{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:05:39Z","timestamp":1782140739888,"version":"3.54.5"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"publisher","award":["222S821"],"award-info":[{"award-number":["222S821"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"publisher","award":["223S129"],"award-info":[{"award-number":["223S129"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejpb.2025.114938","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T16:27:12Z","timestamp":1763656032000},"page":"114938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["N-acetylcysteine loaded electrospun core\/shell nanofibers: a promising system for ferroptosis in spinal cord injury"],"prefix":"10.1016","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4440-494X","authenticated-orcid":false,"given":"Meliha","family":"Gunes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6085-189X","authenticated-orcid":false,"given":"Gizem Kaftan","family":"\u00d6cal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fcnyamin","family":"K\u0131l\u0131cl\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An\u0131l Murat","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-2263","authenticated-orcid":false,"given":"G\u00fcliz","family":"Armagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6010-5902","authenticated-orcid":false,"given":"Sinem Yaprak","family":"Karavana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2025.114938_b0005","first-page":"1","article-title":"Docosahexaenoic acid-loaded polylactic acid core-shell nanofiber membranes for regenerative medicine after spinal cord injury: In vitro and in vivo study","volume":"21","author":"Liu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejpb.2025.114938_b0010","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/procel\/pwad003","article-title":"Recent progress and challenges in the treatment of spinal cord injury","volume":"14","author":"Tian","year":"2023","journal-title":"Protein Cell"},{"key":"10.1016\/j.ejpb.2025.114938_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-023-01477-6","article-title":"Spinal cord injury: molecular mechanisms and therapeutic interventions","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"10.1016\/j.ejpb.2025.114938_b0020","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1007\/s11064-023-03993-x","article-title":"Research progress of antioxidants in oxidative stress therapy after spinal cord injury","volume":"48","author":"Zhang","year":"2023","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejpb.2025.114938_b0025","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/sc.2011.111","article-title":"Oxidative stress in spinal cord injury and antioxidant-based intervention","volume":"50","author":"Jia","year":"2011","journal-title":"Spinal Cord"},{"key":"10.1016\/j.ejpb.2025.114938_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-024-04077-5","article-title":"Mechanism and prospects of mitochondrial transplantation for spinal cord injury treatment","volume":"15","author":"Wang","year":"2024","journal-title":"Stem Cell Research and Therapy"},{"key":"10.1016\/j.ejpb.2025.114938_b0035","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3892\/mmr.2015.3390","article-title":"N-acetylcysteine treatment following spinal cord trauma reduces neural tissue damage and improves locomotor function in mice","volume":"12","author":"Guo","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejpb.2025.114938_b0040","article-title":"Recent advances in nanomaterials for the treatment of spinal cord injury","volume":"18","author":"Gong","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.ejpb.2025.114938_b0045","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1089\/neu.2015.4165","article-title":"Electrospun fibers for spinal cord injury research and regeneration","volume":"33","author":"Schaub","year":"2016","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.ejpb.2025.114938_b0050","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.2147\/DDDT.S191240","article-title":"Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation","volume":"13","author":"Abdel-Wahab","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.ejpb.2025.114938_b0055","first-page":"6647","article-title":"Neuroprotectiee effects of N-Acetyl cysteine on primary hippocampus neurons against hydrogen peroxide-induced injury are mediated eia inhibition of mitogen-Actieated protein kinases signal transduction and antioxidatiee action","volume":"17","author":"Wu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejpb.2025.114938_b0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041086","article-title":"Neuroprotective effects of