{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:51:22Z","timestamp":1772938282326,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304425"],"award-info":[{"award-number":["82304425"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010018","name":"Liaoning Province Doctoral Start-up Foundation","doi-asserted-by":"publisher","award":["2024-BS-071"],"award-info":[{"award-number":["2024-BS-071"]}],"id":[{"id":"10.13039\/501100010018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ejpb.2025.114863","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T23:30:18Z","timestamp":1757115018000},"page":"114863","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effect of the combination of ion-pairs strategies and permeation enhancers on iguratimod transdermal patch against rheumatoid arthritis"],"prefix":"10.1016","volume":"216","author":[{"given":"Yuyi","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-3811","authenticated-orcid":false,"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4081-8443","authenticated-orcid":false,"given":"Dongkai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2025.114863_b0005","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet (London, England)"},{"issue":"2006","key":"10.1016\/j.ejpb.2025.114863_b0010","first-page":"182","article-title":"Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: a systematic review","volume":"36","author":"Alamanos","year":"1987","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.ejpb.2025.114863_b0015","doi-asserted-by":"crossref","first-page":"475","DOI":"10.55563\/clinexprheumatol\/l9lyen","article-title":"Pathogenesis of rheumatoid arthritis: one year in review 2022","volume":"40","author":"Petrelli","year":"2022","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.ejpb.2025.114863_b0020","doi-asserted-by":"crossref","first-page":"e594","DOI":"10.1016\/S2665-9913(23)00211-4","article-title":"Global, regional, and national burden of rheumatoid arthritis, 1990\u20132020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021","volume":"5","author":"Black","year":"2023","journal-title":"Lancet Rheumatol."},{"key":"10.1016\/j.ejpb.2025.114863_b0025","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1016\/S0140-6736(17)31491-5","article-title":"Novel treatment strategies in rheumatoid arthritis","volume":"389","author":"Burmester","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ejpb.2025.114863_b0030","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1365-2249.2005.02744.x","article-title":"New therapies for rheumatoid arthritis","volume":"140","author":"Goldblatt","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ejpb.2025.114863_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113074","article-title":"Application and pharmacological mechanism of methotrexate in rheumatoid arthritis","volume":"150","author":"Zhao","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejpb.2025.114863_b0040","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jconrel.2021.06.035","article-title":"Strategies for transdermal drug delivery against bone disorders: a preclinical and clinical update","volume":"336","author":"Sharma","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2025.114863_b0045","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s11705-019-1913-1","article-title":"Enhanced penetration strategies for transdermal delivery","volume":"14","author":"Pan","year":"2020","journal-title":"Front. Chem. Sci. Eng."},{"key":"10.1016\/j.ejpb.2025.114863_b0050","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jconrel.2020.09.016","article-title":"Recent trends, challenges and future outlook of transdermal drug delivery systems for rheumatoid arthritis therapy","volume":"327","author":"Qindeel","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2025.114863_b0055","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.addr.2017.08.009","article-title":"Device-assisted transdermal drug delivery","volume":"127","author":"Lee","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejpb.2025.114863_b0060","article-title":"A review on the mechanisms, applications, and clinical trials of advanced technologies in the transdermal drug delivery system","author":"Aziz","year":"2024","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.ejpb.2025.114863_b0065","article-title":"Drug-loaded hydrogel microneedles for sustainable transdermal delivery of macromolecular proteins","author":"Chandran","year":"2025","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.ejpb.2025.114863_b0070","unstructured":"Q. Pan, Y. Yu, D. Chen, G. Jiao, X. Liu, Enhanced penetration strategies for transdermal delivery."},{"key":"10.1016\/j.ejpb.2025.114863_b0075","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jconrel.2020.09.016","article-title":"Recent trends, challenges and future outlook of transdermal drug delivery systems for rheumatoid arthritis therapy","volume":"327","author":"Qindeel","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2025.114863_b0080","doi-asserted-by":"crossref","DOI":"10.1002\/bmm2.70001","article-title":"Innovative transdermal drug delivery systems: benefits, challenges, and emerging application","author":"Shah","year":"2025","journal-title":"Bmemat"},{"key":"10.1016\/j.ejpb.2025.114863_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2024.106435","article-title":"Combining ion-pair strategy and chemical enhancers to develop mirtazapine long-acting transdermal patches for depression treatment","volume":"103","author":"Liu","year":"2025","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ejpb.2025.114863_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.121190","article-title":"Effect of the combination of permeation