{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:10:14Z","timestamp":1790111414965,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014810","name":"Fondazione Banco di Sardegna","doi-asserted-by":"publisher","award":["J89J21015120005"],"award-info":[{"award-number":["J89J21015120005"]}],"id":[{"id":"10.13039\/100014810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009873","name":"Autonomous Region of Sardinia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ejpb.2026.115165","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:24:23Z","timestamp":1782343463000},"page":"115165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hyaluronic acid and PEA-based Rutin-loaded nanoparticles as new cardioprotective tool against anthracycline-induced cardiotoxicity"],"prefix":"10.1016","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2251-0417","authenticated-orcid":false,"given":"Carla","family":"Serri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Quagliariello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Pio di Cagno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Giunchedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-8179","authenticated-orcid":false,"given":"Giovanna","family":"Rassu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Maurea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Gavini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2026.115165_b0005","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/FPC.0b013e32833ffb56","article-title":"Doxorubicin pathways: pharmacodynamics and adverse effects","volume":"21","author":"Thorn","year":"2011","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.ejpb.2026.115165_b0010","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s13346-024-01648-0","article-title":"A comprehensive review on doxorubicin: mechanisms, toxicity, clinical trials, combination therapies and nanoformulations in breast cancer","volume":"15","author":"Bisht","year":"2025","journal-title":"Drug Deliv. and Transl. Res."},{"key":"10.1016\/j.ejpb.2026.115165_b0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3390\/jcdd12060207","article-title":"Doxorubicin-induced cardiotoxicity: a comprehensive update","volume":"12","author":"Bhutani","year":"2025","journal-title":"JCDD"},{"key":"10.1016\/j.ejpb.2026.115165_b0020","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.2174\/092986709788803312","article-title":"Doxorubicin: the good, the bad and the ugly effect","volume":"16","author":"Carvalho","year":"2009","journal-title":"CMC"},{"key":"10.1016\/j.ejpb.2026.115165_b0025","doi-asserted-by":"crossref","DOI":"10.4172\/2157-7439.1000519","article-title":"Advances in delivery systems for doxorubicin","volume":"09","author":"Zhao","year":"2018","journal-title":"J. Nanomed. Nanotechnol."},{"key":"10.1016\/j.ejpb.2026.115165_b0030","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3390\/cancers16081487","article-title":"The sGCa vericiguat exhibit cardioprotective and anti-sarcopenic effects through NLRP-3 pathways: potential benefits for anthracycline-treated cancer patients","volume":"16","author":"Quagliariello","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.ejpb.2026.115165_b0035","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3390\/pharmaceutics16080985","article-title":"Hyaluronic acid-based nanoparticles loaded with Rutin as Vasculo-protective tools against anthracycline-induced endothelial damages","volume":"16","author":"Serri","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2026.115165_b0040","article-title":"NLRP3 inflammasome as a therapeutic target in doxorubicin-induced cardiotoxicity: role of phytochemicals","volume":"16","author":"Zhao","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejpb.2026.115165_b0045","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s10787-025-01671-8","article-title":"Rutin: a pain-relieving flavonoid","volume":"33","author":"Forouzanfar","year":"2025","journal-title":"Inflammopharmacol"},{"key":"10.1016\/j.ejpb.2026.115165_b0050","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13921","article-title":"Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy","volume":"23","author":"Liu","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.ejpb.2026.115165_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.144636","article-title":"Role of natural plant extracts and hyaluronic acid derivatives in intranasal strategies for brain delivery. A review","volume":"315","author":"Boualam","year":"2025","journal-title":"Int. J. Biol. Macromolecules"},{"key":"10.1016\/j.ejpb.2026.115165_b0060","doi-asserted-by":"crossref","DOI":"10.1039\/D5TB00147A","article-title":"Recent progress in ZIF\u2013polymer composites for advanced drug delivery applications","author":"Perveen","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ejpb.2026.115165_b0065","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2147\/IJN.S481917","article-title":"Hyaluronic acid-based hybrid nanoparticles as promising carriers for the intranasal administration of dimethyl fumarate","volume":"20","author":"Serri","year":"2025","journal-title":"IJN"},{"key":"10.1016\/j.ejpb.2026.115165_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.137129","article-title":"Hyaluronic acid application strategies for plant bioactive component delivery: a review","volume":"282","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2026.115165_b0075","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00784-024-05955-1","article-title":"Effect of hyaluronic acid on palatal wound healing: a systematic review","volume":"28","author":"Joshi","year":"2024","journal-title":"Clin. Oral Invest."},{"key":"10.1016\/j.ejpb.2026.115165_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123459","article-title":"Application of hyaluronic acid-based nanoparticles for cancer combination therapy","volume":"646","author":"Yang","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2026.115165_b0085","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.carbpol.2015.12.031","article-title":"Spontaneous arrangement of a tumor targeting hyaluronic acid shell on irinotecan loaded PLGA nanoparticles","volume":"140","author":"Giarra","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2026.115165_b0090","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s40122-024-00685-4","article-title":"A decades-long journey of palmitoylethanolamide (PEA) for chronic neuropathic pain management: a comprehensive narrative review","volume":"14","author":"Varrassi","year":"2025","journal-title":"Pain Ther."