{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:25:19Z","timestamp":1792085119109,"version":"4.4.0"},"reference-count":148,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1016\/j.ejphar.2004.02.049","type":"journal-article","created":{"date-parts":[[2004,4,14]],"date-time":"2004-04-14T09:27:06Z","timestamp":1081934826000},"page":"115-125","source":"Crossref","is-referenced-by-count":359,"title":["Glucose metabolism and insulin receptor signal transduction in Alzheimer disease"],"prefix":"10.1016","volume":"490","author":[{"given":"Siegfried","family":"Hoyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2004.02.049_BIB1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF02935589","article-title":"Insulin and insulin-like growth factor receptors in the nervous system","volume":"3","author":"Adamo","year":"1989","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0959-437X(98)80062-2","article-title":"Mechanism of activation and function of protein kinase B","volume":"8","author":"Alessi","year":"1998","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/exnr.2002.7912","article-title":"\u03b2-Amyloid neurotoxicity is exacerbated during glycolysis inhibition and mitochondrial impairment in the rat hippocampus in vivo and in isolated nerve terminals: implications for Alzheimer's disease","volume":"176","author":"Arias","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1103\/PhysRevA.38.364","article-title":"Self-organized criticality","volume":"38","author":"Bak","year":"1988","journal-title":"Phys. Rev., A"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB5","first-page":"3S13","article-title":"Parasympathic activity changes insulin response to glucose and neurotransmitters","volume":"28","author":"Balbo","year":"2002","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB6","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1210\/en.134.4.1952","article-title":"Insulin receptor substrate-I (IRS-I) expression in rat brain","volume":"134","author":"Baskin","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB7","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1001\/archneur.56.9.1121","article-title":"Brain choline acetyltransferase and mental function in Alzheimer disease","volume":"56","author":"Baskin","year":"1999","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3940(99)00135-4","article-title":"Insulin-degrading enzyme in Alzheimer's disease brain: prominent localization in neurons and senile plaques","volume":"263","author":"Bernstein","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB9","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1046\/j.1471-4159.1996.67031164.x","article-title":"Changes of activity and isoenzyme pattern of phosphofructokinase in the brains of patients with Alzheimer's disease","volume":"67","author":"Bigl","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s007020050174","article-title":"Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease","volume":"106","author":"Bigl","year":"1999","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0169-328X(00)00019-X","article-title":"Altered phosphofructokinase mRNA levels but unchanged isoenzyme pattern in brains from patients with Alzheimer's disease","volume":"76","author":"Bigl","year":"2000","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00702-002-0772-x","article-title":"Cortical glucose metabolism is altered in aged transgenic Tg 2576 mice that demonstrate Alzheimer plaque pathology","volume":"110","author":"Bigl","year":"2003","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB13","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1212\/WNL.39.11.1423","article-title":"In vito 31P-NMR profiles of Alzheimer disease and multiple subcortical infarct dementia","volume":"39","author":"Brown","year":"1989","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.0954-6820.1983.tb03756.x","article-title":"Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type","volume":"213","author":"Bucht","year":"1983","journal-title":"Acta Med. Scand."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1042\/bj3120163","article-title":"A hierarchy of ATP-consuming processes in mammalian cells","volume":"312","author":"Buttgereit","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00001756-200203040-00008","article-title":"Comparison of gene expression in old versus young rat hippocampus by cDNA array","volume":"13","author":"Cho","year":"2002","journal-title":"NeuroReport"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB17","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/S0021-9258(19)75716-0","article-title":"Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin","volume":"262","author":"Chou","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB18","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1210\/en.134.4.1611","article-title":"Male Fischer 344\/N rats show a progressive central impairment of the hypothalamic\u2013pituitary\u2013adrenal axis with advancing age","volume":"134","author":"Cizza","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB19","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/nm0997-1021","article-title":"Alzheimer's A\u03b2 (1\u201342) is generated in the endoplasmic reticulum\/intermediate compartment of NT2N cells","volume":"3","author":"Cook","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0002-9440(10)63822-9","article-title":"Reduced hippocampal insulin degrading enzyme in late onset Alzheimer's disease is associated with the apolipoprotein E-\u03b5 4 allele","volume":"162","author":"Cook","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB21","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1212\/WNL.50.1.164","article-title":"Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype","volume":"50","author":"Craft","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB22","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000054469","article-title":"Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender","volume":"70","author":"Craft","year":"1999","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB23","doi-asserted-by":"crossref","first-page":"S272","DOI":"10.1016\/S0197-4580(00)83176-0","article-title":"Effects