{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:15:24Z","timestamp":1783181724249,"version":"3.54.6"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Republic of Poland Ministry of Science and Higher Education","doi-asserted-by":"publisher","award":["0912\/SBAD\/2504"],"award-info":[{"award-number":["0912\/SBAD\/2504"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004569","name":"Republic of Poland Ministry of Science and Higher Education","doi-asserted-by":"publisher","award":["0912\/SPHD\/2521"],"award-info":[{"award-number":["0912\/SPHD\/2521"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006111","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005856","name":"NOVA University Lisbon NOVA School of Science &amp; Technology","doi-asserted-by":"publisher","award":["LA\/P\/0006\/2020 (DOI 10.54499\/LA\/P\/0006\/2020"],"award-info":[{"award-number":["LA\/P\/0006\/2020 (DOI 10.54499\/LA\/P\/0006\/2020"]}],"id":[{"id":"10.13039\/501100005856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004239","name":"Politechnika Pozna\u0144ska","doi-asserted-by":"publisher","award":["UID\/50011\/2025"],"award-info":[{"award-number":["UID\/50011\/2025"]}],"id":[{"id":"10.13039\/501100004239","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ejpb.2026.115100","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T22:56:22Z","timestamp":1779058582000},"page":"115100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Structure\u2013Permeability relationships of Vitamin-B-Based quaternary ammonium salts for oral drug development"],"prefix":"10.1016","volume":"225","author":[{"given":"Adriana","family":"Olejniczak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8895-0614","authenticated-orcid":false,"given":"Mara G.","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4364-8267","authenticated-orcid":false,"given":"Micha\u0142","family":"Niemczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2026.115100_b0005","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3390\/pharmaceutics15020484","article-title":"Advances in Oral Drug delivery Systems: challenges and Opportunities","volume":"15","author":"Lou","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2026.115100_b0010","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1021\/acssuschemeng.8b04696","article-title":"Ionic Liquids Derived from Vitamin C as Multifunctional active Ingredients for Sustainable Stored-Product Management","volume":"7","author":"Niemczak","year":"2019","journal-title":"ACS Sustain. Chem. Eng."},{"key":"10.1016\/j.ejpb.2026.115100_b0015","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1080\/09593330.2016.1217941","article-title":"Removal of herbicidal ionic liquids by electrochemical advanced oxidation processes combined with biological treatment","volume":"38","author":"P\u0119ziak-Kowalska","year":"2017","journal-title":"Environ. Technol."},{"key":"10.1016\/j.ejpb.2026.115100_b0020","doi-asserted-by":"crossref","first-page":"18355","DOI":"10.1039\/D0RA03664A","article-title":"Combining amino acids and carbohydrates into readily biodegradable, task specific ionic liquids","volume":"10","author":"Brz\u0119czek-Szafran","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejpb.2026.115100_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021360","article-title":"Adjustment of the Structure of the Simplest Amino Acid present in Nature\u2014Glycine, toward more Environmentally Friendly Ionic Forms of Phenoxypropionate-based Herbicides","volume":"24","author":"Olejniczak","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejpb.2026.115100_b0030","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1021\/acs.molpharmaceut.4c00543","article-title":"Unraveling the potential of Vitamin B3-Derived Salts with a Salicylate Anion as Dermal active Agents for Acne Treatment","volume":"21","author":"Olejniczak","year":"2024","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejpb.2026.115100_b0035","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.nanoms.2024.06.010","article-title":"Ionogels as advanced materials for overcoming challenges in wound healing and drug delivery","volume":"7","author":"Pedro","year":"2025","journal-title":"Nano Mater. Sci."},{"issue":"20","key":"10.1016\/j.ejpb.2026.115100_b0040","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.1021\/acs.est.2c08244","article-title":"Quaternary ammonium compounds: a chemical class of emerging concern","volume":"57","author":"Arnold","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ejpb.2026.115100_b0045","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejps.2007.02.001","article-title":"Permeation of permanently positive charged molecules through artificial membranes\u2014Influence of physico-chemical properties","volume":"31","author":"Fischer","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2026.115100_b0050","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.3390\/biomedicines11102686","article-title":"Novel Para-Aminobenzoic Acid Analogs and their potential Therapeutic applications","volume":"11","author":"Haroon","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejpb.2026.115100_b0055","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.pbb.2012.02.012","article-title":"Nicotinic acid induces antinociceptive and anti-inflammatory effects in different experimental models","volume":"101","author":"Godin","year":"2012","journal-title":"Pharmacol. Biochem. Behav"},{"issue":"2","key":"10.1016\/j.ejpb.2026.115100_b0060","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3390\/medicina61020254","article-title":"Nicotinamide: A multifaceted molecule in skin health and