{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:59:30Z","timestamp":1784221170663,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014786","name":"Northern Border University","doi-asserted-by":"publisher","award":["NBU-SAFIR-202"],"award-info":[{"award-number":["NBU-SAFIR-202"]}],"id":[{"id":"10.13039\/501100014786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007471","name":"Northern Borders University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ejpb.2025.114747","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T22:37:29Z","timestamp":1747262249000},"page":"114747","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Stabilising indocyanine green J-aggregate theranostics in biological milieu via liposomal envelopment"],"prefix":"10.1016","volume":"213","author":[{"given":"Hamoud","family":"Alotaibi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taher","family":"Hatahet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafa\u2019 T.","family":"Al-Jamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ejpb.2025.114747_b0005","doi-asserted-by":"crossref","first-page":"762","DOI":"10.7150\/thno.14988","article-title":"Current approaches of photothermal therapy in treating cancer metastasis with nanotherapeutics","volume":"6","author":"Zou","year":"2016","journal-title":"Theranostics"},{"issue":"9","key":"10.1016\/j.ejpb.2025.114747_b0010","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3390\/polym10090961","article-title":"Near-infrared-responsive cancer photothermal and photodynamic therapy using gold nanoparticles","volume":"10","author":"Kim","year":"2018","journal-title":"Polymers"},{"key":"10.1016\/j.ejpb.2025.114747_b0015","article-title":"Toxicity of gold nanoparticles (AuNPs): A review","volume":"26","author":"Sani","year":"2021","journal-title":"Biochem. Biophys. Rep."},{"issue":"3502","key":"10.1016\/j.ejpb.2025.114747_b0020","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/1381009a0","article-title":"Spectral absorption and fluorescence of dyes in the molecular state","volume":"138","author":"Jelley","year":"1936","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114747_b0025","doi-asserted-by":"crossref","DOI":"10.1088\/2050-6120\/aa8d0d","article-title":"Fluorescent J-aggregates of cyanine dyes: basic research and applications review","volume":"6","author":"Bricks","year":"2017","journal-title":"Method. Appl. Fluoresc."},{"issue":"4","key":"10.1016\/j.ejpb.2025.114747_b0030","doi-asserted-by":"crossref","first-page":"430","DOI":"10.7150\/ntno.19935","article-title":"Nano-sized indocyanine green J-aggregate as a one-component theranostic agent","volume":"1","author":"Liu","year":"2017","journal-title":"Nanotheranostics"},{"issue":"37","key":"10.1016\/j.ejpb.2025.114747_b0035","article-title":"Fluorescence imaging analysis of distribution of indocyanine green in molecular and nanoform in tumor model","volume":"1","author":"Farrakhova","year":"2022","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"12","key":"10.1016\/j.ejpb.2025.114747_b0040","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.3390\/nano11123185","article-title":"Analysis of fluorescence decay kinetics of indocyanine green monomers and aggregates in brain tumor model in vivo","volume":"11","author":"Farrakhova","year":"2021","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ejpb.2025.114747_b0045","doi-asserted-by":"crossref","first-page":"113516","DOI":"10.1016\/j.colsurfb.2023.113516","article-title":"Enhanced stability and photothermal efficiency of Indocyanine Green J-aggregates by nanoformulation with Calix[4]arene for photothermal therapy of cancers","volume":"230","author":"Millard","year":"2023","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"19","key":"10.1016\/j.ejpb.2025.114747_b0050","doi-asserted-by":"crossref","first-page":"8909","DOI":"10.1039\/D0NR09058A","article-title":"Exploiting cyanine dye J-aggregates\/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: an innovative concept for smart nanotheranostics","volume":"13","author":"Picchio","year":"2021","journal-title":"Nanoscale"},{"issue":"50","key":"10.1016\/j.ejpb.2025.114747_b0055","doi-asserted-by":"crossref","first-page":"46437","DOI":"10.1021\/acsami.9b14519","article-title":"Indocyanine green J aggregates in polymersomes for near-infrared photoacoustic imaging","volume":"11","author":"Changalvaie","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114747_b0060","first-page":"230","article-title":"Metal ions-bridged J-aggregation mediated nanoassembly composition for breast cancer phototherapy","volume":"17","author":"Chen","year":"2022","journal-title":"Asian