{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:30:04Z","timestamp":1792031404665,"version":"4.4.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ejpb.2025.114816","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T16:02:33Z","timestamp":1753200153000},"page":"114816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["HDL and LDL-bioinspired nanocarriers in acellular targeted delivery of Icariin for cardiac repair post myocardial infarction"],"prefix":"10.1016","volume":"214","author":[{"given":"Nermeen H.","family":"Kamal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7930-483X","authenticated-orcid":false,"given":"Lamia A.","family":"Heikal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basant A.","family":"Bakr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged W.","family":"Helmy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ossama Y.","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","article-title":"Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015","volume":"70","author":"Roth","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114816_b0010","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling\u2013concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an international forum on cardiac remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114816_b0015","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1161\/01.CIR.100.2.193","article-title":"Survival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts","volume":"100","author":"Reinecke","year":"1999","journal-title":"Circulation"},{"issue":"7504","key":"10.1016\/j.ejpb.2025.114816_b0020","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nature13233","article-title":"Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts","volume":"510","author":"Chong","year":"2014","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.ejpb.2025.114816_b0025","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/CIRCRESAHA.110.239848","article-title":"Malignant tumor formation after transplantation of short-term cultured bone marrow mesenchymal stem cells in experimental myocardial infarction and diabetic neuropathy","volume":"108","author":"Jeong","year":"2011","journal-title":"Circ. Res."},{"issue":"9819","key":"10.1016\/j.ejpb.2025.114816_b0030","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(12)60075-0","article-title":"Towards regenerative therapy for cardiac disease","volume":"379","author":"Ptaszek","year":"2012","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.ejpb.2025.114816_b0035","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4103\/0973-7847.79097","article-title":"Role of natural herbs in the treatment of hypertension","volume":"5","author":"Tabassum","year":"2011","journal-title":"Pharmacogn. Rev."},{"issue":"8","key":"10.1016\/j.ejpb.2025.114816_b0040","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1055\/s-0035-1545946","article-title":"Plants and their bioactive compounds with the potential to enhance mechanisms of inherited cardiac regeneration","volume":"81","author":"Zhou","year":"2015","journal-title":"Planta Med."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0045","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/ptr.7592","article-title":"Berberine plays a cardioprotective role by inhibiting macrophage Wnt5a\/\u03b2-catenin pathway in the myocardium of mice after myocardial infarction","volume":"37","author":"Tian","year":"2023","journal-title":"Phytother. Res."},{"issue":"7","key":"10.1016\/j.ejpb.2025.114816_b0050","doi-asserted-by":"crossref","first-page":"11965","DOI":"10.1002\/jcb.28480","article-title":"Curcumin ameliorated myocardial infarction by inhibition of cardiotoxicity in the rat model","volume":"120","author":"Rahnavard","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114816_b0055","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1142\/S0192415X15500627","article-title":"Icaritin attenuates myocardial ischemia and reperfusion injury via anti-inflammatory and anti-oxidative stress effects in rats","volume":"43","author":"Zhang","year":"2015","journal-title":"Am. J. Chin. Med."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114816_b0060","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1177\/0300060518762060","article-title":"Icariin influences cardiac remodeling following myocardial infarction by regulating the CD147\/MMP-9 pathway","volume":"46","author":"Shi","year":"2018","journal-title":"J. Int. Med. Res."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114816_b0065","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/0960327119890826","article-title":"Icariin attenuates isoproterenol-induced cardiac toxicity in Wistar rats via modulating cGMP level and NF-\u03baB signaling cascade","volume":"39","author":"Sharma","year":"2020","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ejpb.2025.114816_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112642","article-title":"Icariin and its metabolites as potential protective phytochemicals against cardiovascular disease: from effects to molecular mechanisms","volume":"147","author":"Zeng","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejpb.2025.114816_b0075","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.biopha.2016.08.016","article-title":"Icariin attenuated oxidative stress induced-cardiac apoptosis by mitochondria protection and ERK activation","volume":"83","author":"Song","year":"2016","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0080","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1186\/s40001-023-01588-4","article-title":"Icariin improves cardiac function and remodeling via the TGF-\u03b21\/Smad signaling pathway in rats following myocardial infarction","volume":"28","author":"Jia","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.ejpb.2025.114816_b0085","doi-asserted-by":"crossref","unstructured":"Ke, Z., et al., Pharmacology-Based Prediction of the Targets and Mechanisms for Icariin against Myocardial Infarction. Medicina (Kaunas), 2023. 