{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:06:13Z","timestamp":1784966773206,"version":"3.55.0"},"reference-count":146,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001537","name":"University of Auckland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001547","name":"CatWalk Spinal Cord Injury Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ejpb.2025.114894","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:20:20Z","timestamp":1760552420000},"page":"114894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Gas-based therapies in chronic wounds: A scoping review of preclinical and clinical data"],"prefix":"10.1016","volume":"217","author":[{"given":"Srikar","family":"Kasha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Hanning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odunayo O.","family":"Mugisho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-0005","authenticated-orcid":false,"given":"Sachin S.","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0005","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-022-00377-3","article-title":"Chronic wounds (Primer)","volume":"8","author":"Falanga","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ejpb.2025.114894_b0010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.thromres.2019.05.001","article-title":"Contribution of platelets, the coagulation and fibrinolytic systems to cutaneous wound healing","volume":"179","author":"Opneja","year":"2019","journal-title":"Thromb. Res."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114894_b0015","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejpb.2025.114894_b0020","article-title":"Wound Healing Phases","author":"Wallace","year":"2023","journal-title":"In: Statpearls [internet]. Statpearls Publishing"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.26502\/fccm.92920302","article-title":"Regulation of collagen I and collagen III in tissue injury and regeneration","volume":"7","author":"Singh","year":"2023","journal-title":"Cardiol. Cardiovas. Med."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114894_b0030","first-page":"159","article-title":"Chronic wounds: evaluation and management","volume":"101","author":"Bowers","year":"2020","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.ejpb.2025.114894_b0035","unstructured":"InformedHealth.org. Overview: Chronic Wounds: Cologne, Germany; Overview: Chronic Wounds; 2022 [updated 2022 Aug 8; cited 2024]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK326431\/."},{"key":"10.1016\/j.ejpb.2025.114894_b0040","first-page":"12","article-title":"Programmed cell death and its role in inflammation","volume":"2","author":"Yang","year":"2015","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.ejpb.2025.114894_b0045","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.annepidem.2018.10.005","article-title":"Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies","volume":"29","author":"Martinengo","year":"2019","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.ejpb.2025.114894_b0050","series-title":"Disclosure: Biagio Manna Declares No Relevant Financial Relationships with Ineligible Companies.: \u00a9 2025, StatPearls Publishing LLC","article-title":"Diabetic Foot Ulcer. In: StatPearls. Treasure Island FL ineligible companies. Disclosure: Syed Ali declares no relevant financial relationships with ineligible companies","author":"Packer","year":"2025"},{"key":"10.1016\/j.ejpb.2025.114894_b0055","unstructured":"A.J.M. Boulton, R.W. Whitehouse, The Diabetic Foot, in: K.R. Feingold, S.F. Ahmed, B. Anawalt, M.R. Blackman, A. Boyce, G. Chrousos, et al., editors. Endotext. South Dartmouth MA: \u00a9 2000-2025, MDText.com, Inc.; 2000."},{"key":"10.1016\/j.ejpb.2025.114894_b0060","series-title":"StatPearls. Treasure Island FL Ineligible Companies. Disclosure: Prasanna Tadi Declares No Relevant Financial Relationships with Ineligible Companies","article-title":"CEAP classification of venous disorders","author":"Zegarra","year":"2025"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0065","first-page":"6","article-title":"The pan pacific clinical practice guideline for the prevention and management of pressure injury","volume":"20","author":"Haesler","year":"2012","journal-title":"Wound Practice Res.: J. Aust. Wound Manage. Assoc."},{"key":"10.1016\/j.ejpb.2025.114894_b0070","first-page":"e19","article-title":"Evidence-based management strategies for treatment of chronic wounds","volume":"9","author":"Werdin","year":"2009","journal-title":"Eplasty"},{"issue":"9","key":"10.1016\/j.ejpb.2025.114894_b0075","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1177\/21621918251359554","article-title":"Human wound and its burden: updated 2025 Compendium of estimates","volume":"14","author":"Sen","year":"2025","journal-title":"Adv. Wound Care"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0080","doi-asserted-by":"crossref","DOI":"10.1002\/sstr.202300151","article-title":"Advances in gas therapeutics for wound healing: mechanisms, delivery materials, and prospects","volume":"5","author":"Ding","year":"2024","journal-title":"Small Struct."},{"issue":"7","key":"10.1016\/j.ejpb.2025.114894_b0085","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejpb.2025.114894_b0090","doi-asserted-by":"crossref","unstructured":"E. Aromataris, C. Lockwood, K. Porritt, B. Pilla, Z. Jordan JBI Manual for Evidence Synthesis 2024 [updated 2024]. Available from: https:\/\/jbi-global-wiki.refined.site\/space\/MANUAL.","DOI":"10.46658\/JBIMES-24-01"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0095","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/wrr.12994","article-title":"Chronic wounds: Treatment consensus","volume":"30","author":"Eriksson","year":"2022","journal-title":"Wound Repair Regen."