{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:47:02Z","timestamp":1792626422578,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2003,11]]},"DOI":"10.1016\/j.ejphar.2003.09.019","type":"journal-article","created":{"date-parts":[[2003,11,15]],"date-time":"2003-11-15T12:01:05Z","timestamp":1068897665000},"page":"249-260","source":"Crossref","is-referenced-by-count":41,"title":["Impaired gastric ulcer healing in diabetic rats: role of heat shock protein, growth factors, prostaglandins and proinflammatory cytokines"],"prefix":"10.1016","volume":"481","author":[{"given":"Igor A.","family":"Harsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Brzozowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Bazela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislaw J.","family":"Konturek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly","family":"Kukharsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teres","family":"Pawlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Pawlowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhart G.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Konturek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2003.09.019_BIB1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0928-4257(01)00015-8","article-title":"Gastric mucosal integrity: gastric mucosal blood flow and microcirculation. An overview","volume":"95","author":"Abdel-Salam","year":"2001","journal-title":"J. Physiol. (Paris)"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB2","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0039-6060(99)70222-9","article-title":"Heat shock protein 72\/73 and impaired wound healing in diabetic and hypercortisolemic states","volume":"125","author":"Bitar","year":"1999","journal-title":"Surgery"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000007585","article-title":"Water extracts of Helicobacter pylori delay healing of chronic gastric ulcers in rats: role of cytokines and gastrin\u2013somatostatin link","volume":"60","author":"Brzozowski","year":"1999","journal-title":"Digestion"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0014-2999(99)00681-0","article-title":"Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia\u2013reperfusion-induced gastric lesions","volume":"385","author":"Brzozowski","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0014-2999(00)00287-9","article-title":"Role of gastric acid secretion in progression of acute gastric erosions induced by ischemia\u2013reperfusion into gastric ulcers","volume":"398","author":"Brzozowski","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/jemt.1102","article-title":"Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers","volume":"53","author":"Brzozowski","year":"2001","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB7","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1572-0241.2002.05537.x","article-title":"GI symptoms in diabetes mellitus are associated with both poor glycemic control and diabetic complications","volume":"97","author":"Bytzer","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB8","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidium thiocyanate\u2013phenol\u2013chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB9","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/00042737-199510000-00003","article-title":"Basic actions of transforming growth factor-\u03b1 and related peptides","volume":"7","author":"Coffey","year":"1995","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB10","first-page":"21","article-title":"Glomerular tumor necrosis factor and interleukin 1 during acute aminonucleoside nephrosis","volume":"64","author":"Diamond","year":"1991","journal-title":"Lab. Invest."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB11","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0002-9440(10)64209-5","article-title":"Sugar-induced modification of fibroblast growth factor 2 reduces its angiogenic activity in vivo","volume":"161","author":"Facchiano","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB12","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1053\/gast.1997.v112.pm9041247","article-title":"Gastric mucosal damage in experimental diabetes in rats: role of endogenous glutathione","volume":"112","author":"Goldin","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/08916939908995378","article-title":"Nitric oxide mediates IL-1beta stimulation of heat shock protein but not IL1beta inhibition of glutamic acid decarboxylase","volume":"29","author":"Hao","year":"1999","journal-title":"Autoimmunity"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB14","doi-asserted-by":"crossref","first-page":"6455","DOI":"10.1073\/pnas.82.19.6455","article-title":"Conserved features of eucaryotic HSP 70 genes revealed by comparision with the nucleotide sequence of human HSP 70","volume":"82","author":"Hunt","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3109\/00365529709025056","article-title":"Expression of epidermal growth factor and transforming growth factor alpha during ulcer healing","volume":"32","author":"Konturek","year":"1997","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0014-2999(01)00748-8","article-title":"Role of leptin in ulcer healing","volume":"414","author":"Konturek","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB17","first-page":"452","article-title":"Activation of genes for superoxide dismutase, interleukin-1\u03b2, tumor necrosis factor alpha (TNF-\u03b1), and intercellular adhesion molecule-1 during healing of ischemia\u2013reperfusion-induced gastric injury","volume":"35","author":"Konturek","year":"2002","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB18","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1159\/000007702","article-title":"Increased susceptibility of diabetic rat gastric mucosa to food deprivation during cold stress","volume":"60","author":"Korolkiewicz","year":"1999","journal-title":"Digestion"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB19","first-page":"248","article-title":"Tumor necrosis factor and interleukin 1. Cytokines with multiple overlapping biological activities","volume":"56","author":"Le","year":"1987","journal-title":"Lab. Invest."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB20","first-page":"301","article-title":"Effect of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats","volume":"287","author":"Lesch","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB21","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.2479986","article-title":"Vascular endothelial growth factor is a secreted angiogenic mitogen","volume":"246","author":"Leung","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB22","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1242\/jcs.110.13.1431","article-title":"Molecular chaperones and the cytoskeleton","author":"Liang","year":"1997","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB23","unstructured":"Masahiro, M., Tsutomu, N., Yoshihiro, M., Yasuyo, S., Yasukozu, O., Shoichi, A., 1999. Rat IL1 antibody and method for measuring IL-1\u03b2. Access-No in Gene Bank E05490."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02775444","article-title":"Peptic ulcer in diabetes mellitus","volume":"11","author":"Masuda","year":"1976","journal-title":"Gastroenterol. Jpn."