59(3).","DOI":"10.3390\/medicina59030420"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0090","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1080\/21691401.2018.1554579","article-title":"mPEG-icariin nanoparticles for treating myocardial ischaemia","volume":"47","author":"Zheng","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.ejpb.2025.114816_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.53388\/BMEC2022004","article-title":"Recent advances in the application of biomimetic nanomedicines in disease treatment","volume":"1","author":"Wu","year":"2022","journal-title":"Biomed. Eng. Commun."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114816_b0100","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00280-018-3626-4","article-title":"Natural low- and high-density lipoproteins as mighty bio-nanocarriers for anticancer drug delivery","volume":"82","author":"Mahmoudian","year":"2018","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114816_b0105","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/lipd.12014","article-title":"The expression of lipoprotein receptors is increased in the infarcted area after myocardial infarction induced in rats with cardiac dysfunction","volume":"53","author":"de Lima","year":"2018","journal-title":"Lipids"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114816_b0110","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00280-008-0738-2","article-title":"Use of cholesterol-rich nanoparticles that bind to lipoprotein receptors as a vehicle to paclitaxel in the treatment of breast cancer: pharmacokinetics, tumor uptake and a pilot clinical study","volume":"63","author":"Pires","year":"2009","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.ejpb.2025.114816_b0115","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.2147\/IJN.S129324","article-title":"Methotrexate carried in lipid core nanoparticles reduces myocardial infarction size and improves cardiac function in rats","volume":"12","author":"Maranh\u00e3o","year":"2017","journal-title":"Int. J. Nanomedicine"},{"issue":"11","key":"10.1016\/j.ejpb.2025.114816_b0120","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1161\/CIRCRESAHA.120.316848","article-title":"Apo AI nanoparticles delivered post myocardial infarction moderate inflammation","volume":"127","author":"Richart","year":"2020","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0125","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ijpharm.2006.07.046","article-title":"Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme","volume":"328","author":"Nikanjam","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114816_b0130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-4939-6591-5_2","article-title":"Thin-film hydration followed by extrusion method for liposome preparation","volume":"1522","author":"Zhang","year":"2017","journal-title":"Methods Mol. Biol."},{"issue":"8","key":"10.1016\/j.ejpb.2025.114816_b0135","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1039\/C9BM00588A","article-title":"Lipoprotein-inspired penetrating nanoparticles for deep tumor-targeted shuttling of indocyanine green and enhanced photo-theranostics","volume":"7","author":"Sheng","year":"2019","journal-title":"Biomater. Sci."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114816_b0140","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2217\/nnm.12.137","article-title":"Near-infrared fluorescent imaging of metastatic ovarian cancer using folate receptor-targeted high-density lipoprotein nanocarriers","volume":"8","author":"Corbin","year":"2013","journal-title":"Nanomedicine"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114816_b0145","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2217\/nnm-2017-0220","article-title":"Phytochylomicron as a dual nanocarrier for liver cancer targeting of luteolin: in vitro appraisal and pharmacodynamics","volume":"13","author":"Elnaggar","year":"2018","journal-title":"Nanomedicine (Lond.)"},{"issue":"12","key":"10.1016\/j.ejpb.2025.114816_b0150","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.3390\/molecules24122322","article-title":"Niosomal nanocarriers for enhanced skin delivery of quercetin with functions of anti-tyrosinase and antioxidant","volume":"24","author":"Lu","year":"2019","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.ejpb.2025.114816_b0155","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3109\/02652048.2013.879932","article-title":"Evaluation of anticancer activity of celastrol liposomes in prostate cancer cells","volume":"31","author":"Wolfram","year":"2014","journal-title":"J. Microencapsul."