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0100","first-page":"67","article-title":"Current endovascular management of the ischaemic diabetic foot","volume":"12","author":"Gerassimidis","year":"2008","journal-title":"Hippokratia"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0105","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1365-2133.2010.09804.x","article-title":"Oxygen in acute and chronic wound healing","volume":"163","author":"Schreml","year":"2010","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0110","article-title":"IGF-1 increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers","volume":"2013","author":"Aydin","year":"2013","journal-title":"J. Diab. Res."},{"issue":"8","key":"10.1016\/j.ejpb.2025.114894_b0115","doi-asserted-by":"crossref","first-page":"7040","DOI":"10.3390\/ijms24087040","article-title":"Hyperbaric oxygen therapy reduces oxidative stress and inflammation, and increases growth factors favouring the healing process of diabetic wounds","volume":"24","author":"Cap\u00f3","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114894_b0120","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1053\/ejvs.2002.1911","article-title":"The role of hyperbaric oxygen therapy in ischaemic diabetic lower extremity ulcers: a double-blind randomised-controlled trial","volume":"25","author":"Abidia","year":"2003","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114894_b0125","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/WON.0000000000000374","article-title":"Adjunctive hyperbaric oxygen therapy for healing of chronic diabetic foot ulcers: a randomized controlled trial","volume":"44","author":"Chen","year":"2017","journal-title":"J. Wound Ostomy Cont. Nurs."},{"key":"10.1016\/j.ejpb.2025.114894_b0130","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.freeradbiomed.2019.04.031","article-title":"Tissue-specific role of Nrf2 in the treatment of diabetic foot ulcers during hyperbaric oxygen therapy","volume":"138","author":"Dhamodharan","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114894_b0135","first-page":"112","article-title":"Hyperbaric oxygen therapy in diabetic foot","volume":"38","author":"Doctor","year":"1992","journal-title":"J. Postgrad. Med."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114894_b0140","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1053\/j.jfas.2008.08.002","article-title":"Effect of hyperbaric oxygen therapy on healing of diabetic foot ulcers","volume":"47","author":"Duzgun","year":"2008","journal-title":"J. Foot Ankle Surg."},{"issue":"4","key":"10.1016\/j.ejpb.2025.114894_b0145","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s10973-019-09129-0","article-title":"Evaluation of hyperbaric oxygen therapy effects in hard-to-heal wounds using thermal imaging and planimetry","volume":"141","author":"Englisz-Jurgielewicz","year":"2020","journal-title":"J. Therm. Anal. Calorim."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114894_b0150","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2337\/dc15-2001","article-title":"Hyperbaric oxygen therapy does not reduce indications for amputation in patients with diabetes with nonhealing ulcers of the lower limb: a prospective, double-blind randomized controlled clinical trial","volume":"39","author":"Fedorko","year":"2016","journal-title":"Diab. Care"},{"issue":"3","key":"10.1016\/j.ejpb.2025.114894_b0155","doi-asserted-by":"crossref","first-page":"423","DOI":"10.33549\/physiolres.931702","article-title":"Collagen synthesis, nitric oxide and asymmetric dimethylarginine in diabetic subjects undergoing hyperbaric oxygen therapy","volume":"59","author":"Gurdol","year":"2010","journal-title":"Physiol. Res."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0160","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/PRS.0000000000007482","article-title":"Hyperbaric oxygen therapy in management of diabetic foot ulcers: indocyanine green angiography may be used as a biomarker to analyze perfusion and predict response to treatment","volume":"147","author":"Hajhosseini","year":"2021","journal-title":"Plast. Reconstr. Surg."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0165","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1056-8727(01)00182-9","article-title":"Hyperbaric oxygen (HBO) therapy in treatment of diabetic foot ulcers: long-term follow-up","volume":"16","author":"Kalani","year":"2002","journal-title":"J. Diabetes Complications"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0170","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00264-008-0623-y","article-title":"Can major amputation rates be decreased in diabetic foot ulcers with hyperbaric oxygen therapy?","volume":"33","author":"Kaya","year":"2009","journal-title":"Int. Orthop."},{"issue":"8","key":"10.1016\/j.ejpb.2025.114894_b0175","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.2337\/diacare.26.8.2378","article-title":"Hyperbaric oxygenation accelerates the healing rate of nonischemic chronic diabetic foot ulcers: a prospective randomized study","volume":"26","author":"Kessler","year":"2003","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0180","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/0970-9185.74924","article-title":"Hyperbaric oxygen therapy as an adjuvant to standard therapy in the treatment of diabetic foot ulcers","volume":"36","author":"Kumar","year":"2020","journal-title":"J. Anaesthesiol. Clin. Pharmacol."},{"issue":"5","key":"10.1016\/j.ejpb.2025.114894_b0185","doi-asserted-by":"crossref","first-page":"998","DOI":"10.2337\/dc09-1754","article-title":"Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes","volume":"33","author":"L\u00f6ndahl","year":"2010","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0190","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1464-5491.2010.03185.x","article-title":"Hyperbaric oxygen therapy improves health-related quality of life in patients with diabetes and chronic foot ulcer","volume":"28","author":"L\u00f6ndahl","year":"2011","journal-title":"Diabet. Med."