018.06.006","article-title":"Selenium nanoparticles: A potent chemotherapeutic agent and an elucidation of its mechanism","author":"Menon","year":"2018","journal-title":"Colloids Surfaces B Biointerfaces 170"},{"key":"10.1016\/j.ejpb.2025.114737_b0085","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.2147\/IJN.S129958","article-title":"Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres","volume":"12","author":"Bai","year":"2017","journal-title":"Int. J. Nanomedicine"},{"issue":"5","key":"10.1016\/j.ejpb.2025.114737_b0090","first-page":"1","article-title":"Engineered nanoparticles interacting with cells: size matters","volume":"12","author":"Shang","year":"2014","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ejpb.2025.114737_b0095","first-page":"835","article-title":"Surface decoration by Spirulina polysaccharide enhances the cellular uptake and anticancer efficacy of selenium nanoparticles","volume":"7","author":"Yang","year":"2012","journal-title":"Int. J. Nanomed."},{"issue":"4","key":"10.1016\/j.ejpb.2025.114737_b0100","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/cells6040039","article-title":"Application of sodium selenite in the prevention and treatment of cancers","volume":"6","author":"Kieliszek","year":"2017","journal-title":"Cells"},{"key":"10.1016\/j.ejpb.2025.114737_b0105","doi-asserted-by":"crossref","unstructured":"J. S. Zheng, S.Y. Zheng, Y.B. Zhang, B. Yu, W. Zheng, F. Yang, T. Chen., Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles, Colloids Surfaces B Biointerfaces 83 (1) (2011) 183\u2013187, doi: 10.1016\/j.colsurfb.2010.11.023.","DOI":"10.1016\/j.colsurfb.2010.11.023"},{"issue":"41","key":"10.1016\/j.ejpb.2025.114737_b0110","doi-asserted-by":"crossref","first-page":"9859","DOI":"10.1021\/jf403564s","article-title":"Induction of apoptosis and cell cycle arrest in A549 human lung adenocarcinoma cells by surface-capping selenium nanoparticles: An effect enhanced by polysaccharide-protein complexes from Polyporus rhinocerus","volume":"61","author":"Wu","year":"2013","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114737_b0115","doi-asserted-by":"crossref","first-page":"13507","DOI":"10.1038\/s41598-021-91738-7","article-title":"Biomedical potential of Anabaena variabilis NCCU-441 based Selenium nanoparticles and their comparison with commercial nanoparticles","volume":"11","author":"Afzal","year":"2021","journal-title":"Sci. Rep."},{"issue":"18","key":"10.1016\/j.ejpb.2025.114737_b0120","doi-asserted-by":"crossref","first-page":"9910","DOI":"10.3390\/ijms22189910","article-title":"Effect of exogenous pH on cell growth of breast cancer cells","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejpb.2025.114737_b0125","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.colsurfb.2012.02.006","article-title":"Selenium nanoparticles inhibit the growth of HeLa and MDA-MB-231 cells through induction of S phase arrest","volume":"94","author":"Luo","year":"2012","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"6","key":"10.1016\/j.ejpb.2025.114737_b0130","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/ki.2012.199","article-title":"Cilastatin protects against cisplatin-induced nephrotoxicity without compromising its anticancer efficiency in rats","volume":"82","author":"Humanes","year":"2012","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114737_b0135","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3390\/biom12030463","article-title":"Is autophagy always a barrier to cisplatin therapy?","volume":"12","author":"Xu","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejpb.2025.114737_b0140","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.3389\/fphys.2018.01898","article-title":"Cisplatin-membrane interactions and their influence on platinum complexes activity and toxicity","volume":"9","author":"Martinho","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejpb.2025.114737_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102641","article-title":"Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion","volume":"61","author":"Toubhans","year":"2023","journal-title":"Redox Biol."},{"issue":"34","key":"10.1016\/j.ejpb.2025.114737_b0150","doi-asserted-by":"crossref","first-page":"55863","DOI":"10.18632\/oncotarget.10150","article-title":"Cytoplasmic vacuolization in cell death and survival","volume":"7","author":"Shubin","year":"2016","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.ejpb.2025.114737_b0155","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1046\/j.1523-1755.2002.00623.x","article-title":"Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidney","volume":"62","author":"Takano","year":"2002","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114737_b0160","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1009272331985","article-title":"Uptake and retention of selenite and selenomethionine in cultured K-562 cells","volume":"13","author":"Frisk","year":"2000","journal-title":"Biometals"},{"issue":"5","key":"10.1016\/j.ejpb.2025.114737_b0165","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.3390\/ijms24054741","article-title":"DNA damage and its role in cancer therapeutics","volume":"24","author":"Moon","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114737_b0170","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1172\/JCI115080","article-title":"Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation","volume":"87","author":"Parker","year":"1991","journal-title":"J. Clin. Invest."