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0160","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1080\/10717544.2022.2120925","article-title":"Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: a repurposing approach","volume":"29","author":"Kharouba","year":"2022","journal-title":"Drug Deliv."},{"issue":"11","key":"10.1016\/j.ejpb.2025.114816_b0165","doi-asserted-by":"crossref","DOI":"10.3390\/nu13114070","article-title":"Icariin protects H9c2 rat cardiomyoblasts from doxorubicin-induced cardiotoxicity: role of caveolin-1 upregulation and enhanced autophagic response","volume":"13","author":"Scicchitano","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.ejpb.2025.114816_b0170","unstructured":"https:\/\/arriveguidelines.org\/arrive-guidelines\/objectives\/13\/explanation. Available from: https:\/\/arriveguidelines.org\/arrive-guidelines\/objectives\/13\/explanation."},{"key":"10.1016\/j.ejpb.2025.114816_b0175","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/434195","article-title":"Metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in rats","volume":"2012","author":"Ashour","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejpb.2025.114816_b0180","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7847142","article-title":"Effects of curcumin nanoparticles in isoproterenol-induced myocardial infarction","volume":"2019","author":"Boarescu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"9","key":"10.1016\/j.ejpb.2025.114816_b0185","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.2174\/0929867326666190516103953","article-title":"Lipoproteins in Atherosclerosis Process","volume":"26","author":"Arnao","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejpb.2025.114816_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.138291","article-title":"Neovascularization-directed bionic eye drops for noninvasive renovation of age-related macular degeneration","volume":"450","author":"Ran","year":"2022","journal-title":"Chem. Eng. J."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114816_b0195","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jconrel.2007.09.007","article-title":"Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle for glioblastoma multiforme","volume":"124","author":"Nikanjam","year":"2007","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0200","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0022-2275(20)30188-7","article-title":"A synthetic low density lipoprotein particle capable of supporting U937 proliferation in vitro","volume":"43","author":"Baillie","year":"2002","journal-title":"J. Lipid Res."},{"issue":"12","key":"10.1016\/j.ejpb.2025.114816_b0205","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s11745-017-4306-6","article-title":"Tissue uptake mechanisms involved in the clearance of non-protein nanoparticles that mimic LDL composition: a study with knockout and transgenic mice","volume":"52","author":"Daminelli","year":"2017","journal-title":"Lipids"},{"issue":"8","key":"10.1016\/j.ejpb.2025.114816_b0210","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/BF02535988","article-title":"Metabolic behavior in rats of a nonprotein microemulsion resembling low-density lipoprotein","volume":"28","author":"Maranh\u00e3o","year":"1993","journal-title":"Lipids"},{"issue":"5","key":"10.1016\/j.ejpb.2025.114816_b0215","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14050930","article-title":"Nanocarrier-based targeted therapies for myocardial infarction","volume":"14","author":"George","year":"2022","journal-title":"Pharmaceutics"},{"issue":"5","key":"10.1016\/j.ejpb.2025.114816_b0220","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14050905","article-title":"Inclusion of a phytomedicinal flavonoid in biocompatible surface-modified chylomicron mimic nanovesicles with improved oral bioavailability and virucidal activity: molecular modeling and pharmacodynamic studies","volume":"14","author":"Zakaria","year":"2022","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0225","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0005-2760(93)90294-J","article-title":"Relationship between the size and phospholipid content of low-density lipoproteins","volume":"1166","author":"Barter","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejpb.2025.114816_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122184","article-title":"Novel bio-inspired lipid nanoparticles for improving the anti-tumoral efficacy of fisetin against breast cancer","volume":"628","author":"Talaat","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114816_b0235","first-page":"170","article-title":"Preparation, pharmacokinetics, and tissue distribution properties of icariin-loaded stealth solid lipid nanoparticles in mice","volume":"4","author":"Liu","year":"2012","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.ejpb.2025.114816_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2023.104297","article-title":"Protective effect of statistically designed and optimized Icariin nanoemulsion on doxorubicin-induced cardiotoxicity: Inhibition of oxidative stress, inflammation, and apoptosis","volume":"81","author":"Md","year":"2023","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ejpb.2025.114816_b0245","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jconrel.2021.08.018","article-title":"High-density lipoprotein in Alzheimer's disease: from potential biomarkers to therapeutics","volume":"338","author":"Jin","year":"2021","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.ejpb.2025.114816_b0250","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3797\/scipharm.1401-10","article-title":"Low density lipid nanoparticles for solid tumor targeting","volume":"82","author":"Shrivastava","year":"2014","journal-title":"Sci. Pharm."