{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:11:02Z","timestamp":1784092262884,"version":"3.55.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ejpb.2025.114782","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T19:26:14Z","timestamp":1749669974000},"page":"114782","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Harnessing dicarboxylate-based salts for enhancing the performance of amorphous solid dispersions: The case of olanzapine"],"prefix":"10.1016","volume":"214","author":[{"given":"Afroditi","family":"Kapourani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6850-1605","authenticated-orcid":false,"given":"Ioannis","family":"Pantazos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-7977","authenticated-orcid":false,"given":"Stamatia","family":"Skoutida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreana N.","family":"Assimopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6765-512X","authenticated-orcid":false,"given":"Panagiotis","family":"Barmpalexis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2025.114782_b0005","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jconrel.2017.06.003","article-title":"Nanosizing techniques for improving bioavailability of drugs","volume":"260","author":"Al-Kassas","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2025.114782_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2024.114513","article-title":"Pharmaceutical approaches for enhancing solubility and oral bioavailability of poorly soluble drugs","volume":"204","author":"Nyamba","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0015","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1021\/acs.molpharmaceut.9b00601","article-title":"Recent advances in understanding the micro- and nanoscale phenomena of amorphous solid dispersions","volume":"16","author":"Ricarte","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0020","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1007\/s11095-023-03547-4","article-title":"The implications of drug-polymer interactions on the physical stability of amorphous solid dispersions","volume":"40","author":"Bookwala","year":"2023","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2025.114782_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123490","article-title":"Amorphous solid dispersions: Stability mechanism, design strategy and key production technique of hot melt extrusion","volume":"646","author":"Han","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0030","doi-asserted-by":"crossref","first-page":"112","DOI":"10.18579\/jpcrkc\/2012\/11\/4\/79364","article-title":"Formulation and in vitro evaluation of mouth dissolving tablet of olanzapine using solid dispersion technique","volume":"11","author":"Brahmbhatt","year":"2012","journal-title":"J. Pharm. Res."},{"key":"10.1016\/j.ejpb.2025.114782_b0035","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3390\/pharmaceutics5040570","article-title":"Design of olanzapine\/lutrol solid dispersions of improved stability and performances","volume":"5","author":"Cavallari","year":"2013","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2025.114782_b0040","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3390\/pharmaceutics12080692","article-title":"Orodispersible polymer films with the poorly water-soluble drug, olanzapine: Hot-melt pneumatic extrusion for single-process 3D printing","volume":"12","author":"Cho","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2025.114782_b0045","first-page":"999","article-title":"Prasad, Olanzapine-PEG 6000 binary systems: In vitro dissolution behavior, physicochemical characterization and mathematical modeling","volume":"72","author":"Krishnamoorthy","year":"2015","journal-title":"Acta Poloniae Pharmaceutica - Drug Research"},{"key":"10.1016\/j.ejpb.2025.114782_b0050","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejpb.2016.03.021","article-title":"Development of micro-fibrous solid dispersions of poorly water-soluble drugs in sucrose using temperature-controlled centrifugal spinning","volume":"103","author":"Marano","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0055","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ijpharm.2016.05.012","article-title":"Solid microcrystalline dispersion films as a new strategy to improve the dissolution rate of poorly water soluble drugs: a case study using olanzapine","volume":"508","author":"Modica de Mohac","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0060","doi-asserted-by":"crossref","first-page":"615","DOI":"10.5599\/admet.1998","article-title":"Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement","volume":"11","author":"Patil","year":"2023","journal-title":"ADMET and DMPK"},{"key":"10.1016\/j.ejpb.2025.114782_b0065","doi-asserted-by":"crossref","unstructured":"K. Venkateskumar, Suchandrasen, P. Verma, Ranjan, Prasad Physicochemical characterization and in vitro dissolution behavior of olanzapine-mannitol solid dispersions, Brazilian Journal of Pharmaceutical Sciences, 48 (2012) 243-255.","DOI":"10.1590\/S1984-82502012000200008"},{"key":"10.1016\/j.ejpb.2025.114782_b0070","first-page":"109","article-title":"Statistical optimization of olanzapine ternary solid dispersions with Pvp K 30 and Peg 20,000 by response surface methodology,","volume":"3","author":"Katharia","year":"2013","journal-title":"J. Appl. Pharmaceutical Sci."