},{"key":"10.1016\/j.ejpb.2026.115165_b0095","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/sj.bjp.0705313","article-title":"Endocannabinoids protect the rat isolated heart against ischaemia","volume":"139","author":"L\u00e9picier","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejpb.2026.115165_b0100","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3390\/futurepharmacol3040058","article-title":"Therapeutic use of palmitoylethanolamide as an anti-inflammatory and immunomodulator","volume":"3","author":"S\u00e1","year":"2023","journal-title":"Future Pharmacology"},{"key":"10.1016\/j.ejpb.2026.115165_b0105","doi-asserted-by":"crossref","first-page":"12812","DOI":"10.3390\/ijms222312812","article-title":"Doxorubicin impairs smooth muscle cell contraction: novel insights in vascular toxicity","volume":"22","author":"Bosman","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.ejpb.2026.115165_b0110","doi-asserted-by":"crossref","first-page":"14041","DOI":"10.3390\/ijms241814041","article-title":"Lyophilization of nanoparticles, does it really work? Overview of the current status and challenges","volume":"24","author":"Gatto","year":"2023","journal-title":"IJMS"},{"key":"10.1016\/j.ejpb.2026.115165_b0115","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejps.2015.03.019","article-title":"New biomimetic barrier PermeapadTM for efficient investigation of passive permeability of drugs","volume":"73","author":"Di Cagno","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2026.115165_b0120","article-title":"Analysis of cell viability by the lactate dehydrogenase assay","volume":"2018","author":"Kumar","year":"2018","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.ejpb.2026.115165_b0125","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/jpm10040179","article-title":"Evidences of CTLA-4 and PD-1 blocking agents-induced cardiotoxicity in cellular and preclinical models","volume":"10","author":"Quagliariello","year":"2020","journal-title":"JPM"},{"key":"10.1016\/j.ejpb.2026.115165_b0130","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/9780470559277.ch150035","article-title":"Use of human induced pluripotent stem cell\u2013derived cardiomyocytes (hiPSC\u2010CMs) to monitor compound effects on cardiac myocyte signaling pathways","volume":"7","author":"Guo","year":"2015","journal-title":"CP Chemical Biology"},{"key":"10.1016\/j.ejpb.2026.115165_b0135","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.numecd.2005.05.003","article-title":"A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress","volume":"15","author":"Del Rio","year":"2005","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.ejpb.2026.115165_b0140","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1161\/CIRCRESAHA.118.311362","article-title":"NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis","volume":"122","author":"Grebe","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejpb.2026.115165_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140450","article-title":"Fucoidan and chitosan electrostatically coated nanoliposomes enhance physicochemical stability and bioavailability of rutin","volume":"301","author":"Han","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2026.115165_b0150","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.yexmp.2008.12.004","article-title":"Nanoparticle-based targeted drug delivery","volume":"86","author":"Singh","year":"2009","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.ejpb.2026.115165_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2024.106490","article-title":"Co-delivery of vinorelbine and rutin by lipid polymer nanoparticles for enhanced liver cancer chemotherapy","volume":"104","author":"Alsulays","year":"2025","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ejpb.2026.115165_b0160","doi-asserted-by":"crossref","first-page":"329","DOI":"10.22159\/ijap.2019v11i5.33615","article-title":"Optimization of sodium deoxycholate-based transfersomes for percutaneous delivery of peptides and proteins","author":"Leonyza","year":"2019","journal-title":"Int. J. Appl. Pharm."},{"key":"10.1016\/j.ejpb.2026.115165_b0165","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.3390\/ma17225480","article-title":"Silibinin-loaded amphiphilic PLGA\u2013poloxamer nanoparticles: physicochemical characterization, release kinetics, and bioactivity evaluation in lung cancer cells","volume":"17","author":"Villapiano","year":"2024","journal-title":"Materials"},{"key":"10.1016\/j.ejpb.2026.115165_b0170","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.3390\/molecules26041039","article-title":"Rutin-loaded solid lipid nanoparticles: characterization and in vitro evaluation","volume":"26","author":"De Gaetano","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejpb.2026.115165_b0175","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.ejps.2013.01.006","article-title":"Drug \u201csupersaturation\u201d states induced by polymeric micelles and liposomes: a mechanistic investigation into permeability enhancements","volume":"48","author":"Di Cagno","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2026.115165_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125170","article-title":"Supramolecular delivery systems for polyphenols: a green approach to predict in vivo permeability through an in vitro setup","volume":"670","author":"Sguizzato","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2026.115165_b0185","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1039\/D2RA07276A","article-title":"Hyaluronic acid-coated gold nanoparticles as a controlled drug delivery system for poorly water-soluble drugs","volume":"13","author":"Kim","year":"2023","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejpb.2026.115165_b0190","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jconrel.2021.01.033","article-title":"Hyaluronic acid and albumin based nanoparticles for drug delivery","volume":"331","author":"Lei","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2026.115165_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.147044","article-title":"Impact of hyaluronic acid molecular weight on silibinin intranasal delivery via hybrid nanoparticle formulation","volume":"323","author":"Serri","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2026.115165_b0200","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3390\/polym10101133","article-title":"Hyaluronic acid-based nanomaterials for cancer therapy","volume":"10","author":"Kim","year":"2018","journal-title":"Polymers"},{"key":"10.1016\/j.ejpb.2026.115165_b0205","doi-asserted-by":"crossref","first-page":"208","DOI":"10.22159\/ijap.2024v16i4.50749","article-title":"Enhancing the absorption of rutin and effective cancer management through hyaluronic acid functionalized nanoparticles","author":"Bhuvaneswari","year":"2024","journal-title":"Int. J. App. Pharm."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641126001864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641126001864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:43:20Z","timestamp":1790109800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641126001864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":41,"alternative-id":["S0939641126001864"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2026.115165","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyaluronic acid and PEA-based Rutin-loaded nanoparticles as new cardioprotective tool against anthracycline-induced cardiotoxicity","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2026.115165","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115165"}}