J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114747_b0065","doi-asserted-by":"crossref","first-page":"5410","DOI":"10.1038\/s41467-021-25452-3","article-title":"Clinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates","volume":"12","author":"Wood","year":"2021","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114747_b0070","doi-asserted-by":"crossref","first-page":"91","DOI":"10.7150\/ntno.41737","article-title":"Liposome-templated indocyanine green J-aggregates for in vivo near-infrared imaging and stable photothermal heating","volume":"4","author":"Cheung","year":"2020","journal-title":"Nanotheranostics"},{"key":"10.1016\/j.ejpb.2025.114747_b0075","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.isci.2019.11.022","article-title":"Utilizing polymer micelle to control dye J-aggregation and enhance its theranostic capability","volume":"22","author":"Shao","year":"2019","journal-title":"Iscience"},{"key":"10.1016\/j.ejpb.2025.114747_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2025.107034","article-title":"Understanding the formulation parameters for engineering indocyanine green J-aggregate lipid nanocapsules and solid lipid nanoparticles as promising photothermal agents","author":"Alotaibi","year":"2025","journal-title":"Eur. J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114747_b0085","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s10555-024-10169-8","article-title":"Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination","volume":"43","author":"Fujimoto","year":"2024","journal-title":"Cancer Metastasis Rev."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114747_b0090","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2174\/1876504101002020012","article-title":"Near-infrared fluorescence imaging in humans with indocyanine green: a review and update","volume":"2","author":"Marshall","year":"2010","journal-title":"Open Surg. Oncol. J. (Online)."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114747_b0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.xphs.2017.05.024","article-title":"Formulation optimization of freeze-dried long-circulating liposomes and in-line monitoring of the freeze-drying process using an NIR spectroscopy tool","volume":"107","author":"Sylvester","year":"2018","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114747_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124456","article-title":"Indocyanine green J-aggregate (IJA) theranostics: challenges and opportunities","author":"Alotaibi","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114747_b0105","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.addr.2012.09.037","article-title":"Liposomal drug delivery systems: from concept to clinical applications","volume":"65","author":"Allen","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"668","key":"10.1016\/j.ejpb.2025.114747_b0110","article-title":"Biodegradable lipid bilayer-assisted indocyanine green J-aggregates for photothermal therapy: formulation, in vitro toxicity and in vivo clearance","volume":"5","author":"Al-Jamal","year":"2025","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114747_b0115","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/jbm.a.32197","article-title":"Effect of size at the nanoscale and bilayer rigidity on skin diffusion of liposomes","volume":"91A","author":"Babu","year":"2009","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"284","key":"10.1016\/j.ejpb.2025.114747_b0120","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jconrel.2018.06.029","article-title":"The effect of light sensitizer localization on the stability of indocyanine green liposomes","volume":"28","author":"Lajunen","year":"2018","journal-title":"J. Control. Release"},{"issue":"56","key":"10.1016\/j.ejpb.2025.114747_b0125","article-title":"Challenge for oral delivery of middle-molecular drugs: Use of osmolarity-sensitive liposome as a drug carrier in the GI tract","volume":"1","author":"Minami","year":"2020","journal-title":"J. Drug Delivery Sci. Technol."},{"issue":"5","key":"10.1016\/j.ejpb.2025.114747_b0130","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41565-022-01086-4","article-title":"Laser-induced nanobubbles safely ablate vitreous opacities in vivo","volume":"17","author":"Sauvage","year":"2022","journal-title":"Nat. Nanotechnol."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125001249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125001249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T23:47:51Z","timestamp":1749512871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641125001249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":26,"alternative-id":["S0939641125001249"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114747","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stabilising indocyanine green J-aggregate theranostics in biological milieu via liposomal envelopment","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114747","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114747"}}