N-acetyl-cysteine and acetyl-L-carnitine after spinal cord injury in adult rats","volume":"7","author":"Karalija","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejpb.2025.114938_b0065","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.expneurol.2014.07.013","article-title":"Early preservation of mitochondrial bioenergetics supports both structural and functional recovery after neurotrauma","volume":"261","author":"Semple","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejpb.2025.114938_b0070","doi-asserted-by":"crossref","unstructured":"A. Horst, J.A. De Souza, M.C.Q. Santos, A.P.K. Riffel, C. Kolberg, W.A. Partata, Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain. 50 (2017) 1\u20137. Doi: 10.1590\/1414-431X20176533.","DOI":"10.1590\/1414-431x20176533"},{"key":"10.1016\/j.ejpb.2025.114938_b0075","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3389\/fneur.2017.00219","article-title":"Protective effect of N-acetylcysteine amide on blast-induced increase in intracranial pressure in rats","volume":"8","author":"Kawoos","year":"2017","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ejpb.2025.114938_b0080","article-title":"Spinal cord injury repair based on drug and cell delivery: from remodeling microenvironment to relay connection formation","volume":"31","author":"Ma","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.ejpb.2025.114938_b0085","doi-asserted-by":"crossref","unstructured":"M. Ismail, S. Ibrahim, A. El-Amir, A.M. EL-Rafei, N.K. Allam, A. Abdellatif, Genistein Loaded Nanofibers Protect Spinal Cord Tissue Following Experimental Injury in Rats, Biomedicines 6 (2018) 96. Doi: 10.3390\/BIOMEDICINES6040096.","DOI":"10.3390\/biomedicines6040096"},{"key":"10.1016\/j.ejpb.2025.114938_b0090","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1039\/D4NA00885E","article-title":"Pyrroloquinoline quinone-loaded coaxial nanofibers prevent oxidative stress after spinal cord injury","volume":"7","author":"Ibrahim","year":"2025","journal-title":"Nanoscale Adv."},{"key":"10.1016\/j.ejpb.2025.114938_b0095","article-title":"Single and multi-dose drug loaded electrospun fiber mats for wound healing applications","volume":"81","author":"Azizo\u011flu","year":"2023","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.ejpb.2025.114938_b0100","article-title":"Dental implants coated with BMP-2- and \u03b1-tocopherol-loaded nanofibers enhance osseointegration","author":"Karata\u015f","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114938_b0105","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.2147\/IJN.S175914","article-title":"Polycaprolactone electrospun fiber scaffold loaded with iPSCs-NSCs and ASCs as a novel tissue engineering scaffold for the treatment of spinal cord injury","volume":"13","author":"Zhou","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ejpb.2025.114938_b0110","doi-asserted-by":"crossref","DOI":"10.1186\/s40824-021-00229-3","article-title":"Polyphenols-loaded electrospun nanofibers in bone tissue engineering and regeneration","volume":"25","author":"Raja","year":"2021","journal-title":"Biomater Res"},{"key":"10.1016\/j.ejpb.2025.114938_b0115","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3390\/polym3010413","article-title":"Electrospun nanofibrous materials for neural tissue engineering","volume":"3","author":"Lee","year":"2011","journal-title":"Polymers"},{"key":"10.1016\/j.ejpb.2025.114938_b0120","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jconrel.2021.03.033","article-title":"Electrospinning for drug delivery applications: a review","volume":"334","author":"Luraghi","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2025.114938_b0125","doi-asserted-by":"crossref","first-page":"28951","DOI":"10.1039\/C7RA00179G","article-title":"Emulsion-based systems for fabrication of electrospun nanofibers: food, pharmaceutical and biomedical applications","volume":"7","author":"Nikmaram","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejpb.2025.114938_b0130","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijpharm.2017.09.043","article-title":"Protein-loaded emulsion electrospun fibers optimized for bioactivity retention and pH-controlled release for peroral delivery of biologic therapeutics","volume":"533","author":"Frizzell","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114938_b0135","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.colsurfb.2009.09.014","article-title":"Encapsulation of proteins in poly(l-lactide-co-caprolactone) fibers by emulsion electrospinning","volume":"75","author":"Li","year":"2010","journal-title":"Colloids Surf. BBiointerfaces"},{"key":"10.1016\/j.ejpb.2025.114938_b0140","article-title":"A bionic multichannel nanofiber conduit carrying Tubastatin a for repairing injured spinal cord","volume":"17","author":"Liao","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.ejpb.2025.114938_b0145","doi-asserted-by":"crossref","unstructured":"L.H. Nguyen, M. Gao, J. Lin, W. Wu, J. Wang, S.Y. Chew, Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug\/gene delivery to direct axon regeneration in spinal cord injury treatment, Scientific Reports. 