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0255","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s12668-022-00941-x","article-title":"A comprehensive review on novel liposomal methodologies, commercial formulations, clinical trials and patents","volume":"12","author":"Andra","year":"2022","journal-title":"Bionanoscience"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0260","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12917-014-0226-3","article-title":"Roles of the antioxidant properties of icariin and its phosphorylated derivative in the protection against duck virus hepatitis","volume":"10","author":"Xiong","year":"2014","journal-title":"BMC Vet. Res."},{"issue":"4","key":"10.1016\/j.ejpb.2025.114816_b0265","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12040346","article-title":"Optimized Icariin phytosomes exhibit enhanced cytotoxicity and apoptosis-inducing activities in ovarian cancer cells","volume":"12","author":"Alhakamy","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2025.114816_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126345","article-title":"Targeting structural flexibility in low density lipoprotein by integrating cryo-electron microscopy and high-speed atomic force microscopy","volume":"252","author":"Cisse","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2025.114816_b0275","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.fluid.2012.03.022","article-title":"Determination of the solubility, dissolution enthalpy and entropy of icariin in water, ethanol, and methanol","volume":"324","author":"Wang","year":"2012","journal-title":"Fluid Phase Equilib."},{"issue":"5","key":"10.1016\/j.ejpb.2025.114816_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e09394","article-title":"Liposomes: structure, composition, types, and clinical applications","volume":"8","author":"Nsairat","year":"2022","journal-title":"Heliyon"},{"issue":"37","key":"10.1016\/j.ejpb.2025.114816_b0285","doi-asserted-by":"crossref","first-page":"7296","DOI":"10.1039\/C5SM01455G","article-title":"Nanoparticle stability in biologically relevant media: influence of polymer architecture","volume":"11","author":"Aguilar-Castillo","year":"2015","journal-title":"Soft Matter"},{"issue":"6","key":"10.1016\/j.ejpb.2025.114816_b0290","doi-asserted-by":"crossref","first-page":"H1447","DOI":"10.1152\/ajpheart.00432.2018","article-title":"Treatment with apolipoprotein A1 protects mice against doxorubicin-induced cardiotoxicity in a scavenger receptor class B, type I-dependent manner","volume":"316","author":"Durham","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"7","key":"10.1016\/j.ejpb.2025.114816_b0295","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1042\/BCJ20170703","article-title":"High-density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation through SR-B1, PI3K, and AKT1 and 2","volume":"475","author":"Durham","year":"2018","journal-title":"Biochem. J"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114816_b0300","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.3390\/ijms25021290","article-title":"High-density lipoproteins at the interface between the NLRP3 inflammasome and myocardial infarction","volume":"25","author":"Carmo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0305","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbrc.2005.07.064","article-title":"Doxorubicin-induced expression of LOX-1 in H9c2 cardiac muscle cells and its role in apoptosis","volume":"335","author":"Spallarossa","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.ejpb.2025.114816_b0310","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.phymed.2004.09.003","article-title":"Protective effect of CardiPro against doxorubicin-induced cardiotoxicity in mice","volume":"13","author":"Mohan","year":"2006","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0315","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40816-019-0146-7","article-title":"Myocardial potency of Caesalpinia bonducella Linn. on doxorubicin induced myocardial infarction in albino rats","volume":"5","author":"Nayagam","year":"2019","journal-title":"Clin. Phytosci."},{"key":"10.1016\/j.ejpb.2025.114816_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111708","article-title":"Doxorubicin-induced cardiotoxicity: an update on the molecular mechanism and novel therapeutic strategies for effective management","volume":"139","author":"Rawat","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0325","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4274\/Tjh.2012.0013","article-title":"The role of nitric oxide in Doxorubicin-induced cardiotoxicity: experimental study","volume":"31","author":"Bahad\u0131r","year":"2014","journal-title":"Turk. J. Haematol."