enhancer and ion-pairs strategies on transdermal delivery of tofacitinib","volume":"611","author":"Song","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114863_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123302","article-title":"Development of mabuterol transdermal patch: Molecular mechanism study of ion-pair improving patch stability","volume":"644","author":"Wang","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114863_b0100","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejpb.2022.12.014","article-title":"Combination of ion-pair strategy and chemical enhancers for design of dexmedetomidine long-acting patches: dual action mechanism induced longer controlled release and better delivery efficiency","volume":"183","author":"Sun","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2025.114863_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119722","article-title":"Enhancing effect of fumaric acid on transdermal penetration of loxoprofen sodium","volume":"588","author":"Zhang","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114863_b0110","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ijpharm.2008.04.008","article-title":"Formulation design of microemulsion for dermal delivery of penciclovir","volume":"360","author":"Zhu","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114863_b0115","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0376-7388(97)00142-7","article-title":"Some observations about the application of Fick's first law for membrane separation of multicomponent mixtures","volume":"135","author":"Kamaruddin","year":"1997","journal-title":"J. Membr. Sci."},{"key":"10.1016\/j.ejpb.2025.114863_b0120","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/jphp.12508","article-title":"Support vector regression to estimate the permeability enhancement of potential transdermal enhancers","volume":"68","author":"Shah","year":"2016","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejpb.2025.114863_b0125","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1016\/j.materresbull.2011.07.021","article-title":"Synthesis, characterization, and controlled release anticorrosion behavior of benzoate intercalated Zn\u2013Al layered double hydroxides","volume":"46","author":"Wang","year":"2011","journal-title":"Mater. Res. Bull."},{"key":"10.1016\/j.ejpb.2025.114863_b0130","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijpharm.2017.08.080","article-title":"Mechanism study on ion-pair complexes controlling skin permeability: effect of ion-pair dissociation in the viable epidermis on transdermal permeation of bisoprolol","volume":"532","author":"Zhao","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114863_b0135","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.vaa.2018.12.009","article-title":"Evaluation of analgesic interaction between morphine, dexmedetomidine and maropitant using hot-plate and tail-flick tests in rats","volume":"46","author":"Karna","year":"2019","journal-title":"Vet. Anaesth. Analg."},{"key":"10.1016\/j.ejpb.2025.114863_b0140","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.pharep.2019.02.005","article-title":"Evidence for antinociceptive effects of combined administration of vitamin E and celecoxib in tail-flick and formalin test in male rats","volume":"71","author":"Shamsi Meymandi","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejpb.2025.114863_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173869","article-title":"Synergistic interaction between matrine and paracetamol in the acetic acid writhing test in mice","volume":"895","author":"Dai","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejpb.2025.114863_b0150","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.pbb.2013.07.021","article-title":"Assessment of the antinociceptive effects of pregabalin alone or in combination with morphine during acetic acid-induced writhing in mice","volume":"110","author":"Shamsi Meymandi","year":"2013","journal-title":"Pharmacol. Biochem. Behav"},{"key":"10.1016\/j.ejpb.2025.114863_b0155","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.lfs.2009.06.006","article-title":"Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice","volume":"85","author":"Stevenson","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.ejpb.2025.114863_b0160","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1136\/annrheumdis-2021-221761","article-title":"Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis","volume":"81","author":"Floudas","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejpb.2025.114863_b0165","article-title":"Effect of different pressure-sensitive adhesives on performance parameters of matrix-type transdermal delivery systems","volume":"12","author":"Bozorg","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2025.114863_b0170","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1081\/DDC-120005629","article-title":"Transdermal delivery of physostigmine: effects of enhancers and pressure-sensitive adhesives","volume":"28","author":"Kim","year":"2002","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejpb.2025.114863_b0175","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s12272-001-1264-8","article-title":"Characterization of monolithic matrix patch system containing tulobuterol","volume":"31","author":"Rhee","year":"2008","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.ejpb.2025.114863_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2022.118752","article-title":"Roles of molecular interaction and mobility on loading capacity and release rate of drug-ionic liquid in long-acting controlled release transdermal