},{"key":"10.1016\/j.ejpb.2025.114782_b0075","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/jps.23894","article-title":"The influence of drug physical state on the dissolution enhancement of solid dispersions prepared via hot-melt extrusion: a case study using olanzapine","volume":"103","author":"Pina","year":"2014","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114782_b0080","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.1021\/acs.molpharmaceut.0c00846","article-title":"A simultaneous differential scanning calorimetry\u2013X-ray diffraction study of olanzapine crystallization from amorphous solid dispersions","volume":"17","author":"Askin","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11095-020-2778-1","article-title":"Spray-drying, solvent-casting and freeze-drying techniques: a comparative study on their suitability for the enhancement of drug dissolution rates","volume":"37","author":"De Mohac","year":"2020","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2025.114782_b0090","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jconrel.2019.11.033","article-title":"Dicarboxylic acid as a linker to improve the content of amorphous drug in drug-in-polymer film: Effects of molecular mobility, electrical conductivity and intermolecular interactions","volume":"317","author":"Quan","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2025.114782_b0095","unstructured":"R. Keltjens, Stable salts of olanzapine in: US7459449B2 (Ed.), 2005."},{"key":"10.1016\/j.ejpb.2025.114782_b0100","unstructured":"T. Kozluk, New salts of olanzapine and method of their preparation in: WO2007032695A1 (Ed.), 2005."},{"key":"10.1016\/j.ejpb.2025.114782_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2021.105836","article-title":"Effect of surfactant on the in vitro dissolution and the oral bioavailability of a weakly basic drug from an amorphous solid dispersion","volume":"162","author":"Tung","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114782_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123004","article-title":"Assessing the performance of thermally crosslinked amorphous solid dispersions with high drug loadings","volume":"640","author":"Kapourani","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0115","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.xphs.2016.09.016","article-title":"Non-sink dissolution behavior and solubility limit of commercial tacrolimus amorphous formulations","volume":"106","author":"Trasi","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114782_b0120","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jconrel.2018.11.003","article-title":"Relationship between amorphous solid dispersion in vivo absorption and in vitro dissolution: phase behavior during dissolution, speciation, and membrane mass transport","volume":"292","author":"Wilson","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2025.114782_b0125","article-title":"Amorphous solubility advantage: theoretical considerations, experimental methods, and contemporary relevance","author":"Ueda","year":"2024","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114782_b0130","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1021\/acs.molpharmaceut.0c00413","article-title":"Experimental, thermodynamic, and molecular modeling evaluation of amorphous simvastatin-poly(vinylpyrrolidone) solid dispersions","volume":"17","author":"Kapourani","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0135","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ejpb.2019.10.010","article-title":"Rivaroxaban polymeric amorphous solid dispersions: Moisture-induced thermodynamic phase behavior and intermolecular interactions","volume":"145","author":"Kapourani","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0140","doi-asserted-by":"crossref","first-page":"o66","DOI":"10.1107\/S160053680302806X","article-title":"Polymorphic form II of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno\u00ad[2,3-b][1,5]\u00adbenzodiazepine","volume":"60","author":"Wawrzycka-Gorczyca","year":"2004","journal-title":"Acta Crystallographica Section E"},{"key":"10.1016\/j.ejpb.2025.114782_b0145","doi-asserted-by":"crossref","first-page":"6997","DOI":"10.1021\/acs.macromol.8b00756","article-title":"An atomistic evaluation of the compatibility and plasticization efficacy of phthalates in poly(vinyl chloride)","volume":"51","author":"Li","year":"2018","journal-title":"Macromolecules"},{"key":"10.1016\/j.ejpb.2025.114782_b0150","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijpharm.2018.12.008","article-title":"Challenging identification of polymorphic mixture: Polymorphs I, II and III in olanzapine raw materials","volume":"556","author":"Testa","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0155","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ijpharm.2005.05.035","article-title":"Thermal behaviour and stability in Olanzapine","volume":"301","author":"Polla","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0160","series-title":"in: Control and Prediction of Solid-State of Pharmaceuticals Experimental and Computational Approaches","first-page":"99","article-title":"Exploring the Crystal Structure Landscape of Olanzapine,","author":"Bhardwaj","year":"2016"},{"key":"10.1016\/j.ejpb.2025.114782_b0165","doi-asserted-by":"crossref","first-page":"14782","DOI":"10.1039\/C5DT00384A","article-title":"Growth characteristics of Ti-based fumaric acid hybrid thin films by molecular layer deposition","volume":"44","author":"Cao","year":"2015","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejpb.2025.114782_b0170","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.3390\/polym13162725","article-title":"The effect of molecular weight on the solubility properties of biocompatible poly(ethylene succinate) polyester","volume":"13","author":"Abdelghafour","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.ejpb.2025.114782_b0175","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/scipharm88020021","article-title":"Improved solubility and dissolution rates in novel multicomponent crystals of piperine with succinic acid","volume":"88","author":"Zaini","year":"2020","journal-title":"Sci. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0180","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1021\/cg034055z","article-title":"Anhydrates and hydrates of olanzapine: Crystallization, solid-state characterization, and structural relationships","volume":"3","author":"Reutzel-Edens","year":"2003","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.ejpb.2025.114782_b0185","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1080\/15533174.2016.1212234","article-title":"Synthesis, thermal properties, and biological study of metal(II) nicotinamide complexes containing fumarate dianion and fumaric acid: Crystal structure of [Ni(H2O)4(nia)2](fum)\u00b7(H2fum)","volume":"47","author":"Tella","year":"2017","journal-title":"Inorg. Nano-Metal Chem."