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114894_b0195","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/wrr.12853","article-title":"Potential markers of healing from near infrared spectroscopy imaging of venous leg ulcer. a randomized controlled clinical trial comparing conventional with hyperbaric oxygen treatment","volume":"28","author":"Longobardi","year":"2020","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.ejpb.2025.114894_b0200","doi-asserted-by":"crossref","unstructured":"Lopes JRA, Dias MDA, Batalha MAB, Guerra LKD, Correa JA. Hyperbaric oxygen therapy for healing chronic foot wounds in diabetic patients: Randomised clinical trial, J. Human Growth Develop. 34(3)430-440.","DOI":"10.36311\/jhgd.v34.16415"},{"issue":"3","key":"10.1016\/j.ejpb.2025.114894_b0205","first-page":"18","article-title":"A prospective, randomized, controlled study of hyperbaric oxygen therapy: effects on healing and oxidative stress of ulcer tissue in patients with a diabetic foot ulcer","volume":"59","author":"Ma","year":"2013","journal-title":"Ostomy Wound Manage."},{"key":"10.1016\/j.ejpb.2025.114894_b0210","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijso.2020.11.012","article-title":"Hyperbaric oxygen therapy in the healing process of foot ulcers in diabetic type 2 patients marked by interleukin 6, vascular endothelial growth factor, and PEDIS score: a randomized controlled trial study","volume":"27","author":"Oley","year":"2020","journal-title":"Internat. J. Surgery Open."},{"key":"10.1016\/j.ejpb.2025.114894_b0215","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2174\/1874192401812010080","article-title":"Hyperbaric oxygen therapy in ischaemic foot ulcers in type 2 diabetes: a clinical trial","volume":"12","author":"Perren","year":"2018","journal-title":"The Open Cardiovas. Med. J."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0220","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2337\/dc17-0654","article-title":"Hyperbaric oxygen therapy in the treatment of ischemic lower- extremity ulcers in patients with diabetes: results of the DAMO2CLES multicenter randomized clinical trial","volume":"41","author":"Santema","year":"2017","journal-title":"Diab. Care"},{"issue":"17","key":"10.1016\/j.ejpb.2025.114894_b0225","doi-asserted-by":"crossref","first-page":"10548","DOI":"10.3390\/ijerph191710548","article-title":"Local hyperbaric oxygen therapy in the treatment of diabetic foot ulcers","volume":"19","author":"Pasek","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0230","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/1534734619829939","article-title":"Adjuvant hyperbaric oxygen therapy enhances healing of nonischemic diabetic foot ulcers compared with standard wound care alone","volume":"18","author":"Salama","year":"2019","journal-title":"Int. J. Low. Extrem. Wounds"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0235","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/wrr.12884","article-title":"Hyperbaric oxygen therapy for nonhealing wounds: Treatment results of a single center","volume":"29","author":"Teguh","year":"2021","journal-title":"Wound Repair Regen."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0240","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1272\/jnms.81.4","article-title":"Evaluation of hyperbaric oxygen therapy for chronic wounds","volume":"81","author":"Ueno","year":"2014","journal-title":"J. Nippon Med. Sch."},{"issue":"4","key":"10.1016\/j.ejpb.2025.114894_b0245","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/wrr.12657","article-title":"The effectiveness of hyperbaric oxygen therapy for healing chronic venous leg ulcers: a randomized, double-blind, placebo-controlled trial","volume":"26","author":"Thistlethwaite","year":"2018","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.ejpb.2025.114894_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118246","article-title":"Hyperbaric oxygen potentiates diabetic wound healing by promoting fibroblast cell proliferation and endothelial cell angiogenesis","volume":"259","author":"Huang","year":"2020","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0255","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/wrr.12782","article-title":"Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase-9","volume":"28","author":"Nguyen","year":"2020","journal-title":"Wound Repair Regen."},{"issue":"10","key":"10.1016\/j.ejpb.2025.114894_b0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108533","article-title":"Hyperbaric oxygen therapy to treat diabetes impaired wound healing in rats","volume":"9","author":"Tuk","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ejpb.2025.114894_b0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177766","article-title":"Hyperbaric oxygen therapy for wound healing in diabetic rats: Varying efficacy after a clinically-based protocol","volume":"12","author":"van Neck","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ejpb.2025.114894_b0270","doi-asserted-by":"crossref","unstructured":"Y. Yin, S.-Y. Wang, D. Xie, S.-M. Pan H-m. Fu, Z-h. Feng et al. Hyperbaric oxygen therapy promotes the browning of white fat and contributes to the healing of diabetic wounds, Internat. Wound J. 21 4 2024 e14867.","DOI":"10.1111\/iwj.14867"},{"issue":"6","key":"10.1016\/j.ejpb.2025.114894_b0275","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.5114\/aoms.2016.62905","article-title":"Effects of hyperbaric oxygen therapy combined with platelet-rich plasma on diabetic wounds: an experimental rat model","volume":"12","author":"Y\u00fcm\u00fcn","year":"2016","journal-title":"Archives Med. Sci."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114894_b0280","first-page":"24","article-title":"Topical wound oxygen therapy in the treatment of severe diabetic foot ulcers: a prospective controlled study","volume":"56","author":"Blackman","year":"2010","journal-title":"Ostomy\/wound Manage."