{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:06:33Z","timestamp":1767888393603,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1016\/j.ejphar.2003.09.069","type":"journal-article","created":{"date-parts":[[2003,11,8]],"date-time":"2003-11-08T12:12:47Z","timestamp":1068293567000},"page":"297-304","source":"Crossref","is-referenced-by-count":11,"title":["Emetic action of the prostanoid TP receptor agonist, U46619, in Suncus murinus (house musk shrew)"],"prefix":"10.1016","volume":"482","author":[{"given":"Kelvin K.W.","family":"Kan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man-P.","family":"Ngan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Rudd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man-K.","family":"Wai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2003.09.069_BIB1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1139\/y90-047","article-title":"The abdominal visceral innervation and the emetic reflex: pathways, pharmacology and plasticity","volume":"68","author":"Andrews","year":"1990","journal-title":"Can. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB2","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/sj.bjp.0703428","article-title":"The emetic and anti-emetic effects of the capsaicin analogue resiniferatoxin in Suncus murinus, the house musk shrew","volume":"130","author":"Andrews","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB3","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0028-3908(88)90092-5","article-title":"Reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesis in the ferret","volume":"27","author":"Barnes","year":"1988","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2003.09.069_BIB4","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0031-9384(87)90250-2","article-title":"Further studies on nicotine-induced emesis: nicotinic mediation in area postrema","volume":"39","author":"Beleslin","year":"1987","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/13813458909075054","article-title":"Area postrema: cholinergic and noradrenergic regulation of emesis. c new concept","volume":"97","author":"Beleslin","year":"1989","journal-title":"Arch. Int. Physiol. Biochim."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB6","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1046\/j.1471-4159.1994.63031163.x","article-title":"Fenfluramine releases serotonin from human brain nerve endings by a dual mechanism","volume":"63","author":"Bonanno","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB7","doi-asserted-by":"crossref","first-page":"R3","DOI":"10.1016\/0014-2999(93)90673-6","article-title":"Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets","volume":"249","author":"Bountra","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB8","first-page":"121","article-title":"International Union of Pharmacology Nomenclature of Adrenoceptors","volume":"46","author":"Bylund","year":"1994","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2307\/3576918","article-title":"Radiation-induced emesis in the dog: effects of lesions and drugs","volume":"108","author":"Carpenter","year":"1986","journal-title":"Radiat. Res."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0163-7258(93)90027-B","article-title":"Muscarinic receptors\u2014characterization, coupling and function","volume":"58","author":"Caulfield","year":"1993","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0024-3205(96)00625-X","article-title":"Ethanol-induced emesis in the house musk shrew, Suncus murinus","volume":"60","author":"Chen","year":"1997","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB12","first-page":"205","article-title":"International Union of Pharmacology Classification of Prostanoid Receptors: properties, distribution, and structure of the receptors and their subtypes","volume":"46","author":"Coleman","year":"1994","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1476-5381.1968.tb07047.x","article-title":"Antagonism of reserpine-induced emesis in pigeons: a screening method for antidepressant activity","volume":"34","author":"Dhawan","year":"1968","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0024-3205(78)90254-0","article-title":"The reserpine receptor","volume":"23","author":"Giachetti","year":"1978","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0014-2999(81)90502-1","article-title":"The effects of 5-hydroxytryptamine-depleting drugs on peptides in the ventral spinal cord","volume":"76","author":"Gilbert","year":"1981","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB16","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0028-3908(01)00182-4","article-title":"The COX inhibitors indomethacin and meloxicam exhibit anti-emetic activity against cisplatin-induced emesis in piglets","volume":"42","author":"Girod","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2003.09.069_BIB17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0014-2999(96)00216-6","article-title":"Broad spectrum antiemetic effects of CP-122,721, a tachykinin NK1 receptor antagonist, in ferrets","volume":"305","author":"Gonsalves","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1053\/sonc.2002.31535","article-title":"New agents, new treatment, and antiemetic therapy","volume":"29","author":"Gralla","year":"2002","journal-title":"Semin. Oncol."},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2003.09.069_BIB19","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000227646","article-title":"Cisplatin and emesis: aspects of treatment and a new trial for delayed emesis using oral dexamethasone plus ondansetron beginning at 16 hours after cisplatin","volume":"53","author":"Gralla","year":"1996","journal-title":"Oncology"},{"key":"10.1016\/j.ejphar.2003.09.069_BIB20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0163-7258(90)90046-5","article-title":"Histamine receptors: subclasses and specific ligands","volume":"47","author":"Haaksma","year":"1990","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0014-2999(92)90562-I","article-title":"Central alpha-adrenoceptor subtypes involved in the emetic pathway in cats","volume":"229","author":"Hikasa","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0163-7258(94)90041-8","article-title":"Dopamine receptors: molecular biology, biochemistry and behavioural aspects","volume":"64","author":"Jackson","year":"1994","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB23","first-page":"274","article-title":"Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin","volume":"3","author":"Jequier","year":"1967","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-2999(94)00622-E","article-title":"The role of alpha-adrenergic mechanisms within the area postrema in dopamine-induced emesis","volume":"272","author":"Jovanovic-Micic","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0014-2999(02)02424-X","article-title":"Action of prostanoids to induce emesis and defecation in the ferret","volume":"453","author":"Kan","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ejphar.2003.08.020","article-title":"Action of prostanoids on the emetic reflex of Suncus murinus (the house musk shrew)","volume":"477","author":"Kan","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0006-8993(89)91467-4","article-title":"d-, l- and dl-Fenfluramine cause long-lasting depletions of serotonin in rat brain","volume":"505","author":"Kleven","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB28","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0091-3057(89)90399-7","article-title":"8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine","volume":"33","author":"Lucot","year":"1989","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-3623(90)90586-B","article-title":"Therapeutic management of nausea and vomiting","volume":"21","author":"Marin","year":"1990","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1254\/jjp.58.321","article-title":"Cisplatin-induced emesis in Suncus murinus","volume":"58","author":"Mutoh","year":"1992","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB31","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1476-5381.1995.tb13293.x","article-title":"Blockade of motion- and cisplatin-induced emesis by a 5-HT2 receptor agonist in Suncus murinus","volume":"114","author":"Okada","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0014-2999(01)01041-X","article-title":"Genital grooming and emesis induced by vanilloids in the house musk shrew","volume":"422","author":"Rudd","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0014-2999(99)00285-X","article-title":"Modulation of emesis by fentanyl and opioid receptor antagonists in Suncus murinus (house musk shrew)","volume":"374","author":"Rudd","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0014-2999(98)00920-0","article-title":"Inhibition of emesis by tachykinin NK1 receptor antagonists in Suncus murinus (house musk shrew)","volume":"366","author":"Rudd","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB35","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0014-2999(01)00915-3","article-title":"Action of glucocorticoids to antagonise cisplatin-induced acute and delayed emesis in the ferret","volume":"417","author":"Sam","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB36","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/sj.bjp.0703283","article-title":"Cisplatin-induced early and delayed emesis in the pigeon","volume":"130","author":"Tanihata","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2003.09.069_BIB37","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0028-3908(96)00020-2","article-title":"Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets","volume":"35","author":"Tattersall","year":"1996","journal-title":"Neuropharmacology"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299903025020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299903025020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T07:22:06Z","timestamp":1550388126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299903025020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":37,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["S0014299903025020"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2003.09.069","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}