{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:49:37Z","timestamp":1791474577745,"version":"4.3.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ejpb.2026.115251","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:49:10Z","timestamp":1790783350000},"page":"115251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effect of TPGS on the colloidal properties and the nasal applicability of thermosensitive Pluronic\u00ae F-127 micelles loaded with risperidone"],"prefix":"10.1016","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2863-129X","authenticated-orcid":false,"given":"Fatima","family":"Rajab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-4728","authenticated-orcid":false,"given":"Bence","family":"Sipos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria In\u00eas","family":"Francisco Livramento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Almeida","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-4813","authenticated-orcid":false,"given":"G\u00e1bor","family":"Katona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildik\u00f3","family":"Cs\u00f3ka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2026.115251_b0005","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.3390\/biomedicines9121834","article-title":"Drug delivery challenges in brain disorders across the blood\u2013brain barrier: novel methods and future considerations for improved therapy","volume":"9","author":"Achar","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejpb.2026.115251_b0010","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s40265-024-02140-2","article-title":"risperidone in situ microparticles: a review in schizophrenia","volume":"85","author":"Syed","year":"2025","journal-title":"Drugs"},{"key":"10.1016\/j.ejpb.2026.115251_b0015","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1080\/10717544.2016.1250140","article-title":"Investigation of the effect of solubility increase at the main absorption site on bioavailability of BCS class II drug (risperidone) using liquisolid technique","volume":"24","author":"Khames","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejpb.2026.115251_b0020","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jconrel.2023.12.054","article-title":"Nanotechnology for enhanced nose-to-brain drug delivery in treating neurological diseases","volume":"366","author":"Huang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2026.115251_b0025","doi-asserted-by":"crossref","first-page":"495","DOI":"10.4155\/tde-2016-0022","article-title":"Challenges in nasal drug absorption: how far have we come?","volume":"7","author":"Agu","year":"2016","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.ejpb.2026.115251_b0030","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s13346-012-0108-9","article-title":"Nasal drug delivery devices: characteristics and performance in a clinical perspective\u2014a review","volume":"3","author":"Djupesland","year":"2013","journal-title":"Drug Deliv. and Transl. Res."},{"key":"10.1016\/j.ejpb.2026.115251_b0035","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3390\/pharmaceutics16040481","article-title":"Nasal delivery to the brain: harnessing nanoparticles for effective drug transport","volume":"16","author":"Gandhi","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2026.115251_b0040","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1039\/D5NR02259B","article-title":"Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery","volume":"18","author":"Paraiso","year":"2026","journal-title":"Nanoscale"},{"key":"10.1016\/j.ejpb.2026.115251_b0045","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3390\/pharmaceutics15030976","article-title":"Polymeric micellar systems\u2014a special emphasis on \u201csmart\u201d drug delivery","volume":"15","author":"Negut","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2026.115251_b0050","doi-asserted-by":"crossref","first-page":"17028","DOI":"10.1039\/C3RA47370H","article-title":"Polymeric micelles as drug delivery vehicles","volume":"4","author":"Ahmad","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejpb.2026.115251_b0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejpb.2016.12.019","article-title":"Polymeric mixed micelles as nanomedicines: Achievements and perspectives","volume":"113","author":"Cagel","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejpb.2026.115251_b0060","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ijpharm.2013.04.084","article-title":"Brain targeting of olanzapine via intranasal delivery of core\u2013shell difunctional block copolymer mixed nanomicellar carriers: In vitro characterization, ex vivo estimation of nasal toxicity and in vivo biodistribution studies","volume":"452","author":"Abdelbary","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2026.115251_b0065","doi-asserted-by":"crossref","unstructured":"C. Bitter, K. Suter-Zimmermann, C. Surber, Nasal Drug Delivery in Humans, in: C. Surber, P. Elsner, M.A. Farage (Eds.), Current Problems in Dermatology, S. Karger AG, 2011: pp. 20\u201335. Doi: 10.1159\/000321044.","DOI":"10.1159\/000321044"},{"key":"10.1016\/j.ejpb.2026.115251_b0070","doi-asserted-by":"crossref","first-page":"17433","DOI":"10.1007\/s10853-022-07711-w","article-title":"Thermo-responsive