{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:50:54Z","timestamp":1791834654073,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473787"],"award-info":[{"award-number":["82473787"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Liaoning Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2026-MS-153"],"award-info":[{"award-number":["2026-MS-153"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ejpb.2026.115257","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:43:44Z","timestamp":1791330224000},"page":"115257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dual-crosslinked self-healing antimicrobial hydrogels with macrophage modulatory activity for accelerated diabetic wound healing"],"prefix":"10.1016","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2336-4576","authenticated-orcid":false,"given":"Sixin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7570-5634","authenticated-orcid":false,"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejpb.2026.115257_b0005","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1620\/tjem.2023.J078","article-title":"LncRNA SNHG16 knockdown promotes diabetic foot ulcer wound healing via sponging miR-31-5p","volume":"261","author":"Chen","year":"2023","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.ejpb.2026.115257_b0010","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/17435889.2025.2466414","article-title":"Smart self-healing hydrogel wound dressings for diabetic wound treatment","volume":"20","author":"Hu","year":"2025","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ejpb.2026.115257_b0015","article-title":"Hydrogel for the treatment of diabetic wounds: a comprehensive review","volume":"11","author":"Bhattacharyya","year":"2025","journal-title":"Curr. Tradit. Med."},{"key":"10.1016\/j.ejpb.2026.115257_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.120058","article-title":"Advances in chitosan-based wound dressings: modifications, fabrications, applications and prospects","volume":"297","author":"Ji","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2026.115257_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.126209","article-title":"A new efficient skin dressing based on sodium alginate\u2013graphene oxide bionanocomposite hydrogel to expedite wound healing process","volume":"685","author":"Rafati","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejpb.2026.115257_b0030","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/01.ASW.0000579700.20404.56","article-title":"Effectiveness of arginine supplementation on wound healing in older adults in acute and chronic settings: a systematic review","volume":"32","author":"Schneider","year":"2019","journal-title":"Adv. Skin Wound Care"},{"key":"10.1016\/j.ejpb.2026.115257_b0035","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1038\/s41598-025-31845-x","article-title":"Association of glycemic variability with oxidative stress and AGE accumulation in type 2 diabetes","volume":"16","author":"Ohara","year":"2026","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejpb.2026.115257_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2026.115713","article-title":"A photothermal-responsive hydrogel with induced-inflammation regulating ability for synergistic infected wound therapy","volume":"265","author":"Li","year":"2026","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ejpb.2026.115257_b0045","article-title":"A Pickering emulsion based on AgNPs for synergistic anti-inflammatory and anti-bacterial therapy of bacteria-infected wound","volume":"121","author":"Guan","year":"2026","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejpb.2026.115257_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2026.156448","article-title":"Moist exposed burn ointment (MEBO) promotes healing of chronic diabetic wounds in rats by regulating inflammatory factors and autophagy","volume":"282","author":"Jiang","year":"2026","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.ejpb.2026.115257_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2026.129752","article-title":"Multifunctional nanozyme systems for combating bacterial infections in wound treatment","volume":"306","author":"Guliy","year":"2026","journal-title":"Talanta"},{"key":"10.1016\/j.ejpb.2026.115257_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.124111","article-title":"Multifunctional nanocomposite chitosan-based hydrogel promotes healing of infected wounds through sustained release of Zn2\u207a and nicotinamide mononucleotide","volume":"368","author":"Zhang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2026.115257_b0065","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1039\/C8NR08375D","article-title":"Tailored Ag\u2013Cu\u2013Mg multielemental nanoparticles for wide-spectrum antibacterial coating","volume":"11","author":"Benetti","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.ejpb.2026.115257_b0070","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.3390\/polym13223861","article-title":"Zinc oxide and copper chitosan composite films with antimicrobial activity","volume":"13","author":"Gamboa-Solana","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.ejpb.2026.115257_b0075","article-title":"Multifunctional gelatin\u2013silk fibroin composite hydrogel for skin wound healing","volume":"113","author":"Chen","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejpb.2026.115257_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153849","article-title":"Protocatechuic aldehyde prevents ischemic injury by attenuating brain microvascular endothelial cell pyroptosis via lncRNA