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114894_b0285","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2337\/dc19-0476","article-title":"A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical topical wound oxygen (TWO2) therapy in the treatment of chronic diabetic foot ulcers: the TWO2 study","volume":"43","author":"Frykberg","year":"2020","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0290","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/1538574412467684","article-title":"Technical and clinical outcome of topical wound oxygen in comparison to conventional compression dressings in the management of refractory nonhealing venous ulcers","volume":"47","author":"Tawfick","year":"2013","journal-title":"Vas. Endovas. Surgery"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0295","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejvs.2009.03.027","article-title":"Does Topical Wound Oxygen (TWO2) offer an improved Outcome over conventional Compression Dressings (CCD) in the Management of Refractory Venous Ulcers (RVU)? a Parallel Observational Comparative Study","volume":"38","author":"Tawfick","year":"2009","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"issue":"11","key":"10.1016\/j.ejpb.2025.114894_b0300","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.bjps.2014.07.010","article-title":"Effect of normobaric hyperoxic therapy on tissue oxygenation in diabetic feet: a pilot study","volume":"67","author":"Moon","year":"2014","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"issue":"11","key":"10.1016\/j.ejpb.2025.114894_b0305","doi-asserted-by":"crossref","DOI":"10.5812\/ircmj.20211","article-title":"Transdermal wound oxygen therapy on pressure ulcer healing: a single-blind multi-center randomized controlled trial","volume":"17","author":"Azimian","year":"2015","journal-title":"Iran. Red Crescent Med. J."},{"issue":"11","key":"10.1016\/j.ejpb.2025.114894_b0310","doi-asserted-by":"crossref","first-page":"652","DOI":"10.12968\/jowc.2017.26.11.652","article-title":"Topical oxygen therapy promotes the healing of chronic diabetic foot ulcers: a pilot study","volume":"26","author":"Hayes","year":"2017","journal-title":"J. Wound Care"},{"issue":"7","key":"10.1016\/j.ejpb.2025.114894_b0315","doi-asserted-by":"crossref","first-page":"426","DOI":"10.12968\/jowc.2018.27.7.426","article-title":"Topical oxygen therapy stimulates healing in difficult, chronic wounds: a tertiary centre experience","volume":"27","author":"Kaufman","year":"2018","journal-title":"J. Wound Care"},{"issue":"Sup5","key":"10.1016\/j.ejpb.2025.114894_b0320","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.12968\/jowc.2021.30.Sup5.S7","article-title":"Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled clinical trial","volume":"30","author":"Serena","year":"2021","journal-title":"J. Wound Care"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0325","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1177\/15347346211053694","article-title":"An observational clinical trial examining the effect of topical oxygen therapy (Natrox\u2122) on the rates of healing of chronic diabetic foot ulcers (OTONAL Trial)","volume":"23","author":"Tang","year":"2024","journal-title":"Int. J. Low. Extrem. Wounds"},{"issue":"6","key":"10.1016\/j.ejpb.2025.114894_b0330","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1111\/wrr.12490","article-title":"Topical oxygen therapy results in complete wound healing in diabetic foot ulcers","volume":"24","author":"Yu","year":"2016","journal-title":"Wound Repair Regen."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114894_b0335","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1111\/iwj.13490","article-title":"The effect of continuous diffusion of oxygen treatment on cytokines, perfusion, bacterial load, and healing in patients with diabetic foot ulcers","volume":"17","author":"Lavery","year":"2020","journal-title":"Int. Wound J."},{"issue":"5","key":"10.1016\/j.ejpb.2025.114894_b0340","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1177\/1932296817695574","article-title":"A prospective, randomized, double-blind multicenter study comparing continuous diffusion of oxygen therapy to sham therapy in the treatment of diabetic foot ulcers","volume":"11","author":"Niederauer","year":"2017","journal-title":"J. Diabetes Sci. Technol."},{"issue":"5","key":"10.1016\/j.ejpb.2025.114894_b0345","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1742-481X.2010.00716.x","article-title":"Low flow oxygenation of full-excisional skin wounds on diabetic mice improves wound healing by accelerating wound closure and reepithelialization","volume":"7","author":"Asmis","year":"2010","journal-title":"Int. Wound J."},{"issue":"4","key":"10.1016\/j.ejpb.2025.114894_b0350","first-page":"12","article-title":"A prospective, randomized, blinded, controlled trial comparing transdermal continuous oxygen delivery to moist wound therapy for the treatment of diabetic foot ulcers","volume":"63","author":"Driver","year":"2017","journal-title":"Ostomy Wound Manage."},{"issue":"11","key":"10.1016\/j.ejpb.2025.114894_b0355","first-page":"19","article-title":"A prospective, randomized clinical study evaluating the effect of transdermal continuous oxygen therapy on biological processes and foot ulcer healing in persons with diabetes mellitus","volume":"59","author":"Driver","year":"2013","journal-title":"Ostomy Wound Manage."},{"key":"10.1016\/j.ejpb.2025.114894_b0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.108743","article-title":"Therapeutic effect of continuous diffusion of oxygen therapy combined with traditional moist wound dressing therapy in the treatment of diabetic foot ulcers","volume":"174","author":"He","year":"2021","journal-title":"Diab. Res. Clin. Pract."