{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:26:33Z","timestamp":1766139993447,"version":"3.48.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020898","name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre","doi-asserted-by":"publisher","award":["200172\/2023\\u20139"],"award-info":[{"award-number":["200172\/2023\\u20139"]}],"id":[{"id":"10.13039\/100020898","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Finep","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Foundation for Research Support of Rio Grande do Sul State","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejpb.2025.114939","type":"journal-article","created":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T22:49:42Z","timestamp":1763938182000},"page":"114939","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Naproxen printlets for extemporaneous dispersion: Designing new medicines for drug delivery through the enteral route"],"prefix":"10.1016","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1341-3982","authenticated-orcid":false,"given":"Nadine Lysyk","family":"Funk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Carvalho","family":"Tavaniello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edilson Valmir","family":"Benvenutti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar Liberato","family":"Petzhold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1373-9336","authenticated-orcid":false,"given":"Karina","family":"Paese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9889-7420","authenticated-orcid":false,"given":"Monique","family":"Deon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruy Carlos","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2025.114939_b0005","first-page":"858","article-title":"ESPEN practical guideline: home enteral nutrition","volume":"40","author":"Bischoff","year":"2023","journal-title":"Nutr. Hosp."},{"key":"10.1016\/j.ejpb.2025.114939_b0010","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.clnesp.2024.01.010","article-title":"Epidemiology of home enteral and parenteral nutrition in adults: comprehensive national data","volume":"60","author":"Buhl","year":"2024","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.ejpb.2025.114939_b0015","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/jcpt.12664","article-title":"Carers\u2019 experiences of home enteral feeding: a survey exploring medicines administration challenges and strategies","volume":"43","author":"Alsaeed","year":"2018","journal-title":"J. Clin. Pharm. Ther."},{"key":"10.1016\/j.ejpb.2025.114939_b0020","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s40266-023-01056-y","article-title":"Crushed tablet administration for patients with dysphagia and enteral feeding: challenges and considerations","volume":"40","author":"Blaszczyk","year":"2023","journal-title":"Drugs Aging"},{"key":"10.1016\/j.ejpb.2025.114939_b0025","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/ncp.10615","article-title":"Enteral medication for the tube-fed patient: making this route safe and effective","volume":"36","author":"Boullata","year":"2021","journal-title":"Nutr. Clin. Pract."},{"key":"10.1016\/j.ejpb.2025.114939_b0030","unstructured":"FDA, Oral Drug Products Administered Via Enteral Feeding Tube: In Vitro Testing and Labeling Recommendations Guidance for Industry, Food Drug Adm. (2021). https:\/\/doi.org\/10.7501\/j.issn.1674-6376.2021.09.005."},{"key":"10.1016\/j.ejpb.2025.114939_b0035","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/jpen.2490","article-title":"Developing guidance for feeding tube administration of oral medications","volume":"47","author":"Klang","year":"2023","journal-title":"J. Parenter. Enter. Nutr."},{"key":"10.1016\/j.ejpb.2025.114939_b0040","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ejpb.2023.08.013","article-title":"Navigating the complexities of medicating paediatric patients: insights from an enteral feeding tube workshop","volume":"191","author":"Walsh","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0045","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15020714","article-title":"Development of 3D printed multi-layered orodispersible films with porous structure applicable as a substrate for inkjet printing","volume":"15","author":"Elbl","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2025.114939_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124299","article-title":"3D printed dispersible efavirenz tablets: a strategy for nasogastric administration in children","volume":"660","author":"Funk","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121750","article-title":"Drug-loaded mesoporous silica on carboxymethyl cellulose hydrogel\u00a0: development of innovative 3D printed hydrophilic films","volume":"620","author":"Schmidt","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0060","article-title":"Bioadhesive 3D-printed skin drug delivery polymeric films\u00a0: from the drug