{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:45:37Z","timestamp":1790862337815,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1016\/j.ejphar.2003.12.023","type":"journal-article","created":{"date-parts":[[2004,1,23]],"date-time":"2004-01-23T10:18:16Z","timestamp":1074853096000},"page":"163-174","source":"Crossref","is-referenced-by-count":59,"title":["Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent models of Parkinson's disease"],"prefix":"10.1016","volume":"486","author":[{"given":"Michael J","family":"O'Neill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey K","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Whalley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline A","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Woodhouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Osborne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Skolnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2003.12.023_BIB1","doi-asserted-by":"crossref","first-page":"11347","DOI":"10.1073\/pnas.89.23.11347","article-title":"Brain-derived neurotrophic factor augments rotational behavior and nigrostriatal dopamine turnover in vivo","volume":"89","author":"Altar","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB2","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0028-3908(03)00104-7","article-title":"Chronic AMPA receptor potentiator (LY451646) treatment increases cell proliferation in adult rat hippocampus","volume":"44","author":"Bai","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB3","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0028-3908(00)00195-7","article-title":"LY392098, a novel AMPA receptor potentiator: electrophysiological studies in prefrontal cortical neurons","volume":"40","author":"Baumbarger","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/373339a0","article-title":"Mesencephalic dopaminergic neurones protected by GDNF from axotomy-induced degeneration in the adult brain","volume":"373","author":"Beck","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0166-2236(96)10072-2","article-title":"GAP-43: an intrinsic determinant of neuronal development and plasticity","volume":"20","author":"Benowitz","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1515\/REVNEURO.1998.9.2.71","article-title":"Experimental models of Parkinson's disease: from static to the dynamic","volume":"9","author":"Bezard","year":"1998","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0006-8993(03)02357-6","article-title":"Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain","volume":"970","author":"Dicou","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB8","doi-asserted-by":"crossref","first-page":"A32","DOI":"10.1038\/19899","article-title":"Prospects for new restorative and neuroprotective treatments in Parkinson's disease","volume":"399","author":"Dunnett","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB9","article-title":"Mapping the functional effects of an AMPA receptor potentiator with 2-deoxyglucose autoradiography","volume":"540.2","author":"Fowler","year":"2002","journal-title":"Abstr. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB10","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/380252a0","article-title":"Functional recovery in parkinsonian monkeys treated with GDNF","volume":"380","author":"Gash","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB11","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/S0028-3908(01)00040-5","article-title":"Pharmacological effects of AMPA receptor potentiators LY392098 and LY404187 on rat neuronal AMPA receptors in vitro","volume":"40","author":"Gates","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB12","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/BF01291788","article-title":"Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man","volume":"103","author":"Gerlach","year":"1999","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB13","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nm850","article-title":"Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease","volume":"9","author":"Gill","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB14","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1523\/JNEUROSCI.18-07-02740.1998","article-title":"Facilitative effects of the ampakine CX516 on short-term memory in rats: enhancement of delayed-nonmatch-to-sample performance","volume":"18","author":"Hampson","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB15","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1523\/JNEUROSCI.18-07-02748.1998","article-title":"Facilitative effects of the ampakine CX516 on short-term memory in rats: correlations with hippocampal neuronal activity","volume":"18","author":"Hampson","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/16269","article-title":"The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn","volume":"397","author":"Hayashi","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB17","first-page":"19","article-title":"Biochemical pathophysiology of Parkinson's disease","volume":"45","author":"Hornykiewicz","year":"1987","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/exnr.2000.7483","article-title":"Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra","volume":"166","author":"Howells","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB19","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1212\/WNL.42.6.1142","article-title":"What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study","volume":"42","author":"Hughes","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB20","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0006-8993(99)02116-2","article-title":"Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer","volume":"847","author":"Klein","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1523\/JNEUROSCI.20-01-00008.2000","article-title":"Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons","volume":"20","author":"Lauterborn","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB22","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0028-3908(01)00006-5","article-title":"Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator","volume":"40","author":"Legutko","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB23","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0028-3908(00)00194-5","article-title":"Antidepressant-like actions of an AMPA receptor potentiator (LY392098)","volume":"40","author":"Li","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB24","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/0166-2236(94)90139-2","article-title":"Neurotrophins and brain insults","volume":"17","author":"Lindvall","year":"1994","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0028-3908(02)00066-7","article-title":"An AMPA receptor potentiator modulates the expression of BDNF: an in vivo study","volume":"43","author":"Mackowiak","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB26","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0028-3908(01)00027-2","article-title":"Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro","volume":"40","author":"Miu","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB27","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0091-3057(02)00842-0","article-title":"Evaluation