{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:48:06Z","timestamp":1782823686024,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ejpb.2026.115076","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:22:36Z","timestamp":1776237756000},"page":"115076","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A biomimetic nanoparticle for the treatment of sepsis via anti-inflammatory, antioxidant, and anticoagulant mechanisms"],"prefix":"10.1016","volume":"223","author":[{"given":"Haijiao","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3268-2163","authenticated-orcid":false,"given":"Ying","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2026.115076_b0005","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global burden of disease study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet (london, England)"},{"key":"10.1016\/j.ejpb.2026.115076_b0010","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejpb.2026.115076_b0015","article-title":"Bioresponsive nanoparticles targeted to infectious microenvironments for sepsis management","volume":"30","author":"Zhang","year":"2018","journal-title":"Adv. Mater. (Deerfield Beach Fla.)"},{"key":"10.1016\/j.ejpb.2026.115076_b0020","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/CCM.0b013e3181c98d21","article-title":"Inflammation and coagulation","volume":"38","author":"Levi","year":"2010","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ejpb.2026.115076_b0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-2362.1997.570614.x","article-title":"The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia","volume":"27","author":"Levi","year":"1997","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.ejpb.2026.115076_b0030","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1007\/s00134-004-2291-8","article-title":"Coagulation in sepsis","volume":"30","author":"Amaral","year":"2004","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.ejpb.2026.115076_b0035","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1182\/blood.2020007208","article-title":"Disseminated intravascular coagulation and its immune mechanisms","volume":"139","author":"Popescu","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.ejpb.2026.115076_b0040","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.tim.2021.12.011","article-title":"Mitochondria-mediated oxidative stress during viral infection","volume":"30","author":"Foo","year":"2022","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ejpb.2026.115076_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102046","article-title":"Nanotherapies for sepsis by regulating inflammatory signals and reactive oxygen and nitrogen species: new insight for treating COVID-19","volume":"45","author":"Chen","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejpb.2026.115076_b0050","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1089\/ars.2021.0027","article-title":"Oxidative stress and endothelial dysfunction in sepsis and acute inflammation","volume":"35","author":"Joffre","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ejpb.2026.115076_b0055","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/0973-7847.194044","article-title":"Overviews of biological importance of quercetin: a bioactive flavonoid","volume":"10","author":"Anand David","year":"2016","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.ejpb.2026.115076_b0060","article-title":"Potential pharmaceutical applications of quercetin in cardiovascular diseases","volume":"15","author":"Papakyriakopoulou","year":"2022","journal-title":"Pharmaceuticals (Basel Switzerland)"},{"key":"10.1016\/j.ejpb.2026.115076_b0065","article-title":"The therapeutic and prophylactic potential of quercetin against COVID-19: an outlook on the clinical studies, inventive compositions, and patent literature","volume":"11","author":"Imran","year":"2022","journal-title":"Antioxidants (basel)"},{"key":"10.1016\/j.ejpb.2026.115076_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.915726","article-title":"Quercetin alleviates lipopolysaccharide-induced inflammatory response in bovine mammary epithelial cells by suppressing TLR4\/NF-\u03baB signaling pathway","volume":"9","author":"Jiang","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.ejpb.2026.115076_b0075","doi-asserted-by":"crossref","first-page":"427","DOI":"10.5114\/aoms.2015.50975","article-title":"Quercetin protects against lipopolysaccharide-induced acute lung injury in rats through suppression of inflammation and oxidative stress","volume":"11","author":"Huang","year":"2015","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.ejpb.2026.115076_b0080","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.1039\/D4TB00228H","article-title":"Carbonization of quercetin into nanogels: a leap in anticoagulant development","volume":"12","author":"Chu","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ejpb.2026.115076_b0085","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.semcancer.2019.07.023","article-title":"Flavonoids nanoparticles in cancer: Treatment, prevention and clinical prospects","volume":"69","author":"Khan","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.ejpb.2026.115076_b0090","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10787-022-01118-4","article-title":"Quercetin-loaded chitosan nanoparticles ameliorate adjuvant-induced arthritis in rats by regulating anti-oxidant enzymes and downregulating pro- and inflammatory cytokines","volume":"31","author":"Hannan","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.ejpb.2026.115076_b0095","article-title":"Suppression of lipopolysaccharide\u2010induced sepsis by tetrahedral framework nucleic acid loaded with quercetin","volume":"32","author":"Liu","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ejpb.2026.115076_b0100","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/s12951-021-01131-9","article-title":"Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics","volume":"19","author":"Zhu","year":"2021","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.ejpb.2026.115076_b0105","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.actbio.2021.09.030","article-title":"Tumor targeting and penetrating biomimetic mesoporous polydopamine nanoparticles facilitate photothermal killing and autophagy blocking for synergistic tumor ablation","volume":"136","author":"Huang","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejpb.2026.115076_b0110","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202401816","article-title":"Evaluation of reactive oxygen species scavenging of polydopamine with different nanostructures","volume":"13","author":"Zheng","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.ejpb.2026.115076_b0115","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.biomaterials.2016.10.003","article-title":"Nanoparticles camouflaged in platelet membrane coating as an