loading in mesoporous silica to the manufacturing process","volume":"15","author":"de Oliveira","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2025.114939_b0065","article-title":"3D printed matrix solid forms : can the drug solubility and dose customisation affect their controlled release behaviour ?","volume":"5","author":"dos Santos","year":"2023","journal-title":"Int. J. Pharm. X"},{"key":"10.1016\/j.ejpb.2025.114939_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124140","article-title":"Paediatric clinical study of 3D printed personalised medicines for rare metabolic disorders","volume":"657","author":"Rodr\u00edguez-Pombo","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics12020172","article-title":"3D printed tablets (Printlets) with braille and moon patterns for visually impaired patients","volume":"12","author":"Awad","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2025.114939_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122066","article-title":"Immediate release 3D printed oral dosage forms : how different polymers have been explored to reach suitable drug release behaviour","volume":"625","author":"Funk","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0085","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jconrel.2021.02.027","article-title":"Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges","volume":"332","author":"Seoane-Via\u00f1o","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2025.114939_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules26133941","article-title":"3D Printing of drug nanocrystals for film formulations","volume":"26","author":"Germini","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejpb.2025.114939_b0095","article-title":"Individualized orodispersible pediatric dosage forms obtained by molding and semi-solid extrusion by 3D printing: a comparative study for hydrochlorothiazide","volume":"66","author":"Su\u00e1rez-Gonz\u00e1lez","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejpb.2025.114939_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2025.107122","article-title":"Semi-solid extruded tablets for personalized pediatric use: development, quality control and in-vitro assessment of enteral tube administration","volume":"211","author":"Bahman","year":"2025","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114939_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics11070334","article-title":"Towards printed pediatric medicines in hospital pharmacies: comparison of 2d and 3d-printed orodispersiblewarfarin films with conventional oral powders in unit dose sachets","volume":"11","author":"\u00d6blom","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2025.114939_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14020443","article-title":"\u2018Tablet-in-syringe\u2019: a novel dosing mechanism for dysphagic patients containing fast-disintegrating tablets fabricated using semisolid extrusion 3D printing","volume":"14","author":"Panraksa","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2025.114939_b0115","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s40256-016-0200-5","article-title":"Clinical pharmacology and cardiovascular safety of naproxen","volume":"17","author":"Angiolillo","year":"2017","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"10.1016\/j.ejpb.2025.114939_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ph15070807","article-title":"Two novel co-crystals of naproxen: comparison of stability solubility and intermolecular Interaction","volume":"15","author":"Xing","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejpb.2025.114939_b0125","article-title":"Insights into drug loading techniques with mesoporous silica nanoparticles: optimization of operating conditions and assessment of drug stability","volume":"96","author":"Khalbas","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejpb.2025.114939_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics16030325","article-title":"Ivermectin-loaded mesoporous silica and polymeric nanocapsules: impact on drug loading in vitro solubility enhancement, and release performance","volume":"16","author":"Velho","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2025.114939_b0135","doi-asserted-by":"crossref","unstructured":"R. de Andrade, R. de C. dos R. Schmidt, L.S. Gomes, L. Colina-Vegas, R. Hinrichs, M.A.Z. Vasconcellos, T.M.H. Costa, M. Deon, W. Villarreal, E.V. Benvenutti, Magnetic Mesoporous Silica for Targeted Drug Delivery of Chloroquine: Synthesis, Characterization, and In Vitro Evaluation, Pharmaceutics 16 (2024) 1\u201314. https:\/\/doi.org\/10.3390\/pharmaceutics16030357.","DOI":"10.3390\/pharmaceutics16030357"},{"key":"10.1016\/j.ejpb.2025.114939_b0140","doi-asserted-by":"crossref","first-page":"7145","DOI":"10.1039\/D1TB01430G","article-title":"Engineering mesoporous silica nanoparticles towards oral delivery of