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000065591","article-title":"Efficacy of vascular endothelial growth factor in the treatment of experimental gastric injury","volume":"66","author":"Matsui","year":"2002","journal-title":"Digestion"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB26","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1023\/A:1018890419648","article-title":"Interleukin-1\u03b2 inhibits growth factor-stimulated restoration of wounded rat gastric epithelial cell monolayers","volume":"43","author":"Nakamura","year":"1998","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1172\/JCI119129","article-title":"The biology of PECAM-1","volume":"99","author":"Newman","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB28","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/nar\/11.6.1759","article-title":"The nucleotide sequence of the rat cytoplasmic \u03b1-actin gene","volume":"11","author":"Nudel","year":"1983","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000171163","article-title":"Diabetes and the gastro-intestinal tract","volume":"5","author":"O'Reilly","year":"1987","journal-title":"Dig. Dis."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB30","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF02235252","article-title":"A method for experimental, penetrating gastric and duodenal ulcers in rats","volume":"16","author":"Okabe","year":"1971","journal-title":"Am. J. Dig. Dis."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.5414\/CPP40111","article-title":"Results of systematic screening for serious gastrointestinal bleeding associated with NSAIDs in Rostock hospitals","volume":"40","author":"Pietzsch","year":"2002","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00004836-200103000-00006","article-title":"Helicobacter pylori prevalence in patients with diabetes and its relationship to dyspeptic symptoms","volume":"32","author":"Quatrini","year":"2001","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB47","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0190-9622(94)70069-9","volume":"30","author":"Samlaska","year":"1994","journal-title":"J. Am. Acad. Dermatol"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB48","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1136\/gut.35.7.909","article-title":"Pentoxifylline prevents inolomethacin induced acute gastric mucosal damage in rats: role of tumor necrosis factor alpha","volume":"35","author":"Santucci","year":"1994","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB33","first-page":"1383","article-title":"Role of cyclooxygenase-2 in the healing of gastric ulcers in rats","volume":"286","author":"Shigeta","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB49","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000007752","article-title":"Pentoxifylline accelerates gastric ulcer in rats: roles of tumor necrosis factor alpha and neutrophils during the early phase of ulcer healing","volume":"61","author":"Shimizu","year":"2000","journal-title":"Digestion"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1089\/dna.1988.7.193","article-title":"Cloning and expression in E. coli of the gene for mouse tumor necrosis factor","volume":"7","author":"Shirai","year":"1988","journal-title":"DNA"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB35","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/sj.bjp.0701672","article-title":"Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats","volume":"123","author":"Schmassmann","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB36","first-page":"40S","article-title":"Vascular approach to gastroduodenal ulceration","volume":"43","author":"Szabo","year":"1998","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB37","first-page":"G1137","article-title":"Localization of cyclooxygenase-2 and regulation of its mRNA expression in gastric ulcers in rats","volume":"275","author":"Takahashi","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB38","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1053\/gast.1997.v112.pm9024295","article-title":"Alterations in duodenal bicarbonate secretion and mucosal susceptibility to acid in diabetic rats","volume":"112","author":"Takehara","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB39","first-page":"200","article-title":"Impaired healing of gastric lesions in streptozotocin-induced diabetic rats: effect of basic fibroblast growth factor","volume":"281","author":"Takeuchi","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB40","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/sj.bjp.0701974","article-title":"Increased susceptibility of gastric mucosa to ulcerogenic stimulation in diabetic rats\u2014role of capsaicin-sensitive sensory neurons","volume":"124","author":"Tashima","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB41","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/S0024-3205(00)00754-2","article-title":"Aggravation of ischemia\/reperfusion-induced gastric lesions in streptozotocin-diabetic rats","volume":"67","author":"Tashima","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB42","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/S0024-3205(00)00746-3","article-title":"Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats","volume":"67","author":"Tashima","year":"2000","journal-title":"Life Sci."},{"issue":"Suppl. B","key":"10.1016\/j.ejphar.2003.09.019_BIB43","doi-asserted-by":"crossref","first-page":"8B","DOI":"10.1155\/2003\/397060","article-title":"The role of interleukin-1beta and other potential genetic markers as indicators of gastric cancer risk","volume":"17","author":"Troost","year":"2003","journal-title":"Can. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2003.09.019_BIB44","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1053\/gast.2000.16510","article-title":"NSAID-induced gastric damage in rats requires for inhibition of both cyclooxygenase-1 and 2","volume":"119","author":"Wallace","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB45","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1136\/gut.48.6.774","article-title":"Acid regulates inflammatory response in a rat model of induction of gastric ulcer recurrence by interleukin-1\u03b2","volume":"48","author":"Watanbe","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2003.09.019_BIB46","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1016\/S0024-3205(01)01337-6","article-title":"Characteristic changes of stress protein expression in streptozotocin-induced diabetic rats","volume":"69","author":"Yamagishi","year":"2001","journal-title":"Life Sci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299903023781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299903023781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T23:27:25Z","timestamp":1623540445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299903023781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11]]},"references-count":49,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["S0014299903023781"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2003.09.019","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2003,11]]}}}