},{"issue":"17","key":"10.1016\/j.ejpb.2025.114737_b0175","doi-asserted-by":"crossref","first-page":"9468","DOI":"10.3390\/ijms22179468","article-title":"Beyond single-cell analysis of metallodrugs by ICP-MS: Targeting cellular substructures","volume":"22","author":"Gal\u00e9","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114737_b0180","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3892\/or.2014.3257","article-title":"Gli1 contributes to cellular resistance to cisplatin through altered cellular accumulation of the drug","volume":"32","author":"Amable","year":"2014","journal-title":"Oncol. Rep."},{"issue":"15","key":"10.1016\/j.ejpb.2025.114737_b0185","doi-asserted-by":"crossref","first-page":"7798","DOI":"10.3390\/ijms22157798","article-title":"Mechanisms of the cytotoxic effect of selenium nanoparticles in different human cancer cell lines","volume":"22","author":"Varlamova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114737_b0190","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1039\/c9mt00215d","article-title":"Selenium nanoparticles alleviate hyperlipidemia and vascular injury in ApoE-deficient mice by regulating cholesterol metabolism and reducing oxidative stress","volume":"12","author":"Guo","year":"2020","journal-title":"Metallomics"},{"key":"10.1016\/j.ejpb.2025.114737_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2020.100975","article-title":"Selenium nanoparticles regulates selenoprotein to boost cytokine-induced killer cells-based cancer immunotherapy","volume":"35","author":"Liu","year":"2020","journal-title":"Nano Today"},{"key":"10.1016\/j.ejpb.2025.114737_b0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnut.2021.665855","article-title":"Effects of selenomethionine on cell viability, selenoprotein expression and antioxidant function in porcine mammary epithelial cells","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ejpb.2025.114737_b0205","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/B978-0-12-405882-8.00005-2","article-title":"Selenoprotein W as biomarker for the efficacy of selenium compounds to act as source for selenoprotein biosynthesis","volume":"527","author":"Kipp","year":"2013","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ejpb.2025.114737_b0210","first-page":"S168","article-title":"Selenium metabolism and biosynthesis of selenoproteins in the human body","volume":"87","author":"Minich","year":"2022","journal-title":"Biochem."},{"key":"10.1016\/j.ejpb.2025.114737_b0215","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.freeradbiomed.2018.07.017","article-title":"Selenium nanoparticles are more efficient than sodium selenite in producing reactive oxygen species and hyper-accumulation of selenium nanoparticles in cancer cells generates potent therapeutic effects","volume":"126","author":"Zhao","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.ejpb.2025.114737_b0220","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/jn\/130.7.1653","article-title":"Selenomethionine: A review of its nutritional significance, metabolism and toxicity","volume":"130","author":"Schrauzer","year":"2000","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114737_b0225","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.taap.2006.09.006","article-title":"Metabolism of 76Se-methylselenocysteine compared with that of 77Se-selenomethionine and 82Se-selenite","volume":"217","author":"Suzuki","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"10","key":"10.1016\/j.ejpb.2025.114737_b0230","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1021\/bi101678a","article-title":"Uptake, distribution, and speciation of selenoamino acids by human cancer cells: X-ray absorption and fluorescence methods","volume":"50","author":"Weekley","year":"2011","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114737_b0235","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00216-005-0007-8","article-title":"Selenium metabolites in human urine after ingestion of selenite, L-selenomethionine, or DL-selenomethionine: A quantitative case study by HPLC\/ICPMS","volume":"383","author":"Kuehnelt","year":"2005","journal-title":"Anal. Bioanal. Chem."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114737_b0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nano14020160","article-title":"Selenium nanoparticles in protecting the brain from stroke: possible signaling and metabolic mechanisms","volume":"14","author":"Turovsky","year":"2024","journal-title":"Nanomaterials"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125001146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125001146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T14:19:44Z","timestamp":1748009984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641125001146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":48,"alternative-id":["S0939641125001146"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114737","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metallomic evaluation of selenium nanoparticles and selenomethionine for the attenuation of cisplatin-induced nephrotoxicity","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114737","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114737"}}