antibody decoy for the treatment of immune thrombocytopenia","volume":"111","author":"Wei","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2026.115076_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121833","article-title":"Targeted photodynamic therapy of glioblastoma mediated by platelets with photo-controlled release property","volume":"290","author":"Xu","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejpb.2026.115076_b0125","doi-asserted-by":"crossref","first-page":"e1825","DOI":"10.1002\/wnan.1825","article-title":"Cell membrane-coated nanoparticles for the treatment of bacterial infection","volume":"14","author":"Ma","year":"2022","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.ejpb.2026.115076_b0130","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41392-021-00631-2","article-title":"Recent progress in targeted delivery vectors based on biomimetic nanoparticles","volume":"6","author":"Chen","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ejpb.2026.115076_b0135","doi-asserted-by":"crossref","first-page":"23746","DOI":"10.1021\/acsnano.3c07555","article-title":"Biomimetic macrophage membrane-camouflaged nanoparticles induce ferroptosis by promoting mitochondrial damage in glioblastoma","volume":"17","author":"Cao","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejpb.2026.115076_b0140","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1080\/10717544.2022.2117434","article-title":"Recent trends in platelet membrane-cloaked nanoparticles for application of inflammatory diseases","volume":"29","author":"Fang","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejpb.2026.115076_b0145","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s10735-025-10442-2","article-title":"Quercetin mitigates sepsis-induced renal injury via inhibiting inflammatory and oxidative pathways in mice","volume":"56","author":"Raheem","year":"2025","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.ejpb.2026.115076_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110363","article-title":"Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1\/AMPK pathways","volume":"96","author":"Sang","year":"2022","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejpb.2026.115076_b0155","article-title":"Platelet membrane-coated nanocarriers targeting plaques to deliver Anti-CD47 antibody for atherosclerotic therapy","volume":"2022","author":"Chen","year":"2022","journal-title":"Research (wash D c)"},{"key":"10.1016\/j.ejpb.2026.115076_b0160","unstructured":"J. Yang, R. Zhang, H. Zhao, H. Qi, J. Li, J.F. Li, X. Zhou, A. Wang, K. Fan, X. Yan, Bioinspired copper single\u2010atom nanozyme as a superoxide dismutase\u2010like antioxidant for sepsis treatment, in: Exploration, Wiley Online Library, 2022, pp. 20210267."},{"key":"10.1016\/j.ejpb.2026.115076_b0165","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4161\/viru.27024","article-title":"Gram-positive and gram-negative bacterial toxins in sepsis: a brief review","volume":"5","author":"Ramachandran","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.ejpb.2026.115076_b0170","doi-asserted-by":"crossref","unstructured":"M.G. Dorrington, I.D.C. Fraser, NF-\u03baB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration, Frontiers in immunology, 10 (2019) 705.","DOI":"10.3389\/fimmu.2019.00705"},{"key":"10.1016\/j.ejpb.2026.115076_b0175","doi-asserted-by":"crossref","first-page":"45006","DOI":"10.1038\/srep45006","article-title":"Resveratrol mitigates lipopolysaccharide-mediated acute inflammation in rats by inhibiting the TLR4\/NF-\u03baBp65\/MAPKs signaling cascade","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejpb.2026.115076_b0180","first-page":"49","article-title":"Nephroprotective effect of L-carvone on a mouse model of lps-induced sepsis-associated renal injury via regulation of TLR4\/NF-kappaB\/AP-1\/IRF-3 and Nrf2\/iNOS molecular signaling cascades","volume":"21","author":"Shareef","year":"2026","journal-title":"J Taibah Univ Med Sci"},{"key":"10.1016\/j.ejpb.2026.115076_b0185","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11033-025-11213-8","article-title":"L-carvone alleviates lipopolysaccharide-Induced acute kidney injury via modulating MyD88-dependent and independent signaling pathways in mice","volume":"53","author":"Shareef","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ejpb.2026.115076_b0190","article-title":"Antiviral and anti\u2010inflammatory treatment with multifunctional alveolar macrophage\u2010like nanoparticles in a surrogate mouse model of COVID\u201019","volume":"8","author":"Li","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejpb.2026.115076_b0195","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbrc.2022.03.159","article-title":"Therapeutic effect of quercetin polymeric nanoparticles on ischemia\/reperfusion-induced acute kidney injury in mice","volume":"608","author":"Huang","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejpb.2026.115076_b0200","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1021\/acs.nanolett.0c04759","article-title":"A cationic metal-organic framework to scavenge cell-free DNA for severe sepsis management","volume":"21","author":"Liu","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.ejpb.2026.115076_b0205","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.2147\/DDDT.S370460","article-title":"Alpha-chymotrypsin protects against acute lung, kidney, and liver injuries and increases survival in CLP-induced sepsis in rats through inhibition of TLR4\/NF-\u03baB pathway","volume":"16","author":"Senousy","year":"2022","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.ejpb.2026.115076_b0210","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6501046","article-title":"Measurement and clinical significance of biomarkers of oxidative stress in humans","volume":"2017","author":"Marrocco","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejpb.2026.115076_b0215","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13054-017-1678-1","article-title":"New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management","volume":"21","author":"Kroschinsky","year":"2017","journal-title":"Crit. Care"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641126000974?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641126000974?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:27:55Z","timestamp":1782822475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641126000974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":43,"alternative-id":["S0939641126000974"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2026.115076","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A biomimetic nanoparticle for the treatment of sepsis via anti-inflammatory, antioxidant, and anticoagulant mechanisms","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2026.115076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115076"}}