vancomycin","volume":"9","author":"Ndayishimiye","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ejpb.2025.114939_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.micromeso.2024.113458","article-title":"Naproxen-loaded mesoporous silica nanoparticles: how can the process of incorporation affect drug placement, drug release and the in vitro naproxen irritant potential?","volume":"384","author":"Funk","year":"2025","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.ejpb.2025.114939_b0150","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ijpharm.2018.08.004","article-title":"Mesoporous silica nanoparticles for enhanced lidocaine skin delivery","volume":"550","author":"Nafisi","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0155","unstructured":"S.J. Gregg, K.S.. Sing, Adsorption, surface area, and porosity, Second Edi, Academic Press, 1982."},{"key":"10.1016\/j.ejpb.2025.114939_b0160","unstructured":"P.A. Webb, C. Orr, Analytical Methods in Fine Particle Technology, Micromeritics (1997) 1\u2013325. https:\/\/books.google.com\/books\/about\/Analytical_Methods_in_Fine_Particle_Tech.html?hl=pt-BR&id=jVNvAAAACAAJ (accessed November 15, 2022)."},{"key":"10.1016\/j.ejpb.2025.114939_b0165","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1208\/s12248-010-9185-1","article-title":"DDSolver: an add-in program for modeling and comparison of drug dissolution profiles","volume":"12","author":"Zhang","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.ejpb.2025.114939_b0170","article-title":"Nanoliposomal in situ gel of fluoxetine and embelin as a potent intervention for depression via the intranasal route in CUMS animal model","volume":"99","author":"Ali","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejpb.2025.114939_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12249-023-02534-7","article-title":"Inclusion complex of Ibuprofen-\u03b2-Cyclodextrin incorporated in gel for mucosal delivery: optimization using an experimental design","volume":"24","author":"Upadhyay","year":"2023","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2025.114939_b0180","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2133.1986.tb02123.x","article-title":"The hen\u2019s egg test (HET)\u2014an alternative toxicity test","volume":"115","author":"L\u00fcpke","year":"1986","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ejpb.2025.114939_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2024.124680","article-title":"Characterization and performance evaluation of pH-sensitive drug delivery of mesoporous silica with honeycomb structure for treatment of cancer","volume":"401","author":"Duan","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ejpb.2025.114939_b0190","doi-asserted-by":"crossref","DOI":"10.3390\/polym14061108","article-title":"Rheological investigation of hydroxypropyl cellulose\u2013based filaments for material extrusion 3D printing","volume":"14","author":"Than","year":"2022","journal-title":"Polymers (Basel)."},{"key":"10.1016\/j.ejpb.2025.114939_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfoodeng.2019.109691","article-title":"3D printing of egg yolk and white with rice flour blends","volume":"265","author":"Anukiruthika","year":"2020","journal-title":"J. Food Eng."},{"key":"10.1016\/j.ejpb.2025.114939_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2024.114372","article-title":"Design and evaluation of curcumin-loaded poloxamer hydrogels as injectable depot formulations","volume":"201","author":"Jose","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124402","article-title":"Regulations on excipients used in 3D printing of pediatric oral forms","volume":"662","author":"Monteil","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124070","article-title":"Rheological insights into 3D printing of drug products: drug nanocrystal-poloxamer gels for semisolid extrusion","volume":"655","author":"Junnila","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0215","article-title":"Assessing bioink shape fidelity to aid material development in 3D bioprinting","volume":"10","author":"Ribeiro","year":"2018","journal-title":"Biofabrication"},{"key":"10.1016\/j.ejpb.2025.114939_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11095-018-2405-6","article-title":"Immediate release 3D-printed tablets produced via fused deposition modeling of a thermo-sensitive drug","volume":"35","author":"Kempin","year":"2018","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2025.114939_b0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics12080692","article-title":"Orodispersible polymer films with the poorly water-soluble drug, olanzapine: hot-melt pneumatic extrusion for single-process 3D printing","volume":"12","author":"Cho","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2025.114939_b0230","article-title":"Three-dimensional printing personalized acetaminophen sustained-release tablets using hot melt