7 (2017) 1\u201312. Doi: 10.1038\/srep42212.","DOI":"10.1038\/srep42212"},{"key":"10.1016\/j.ejpb.2025.114938_b0150","doi-asserted-by":"crossref","first-page":"190","DOI":"10.14227\/DT290422P190","article-title":"Dissolution method troubleshooting: an industry perspective","volume":"29","author":"Mann","year":"2022","journal-title":"Dissolut. Technol."},{"key":"10.1016\/j.ejpb.2025.114938_b0155","first-page":"31","article-title":"The impact of EDTA and selenite on the stability of insulin in cell culture media, international journal of biochemistry","volume":"1","author":"Prakasha Gowda","year":"2023","journal-title":"Advances"},{"key":"10.1016\/j.ejpb.2025.114938_b0160","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejps.2014.10.002","article-title":"In vitro dissolution similarity factor (f2) and in vivo bioequivalence criteria, how and when do they match? Using a BCS Class II Drug as a Simulation Example","volume":"66","author":"Xie","year":"2015","journal-title":"Eur. J. Pharmaceutical Sci."},{"key":"10.1016\/j.ejpb.2025.114938_b0165","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3390\/polym17030313","article-title":"Polyhydroxybutyrate as a novel biopolymer for dental restorative materials: biological and morphological analysis","volume":"17","author":"Atalayin Ozkaya","year":"2025","journal-title":"Polymers"},{"key":"10.1016\/j.ejpb.2025.114938_b0170","doi-asserted-by":"crossref","unstructured":"M. Sharif-Alhoseini, M. Khormali, M. Rezaei, M. Safdarian, A. Hajighadery, M.M. Khalatbari, M. Safdarian, S. Meknatkhah, M. Rezvan, M. Chalangari, P. Derakhshan, V. Rahimi-Movaghar, Animal models of spinal cord injury: a systematic review, Spinal Cord. 55 (2017) 714\u2013721. Doi: 10.1038\/sc.2016.187.","DOI":"10.1038\/sc.2016.187"},{"key":"10.1016\/j.ejpb.2025.114938_b0175","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4103\/0976-500X.119726","article-title":"How to calculate sample size in animal studies","volume":"4","author":"Charan","year":"2013","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.ejpb.2025.114938_b0180","first-page":"38","article-title":"Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat","volume":"10","author":"Rivlin","year":"1978","journal-title":"Surg. Neurol."},{"key":"10.1016\/j.ejpb.2025.114938_b0185","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1242\/dmm.025833","article-title":"Rat models of spinal cord injury: from pathology to potential therapies","volume":"9","author":"Kjell","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ejpb.2025.114938_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114943","article-title":"Ferroptosis in the neurovascular unit after spinal cord injury","volume":"381","author":"Huang","year":"2024","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejpb.2025.114938_b0195","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/neu.2006.23.635","article-title":"Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains","volume":"23","author":"Basso","year":"2006","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.ejpb.2025.114938_b0200","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jneumeth.2007.09.013","article-title":"An inclined plane system with microcontroller to determine limb motor function of laboratory animals","volume":"168","author":"Chang","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ejpb.2025.114938_b0205","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1016\/j.biomaterials.2008.06.028","article-title":"Electrospun poly (lactic acid-co-glycolic acid) scaffolds for skin tissue engineering","volume":"29","author":"Kumbar","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2025.114938_b0210","doi-asserted-by":"crossref","DOI":"10.1002\/mame.201600364","article-title":"Fabrication of Core\/Shell Nanofibers with Desirable Mechanical and Antibacterial Properties by Pickering Emulsion Electrospinning","volume":"302","author":"Cai","year":"2017","journal-title":"Macromol. Mater. Eng."