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114894_b0365","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.taap.2015.08.005","article-title":"Dextran-shelled oxygen-loaded nanodroplets reestablish a normoxia-like pro-angiogenic phenotype and behavior in hypoxic human dermal microvascular endothelium","volume":"288","author":"Basilico","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"37","key":"10.1016\/j.ejpb.2025.114894_b0370","doi-asserted-by":"crossref","first-page":"19766","DOI":"10.1021\/acs.langmuir.4c02549","article-title":"Assembly of emulsion-based cascade vehicles for combination oxygen\u2013chemotherapy in diabetic wound healing","volume":"40","author":"Zhang","year":"2024","journal-title":"Langmuir"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0375","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s12951-023-02048-1","article-title":"Functional molecule-mediated assembled copper nanozymes for diabetic wound healing","volume":"21","author":"Huang","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"4","key":"10.1016\/j.ejpb.2025.114894_b0380","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.xphs.2023.10.011","article-title":"Oxygenated hydrogel promotes re-epithelialization and reduces inflammation in a perturbed wound model in rat","volume":"113","author":"Tan","year":"2024","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114894_b0385","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.2147\/IJN.S213883","article-title":"Preparation and in vivo evaluation of a topical hydrogel system incorporating highly skin-permeable growth factors, quercetin, and oxygen carriers for enhanced diabetic wound-healing therapy","volume":"14","author":"Jee","year":"2019","journal-title":"Int. J. Nanomed."},{"issue":"8","key":"10.1016\/j.ejpb.2025.114894_b0390","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1089\/wound.2018.0887","article-title":"Fluorinated methacrylamide chitosan hydrogel dressings improve regenerated wound tissue quality in diabetic wound healing","volume":"8","author":"Patil","year":"2019","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.ejpb.2025.114894_b0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121401","article-title":"Nano-oxygenated hydrogels for locally and permeably hypoxia relieving to heal chronic wounds","volume":"282","author":"Yang","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2025.114894_b0400","unstructured":"Zhuge D, Yang S, Pan X, Xiao Y, Wang X, Wang W, et al. Ultrasound-triggered oxygen release system for accelerating wound healing of diabetic foot ulcers. Adv. Healthcare Mater. n\/a(n\/a):2403224."},{"key":"10.1016\/j.ejpb.2025.114894_b0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122029","article-title":"All-in-one bioactive properties of photothermal nanofibers for accelerating diabetic wound healing","volume":"295","author":"Zhao","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2025.114894_b0410","article-title":"Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation","volume":"7(35):eabj0153","author":"Guan","year":"2021","journal-title":"Sci. Adv."},{"issue":"16","key":"10.1016\/j.ejpb.2025.114894_b0415","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202303314","article-title":"Calcium peroxide-based hydrogel patch with sustainable oxygenation for diabetic wound healing","volume":"13","author":"Li","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.ejpb.2025.114894_b0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130256","article-title":"A Poloxamer 407\/chitosan-based thermosensitive hydrogel dressing for diabetic wound healing via oxygen production and dihydromyricetin release","volume":"263","author":"Liu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2025.114894_b0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125081","article-title":"Sprayable alginate hydrogel dressings with oxygen production and exosome loading for the treatment of diabetic wounds","volume":"242","author":"Zhang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2025.114894_b0430","article-title":"Oxygen generating polymeric nano fibers that stimulate angiogenesis and show efficient wound healing in a diabetic wound model","volume":"15(null):3511\u201322","author":"Zehra","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejpb.2025.114894_b0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.131670","article-title":"Poly (vinyl alcohol)\/sodium alginate\/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing","volume":"268","author":"Chai","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"21","key":"10.1016\/j.ejpb.2025.114894_b0440","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1039\/D2TB00343K","article-title":"Bio-fabricated nanocomposite hydrogel with ROS scavenging and local oxygenation accelerates diabetic wound healing","volume":"10","author":"Pu","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ejpb.2025.114894_b0445","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jcis.2022.03.040","article-title":"Multifunctional hydrogel platform for biofilm scavenging and O2 generating with photothermal effect on diabetic chronic wound healing","volume":"617","author":"Wang","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ejpb.2025.114894_b0450","article-title":"Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes","volume":"6(20):eaba4311","author":"Chen","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejpb.2025.114894_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136669","article-title":"Microenvironmental pH modulating oxygen self-boosting microalgal prodrug carboxymethyl chitosan\/hyaluronic acid\/puerarin hydrogel for accelerating wound healing in diabetic rats","volume":"282","author":"Su","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0460","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.apsb.2022.06.012","article-title":"Chlorella sp.