},{"key":"10.1016\/j.ejpb.2025.114816_b0330","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/BF02912874","article-title":"Biochemical markers of myocardial injury","volume":"22","author":"Nigam","year":"2007","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.ejpb.2025.114816_b0335","series-title":"Biochemistry, High Density Lipoprotein. StatPearls. Treasure Island (FL): StatPearls Publishing. Copyright \u00a9 2025","author":"Bailey","year":"2025"},{"issue":"10","key":"10.1016\/j.ejpb.2025.114816_b0345","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1021\/acs.bioconjchem.9b00552","article-title":"The Composition of Reconstituted High-Density Lipoproteins (rHDL) dictates the Degree of rHDL Cargo- and Size-Remodeling via Direct Interactions with Endogenous Lipoproteins","volume":"30","author":"Pedersb\u00e6k","year":"2019","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejpb.2025.114816_b0350","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.jconrel.2020.09.038","article-title":"A systematic review of the biodistribution of biomimetic high-density lipoproteins in mice","volume":"328","author":"Pedersb\u00e6k","year":"2020","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0355","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/antiox13010057","article-title":"Antioxidant and anti-inflammatory functions of high-density lipoprotein in Type 1 and Type 2 diabetes","volume":"13","author":"Denimal","year":"2024","journal-title":"Antioxidants"},{"issue":"4","key":"10.1016\/j.ejpb.2025.114816_b0360","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1194\/jlr.M800015-JLR200","article-title":"Increased methionine sulfoxide content of apoA-I in type 1 diabetes","volume":"49","author":"Brock","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ejpb.2025.114816_b0365","doi-asserted-by":"crossref","unstructured":"Das, A., et al., An Updated Review on the Role of Nanoformulated Phytochemicals in Colorectal Cancer. Medicina (Kaunas), 2023. 59(4).","DOI":"10.3390\/medicina59040685"},{"issue":"6","key":"10.1016\/j.ejpb.2025.114816_b0370","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0022-2828(85)80031-6","article-title":"Comparative morphometry of the mitochondria and activity of some enzymes in the myocardium of small mammals","volume":"17","author":"Oron","year":"1985","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0375","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s10517-015-2909-6","article-title":"Stimulation of proliferation and differentiation of rat resident myocardial cells with apoptotic bodies of cardiomyocytes","volume":"159","author":"Tyukavin","year":"2015","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.ejpb.2025.114816_b0380","doi-asserted-by":"crossref","DOI":"10.1177\/2374289520976639","article-title":"Educational case: myocardial infarction: histopathology and timing of changes","volume":"7","author":"Ghafoor","year":"2020","journal-title":"Acad. Pathol."},{"issue":"7","key":"10.1016\/j.ejpb.2025.114816_b0385","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.crhy.2011.06.001","article-title":"Nanomedicine, nanotechnology in medicine","volume":"12","author":"Boisseau","year":"2011","journal-title":"C. R. Phys."},{"issue":"11","key":"10.1016\/j.ejpb.2025.114816_b0390","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.2174\/1871520619666190820145930","article-title":"Cancer nanotheranostics: a nanomedicinal approach for cancer therapy and diagnosis","volume":"20","author":"Kundu","year":"2020","journal-title":"Anticancer Agents Med. Chem."},{"issue":"5","key":"10.1016\/j.ejpb.2025.114816_b0395","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1007\/s00330-018-5875-3","article-title":"Prognosis-based definition of left ventricular remodeling after ST-elevation myocardial infarction","volume":"29","author":"Reindl","year":"2019","journal-title":"Eur. Radiol."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114816_b0400","article-title":"Pharmacological modulation of cardiac remodeling after myocardial infarction","volume":"2020","author":"Zhao","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"8","key":"10.1016\/j.ejpb.2025.114816_b0405","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3390\/life12081111","article-title":"Left Ventricular Remodeling after Myocardial Infarction: from Physiopathology to Treatment","volume":"12","author":"Leanc\u0103","year":"2022","journal-title":"Life"},{"issue":"4","key":"10.1016\/j.ejpb.2025.114816_b0410","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1536\/ihj.16-457","article-title":"Nanoparticle-mediated delivery of pitavastatin to monocytes\/macrophages inhibits left ventricular remodeling after acute myocardial infarction by inhibiting monocyte-mediated inflammation","volume":"58","author":"Mao","year":"2017","journal-title":"Int. Heart J."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125001936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125001936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T15:17:41Z","timestamp":1753975061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641125001936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":81,"alternative-id":["S0939641125001936"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114816","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HDL and LDL-bioinspired nanocarriers in acellular targeted delivery of Icariin for cardiac repair post myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114816","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114816"}}