patch","volume":"352","author":"Yang","year":"2022","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ejpb.2025.114863_b0185","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1517\/17425247.2016.1140146","article-title":"Drug crystallization - implications for topical and transdermal delivery","volume":"13","author":"Hadgraft","year":"2016","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejpb.2025.114863_b0190","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijpharm.2010.04.042","article-title":"Inhibition of crystallization in drug-in-adhesive-type transdermal patches","volume":"394","author":"Jain","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114863_b0195","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1208\/s12249-017-0865-3","article-title":"Solid-state stability issues of drugs in transdermal patch formulations","volume":"19","author":"Sharma","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2025.114863_b0200","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejpb.2005.10.005","article-title":"Physicochemical characterization and drug release properties of Eudragit\u00ae E PO\/Eudragit\u00ae L 100-55 interpolyelectrolyte complexes","volume":"63","author":"Moustafine","year":"2006","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2025.114863_b0205","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jddst.2017.04.033","article-title":"Purification of isopropyl fatty acids markedly changed the skin permeation of a model hydrophilic chemical","volume":"39","author":"Qi","year":"2017","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ejpb.2025.114863_b0210","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijpharm.2011.07.027","article-title":"Ion pairs of risedronate for transdermal delivery and enhanced permeation rate on hairless mouse skin","volume":"419","author":"Nam","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114863_b0215","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1016\/j.apsb.2023.05.025","article-title":"Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis","volume":"13","author":"Xu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejpb.2025.114863_b0220","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/17425247.2020.1713087","article-title":"Permeation enhancers in transdermal drug delivery: benefits and limitations","volume":"17","author":"Kov\u00e1cik","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejpb.2025.114863_b0225","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3109\/10717544.2014.935532","article-title":"Permeation enhancer strategies in transdermal drug delivery","volume":"23","author":"Marwah","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejpb.2025.114863_b0230","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.646554","article-title":"Enhancing permeation of drug molecules across the skin via delivery in nanocarriers: novel strategies for effective transdermal applications","volume":"9","author":"Yu","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ejpb.2025.114863_b0235","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jconrel.2004.06.001","article-title":"A study of microemulsion systems for transdermal delivery of triptolide","volume":"98","author":"Chen","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2025.114863_b0240","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jconrel.2013.12.005","article-title":"Dermic diffusion and stratum corneum: a state of the art review of mathematical models","volume":"177","author":"Couto","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2025.114863_b0245","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijbiomac.2011.10.006","article-title":"Preparation and characterization of chitosan-polyvinyl alcohol blend hydrogels for the controlled release of nano-insulin","volume":"50","author":"Zu","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2025.114863_b0250","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejpb.2005.02.001","article-title":"Polymethacrylates as crystallization inhibitors in monolayer transdermal patches containing ibuprofen","volume":"60","author":"Cilurzo","year":"2005","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2025.114863_b0255","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s11095-012-0901-7","article-title":"Induction and inhibition of crystallization in drug-in-adhesive-type transdermal patches","volume":"30","author":"Jain","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2025.114863_b0260","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/(SICI)1097-4636(19990315)44:4<397::AID-JBM5>3.0.CO;2-Q","article-title":"Crystallization of \u03b2-estradiol in an acrylic transdermal drug delivery system","volume":"44","author":"Variankaval","year":"1999","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.ejpb.2025.114863_b0265","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijpharm.2009.09.028","article-title":"Wistar rat skin as surrogate for human skin in nortriptyline hydrochloride patch studies","volume":"384","author":"Melero","year":"2010","journal-title":"Int. J. Pharm."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125002401?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125002401?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T08:54:52Z","timestamp":1772873692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641125002401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":53,"alternative-id":["S0939641125002401"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114863","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of the combination of ion-pairs strategies and permeation enhancers on iguratimod transdermal patch against rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114863","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114863"}}