extrusion","volume":"66","author":"Liu","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejpb.2025.114939_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2024.110463","article-title":"Fabrication of edible inks for 3D printing as a dysphagia food: a emerging application of bigels","volume":"157","author":"Chao","year":"2024","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.ejpb.2025.114939_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119983","article-title":"3D printing of extended-release tablets of theophylline using hydroxypropyl methylcellulose (HPMC) hydrogels","volume":"591","author":"Cheng","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0245","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3390\/gels9070517","article-title":"Essential guide to hydrogel rheology in extrusion 3D printing: how to measure it and why it matters?","volume":"9","author":"Herrada-Manch\u00f3n","year":"2023","journal-title":"Gels"},{"key":"10.1016\/j.ejpb.2025.114939_b0250","doi-asserted-by":"crossref","DOI":"10.3390\/gels8010028","article-title":"Effect on rheological properties and 3D printability of biphasic calcium phosphate microporous particles in hydrocolloid-based hydrogels","volume":"8","author":"Herrada-Manch\u00f3n","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.ejpb.2025.114939_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124017","article-title":"Pimobendan controlled release guar gum printlets: tailoring drug doses for personalised veterinary medicines","volume":"655","author":"Le\u00e3o","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0260","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/abb2d8","article-title":"A rheological approach to assess the printability of thermosensitive chitosan-based biomaterial inks","volume":"16","author":"Rahimnejad","year":"2021","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.ejpb.2025.114939_b0265","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.3390\/molecules28062766","article-title":"Rheology as a tool for fine-tuning the properties of printable bioinspired gels","volume":"28","author":"Bercea","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.ejpb.2025.114939_b0270","unstructured":"USP, The United States Pharmacopoeia, United States Pharmacopeical Conv. (2022). http:\/\/app.uspnf.com\/uspnf\/pub\/index?usp=41&nf=36&s=1&officialOn=August%0A1,%0A2018."},{"key":"10.1016\/j.ejpb.2025.114939_b0275","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.xphs.2020.01.015","article-title":"Development of 3D printed tablets by fused deposition modeling using polyvinyl alcohol as polymeric matrix for rapid drug release","volume":"109","author":"Wei","year":"2020","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2025.114939_b0280","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13071036","article-title":"Impact of matrix surface area on griseofulvin release from extrudates prepared via nanoextrusion","volume":"13","author":"Li","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2025.114939_b0285","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tca.2005.09.011","article-title":"Physicochemical studies on solid dispersions of poorly water-soluble drugs: evaluation of capabilities and limitations of thermal analysis techniques","volume":"439","author":"Bikiaris","year":"2005","journal-title":"Thermochim Acta"},{"key":"10.1016\/j.ejpb.2025.114939_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2019.112937","article-title":"Solid-state analysis of amorphous solid dispersions: why DSC and XRPD may not be regarded as stand-alone techniques","volume":"178","author":"Dedroog","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejpb.2025.114939_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122576","article-title":"Investigating the physicochemical properties of solid dispersions based on semicrystalline carriers: a case study with ketoprofen","volume":"632","author":"Bertoni","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0300","article-title":"An effective polyvinyl alcohol for the solubilization of poorly water-soluble drugs in solid dispersion formulations","volume":"55","author":"Umemoto","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejpb.2025.114939_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120635","article-title":"Highlights in poloxamer-based drug delivery systems as strategy at local application for vaginal infections","volume":"602","author":"Carvalho","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0310","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1021\/ma00068a010","article-title":"Poly(ethylene oxide)\u2014poly(propylene oxide)\u2014poly(ethylene oxide) triblock copolymers in aqueous solution the influence of relative block size","volume":"26","author":"Mortensen","year":"1993","journal-title":"Macromolecules"},{"key":"10.1016\/j.ejpb.2025.114939_b0315","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3390\/jfb13040275","article-title":"Adsorption and release properties of