},{"key":"10.1016\/j.ejpb.2025.114782_b0190","doi-asserted-by":"crossref","first-page":"629","DOI":"10.26554\/sti.2024.9.3.629-636","article-title":"A comparison study between green synthesis of microwave irradiation and solvent evaporation methods in the formation of p-methoxycinnamic acid-succinic acid cocrystals,","volume":"9","author":"Sulistyowaty","year":"2024","journal-title":"Sci. Technol. Indonesia"},{"key":"10.1016\/j.ejpb.2025.114782_b0195","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijpharm.2006.07.023","article-title":"Solid state characterization of olanzapine polymorphs using vibrational spectroscopy","volume":"326","author":"Ayala","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0200","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1475-2859-11-24","article-title":"Reconstruction of cytosolic fumaric acid biosynthetic pathways in Saccharomyces cerevisiae","volume":"11","author":"Xu","year":"2012","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ejpb.2025.114782_b0205","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1021\/acs.molpharmaceut.1c00141","article-title":"Analytical and computational methods for the determination of drug-polymer solubility and miscibility","volume":"18","author":"Thakore","year":"2021","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0210","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1021\/acs.molpharmaceut.1c00519","article-title":"What are the important factors that influence API crystallization in miscible amorphous API\u2013excipient mixtures during long-term storage in the glassy state?","volume":"19","author":"Newman","year":"2022","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0215","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/jps.21138","article-title":"Role of thermodynamic, molecular, and kinetic factors in crystallization from the Amorphous State","volume":"97","author":"Bhugra","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114782_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/js9601896","article-title":"Characteristics and significance of the amorphous state in pharmaceutical systems","volume":"86","author":"Hancock","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114782_b0225","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1208\/s12249-017-0861-7","article-title":"Effects of the preparation process on the properties of amorphous solid dispersions","volume":"19","author":"Huang","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2025.114782_b0230","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1023\/B:PHAM.0000033003.17251.c3","article-title":"Effect of preparation method on physical properties of amorphous trehalose","volume":"21","author":"Surana","year":"2004","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2025.114782_b0235","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1208\/s12249-019-1562-1","article-title":"Commentary: Considerations in the measurement of glass transition temperatures of pharmaceutical amorphous solids","volume":"21","author":"Newman","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2025.114782_b0240","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1211\/jpp.61.12.0001","article-title":"Review: physical chemistry of solid dispersions","volume":"61","author":"Janssens","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2025.114782_b0245","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1021\/acs.cgd.8b01881","article-title":"Olanzapine form IV: Discovery of a new polymorphic form enabled by computed crystal energy landscapes","volume":"19","author":"Askin","year":"2019","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.ejpb.2025.114782_b0250","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.addr.2007.05.010","article-title":"Salt formation to improve drug solubility","volume":"59","author":"Serajuddin","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2025.114782_b0255","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1021\/mp500711c","article-title":"Evolution of supersaturation of amorphous pharmaceuticals: nonlinear rate of supersaturation generation regulated by matrix diffusion","volume":"12","author":"Sun","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0260","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1021\/acs.molpharmaceut.6b00202","article-title":"Exploiting the phenomenon of liquid-liquid phase separation for enhanced and sustained membrane transport of a poorly water-soluble drug","volume":"13","author":"Indulkar","year":"2016","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2025.114782_b0265","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1021\/cg301679h","article-title":"Liquid\u2013liquid phase separation in highly supersaturated aqueous solutions of poorly water-soluble drugs: Implications for solubility enhancing formulations","volume":"13","author":"Ilevbare","year":"2013","journal-title":"Cryst. Growth Des."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125001596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125001596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T15:13:08Z","timestamp":1753974788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641125001596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":53,"alternative-id":["S0939641125001596"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114782","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Harnessing dicarboxylate-based salts for enhancing the performance of amorphous solid dispersions: The case of olanzapine","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114782","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114782"}}