{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:43:05Z","timestamp":1790318585288,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Medicinska Forskningsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010761","name":"Svenska F\u00f6reningen f\u00f6r Allergologi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1016\/j.ejphar.2004.02.033","type":"journal-article","created":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T05:27:20Z","timestamp":1080797240000},"page":"117-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Up-regulation of bradykinin receptors in a murine in-vitro model of chronic airway inflammation"],"prefix":"10.1016","volume":"489","author":[{"given":"Yaping","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Adner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars-Olaf","family":"Cardell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2004.02.033_BIB1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/sj.bjp.0704928","article-title":"An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNF-\u03b1 up-regulates 5-HT2A-mediated contraction","volume":"137","author":"Adner","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB2","doi-asserted-by":"crossref","first-page":"27489","DOI":"10.1074\/jbc.270.46.27489","article-title":"PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo","volume":"270","author":"Alessi","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB3","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1136\/thx.47.11.979","article-title":"Bradykinin and asthma","volume":"47","author":"Barnes","year":"1992","journal-title":"Thorax"},{"key":"10.1016\/j.ejphar.2004.02.033_BIB4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1476-5381.1985.tb08934.x","article-title":"Further analysis of anomalous pKB values for histamine H2-receptor antagonists on the mouse isolated stomach assay","volume":"86","author":"Black","year":"1985","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB5","first-page":"16","article-title":"Airway inflammation and structural changes in airway hyper-responsiveness and asthma: an overview","volume":"5","author":"Boulet","year":"1998","journal-title":"Can. Respir. J."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB6","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1164\/ajrccm.161.5.9903102","article-title":"Asthma. From bronchoconstriction to airways inflammation and remodeling","volume":"161","author":"Bousquet","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1164\/ajrccm\/147.2.291","article-title":"Elevated release of tumor necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma","volume":"147","author":"Cembrzynska-Nowak","year":"1993","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB8","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1164\/ajrccm\/145.4_Pt_1.900","article-title":"Elevation of tissue kallikrein and kinin in the airways of asthmatic subjects after endobronchial allergen challenge","volume":"145","author":"Christiansen","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0166-2236(93)90133-7","article-title":"Bradykinin and inflammatory pain","volume":"16","author":"Dray","year":"1993","journal-title":"Trends. Neurosci."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB10","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1378\/chest.98.3.528","article-title":"Inflammatory markers in bronchoalveolar lavage and in bronchial biopsy in asthma during remission","volume":"98","author":"Foresi","year":"1990","journal-title":"Chest"},{"key":"10.1016\/j.ejphar.2004.02.033_BIB11","first-page":"176","article-title":"Bradykinin-induced bronchoconstriction in humans. Mode of action","volume":"135","author":"Fuller","year":"1987","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1569-9048(03)00148-4","article-title":"Mechanisms of inflammation-mediated airway smooth muscle plasticity and airways remodeling in asthma","volume":"137","author":"Halayko","year":"2003","journal-title":"Res. Physiol. Neurobiol."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB13","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1164\/ajrccm.160.5.9901029","article-title":"Contribution of bradykinin B1 and B2 receptors in allergen-induced bronchial hyperresponsiveness","volume":"160","author":"Huang","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1476-5381.1990.tb12092.x","article-title":"The effect of peptidase inhibitors on bradykinin-induced bronchoconstriction in guinea-pigs in vivo","volume":"101","author":"Ichinose","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB15","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0022-3565(25)13021-8","article-title":"Bradykinin-induced bronchoconstriction in guinea pig in vivo: role of neural mechanisms","volume":"253","author":"Ichinose","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB16","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/sj.bjp.0704994","article-title":"An assay to evaluate the long term effects of inflammatory mediators on airway smooth muscle: evidence that TNF-\u03b1 up-regulates 5-HT2A mediated contraction","volume":"137","author":"Johnson","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1067\/mai.2002.121316","article-title":"Pathways for bradykinin formation and inflammatory disease","volume":"109","author":"Kaplan","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1034\/j.1399-3003.1999.14a12.x","article-title":"Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodelling","volume":"14","author":"Laprise","year":"1999","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB19","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.4049\/jimmunol.160.3.1419","article-title":"Role of the mitogen-activated protein kinases in the expression of the kinin B1 receptors induced by tissue injury","volume":"160","author":"Larrivee","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB20","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/sj.bjp.0701741","article-title":"Involvement of bradykinin B1 and B2 receptors in relaxation of mouse isolated trachea","volume":"123","author":"Li","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB21","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0945-053X(02)00007-0","article-title":"Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-\u03ba B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes","volume":"21","author":"Liacini","year":"2002","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB22","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0014-4827(03)00180-0","article-title":"Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes","volume":"288","author":"Liacini","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB23","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1139\/y80-088","article-title":"Kinin receptors in experimental inflammation","volume":"58","author":"Marceau","year":"1980","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB24","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0031-6997(24)01371-1","article-title":"The B1 receptors for kinins","volume":"50","author":"Marceau","year":"1998","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB25","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/glia.10168","article-title":"Cytokine-stimulated inducible nitric oxide synthase expression in astroglia: role of Erk mitogen-activated protein kinase and NF-kappaB","volume":"41","author":"Marcus","year":"2003","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2004.02.033_BIB26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0014-2999(00)00323-X","article-title":"Regulation of bradykinin receptor gene expression in human lung fibroblasts","volume":"397","author":"Phagoo","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB27","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1164\/ajrccm\/142.6_Pt_1.1367","article-title":"Comparative airway response to inhaled bradykinin, kallidin, and [des-Arg9]bradykinin in normal and asthmatic subjects","volume":"142","author":"Polosa","year":"1990","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev.iy.06.040188.000405","article-title":"Kinin formation: mechanisms and role in inflammatory disorders","volume":"6","author":"Proud","year":"1988","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(25)06836-X","article-title":"Pharmacology of bradykinin and related kinins","volume":"32","author":"Regoli","year":"1980","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB30","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1164\/ajrccm.159.2.9804132","article-title":"Airway neural responses to kinins: tachyphylaxis and role of receptor subtypes","volume":"159","author":"Reynolds","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB31","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/0196-9781(94)90122-8","article-title":"Effects of peptidase inhibitors on bradykinin-induced bronchoconstriction in the rat","volume":"15","author":"Schilero","year":"1994","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2004.02.033_BIB32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0014-2999(98)00350-1","article-title":"Nitric oxide-mediated relaxation induced by bradykinin in the isolated mouse trachea","volume":"352","author":"Sipahi","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1046\/j.1440-1711.2001.00980.x","article-title":"Tumour necrosis factor-alpha: the role of this multifunctional cytokine in asthma","volume":"79","author":"Thomas","year":"2001","journal-title":"Immunol. Cell. Biol."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB34","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1164\/ajrccm.152.1.7599866","article-title":"Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects","volume":"152","author":"Thomas","year":"1995","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB35","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0014-5793(89)81331-6","article-title":"Bradykinin stimulates tumor necrosis factor and interleukin-1 release from macrophages","volume":"247","author":"Tiffany","year":"1989","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2004.02.033_BIB36","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/PL00005020","article-title":"Pharmacology and mode of action of bradykinin on mouse-isolated trachea","volume":"356","author":"van Heuven-Nolsen","year":"1997","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429990400189X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429990400189X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T03:57:57Z","timestamp":1762142277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429990400189X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":36,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S001429990400189X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2004.02.033","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Up-regulation of bradykinin receptors in a murine in-vitro model of chronic airway inflammation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2004.02.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}