},{"key":"10.1016\/j.ejpb.2025.114938_b0215","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/09205063.2014.982241","article-title":"Emulsion electrospinning of polycaprolactone: influence of surfactant type towards the scaffold properties","volume":"26","author":"Hu","year":"2015","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.ejpb.2025.114938_b0220","doi-asserted-by":"crossref","unstructured":"A. Faglie, R. Emerine, S.F. Chou, Effects of Poloxamers as Excipients on the Physicomechanical Properties, Cellular Biocompatibility, and In Vitro Drug Release of Electrospun Polycaprolactone (PCL) Fibers, Polymers 2023, Vol. 15, Page 2997 15 (2023) 2997. Doi: 10.3390\/POLYM15142997.","DOI":"10.3390\/polym15142997"},{"key":"10.1016\/j.ejpb.2025.114938_b0225","doi-asserted-by":"crossref","unstructured":"M. Stirpe, B. Brugnoli, G. Donelli, I. Francolini, C. Vuotto, Poloxamer 338 Affects Cell Adhesion and Biofilm Formation in Escherichia coli: Potential Applications in the Management of Catheter-Associated Urinary Tract Infections, (n.d.). Doi: 10.3390\/pathogens9110885.","DOI":"10.3390\/pathogens9110885"},{"key":"10.1016\/j.ejpb.2025.114938_b0230","first-page":"1590","article-title":"N-acetylcysteine-loaded electrospun mats improve wound healing in mice and human fibroblast proliferation in vitro: a potential application of nanotechnology in wound care","volume":"23","author":"Seyedian","year":"2020","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.ejpb.2025.114938_b0235","article-title":"Enhancing topical delivery of N-acetylcysteine and collagen via a novel electrospun collagen\/PMMA nanofibrous mats as facial mask development: Nanofibers optimization and In vitro experiments","volume":"104","author":"Elbadry","year":"2025","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.ejpb.2025.114938_b0240","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jconrel.2019.12.001","article-title":"Nanoparticles with antioxidant enzymes protect injured spinal cord from neuronal cell apoptosis by attenuating mitochondrial dysfunction","volume":"317","author":"Andrabi","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2025.114938_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.146143","article-title":"Bioengineering of chitosan\/citric acid\/curcumin nanofiber scaffolds for treatment of spinal cord injury","volume":"321","author":"Prabhakar","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2025.114938_b0250","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1208\/s12248-010-9185-1","article-title":"DDSolver: an add-in program for modeling and comparison of drug dissolution profiles","volume":"12","author":"Zhang","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.ejpb.2025.114938_b0255","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0928-0987(01)00095-1","article-title":"Modeling and comparison of dissolution profiles","volume":"13","author":"Costa","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114938_b0260","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3390\/jfb14060331","article-title":"Investigation of the real-time release of doxycycline from PLA-based nanofibers","volume":"14","author":"Farkas","year":"2023","journal-title":"J Funct Biomater"},{"key":"10.1016\/j.ejpb.2025.114938_b0265","doi-asserted-by":"crossref","unstructured":"P. Huo, X. Han, W. Zhang, J. Zhang, P. Kumar, B. Liu, Electrospun Nanofibers of Polycaprolactone\/Collagen as a Sustained-Release Drug Delivery System for Artemisinin, Pharmaceutics 2021, Vol. 13, Page 1228 13 (2021) 1228. Doi: 10.3390\/PHARMACEUTICS13081228.","DOI":"10.3390\/pharmaceutics13081228"},{"issue":"2007","key":"10.1016\/j.ejpb.2025.114938_b0270","first-page":"2853","article-title":"Clip compression model is useful for thoracic spinal cord injuries: histologic and functional correlates","volume":"32","author":"Poon","year":"1976","journal-title":"Spine (phila Pa"},{"key":"10.1016\/j.ejpb.2025.114938_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2023.102231","article-title":"Conducting spinal cord injury model with clip compression in rodents: Pearls and pitfalls","volume":"10","author":"Vahabi","year":"2023","journal-title":"MethodsX"},{"key":"10.1016\/j.ejpb.2025.114938_b0280","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1002\/jnr.25120","article-title":"Animal models of compression spinal cord injury","volume":"100","author":"Ridlen","year":"2022","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejpb.2025.114938_b0285","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejpb.2025.114938_b0290","doi-asserted-by":"crossref","first-page":"532","DOI":"10.4103\/1673-5374.245480","article-title":"Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis","volume":"14","author":"Yao","year":"2019","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ejpb.2025.114938_b0295","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.18","article-title":"Traumatic spinal cord injury","volume":"3","author":"Ahuja","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ejpb.2025.114938_b0300","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5312\/wjo.v6.i1.17","article-title":"Acute complications of spinal cord injuries","volume":"6","author":"Hagen","year":"2015","journal-title":"World J. Orthop."