drug delivery system naproxen-SBA-15: effect of surface polarity, sodium\/acid drug form and pH","volume":"13","author":"Zau\u0161ka","year":"2022","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.ejpb.2025.114939_b0320","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.msec.2018.11.013","article-title":"Chitosan hydrogels containing nanoencapsulated phenytoin for cutaneous use: skin permeation\/penetration and efficacy in wound healing","volume":"96","author":"Cardoso","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ejpb.2025.114939_b0325","article-title":"A potential thermosensitive poloxamer 407-based in situ hydrogel containing moxifloxacin-loaded silk fibroin nanoparticles for prolonged ocular delivery","volume":"99","author":"Chomchalao","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejpb.2025.114939_b0330","unstructured":"R. White, V. Bradnam, Handbook of Drug Administration via Enteral Feeding Tubes, 3rd Editio, Pharmaceutical Press, 2015."},{"key":"10.1016\/j.ejpb.2025.114939_b0335","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/17425247.2020.1731469","article-title":"Formulation strategies to modulate drug release from poloxamer based in situ gelling systems","volume":"17","author":"Abdeltawab","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejpb.2025.114939_b0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/gels9100817","article-title":"Lamotrigine-loaded poloxamer-based thermo-responsive sol\u2013gel: formulation in vitro assessment, ex vivo permeation, and toxicology study","volume":"9","author":"Riaz","year":"2023","journal-title":"Gels"},{"key":"10.1016\/j.ejpb.2025.114939_b0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122029","article-title":"Redispersible 3D printed nanomedicines\u00a0: an original application of the semisolid extrusion technique","volume":"624","author":"de Oliveira","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0350","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/s13346-022-01227-1","article-title":"Thermosensitive and mucoadhesive hydrogel containing curcumin-loaded lipid-core nanocapsules coated with chitosan for the treatment of oral squamous cell carcinoma","volume":"13","author":"Ortega","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ejpb.2025.114939_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2021.105259","article-title":"Ferulic acid-loaded nanocapsules: evaluation of mucosal interaction, safety and antioxidant activity in human mononucleated cells","volume":"78","author":"Rampelotto","year":"2022","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.ejpb.2025.114939_b0360","doi-asserted-by":"crossref","first-page":"19626","DOI":"10.1021\/acsnano.2c03990","article-title":"Bridging the in vitro to in vivo gap: using the chick embryo model to accelerate nanoparticle validation and qualification for in vivo studies","volume":"16","author":"Butler","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejpb.2025.114939_b0365","doi-asserted-by":"crossref","unstructured":"R. dos A. Miguel, A.S. Hirata, G.C. Salata, A.C. Apolin\u00e1rio, V.M. Barroso, K. Ishida, J.J. La Clair, W. Fenical, T.S. Martins, L. V. Costa-Lotufo, L.B. Lopes, Topical delivery of seriniquinone for treatment of skin cancer and fungal infections is enabled by a liquid crystalline lamellar phase, Eur. J. Pharm. Sci. 192 (2024). https:\/\/doi.org\/10.1016\/j.ejps.2023.106635.","DOI":"10.1016\/j.ejps.2023.106635"},{"key":"10.1016\/j.ejpb.2025.114939_b0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2015.05.023","article-title":"The hen\u2019s egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of a cysteamine-containing gel: quantification using Photoshop\u00ae and ImageJ","volume":"490","author":"McKenzie","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2025.114939_b0375","doi-asserted-by":"crossref","unstructured":"R.L. Wilson, C.E. Stevenson, Anatomy and Physiology of the Stomach, in: Shackelford\u2019s Surg. Aliment. Tract 2 Vol. Set, Eighth Edi, Elsevier Inc., 2019: pp. 634\u2013646. https:\/\/doi.org\/10.1016\/B978-0-323-40232-3.00056-X.","DOI":"10.1016\/B978-0-323-40232-3.00056-X"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125003170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641125003170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:22:56Z","timestamp":1766139776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641125003170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":75,"alternative-id":["S0939641125003170"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114939","relation":{},"ISSN":["0939-6411"],"issn-type":[{"type":"print","value":"0939-6411"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Naproxen printlets for extemporaneous dispersion: Designing new medicines for drug delivery through the enteral route","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114939","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114939"}}