-ameliorated undesirable microenvironment promotes diabetic wound healing","volume":"13","author":"Wu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"6","key":"10.1016\/j.ejpb.2025.114894_b0465","doi-asserted-by":"crossref","first-page":"7725","DOI":"10.1021\/acsami.2c18809","article-title":"Separable microneedles with photosynthesis-driven oxygen manufactory for diabetic wound healing","volume":"15","author":"Zhao","year":"2023","journal-title":"ACS Appl. Mater. Interf."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0470","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/wrr.12630","article-title":"Multicenter, randomized controlled, observer-blinded study of a nitric oxide generating treatment in foot ulcers of patients with diabetes\u2014ProNOx1 study","volume":"26","author":"Edmonds","year":"2018","journal-title":"Wound Repair Regen."},{"issue":"8","key":"10.1016\/j.ejpb.2025.114894_b0475","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.nano.2012.02.014","article-title":"Nitric oxide-releasing nanoparticles accelerate wound healing in NOD-SCID mice","volume":"8","author":"Blecher","year":"2012","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"issue":"12","key":"10.1016\/j.ejpb.2025.114894_b0480","doi-asserted-by":"crossref","first-page":"5595","DOI":"10.1021\/acs.nanolett.3c01023","article-title":"Two-pronged microbe delivery of nitric oxide and oxygen for diabetic wound healing","volume":"23","author":"Chen","year":"2023","journal-title":"Nano Lett."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114894_b0485","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202103449","article-title":"Porous MOF microneedle array patch with photothermal responsive nitric oxide delivery for wound healing","volume":"9","author":"Yao","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejpb.2025.114894_b0490","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jconrel.2022.08.018","article-title":"In situ hydrogel capturing nitric oxide microbubbles accelerates the healing of diabetic foot","volume":"350","author":"Zhao","year":"2022","journal-title":"J. Control. Release"},{"issue":"16","key":"10.1016\/j.ejpb.2025.114894_b0495","doi-asserted-by":"crossref","first-page":"18319","DOI":"10.1021\/acsami.0c01792","article-title":"Copper-based Metal\u2013Organic Framework as a Controllable Nitric Oxide-Releasing Vehicle for Enhanced Diabetic Wound Healing","volume":"12","author":"Zhang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejpb.2025.114894_b0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122894","article-title":"Glucose-activated self-cascade antibacterial and pro-angiogenesis nanozyme-functionalized chitosan-arginine thermosensitive hydrogel for chronic diabetic wounds healing","volume":"348","author":"Chen","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2025.114894_b0505","article-title":"Preparation and safety evaluation of centella asiatica total glycosides nitric oxide gel and its therapeutic effect on diabetic cutaneous ulcers","volume":"2022(1):1419146","author":"Liu","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.ejpb.2025.114894_b0510","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1060758","article-title":"Nitric oxide-releasing gel accelerates healing in a diabetic murine splinted excisional wound model","volume":"10","author":"Sivaraj","year":"2023","journal-title":"Front. Med."},{"key":"10.1016\/j.ejpb.2025.114894_b0515","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbae062","article-title":"Combined therapeutic strategy based on blocking the deleterious effects of AGEs for accelerating diabetic wound healing","volume":"11","author":"Yang","year":"2024","journal-title":"Regener. Biomater."},{"key":"10.1016\/j.ejpb.2025.114894_b0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111747","article-title":"Development of nitric oxide releasing visible light crosslinked gelatin methacrylate hydrogel for rapid closure of diabetic wounds","volume":"140","author":"Zahid","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejpb.2025.114894_b0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132736","article-title":"All-in-one polysaccharide hydrogel with resistant vascular burst pressure and cooperative wound microenvironment regulation for fatal arterial hemorrhage and diabetic wound healing","volume":"272","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0530","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/1843995","article-title":"Physical treatment of diabetic foot ulcers\u2014preliminary study for topical application of oxygen or ozone auxiliary treatment of diabetic foot ulcers","volume":"2023","author":"Pasek","year":"2023","journal-title":"Dermatol. Ther."},{"issue":"3","key":"10.1016\/j.ejpb.2025.114894_b0535","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.3390\/ijerph20031967","article-title":"Topical hyperbaric oxygen therapy versus local ozone therapy in healing of venous leg ulcers","volume":"20","author":"Pasek","year":"2023","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"12","key":"10.1016\/j.ejpb.2025.114894_b0540","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1089\/dia.2011.0018","article-title":"Efficacy of ozone\u2013oxygen therapy for the treatment of diabetic foot ulcers","volume":"13","author":"Wainstein","year":"2011","journal-title":"Diabetes Technol. Ther."