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Biol."},{"key":"10.1016\/j.ejpb.2025.114789_b0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.copbio.2024.103252","article-title":"Synthetic cells in tissue engineering","volume":"92","author":"Burgstaller","year":"2025","journal-title":"Curr. Opin. Biotechnol."},{"issue":"10","key":"10.1016\/j.ejpb.2025.114789_b0600","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1073\/pnas.1414156112","article-title":"Detecting cancers through tumor-activatable minicircles that lead to a detectable blood biomarker","volume":"112","author":"Ronald","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejpb.2025.114789_b0605","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.addr.2020.04.010","article-title":"Delivery of CRISPR\/Cas systems for cancer gene therapy and immunotherapy","volume":"168","author":"Song","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6625","key":"10.1016\/j.ejpb.2025.114789_b0610","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1126\/science.ade0156","article-title":"Multidimensional control of therapeutic human cell function with synthetic gene circuits","volume":"378","author":"Li","year":"2022","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114789_b0615","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.xphs.2019.10.003","article-title":"Immunogenicity of Cas9 protein","volume":"109","author":"Mehta","year":"2020","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114789_b0620","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41591-018-0326-x","article-title":"Identification of preexisting adaptive immunity to Cas9 proteins in humans","volume":"25","author":"Charlesworth","year":"2019","journal-title":"Nat. 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Rev."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114789_b0665","article-title":"Elucidation and refinement of synthetic receptor mechanisms","volume":"5","author":"Edelstein","year":"2020","journal-title":"Synth. Biol. (oxf)"},{"issue":"6376","key":"10.1016\/j.ejpb.2025.114789_b0670","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad1067","article-title":"Programming gene and engineered-cell therapies with synthetic biology","volume":"359","author":"Kitada","year":"2018","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.ejpb.2025.114789_b0675","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41580-018-0024-z","article-title":"Designing cell function: assembly of synthetic gene circuits for cell biology applications","volume":"19","author":"Xie","year":"2018","journal-title":"Nat. Rev. Mol. 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