of insulin on cerebrospinal levels of A\u03b242","volume":"21","author":"Craft","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB24","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/378785a0","article-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated protein kinase","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0014-5793(97)00240-8","article-title":"Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-sensitive pathways in skeletal muscle and adipose tissue","volume":"406","author":"Cross","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB26","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1046\/j.1365-2559.2001.01082.x","article-title":"Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease","volume":"38","author":"D'Andrea","year":"2001","journal-title":"Histopathology"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB27","doi-asserted-by":"crossref","first-page":"8445","DOI":"10.1016\/S0021-9258(17)37214-9","article-title":"Insulin gene expression and insulin synthesis in mammalian neuronal cells","volume":"269","author":"Devaskar","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB28","doi-asserted-by":"crossref","first-page":"7429","DOI":"10.1073\/pnas.87.19.7429","article-title":"Protein dissociation from GRP 78 and secretion are blocked by depletion of cellular ATP levels","volume":"87","author":"Dorner","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB29","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1212\/WNL.36.7.879","article-title":"Positron emission tomography in Alzheimer's disease","volume":"36","author":"Duara","year":"1986","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB30","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1210\/edrv-9-3-319","article-title":"Insulin degradation: mechanisms, products, and significance","volume":"9","author":"Duckworth","year":"1988","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB31","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0736-5748(94)90053-1","article-title":"Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats","volume":"12","author":"Duelli","year":"1994","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000017234","article-title":"Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease","volume":"11","author":"Eckert","year":"2000","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB33","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/jcbfm.1989.2","article-title":"ATP and brain function","volume":"9","author":"Erecinska","year":"1989","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB34","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1073\/pnas.0230450100","article-title":"Insulin-degrading enzyme regulates the levels of insulin, amyloid \u03b2-protein, and the \u03b2-amyloid precursor protein intracellular domain in vivo","volume":"100","author":"Farris","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB35","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/ana.410160605","article-title":"Cortical abnormalities in Alzheimer's disease","volume":"16","author":"Foster","year":"1984","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB36","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s007020050068","article-title":"Insulin and insulin receptors in the brain in aging and sporadic Alzheimer's disease","volume":"105","author":"Fr\u00f6lich","year":"1998","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB37","first-page":"1","article-title":"Altered cerebral energy metabolism in Alzheimer's disease: a PET study","volume":"35","author":"Fukuyama","year":"1994","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB38","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1523\/JNEUROSCI.21-08-02561.2001","article-title":"Stimulation of \u03b2-amyloid precursor protein trafficking by insulin reduces intraneuronal \u03b2-amyloid and requires mitogen-activated protein kinase signaling","volume":"21","author":"Gasparini","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB39","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00702-003-0015-9","article-title":"Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene","volume":"110","author":"Ghidoni","year":"2003","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB40","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/bj1480017","article-title":"Decreased synthesis of acetylcholine accompanying impaired oxidation of pyruvic acid in rat brain minces","volume":"148","author":"Gibson","year":"1975","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB41","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1172\/JCI116424","article-title":"Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo","volume":"91","author":"Giorgino","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB42","first-page":"1","article-title":"Regulation of insulin receptor signalling by protein-tyrosine dephosphorylation","volume":"3","author":"Goldstein","year":"1993","journal-title":"Receptor"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB43","first-page":"765","article-title":"Dephosphorylation of Alzheimer disease abnormally phosphorylated tau: decrease in Alzheimer disease","volume":"61","author":"Gong","year":"1994","journal-title":"Diabetologica"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0002-9440(10)64700-1","article-title":"Intraneuronal \u03b2A42 accumulation in human brain","volume":"156","author":"Gouras","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB45","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1073\/pnas.96.2.742","article-title":"Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer \u03b2-amyloid peptides","volume":"96","author":"Greenfield","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB46","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1007\/BF00400192","article-title":"The insulin receptor: signalling mechanism and contribition to the pathogenesis of insulin