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0545","article-title":"Increased growth factors play a role in wound healing promoted by noninvasive oxygen-ozone therapy in diabetic patients with foot ulcers","volume":"2014","author":"Zhang","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.ejpb.2025.114894_b0550","doi-asserted-by":"crossref","first-page":"176","DOI":"10.12968\/jowc.2014.23.4.176","article-title":"Aqueous oxygen peroxide treatment of VLUs in a primary care-based randomised, double-blind, placebo-controlled trial","volume":"23","author":"O'Halloran","year":"2014","journal-title":"J. Wound Care"},{"key":"10.1016\/j.ejpb.2025.114894_b0555","first-page":"223","article-title":"The role of carbon dioxide therapy in the treatment of chronic wounds","volume":"24","author":"Brandi","year":"2010","journal-title":"Vivo"},{"key":"10.1016\/j.ejpb.2025.114894_b0560","first-page":"81","article-title":"Clinical prospective study on the use of subcutaneous carboxytherapy in the treatment of diabetic foot ulcer","volume":"32","author":"Khiat","year":"2018","journal-title":"Surg. Technol. Internat."},{"key":"10.1016\/j.ejpb.2025.114894_b0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2020.104100","article-title":"Transcutaneous application of the gaseous CO2 for improvement of the microvascular function in patients with diabetic foot ulcers","volume":"133","author":"Fin\u017egar","year":"2021","journal-title":"Microvasc. Res."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114894_b0570","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1111\/iwj.13436","article-title":"The effect of transcutaneous application of gaseous CO2 on diabetic chronic wound healing\u2014A double-blind randomized clinical trial","volume":"17","author":"Macura","year":"2020","journal-title":"Int. Wound J."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0575","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/iwj.13031","article-title":"Carboxytherapy: Controls the inflammation and enhances the production of fibronectin on wound healing under venous insufficiency","volume":"16","author":"Brochado","year":"2019","journal-title":"Int. Wound J."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0580","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1021\/acs.nanolett.1c03693","article-title":"Symbiotic algae\u2013bacteria dressing for producing hydrogen to accelerate diabetic wound healing","volume":"22","author":"Chen","year":"2022","journal-title":"Nano Lett."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0585","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12951-025-03115-5","article-title":"Probiotic active gel promotes diabetic wound healing through continuous local glucose consumption and antioxidant","volume":"23","author":"Wang","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"48","key":"10.1016\/j.ejpb.2025.114894_b0590","doi-asserted-by":"crossref","first-page":"55392","DOI":"10.1021\/acsami.3c12672","article-title":"pH-responsive injectable multifunctional Pluronic F127\/gelatin-based hydrogels with hydrogen production for treating diabetic wounds","volume":"15","author":"Zhang","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"51","key":"10.1016\/j.ejpb.2025.114894_b0595","doi-asserted-by":"crossref","first-page":"70256","DOI":"10.1021\/acsami.4c15674","article-title":"Dynamic hyaluronic acid hydrogels for comprehensively regulating inflammation, angiogenesis, and metabolism to effectively proheal diabetic wounds","volume":"16","author":"Chen","year":"2024","journal-title":"ACS Appl. Mater. Interf."},{"issue":"17","key":"10.1016\/j.ejpb.2025.114894_b0600","doi-asserted-by":"crossref","first-page":"6931","DOI":"10.1021\/acs.analchem.3c00230","article-title":"Photoactivated hydrogen sulfide donor with a near-infrared fluorescence report system for accelerated chronic wound healing","volume":"95","author":"Yuan","year":"2023","journal-title":"Anal. Chem."},{"issue":"8","key":"10.1016\/j.ejpb.2025.114894_b0605","doi-asserted-by":"crossref","first-page":"8505","DOI":"10.1021\/acsnano.9b05124","article-title":"Hydrogen gas from inflammation treatment to cancer therapy","volume":"13","author":"Wu","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejpb.2025.114894_b0610","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jare.2023.05.009","article-title":"Novel ray of hope for diabetic wound healing: Hydrogen sulfide and its releasing agents","volume":"58","author":"Shi","year":"2024","journal-title":"J. Adv. Res."},{"issue":"Suppl 1","key":"10.1016\/j.ejpb.2025.114894_b0615","doi-asserted-by":"crossref","first-page":"131S","DOI":"10.1097\/PRS.0b013e3181fbe2bf","article-title":"Hyperbaric oxygen: its mechanisms and efficacy","volume":"127","author":"Thom","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.ejpb.2025.114894_b0620","unstructured":"M. Davis, Hyperbaric Medicine [Internet]. New Zealand: Te Whatu Ora - Waitaha Canterbury; [updated 28 June 2022; cited 2025 27 May]. Available from: https:\/\/www.cdhb.health.nz\/health-services\/hyperbaric-medicine\/."},{"key":"10.1016\/j.ejpb.2025.114894_b0625","unstructured":"Bridgeport Hospital. Hyperbaric Oxygen Therapy [Internet]. Connecticut, USA: Yale New Haven Health; [cited 2025 27 May]. Available from: https:\/\/www.bridgeporthospital.org\/services\/wound-care\/hyperbaric-oxygen-therapy."},{"key":"10.1016\/j.ejpb.2025.114894_b0630","unstructured":"FDA. Hyperbaric Oxygen Therapy: Get the Facts [Internet]. United States of America: United States Food & Drug Administration; 2021 [updated 26 July 2021; cited 2025 27 May]. Available from: https:\/\/www.fda.gov\/consumers\/consumer-updates\/hyperbaric-oxygen-therapy-get-facts."},{"key":"10.1016\/j.ejpb.2025.114894_b0635","article-title":"Evidence review: Hyperbaric oxygen therapy for diabetic lower limb ulceration refractory to best standard care [Review]","author":"England","year":"2017","journal-title":"England: National Health Service"},{"key":"10.1016\/j.ejpb.2025.114894_b0640","unstructured":"National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management [Internet]London: NICE; 2015 [cited 2025. Available from: https:\/\/www.nice.org.uk\/guidance\/ng19\/resources\/diabetic-foot-problems-prevention-and-management-pdf-1837279828933."