beyond","volume":"61","author":"Camillo","year":"2025","journal-title":"Medicina"},{"key":"10.1016\/j.ejpb.2026.115100_b0065","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1039\/D1RA07499G","article-title":"Development of a gliclazide ionic liquid and its mesoporous silica particles: an effective formulation strategy to improve oral absorption properties","volume":"12","author":"Zhou","year":"2022","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejpb.2026.115100_b0070","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.ejmech.2004.06.012","article-title":"A topological sub-structural approach for predicting human intestinal absorption of drugs","volume":"39","author":"P\u00e9rez","year":"2004","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejpb.2026.115100_b0075","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1080\/17460441.2021.1961741","article-title":"An update on the importance of plasma protein binding in drug discovery and development","volume":"16","author":"Di","year":"2021","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.ejpb.2026.115100_b0080","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202100542","article-title":"Recent advances in the Prediction of Pharmacokinetics Properties in Drug Design Studies: a Review","volume":"17","author":"Pantale\u00e3o","year":"2022","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejpb.2026.115100_b0085","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jchromb.2018.09.017","article-title":"A new approach to examining the extraction process of Zhishi and Zhiqiao considering the synergistic effect of complex mixtures by PAMPA","volume":"1099","author":"Li","year":"2018","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.ejpb.2026.115100_b0090","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.ejps.2012.01.011","article-title":"Skin\u2013PAMPA: a new method for fast prediction of skin penetration","volume":"45","author":"Sink\u00f3","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2026.115100_b0095","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1016\/j.bmc.2007.03.040","article-title":"QSAR study on permeability of hydrophobic compounds with artificial membranes","volume":"15","author":"Fujikawa","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejpb.2026.115100_b0100","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/cbdv.200900112","article-title":"In silico Prediction of Human Oral Absorption based on QSAR analyses of PAMPA Permeability","volume":"6","author":"Akamatsu","year":"2009","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.ejpb.2026.115100_b0105","first-page":"160","article-title":"Evaluation of Ion-pair Formation of Adefovir to Improve Permeation across Artificial and Biological Membranes., J. Pharm. Pharm. Sci. a Publ. can. Soc. Pharm. Sci. Soc. can. Des","volume":"21","author":"Darsazan","year":"2018","journal-title":"Sci. Pharm."},{"key":"10.1016\/j.ejpb.2026.115100_b0110","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1039\/D4RA07975B","article-title":"A dual antibacterial action of soft quaternary ammonium compounds: bacteriostatic effects, membrane integrity, and reduced in vitro and in vivo toxicity","volume":"15","author":"Crn\u010devi\u0107","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejpb.2026.115100_b0115","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1023\/A:1007581202873","article-title":"Mechanistic Studies on Surfactant-Induced Membrane Permeability Enhancement","volume":"17","author":"Xia","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2026.115100_b0120","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1021\/acs.jmedchem.5b00104","article-title":"pkCSM: predicting Small-Molecule Pharmacokinetic and Toxicity Properties using Graph-based Signatures","volume":"58","author":"Pires","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejpb.2026.115100_b0125","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejpb.2026.115100_b0130","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1177\/108705710100600309","article-title":"High Throughput Prediction of Oral Absorption: Improvement of the Composition of the Lipid solution used in Parallel Artificial Membrane Permeation Assay","volume":"6","author":"Sugano","year":"2001","journal-title":"SLAS Discov."},{"key":"10.1016\/j.ejpb.2026.115100_b0135","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.bpj.2012.08.023","article-title":"Interfacial Tension and Surface pressure of High Density Lipoprotein, LowDensity Lipoprotein, and Related Lipid Droplets","volume":"103","author":"Ollila","year":"2012","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejpb.2026.115100_b0140","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1021\/ci600343x","article-title":"ADME Evaluation in Drug Discovery. 7. Prediction of Oral Absorption by Correlation and Classification","volume":"47","author":"Hou","year":"2007","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ejpb.2026.115100_b0145","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.toxrep.2020.01.004","article-title":"Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals\/drugs for estimation of oral absorption as a putative marker of hepatotoxicity","volume":"7","author":"Kamiya","year":"2020","journal-title":"Toxicol. Reports"},{"key":"10.1016\/j.ejpb.2026.115100_b0150","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s11095-019-2717-1","article-title":"A Cell-Free Approach based on Phospholipid Characterization for Determination of the Cell specific Unbound Drug Fraction (fu,cell)","volume":"36","author":"Treyer","year":"2019","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2026.115100_b0155","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3390\/pharmaceutics12050393","article-title":"The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and