resistance","volume":"34","author":"H\u00e4ring","year":"1991","journal-title":"Diabetologica"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1042\/bj2340059","article-title":"Decreased tyrosine kinase activity of insulin receptor isolated from rat adipocytes rendered insulin-resistant by catecholamine treatment in vitro","volume":"234","author":"H\u00e4ring","year":"1986","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB48","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road of therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB49","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/nm0997-1016","article-title":"Distinct sites of intracelllular production for Alzheimer's disease A\u03b2 40\/42 amyloid peptides","volume":"3","author":"Hartmann","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB50","doi-asserted-by":"crossref","first-page":"8527","DOI":"10.1016\/S0021-9258(18)32085-4","article-title":"Structural differences between insulin receptors in the brain and peripheral target tissues","volume":"258","author":"Heidenreich","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB51","first-page":"110","article-title":"Experimental study of critical mass fluctuations in an evolving sandpile","volume":"69","author":"Held","year":"1990","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB52","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/jnr.490310310","article-title":"Nerve growth factor and choline acetyltransferase activity levels in the rat brain following experimental impairment of cerebral glucose and energy metabolism","volume":"31","author":"Hellweg","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB53","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0304-3940(94)91102-9","article-title":"Short-term or long-term intracerebroventricular (ivc) infusion of insulin exhibits a discrete anabolic effect on cerebral energy metabolism in the rat","volume":"175","author":"Henneberg","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB54","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0167-4943(95)00646-3","article-title":"Desensitization of the neuronal insulin receptor: a new approach in the etiopathogenesis of late-onset sporadic dementia of the Alzheimer type (SDAT)?","volume":"21","author":"Henneberg","year":"1995","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB55","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1006\/nimg.2002.1208","article-title":"Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET","volume":"17","author":"Herholz","year":"2002","journal-title":"NeuroImage"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB56","first-page":"1","article-title":"Non-equilibrium dynamics of biological processes","volume":"364","author":"Hess","year":"1983","journal-title":"Hoppe-Seyler Z. Physiol. Chem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB57","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/BF00322848","article-title":"Order and chaos in chemistry and biology","volume":"337","author":"Hess","year":"1990","journal-title":"Fresenius' J. Anal. Chem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB58","first-page":"1128","article-title":"Autoradiographic localization of insulin receptors in rat brain: prominences in olfactory and limbic areas","volume":"17","author":"Hill","year":"1986","journal-title":"Diabetologica"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB59","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1042\/bj3490657","article-title":"Early-life programming of susceptibility to dysregulation of glucose metabolism and the development of type 2 diabetes mellitus","volume":"349","author":"Holness","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB60","doi-asserted-by":"crossref","first-page":"19547","DOI":"10.1074\/jbc.272.31.19547","article-title":"Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons","volume":"272","author":"Hong","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF03159971","article-title":"Oxidative energy metabolism in Alzheimer brain. Studies in early-onset and late-onset cases","volume":"16","author":"Hoyer","year":"1992","journal-title":"Mol. Chem. Neuropathol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB62","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2165\/00002512-199506030-00004","article-title":"Age-related changes in cerebral oxidative metabolism. Implications for drug therapy","volume":"6","author":"Hoyer","year":"1995","journal-title":"Drugs Aging"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB63","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s007020050067","article-title":"Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis","volume":"105","author":"Hoyer","year":"1998","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB64","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0531-5565(00)00156-X","article-title":"Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update","volume":"35","author":"Hoyer","year":"2000","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB65","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s007020200028","article-title":"The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update","volume":"109","author":"Hoyer","year":"2000","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB66","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s007020200082","article-title":"The aging brain. Changes in the neuronal insulin\/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review","volume":"109","author":"Hoyer","year":"2000","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB67","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF01258634","article-title":"Cerebral excess release of neurotransmitter amino acids subsequent to reduced glucose metabolism in early-onset dementia of Alzheimer type","volume":"75","author":"Hoyer","year":"1989","journal-title":"J. Neural Transm. (Gen.Sect)"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB68","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF00314304","article-title":"Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type?","volume":"235","author":"Hoyer","year":"1988","journal-title":"J. Neurol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB69","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/0304-3940(90)90691-2","article-title":"Ammonia is endogenously generated in the brain in the presence of presumed and verified dementia of Alzheimer type","volume":"117","author":"Hoyer","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02251132","article-title":"Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer-type: a cross-sectional comparison against advanced late-onset dementia and incipient early-onset cases","volume":"3","author":"Hoyer","year":"1991","journal-title":"J. Neural Transm. (PD-Sect.)"