of the mGluR2\/3 agonist LY379268 in rodent models of Parkinson's Disease","volume":"73","author":"Murray","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB28","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1124\/jpet.103.049445","article-title":"LY503430, a novel AMPA receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease","volume":"306","author":"Murray","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB29","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0006-8993(01)02866-9","article-title":"GDNF is a major component of trophic activity in DA-depleted striatum for survival and neurite extension of DAergic neurons","volume":"916","author":"Nakajima","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB30","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1046\/j.1460-9568.2000.00196.x","article-title":"Transcriptional and post-transcriptional regulation of a brain growth protein: regional differentiation and regeneration induced by GAP-43","volume":"12","author":"Namgung","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB31","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0306-4522(98)00496-5","article-title":"Brain-derived neurotrophic factor regulates the expression of AMPA receptor proteins in neocortical neurons","volume":"88","author":"Narisawa-Saito","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB32","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1073\/pnas.96.5.2461","article-title":"Growth factor-mediated Fyn signaling regulates alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons","volume":"96","author":"Narisawa-Saito","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB33","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995","article-title":"Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments","volume":"15","author":"Nibuya","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB34","first-page":"89","article-title":"Pharmacological approaches to disease modifying therapies in Parkinson's disease","volume":"2","author":"O'Neill","year":"2002","journal-title":"Expert Rev. Neurotherapeutics"},{"issue":"4","key":"10.1016\/j.ejphar.2003.12.023_BIB35","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2174\/1568007023339166","article-title":"The role of neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration","volume":"1","author":"O'Neill","year":"2002","journal-title":"Curr. Drug Targets. CNS Neurol. Disord."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB36","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.1021\/jm0002836","article-title":"Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)-propanoic acid (AMPA) receptors","volume":"43","author":"Ornstein","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB38","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1997"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB39","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1986"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1527-3458.2002.tb00228.x","article-title":"LY404187: a novel positive allosteric modulator of AMPA receptors","volume":"8","author":"Quirk","year":"2002","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB41","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1006\/exnr.1999.7296","article-title":"Sequential administration of GDNF into the substantia nigra and straitum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-hydroxydopamine lesion model","volume":"161","author":"Rosenbald","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB42","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0166-2236(00)01672-6","article-title":"The neurotrophin hypothesis for synaptic plasticity","volume":"23","author":"Schinder","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0306-4522(96)00093-0","article-title":"Comparative study of brain-derived neurotrophic factor messenger RNA and protein at the cellular level suggests multiple roles in hippocampus, striatum and cortex","volume":"74","author":"Schmidt-Kastner","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/(SICI)1097-4695(199910)41:1<127::AID-NEU16>3.0.CO;2-J","article-title":"Molecular mechanisms underlying activity-dependent regulation of BDNF expression","volume":"41","author":"Shieh","year":"1999","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB45","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0896-6273(00)81011-9","article-title":"Identification of a signaling pathway involved in calcium regulation of BDNF expression","volume":"20","author":"Shieh","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB46","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0091-3057(96)00169-4","article-title":"Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)","volume":"56","author":"Siuciak","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB47","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1006\/phrs.2000.0806","article-title":"Current perspectives on the development of non-biogenic amine-based antidepressants","volume":"43","author":"Skolnick","year":"2001","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB48","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1073\/pnas.91.2.777","article-title":"Facilitation of glutamate receptors enhances memory","volume":"91","author":"Staubli","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB49","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0896-6273(00)81010-7","article-title":"Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism","volume":"20","author":"Tao","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB50","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/373335a0","article-title":"Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo","volume":"373","author":"Tomac","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB51","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0028-3908(01)00031-4","article-title":"Potentiation of responses to AMPA on central neurones by LY392098 and LY404187 in vivo","volume":"40","author":"Vandergriff","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2003.12.023_BIB52","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1002\/j.1460-2075.1990.tb07564.x","article-title":"Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors","volume":"9","author":"Zafra","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2003.12.023_BIB53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7742(08)60277-9","article-title":"Animal models of Parkinsonism using selective neurotoxins: clinical and basic implications","volume":"31","author":"Zigmond","year":"1989","journal-title":"Int. Rev. Neurobiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299903027912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299903027912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,29]],"date-time":"2020-03-29T07:15:41Z","timestamp":1585466141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299903027912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["S0014299903027912"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2003.12.023","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2004,2]]}}}