PNIPAAm-b-PLA amphiphilic block copolymer micelle as nanoplatform for docetaxel drug release","volume":"57","author":"Ghasemi","year":"2022","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.ejpb.2026.115251_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2023.111846","article-title":"Thermoresponsive nanocomposite hydrogels based on Gelatin\/poly (N\u2013isopropylacrylamide) (PNIPAM) for controlled drug delivery","volume":"186","author":"Gheysoori","year":"2023","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.ejpb.2026.115251_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119046","article-title":"Facile nose-to-brain delivery of rotigotine-loaded polymer micelles thermosensitive hydrogels: In vitro characterization and in vivo behavior study","volume":"577","author":"Wang","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2026.115251_b0085","doi-asserted-by":"crossref","unstructured":"M. Pourbakhsh, M. Jabraili, M. Akbari, M. Jaymand, R. Jahanban Esfahlan, Poloxamer-based drug delivery systems: Frontiers for treatment of solid tumors, Materials Today Bio 32 (2025) 101727. Doi: 10.1016\/j.mtbio.2025.101727.","DOI":"10.1016\/j.mtbio.2025.101727"},{"key":"10.1016\/j.ejpb.2026.115251_b0090","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3390\/gels10080521","article-title":"Comparative study of TPGS and soluplus polymeric micelles embedded in poloxamer 407 in situ gels for intranasal administration","volume":"10","author":"Sipos","year":"2024","journal-title":"Gels"},{"key":"10.1016\/j.ejpb.2026.115251_b0095","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1208\/s12249-018-1098-9","article-title":"Pluronic-based mixed polymeric micelles enhance the therapeutic potential of curcumin","volume":"19","author":"Akbar","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ejpb.2026.115251_b0100","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jcis.2020.01.029","article-title":"pH-sensitive pluronic micelles combined with oxidative stress amplification for enhancing multidrug resistance breast cancer therapy","volume":"565","author":"Cheng","year":"2020","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ejpb.2026.115251_b0105","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3389\/fphar.2019.00769","article-title":"Synthesis of TPGS\/curcumin nanoparticles by thin-film hydration and evaluation of their anti-colon cancer efficacy in vitro and in vivo","volume":"10","author":"Li","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejpb.2026.115251_b0110","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1038\/s41598-017-03123-y","article-title":"Pluronic F127 and D-\u03b1-tocopheryl polyethylene glycol succinate (TPGS) mixed micelles for targeting drug delivery across the blood brain barrier","volume":"7","author":"Meng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejpb.2026.115251_b0115","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.3390\/pharmaceutics17091147","article-title":"Development and characterization of citalopram-loaded thermosensitive polymeric micelles for nasal administration","volume":"17","author":"Rajab","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejpb.2026.115251_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2021.105960","article-title":"Development of dexamethasone-loaded mixed polymeric micelles for nasal delivery","volume":"166","author":"Sipos","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejpb.2026.115251_b0125","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jcis.2019.12.096","article-title":"Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development","volume":"565","author":"Shriky","year":"2020","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ejpb.2026.115251_b0130","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3390\/ph15020249","article-title":"Utilization of polymeric micelles as a lucrative platform for efficient brain deposition of olanzapine as an antischizophrenic drug via intranasal delivery","volume":"15","author":"Abo El-Enin","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejpb.2026.115251_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2021.127801","article-title":"Foamability and stability of anionic surfactant-anionic polymer solutions: Influence of ionic strength, polymer concentration, and molecular weight","volume":"632","author":"Kedir","year":"2022","journal-title":"Colloids Surf A Physicochem Eng Asp"}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641126002729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0939641126002729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:51:19Z","timestamp":1791471079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0939641126002729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":27,"alternative-id":["S0939641126002729"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2026.115251","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of TPGS on the colloidal properties and the nasal applicability of thermosensitive Pluronic\u00ae F-127 micelles loaded with risperidone","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2026.115251","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115251"}}