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB71","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1097\/00001756-199307000-00039","article-title":"Stimulation of glycolytic key enzymes in cerebral cortex by insulin","volume":"4","author":"Hoyer","year":"1993","journal-title":"NeuroReport"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB72","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0169-328X(99)00325-3","article-title":"Age-dependent increase in C7-1 gene expression in rat frontal cortex","volume":"75","author":"Hung","year":"2000","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB73","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0925-4439(01)00049-7","article-title":"The unfolded protein response and Alzheimer's disease","volume":"1536","author":"Imaizumi","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB74","doi-asserted-by":"crossref","first-page":"10897","DOI":"10.1016\/S0021-9258(19)50102-8","article-title":"Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments","volume":"267","author":"Ishiguro","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB75","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0014-5793(93)81066-9","article-title":"Glycogen synthase kinase 3-beta is identical to tau protein kinase I generating several epitopes of paired helical filaments","volume":"325","author":"Ishiguro","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB76","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1073\/pnas.98.4.1930","article-title":"The effects of aging on gene expression in the hypothalamus and cortex of mice","volume":"98","author":"Jiang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB77","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0197-4580(00)00211-6","article-title":"Copernicus revisited: amyloid beta in Alzheimer's disease","volume":"22","author":"Joseph","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB78","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1101\/gad.13.10.1211","article-title":"Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls","volume":"13","author":"Kaufman","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB79","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/hbeh.1999.1525","article-title":"Earyl stress and genetic influences on hypothalamic\u2013pituitary\u2013adrenal axis functioning in adulthood","volume":"36","author":"King","year":"1999","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB80","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1210\/en.132.2.604","article-title":"Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues","volume":"132","author":"Kuo","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB81","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0014-5793(94)00387-4","article-title":"Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme","volume":"345","author":"Kurochkin","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB82","doi-asserted-by":"crossref","first-page":"7463","DOI":"10.1073\/pnas.84.21.7463","article-title":"Insulin stimulates choline acetyltransferase activity in cultured embryonic chicken retina neurons","volume":"84","author":"Kyriakis","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB83","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/BF00965689","article-title":"Neurotoxicity of ammonia and fatty acids: differential inhibition of mitochondrial dehydrogenases by ammonia and fatty acids coenyme A derivatives","volume":"16","author":"Lai","year":"1991","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB84","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1037\/0735-7044.112.5.1199","article-title":"Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats","volume":"112","author":"Lannert","year":"1998","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB85","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0006-8993(94)90653-X","article-title":"Glucose transporter 2 (GLUT2): expression in specific brain nuclei","volume":"638","author":"Leloup","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB86","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0169-328X(98)00097-7","article-title":"Specific inhibition of GLUT2 in arcuate nucleus by antisence oligonucleotides suppresses nervous control of insulin secretion","volume":"57","author":"Leloup","year":"1998","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB87","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1046\/j.1471-4159.1999.0720576.x","article-title":"Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3\u03b2 and Fyn tyrosine kinase","volume":"72","author":"Lesort","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB88","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1523\/JNEUROSCI.14-05-02893.1994","article-title":"Basal cortical levels and cognitive deficits in human aging","volume":"14","author":"Lupien","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB89","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0014-5793(92)81496-9","article-title":"Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau","volume":"314","author":"Mandelkow","year":"1992","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB90","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0006-8993(99)01981-2","article-title":"Increased cerebral spinal fluid cAMP levels in Alzheimer's