Xist","volume":"94","author":"Guo","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejpb.2026.115257_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105877","article-title":"Inhibitory effect of protocatechualdehyde on Yersinia enterocolitica and its critical virulence factors","volume":"173","author":"Meng","year":"2022","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.ejpb.2026.115257_b0090","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/s12951-022-01686-1","article-title":"Thrombus-specific\/responsive biomimetic nanomedicine for spatiotemporal thrombolysis and alleviation of myocardial ischemia\/reperfusion injury","volume":"20","author":"Guo","year":"2022","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.ejpb.2026.115257_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2023.106145","article-title":"Hydrogels: an overview of its classifications, properties, and applications","volume":"147","author":"Mehta","year":"2023","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.ejpb.2026.115257_b0100","article-title":"Recent trends in hydrogel-based formulation for the treatment of diabetic wounds: a review","volume":"107","author":"Bhattacharjee","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejpb.2026.115257_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.145625","article-title":"Silver-decorated lysozyme-hemin nanocomposite loaded into thermosensitive hydrogel for on-demand management of MRSA-infected wounds","volume":"320","author":"Le","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2026.115257_b0110","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202000396","article-title":"Development of a mechanically strong nondegradable protein hydrogel with a sponge-like morphology","volume":"21","author":"Wang","year":"2021","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.ejpb.2026.115257_b0115","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3390\/gels8090568","article-title":"Hydrogel and effects of crosslinking agent on cellulose-based hydrogels: a review","volume":"8","author":"Nasution","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.ejpb.2026.115257_b0120","doi-asserted-by":"crossref","first-page":"26882","DOI":"10.1039\/D2RA04841H","article-title":"A methylcellulose\/agarose hydrogel as an innovative scaffold for tissue engineering","volume":"12","author":"Niemczyk-Soczynska","year":"2022","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejpb.2026.115257_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117705","article-title":"Dual-crosslinked, self-healing and thermo-responsive methylcellulose\/chitosan oligomer copolymer hydrogels","volume":"258","author":"Yeo","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2026.115257_b0130","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s40820-022-00928-z","article-title":"Bioinspired injectable self-healing hydrogel sealant with fault-tolerant and repeated thermo-responsive adhesion for sutureless post-wound-closure and wound healing","volume":"14","author":"Liang","year":"2022","journal-title":"Nano-Micro Lett."},{"key":"10.1016\/j.ejpb.2026.115257_b0135","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.ijbiomac.2020.08.109","article-title":"Research status of self-healing hydrogel for wound management: a review","volume":"164","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2026.115257_b0140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.actbio.2021.01.038","article-title":"A double-crosslinked self-healing antibacterial hydrogel with enhanced mechanical performance for wound treatment","volume":"124","author":"Wang","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejpb.2026.115257_b0145","doi-asserted-by":"crossref","DOI":"10.1002\/marc.202100025","article-title":"Advances in injectable and self-healing polysaccharide hydrogel based on the Schiff base reaction","volume":"42","author":"Mo","year":"2021","journal-title":"Macromol. Rapid Commun."},{"key":"10.1016\/j.ejpb.2026.115257_b0150","first-page":"164","article-title":"Chitosan based bioactive materials in tissue engineering applications\u2014A review","volume":"5","author":"Islam","year":"2020","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ejpb.2026.115257_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125136","article-title":"Quaternized chitosan (nano)fibers: a journey from preparation to high performance applications","volume":"242","author":"Marin","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2026.115257_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122865","article-title":"Quaternized chitosan-based biomimetic nanozyme hydrogels with ROS scavenging, oxygen generating, and antibacterial capabilities for diabetic wound repair","volume":"348","author":"Wang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejpb.2026.115257_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114346","article-title":"Multifunctional injectable oxidized sodium alginate\/carboxymethyl chitosan hydrogel for rapid hemostasis","volume":"245","author":"Liu","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ejpb.2026.115257_b0170","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.ijbiomac.2018.08.153","article-title":"Facile synthesis and characterization of cross-linked chitosan quaternary ammonium salt membrane for antibacterial coating of piezoelectric sensors","volume":"120","author":"Li","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejpb.2026.115257_b0175","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1186\/s12951-023-02174-w","article-title":"Hollow manganese dioxide-chitosan hydrogel for the treatment of atopic dermatitis through inflammation-suppression and ROS