{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:09:42Z","timestamp":1790111382448,"version":"4.0.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ejpb.2026.115124","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T16:08:17Z","timestamp":1779984497000},"page":"115124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Development of 3D-printed granisetron hydrogels with temperature-sensitive drug release"],"prefix":"10.1016","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2247-324X","authenticated-orcid":false,"given":"Can","family":"Cetin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3610-1914","authenticated-orcid":false,"given":"Onur Cem","family":"Namli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-582X","authenticated-orcid":false,"given":"Gulengul","family":"Duman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-7737","authenticated-orcid":false,"given":"Zeynep Gunes","family":"Tepe Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9554-5158","authenticated-orcid":false,"given":"Okan","family":"Kuzhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejpb.2026.115124_b0005","doi-asserted-by":"crossref","DOI":"10.1188\/02.CJON.94-102","article-title":"Chemotherapy-induced nausea and vomiting","volume":"6","author":"Bender","year":"2002","journal-title":"Clin. J. Oncol. Nurs."},{"issue":"316","key":"10.1016\/j.ejpb.2026.115124_b0010","first-page":"25","article-title":"Postoperative and postdischarge nausea and vomiting after ambulatory surgery: an update","volume":"4","author":"Kovac","year":"2014","journal-title":"Curr. Anesthesiol. Rep."},{"key":"10.1016\/j.ejpb.2026.115124_b0015","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2165\/00003495-199142050-00007","article-title":"Granisetron: a review of its pharmacological properties and therapeutic use as an antiemetic","volume":"42","author":"Plosker","year":"1991","journal-title":"Drugs"},{"key":"10.1016\/j.ejpb.2026.115124_b0020","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1634\/theoncologist.9-6-673","article-title":"Granisetron: an update on its clinical use in the management of nausea and vomiting","volume":"9","author":"Aapro","year":"2004","journal-title":"Oncol"},{"key":"10.1016\/j.ejpb.2026.115124_b0025","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2165\/00003495-199448050-00008","article-title":"Granisetron","volume":"48","author":"Yarker","year":"1994","journal-title":"Drugs"},{"key":"10.1016\/j.ejpb.2026.115124_b0030","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1208\/s12249-018-1019-y","article-title":"Transdermal delivery of ondansetron hydrochloride via bilosomal systems: in vitro, ex vivo, and in vivo characterization studies","volume":"19","author":"Ammar","year":"2018","journal-title":"AAPS PharmSciTech"},{"issue":"3 Part A","key":"10.1016\/j.ejpb.2026.115124_b0035","first-page":"99","article-title":"Recent approaches in transdermal drug delivery systems","volume":"2","author":"Bhowmik","year":"2013","journal-title":"Pharma Innov."},{"key":"10.1016\/j.ejpb.2026.115124_b0040","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4103\/0973-8398.154707","article-title":"Formulation and development of industry-feasible proniosomal transdermal drug delivery system of granisetron hydrochloride","author":"Patil","year":"2015","journal-title":"Asian J Pharm AJP."},{"issue":"4","key":"10.1016\/j.ejpb.2026.115124_b0045","first-page":"317","article-title":"Design, optimization and characterization of granisetron HCl loaded nano-gel for transdermal delivery","volume":"5","author":"Aggarwal","year":"2017","journal-title":"Pharm. Nanotechnol."},{"issue":"1","key":"10.1016\/j.ejpb.2026.115124_b0050","first-page":"36","article-title":"Organogels, hydrogels and bigels as transdermal post harvest quality of banana fruits","volume":"45","author":"Ibrahim","year":"2018","journal-title":"J Plant Biotechnol."},{"key":"10.1016\/j.ejpb.2026.115124_b0055","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1177\/1078155209104063","article-title":"Pharmacokinetics of a granisetron transdermal system for the treatment of chemotherapy-induced nausea and vomiting","volume":"15","author":"Howell","year":"2009","journal-title":"J. Oncol. Pharm. Pract."},{"issue":"5","key":"10.1016\/j.ejpb.2026.115124_b0060","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1021\/ma702269c","article-title":"Effects of PEO\u2212PPO Diblock Impurities on the Cubic Structure of Aqueous PEO\u2212PPO\u2212PEO Pluronics Micelles: fcc and bcc Ordered Structures in F127","volume":"41","author":"Mortensen","year":"2008","journal-title":"Macromolecules"},{"key":"10.1016\/j.ejpb.2026.115124_b0065","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jconrel.2016.06.015","article-title":"A 3D-printed local drug delivery patch for pancreatic cancer growth suppression","volume":"238","author":"Yi","year":"2016","journal-title":"J. Control. Release"},{"issue":"12","key":"10.1016\/j.ejpb.2026.115124_b0070","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1039\/c2sm06463d","article-title":"Hyaluronic acid-based hydrogels: from a natural polysaccharide to complex networks","volume":"8","author":"Xu","year":"2012","journal-title":"Soft Matter"},{"issue":"5","key":"10.1016\/j.ejpb.2026.115124_b0075","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3390\/polym13050794","article-title":"Three-dimensional printable hydrogel using a hyaluronic acid\/sodium alginate bio-ink","volume":"13","author":"Lee","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.ejpb.2026.115124_b0080","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.actbio.2020.01.046","article-title":"Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs","volume":"106","author":"Antich","year":"2020","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.ejpb.2026.115124_b0085","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1081\/DDC-100103735","article-title":"Poloxamer 407 as a thermogelling and adhesive polymer for rectal administration of short-chain fatty acids","volume":"27","author":"Charrueau","year":"2001","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejpb.2026.115124_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2024.105353","article-title":"Development and evaluation of a 3D-printed ocular insert containing liposomal moxifloxacin","volume":"92","author":"Duman","year":"2024","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ejpb.2026.115124_b0115","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5173(93)90023-9","article-title":"The routes of penetration of ions and 5-fluorouracil across human skin and the mechanisms of action of terpene skin penetration enhancers","volume":"94","author":"Cornwell","year":"1993","journal-title":"Int. J. Pharm."},{"issue":"202","key":"10.1016\/j.ejpb.2026.115124_b0090","first-page":"209","article-title":"Cutaneous vasomotor reactions in response to controlled heat applied on various body regions of healthy humans: evaluation of time course and application parameters","volume":"3","author":"Gazerani","year":"2011","journal-title":"Int J Physiol Pathophysiol Pharmacol."},{"key":"10.1016\/j.ejpb.2026.115124_b0095","doi-asserted-by":"crossref","unstructured":"Wood DG, Brown MB, Jones SA. Understanding heat-facilitated drug transport across human epidermis. Eur J Pharm Biopharm. 2012; 81:642\u20139. This paper studied the effects of heat on drug release and permeation with a topical formulation. 10.1016\/j.ejpb.2012.03.019 [PubMed: 22504388].","DOI":"10.1016\/j.ejpb.2012.03.019"},{"issue":"236","key":"10.1016\/j.ejpb.2026.115124_b0100","first-page":"242","article-title":"Effect of locally controlled heat on transdermal delivery of nicotine","volume":"3","author":"Petersen","year":"2011","journal-title":"Int J Physiol Pathophysiol Pharmacol."},{"issue":"5","key":"10.1016\/j.ejpb.2026.115124_b0105","first-page":"20","volume":"102","author":"Barcroft","year":"1943","journal-title":"J. Physiol."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641126001451?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641126001451?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:41:04Z","timestamp":1790109664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641126001451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":23,"alternative-id":["S0939641126001451"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2026.115124","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of 3D-printed granisetron hydrogels with temperature-sensitive drug release","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2026.115124","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115124"}}