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Med."},{"issue":"1","key":"10.1016\/j.ejpb.2026.115210_b0480","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.celrep.2017.09.034","article-title":"M. tuberculosis-initiated human mannose receptor signaling regulates macrophage recognition and vesicle trafficking by FcR\u03b3-chain, Grb2, and SHP-1","volume":"21","author":"Rajaram","year":"2017","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.ejpb.2026.115210_b0485","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1432-1033.1986.tb09756.x","article-title":"Transport and processing of endocytosed lysosomal alpha-glucosidase in cultured human skin fibroblasts","volume":"158","author":"Oude Elferink","year":"1986","journal-title":"Eur. J. 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Virol."},{"key":"10.1016\/j.ejpb.2026.115210_b0500","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1038\/s41598-022-12397-w","article-title":"The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts","volume":"12","author":"Matsumoto","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejpb.2026.115210_b0505","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1038\/s41598-018-24918-7","article-title":"Essential role of the a3 isoform of V-ATPase in secretory lysosome trafficking via Rab7 recruitment","volume":"8","author":"Matsumoto","year":"2018","journal-title":"Sci. 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Ed."},{"issue":"6","key":"10.1016\/j.ejpb.2026.115210_b0550","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1021\/bc1000609","article-title":"Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape","volume":"21","author":"Chang","year":"2010","journal-title":"Bioconjug. 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Pharm."},{"issue":"44","key":"10.1016\/j.ejpb.2026.115210_b0635","doi-asserted-by":"crossref","first-page":"50889","DOI":"10.1021\/acsami.3c11756","article-title":"Chitosan-alginate polymeric nanocomposites as a potential oral vaccine carrier against influenza virus infection","volume":"15","author":"Kang","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"4","key":"10.1016\/j.ejpb.2026.115210_b0640","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1007\/s13346-022-01274-8","article-title":"A membrane-free microfluidic approach to mucus permeation for efficient differentiation of mucoadhesive and mucopermeating nanoparticulate systems","volume":"13","author":"Wright","year":"2023","journal-title":"Drug Deliv. Transl. 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