},{"issue":"6","key":"10.1016\/j.ejpb.2025.114894_b0645","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1053\/j.jfas.2018.05.011","article-title":"Efficacy of hyperbaric oxygen therapy in diabetic foot ulcers based on wagner classification","volume":"57","author":"Erdo\u011fan","year":"2018","journal-title":"J. Foot Ankle Surg."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0650","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1055\/s-0034-1366974","article-title":"Update on middle ear barotrauma after hyperbaric oxygen therapy-insights on pathophysiology","volume":"18","author":"Lima","year":"2014","journal-title":"Internat. Arch.Otorhinolaryngology."},{"key":"10.1016\/j.ejpb.2025.114894_b0655","unstructured":"American Diabetes Association Professional Practice Committee, 12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes\u20142025, Diab. Care 48(Supplement_1):S252\u2013S65 (2024)."},{"issue":"Sup3","key":"10.1016\/j.ejpb.2025.114894_b0660","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.12968\/jowc.2022.31.Sup3.S20","article-title":"Guidelines for the use of topical oxygen therapy in the treatment of hard-to-heal wounds based on a Delphi consensus","volume":"31","author":"Serena","year":"2022","journal-title":"J. Wound Care"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0665","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0939-6411(97)00119-7","article-title":"Collagen microparticles: carriers for glucocorticosteroids","volume":"45","author":"Berthold","year":"1998","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2025.114894_b0670","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1515\/biol-2018-0035","article-title":"Nanoparticles as carriers of proteins, peptides and other therapeutic molecules","volume":"13","author":"Pudlarz","year":"2018","journal-title":"Open Life Sci."},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0675","doi-asserted-by":"crossref","first-page":"83","DOI":"10.7150\/ntno.43808","article-title":"Phospholipid oxygen microbubbles for image-guided therapy","volume":"4","author":"Reusser","year":"2020","journal-title":"Nanotheranostics"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0680","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ultrasmedbio.2018.09.022","article-title":"Microbubble formulations: synthesis, stability, modeling and biomedical applications","volume":"45","author":"Upadhyay","year":"2019","journal-title":"Ultrasound Med. Biol."},{"issue":"5","key":"10.1016\/j.ejpb.2025.114894_b0685","doi-asserted-by":"crossref","first-page":"e4984","DOI":"10.1097\/GOX.0000000000004984","article-title":"Scoping review of hydrogel therapies in the treatment of diabetic chronic wounds","volume":"11","author":"Sharma","year":"2023","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"10.1016\/j.ejpb.2025.114894_b0690","doi-asserted-by":"crossref","unstructured":"V. Gounden, M. Singh, Hydrogels and Wound Healing: Current and Future Prospects 10 (2024) Gels (Basel, Switzerland).","DOI":"10.3390\/gels10010043"},{"key":"10.1016\/j.ejpb.2025.114894_b0695","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2020.102146","article-title":"Drug release from hydrogel-based matrix systems partially coated: experiments and modeling","volume":"61","author":"De Piano","year":"2021","journal-title":"J. Drug Delivery Sci. Technol."},{"issue":"12","key":"10.1016\/j.ejpb.2025.114894_b0700","doi-asserted-by":"crossref","DOI":"10.1038\/natrevmats.2016.71","article-title":"Designing hydrogels for controlled drug delivery","volume":"1","author":"Li","year":"2016","journal-title":"Nat. Rev. Mater."},{"issue":"4","key":"10.1016\/j.ejpb.2025.114894_b0705","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202115021","article-title":"Controlling syneresis of hydrogels using organic salts","volume":"61","author":"Panja","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0710","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0022-3093(88)90008-7","article-title":"Aging and drying of gels","volume":"100","author":"Scherer","year":"1988","journal-title":"J. Non Cryst. Solids"},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0715","doi-asserted-by":"crossref","first-page":"10893","DOI":"10.1038\/s41598-018-29269-x","article-title":"Mechanical interactions between bacteria and hydrogels","volume":"8","author":"Kandemir","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ejpb.2025.114894_b0720","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1186\/s13104-018-3811-x","article-title":"Cell-gel interactions of in-gel propagating bacteria","volume":"11","author":"Serwer","year":"2018","journal-title":"BMC. Res. Notes"},{"issue":"2","key":"10.1016\/j.ejpb.2025.114894_b0725","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00424-020-02482-2","article-title":"Perfluorocarbon-based oxygen carriers: from physics to physiology","volume":"473","author":"J\u00e4gers","year":"2021","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.ejpb.2025.114894_b0730","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.addr.2021.02.005","article-title":"Metal-organic frameworks for therapeutic gas delivery","volume":"171","author":"Zhou","year":"2021","journal-title":"Adv. Drug Deliv. Rev."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125002711?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125002711?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T22:01:07Z","timestamp":1769810467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641125002711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":146,"alternative-id":["S0939641125002711"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114894","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gas-based therapies in chronic wounds: A scoping review of preclinical and clinical data","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114894","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114894"}}