},{"key":"10.1016\/j.ejpb.2025.114938_b0305","doi-asserted-by":"crossref","DOI":"10.1002\/jsp2.1344","article-title":"Silibinin promotes healing in spinal cord injury through anti-ferroptotic mechanisms","author":"Vahabi","year":"2024","journal-title":"JOR Spine"},{"key":"10.1016\/j.ejpb.2025.114938_b0310","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/01616412.2021.2024737","article-title":"N-Acetylcysteine alleviates spinal cord injury in rats after early decompression surgery by regulating inflammation and apoptosis","volume":"44","author":"Guo","year":"2022","journal-title":"Neurol. Res."},{"key":"10.1016\/j.ejpb.2025.114938_b0315","first-page":"767","article-title":"N-acetyl-L-cysteine averts ferroptosis by fostering glutathione peroxidase 4, Cell","volume":"32","author":"Zheng","year":"2025","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ejpb.2025.114938_b0320","doi-asserted-by":"crossref","first-page":"28097","DOI":"10.1074\/jbc.M115.680090","article-title":"Ablation of the ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis","volume":"290","author":"Chen","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejpb.2025.114938_b0325","doi-asserted-by":"crossref","first-page":"33960","DOI":"10.1021\/acsnano.5c09794","article-title":"Adaptive phenol-based hydrogel embedded with metformin nanoparticles targets oxidative stress and ferroptosis for spinal cord injury repair","volume":"19","author":"Feng","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejpb.2025.114938_b0330","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/pharmaceutics17050573","article-title":"Synergistic antioxidant and anti-ferroptosis therapy via BPNS-encapsulated thermoresponsive chitosan hydrogel for spinal cord injury regeneration","volume":"17","author":"Liu","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2025.114938_b0335","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.4103\/1673-5374.274332","article-title":"Multimodal treatment for spinal cord injury: a sword of neuroregeneration upon neuromodulation","volume":"15","author":"Zheng","year":"2020","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ejpb.2025.114938_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.104973","article-title":"Biomaterials and strategies for repairing spinal cord lesions","volume":"144","author":"Jeong","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejpb.2025.114938_b0345","doi-asserted-by":"crossref","unstructured":"Y. Dai, W. Wang, X. Zhou, L. li, Y. Tang, M. Shao, F. Lyu, Y. Dai, W. Wang, X. Zhou, L. li, Y. Tang, M. Shao, F. Lyu, Biomimetic Electrospun PLLA\/PPSB Nanofibrous Scaffold Combined with Human Neural Stem Cells for Spinal Cord Injury Repair, ACSAN 6 (2023) 5980\u20135993. Doi: 10.1021\/ACSANM.3C00374.","DOI":"10.1021\/acsanm.3c00374"},{"key":"10.1016\/j.ejpb.2025.114938_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102615","article-title":"SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc","volume":"60","author":"Jiang","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejpb.2025.114938_b0355","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1007\/s12035-016-0089-7","article-title":"Tissue-engineered regeneration of hemisected spinal cord using human endometrial stem cells, poly \u03b5-caprolactone scaffolds, and crocin as a neuroprotective agent","volume":"54","author":"Terraf","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejpb.2025.114938_b0360","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1007\/s12031-020-01601-z","article-title":"Asiaticoside inhibits neuronal apoptosis and promotes functional recovery after spinal cord injury in rats","volume":"70","author":"Fan","year":"2020","journal-title":"J. Mol. Neurosci."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125003169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125003169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:22:28Z","timestamp":1766139748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641125003169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":72,"alternative-id":["S0939641125003169"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114938","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-acetylcysteine loaded electrospun core\/shell nanofibers: a promising system for ferroptosis in spinal cord injury","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114938","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114938"}}