Bioavailability","volume":"12","author":"van der Merwe","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2026.115100_b0160","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.molliq.2018.05.071","article-title":"Identification of new pyridinium ionic liquids tagged with Schiff bases: Design, synthesis, in silico ADMET predictions and biological evaluations","volume":"264","author":"Rezki","year":"2018","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ejpb.2026.115100_b0165","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.3390\/ijms20122865","article-title":"A Profile of the In Vitro Anti-Tumor activity and In Silico ADME predictions of Novel Benzothiazole Amide-Functionalized Imidazolium Ionic Liquids","volume":"20","author":"Al-blewi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejpb.2026.115100_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115916","article-title":"Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors","volume":"263","author":"Di Stefano","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejpb.2026.115100_b0175","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.3390\/ijms26104772","article-title":"Application of Lipophilic Prodrug Charge Masking Strategy to Obtain Novel, potential Oxytocin Prodrugs","volume":"26","author":"Gitlin-Domagalska","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejpb.2026.115100_b0180","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3390\/ph17101329","article-title":"In Vitro Evaluation of Pharmacokinetic Properties of selected dual COX-2 and 5-LOX Inhibitors","volume":"17","author":"Bo\u0161kovi\u0107","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejpb.2026.115100_b0185","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3390\/ijms24021121","article-title":"Stereoselective Synthesis and Antiproliferative Activities of Tetrafunctional Diterpene Steviol Derivatives","volume":"24","author":"Bai","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejpb.2026.115100_b0190","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/cben.202300027","article-title":"Kinetic Modeling to Explain the Release of Medicine from Drug delivery Systems","volume":"10","author":"Askarizadeh","year":"2023","journal-title":"ChemBioEng Rev."},{"key":"10.1016\/j.ejpb.2026.115100_b0195","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.996607","article-title":"Intestinal permeability of agaro-oligosaccharides: Transport across Caco-2 cell monolayers and pharmacokinetics in rats","volume":"9","author":"Shirai","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ejpb.2026.115100_b0200","first-page":"210","article-title":"Surface active drugs: self-association and interaction with membranes and surfactants. Physicochemical and biological aspects","author":"Schreier","year":"1508","journal-title":"Biochim. Biophys. Acta - Biomembr."},{"key":"10.1016\/j.ejpb.2026.115100_b0205","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.mibio.2003.09.014","article-title":"Determination of lipophilicity and its use as a predictor of blood\u2013brain barrier penetration of molecular imaging agents","volume":"5","author":"Waterhouse","year":"2003","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.ejpb.2026.115100_b0210","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.xphs.2020.09.053","article-title":"Affinity of Lipophilic Drugs to mixed Lipid Aggregates in simulated Gastrointestinal Fluids","volume":"110","author":"Fagerberg","year":"2021","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2026.115100_b0215","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/A:1018879014281","article-title":"Surface activity and Concentration Dependent Intestinal Permeability in the Rat","volume":"16","author":"Lindahl","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejpb.2026.115100_b0220","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0021-9797(89)90261-0","article-title":"Micellar properties of nicotinamide-based surfactants","volume":"132","author":"Kalyanasundaram","year":"1989","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ejpb.2026.115100_b0225","doi-asserted-by":"crossref","first-page":"28799","DOI":"10.1039\/C9RA04226A","article-title":"Micellization, surface activities and thermodynamics study of pyridinium-based ionic liquid surfactants in aqueous solution","volume":"9","author":"Fu","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejpb.2026.115100_b0230","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1021\/acs.jmedchem.6b01483","article-title":"Nonclassical size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules","volume":"60","author":"Pye","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejpb.2026.115100_b0235","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jconrel.2004.10.012","article-title":"Influence of molecular weight on oral absorption of water soluble chitosans","volume":"102","author":"Chae","year":"2005","journal-title":"J. Control. Release"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641126001219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641126001219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:17:45Z","timestamp":1783178265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641126001219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":47,"alternative-id":["S0939641126001219"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2026.115100","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure\u2013Permeability relationships of Vitamin-B-Based quaternary ammonium salts for oral drug development","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2026.115100","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115100"}}