scavenging","volume":"21","author":"Wu","year":"2023","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.ejpb.2026.115257_b0180","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.actbio.2024.02.047","article-title":"Adhesive hydrogel releases protocatechualdehyde-Fe3\u207a complex to promote three healing stages for accelerated therapy of oral ulcers","volume":"178","author":"Wang","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejpb.2026.115257_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2025.114322","article-title":"Hydrogels with TA\/Cu2\u207a release and NIR-II photothermal synergistic antibacterial and antioxidant properties for healing of bacterial-infected wounds","volume":"239","author":"Zhao","year":"2025","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.ejpb.2026.115257_b0190","first-page":"306","article-title":"Microenvironment responsive nanocomposite hydrogel with NIR photothermal therapy, vascularization and anti-inflammation for diabetic infected wound healing","volume":"26","author":"Zhu","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ejpb.2026.115257_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2026.140000","article-title":"Quaternized chitosan enhancing tetracycline hydrochloride slow-release property of polyacrylamide-based hydrogels","volume":"738","author":"Zhang","year":"2026","journal-title":"Colloids Surf A Physicochem Eng Asp"},{"key":"10.1016\/j.ejpb.2026.115257_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.reactfunctpolym.2025.106571","article-title":"Construction of quaternized chitosan\/oxidized dextran photothermal antibacterial self-healing hydrogels and their application in local drug delivery","volume":"219","author":"Ye","year":"2026","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.ejpb.2026.115257_b0205","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202503143","article-title":"Supramolecular hydrogel microneedles achieve a three-in-one antibacterial wound treatment","volume":"14","author":"Li","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.ejpb.2026.115257_b0210","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jiec.2024.11.029","article-title":"Synthesis and comprehensive characterization of PVA\/chitosan\/Cu nanowires wound dressing hydrogel for effective in vitro wound healing","volume":"146","author":"Jallab","year":"2025","journal-title":"J. Ind. Eng. Chem."},{"key":"10.1016\/j.ejpb.2026.115257_b0215","doi-asserted-by":"crossref","first-page":"55392","DOI":"10.1021\/acsami.3c12672","article-title":"pH-responsive injectable multifunctional Pluronic F127\/gelatin-based hydrogels with hydrogen production for treating diabetic wounds","volume":"15","author":"Zhang","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejpb.2026.115257_b0220","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/biomedicines14010051","article-title":"ZIF-8 hydrogel-mediated regulation of macrophage phenotype accelerates frostbite wound healing","volume":"14","author":"Lou","year":"2026","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejpb.2026.115257_b0225","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jconrel.2021.11.027","article-title":"A spatiotemporal release platform based on pH\/ROS stimuli-responsive hydrogel in wound repairing","volume":"341","author":"Wu","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejpb.2026.115257_b0230","article-title":"Green tea derivative driven smart hydrogels with desired functions for chronic diabetic wound treatment","volume":"31","author":"Zhao","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ejpb.2026.115257_b0235","article-title":"Sustained-release CGRP microspheres accelerate diabetic wound healing by synergistically promoting neurovascular regeneration through modulation of macrophage and endothelial cell functions","volume":"37","author":"Zhao","year":"2026","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.ejpb.2026.115257_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.135691","article-title":"All-in-one: Harnessing multifunctional injectable natural hydrogels for ordered therapy of bacteria-infected diabetic wounds","volume":"439","author":"Qi","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.ejpb.2026.115257_b0245","first-page":"1","article-title":"Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing","volume":"17","author":"Zhou","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ejpb.2026.115257_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.matchemphys.2026.132224","article-title":"Design of hyaluronic acid-based glutathione-gelatin-collagen-laminin loaded 3D bioactive transdermal tissue scaffold: Determination of biocompatibility, antimicrobial and ROS","volume":"355","author":"Kilic","year":"2026","journal-title":"Mater. Chem. Phys."}],"container-title":["European Journal of Pharmaceutics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093964112600278X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093964112600278X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:39:04Z","timestamp":1791833944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S093964112600278X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":50,"alternative-id":["S093964112600278X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejpb.2026.115257","relation":{},"ISSN":["0939-6411"],"issn-type":[{"value":"0939-6411","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-crosslinked self-healing antimicrobial hydrogels with macrophage modulatory activity for accelerated diabetic wound healing","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutics and Biopharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejpb.2026.115257","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115257"}}