disease","volume":"846","author":"Martinez","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB91","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1111\/j.1471-4159.1993.tb07436.x","article-title":"Brain \u03b1-ketoglutarate dehydrogenase complex activity in Alzheimer's disease","volume":"61","author":"Mastrogiacomo","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB92","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/A:1027325304203","article-title":"Degradatation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme","volume":"22","author":"McDermott","year":"1997","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB93","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0303-7207(02)00432-X","article-title":"Insulin and glucose regulate the expression of the DNA repair enzyme XPD","volume":"201","author":"Merkel","year":"2003","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB94","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1046\/j.1471-4159.1999.0722278.x","article-title":"Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death","volume":"72","author":"Michikawa","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB95","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0197-4580(92)90015-P","article-title":"Differences of regional cerebral glucose metabolism between presenile and senile dementia of Alzheimer type","volume":"13","author":"Mielke","year":"1992","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB96","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1137\/0150098","article-title":"Synchronization of pulse-coupled biological oscillators","volume":"50","author":"Mirollo","year":"1990","journal-title":"SIAM J. Appl. Math."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB97","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1073\/pnas.87.12.4453","article-title":"Location of phosphotyrosine-containing proteins by immunocytochemistry in the rat forebrain corresponds to the distribution of the insulin receptor","volume":"87","author":"Moss","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB99","doi-asserted-by":"crossref","first-page":"8745","DOI":"10.1523\/JNEUROSCI.20-23-08745.2000","article-title":"Insulysin hydrolyzes amyloid \u03b2 peptide to products that are neither neurotoxic nor deposit on amyloid plaques","volume":"20","author":"Mukherjee","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB98","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/00002093-199809000-00012","article-title":"Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinial fluid of Alzheimer disease patients are not related to apolipoprotein E4","volume":"12","author":"Mulder","year":"1998","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB100","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0304-3940(91)90260-Z","article-title":"Local action of the diabetogenic drug, streptozotocin, on glucose and energy metabolism in rat brain cortex","volume":"128","author":"Nitsch","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB101","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1126\/science.1411529","article-title":"Release of Alzheimer amyloid precursor derivates stimulated by activation of muscarinic acetylcholine receptors","volume":"258","author":"Nitsch","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB102","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1073\/pnas.89.5.1671","article-title":"Evidence for a membrane defect in Alzheimer disease brain","volume":"89","author":"Nitsch","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB103","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/jnr.490410308","article-title":"Axonal atrophy in aging is associated with a decline in neurofilament gene expression","volume":"41","author":"Parhad","year":"1995","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB104","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1023\/A:1007527721160","article-title":"Degradation of soluble amyloid \u03b2-peptides 1\u201340, 1\u201342, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brain","volume":"25","author":"Perez","year":"2000","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB105","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0168-9525(00)89161-1","article-title":"Genetic susceptibility to Alzheimer disease","volume":"11","author":"Pericak-Vance","year":"1995","journal-title":"Trends Genet."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB106","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3940(80)90220-7","article-title":"Coenzyme A-acetylating enzymes in Alzheimer's disease: possible cholinergic \u201ccompartment\u201d of pyruvate dehydrogenase","volume":"18","author":"Perry","year":"1980","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB107","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0893-133X(98)00054-2","article-title":"Cerebrospinal fluid epinephrine in Alzheimer's disease and normal aging","volume":"19","author":"Peskind","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB108","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1046\/j.1471-4159.1999.0732316.x","article-title":"The phosphatidylinositol 3-kinase inhibitor wortmannin alters the metabolism of the Alzheimer's amyloid precursor protein","volume":"73","author":"Petanceska","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB109","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0197-4580(95)02017-9","article-title":"Changes in brain membrane phospholipid and high-energy phosphate metabolism precede dementia","volume":"16","author":"Pettegrew","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nature01640","article-title":"GSK-3\u03b1 regulates production of Alzheimer's disease amyloid-\u03b2 peptides","volume":"423","author":"Phiel","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB111","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0736-5748(93)90021-5","article-title":"Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus","volume":"11","author":"Plaschke","year":"1993","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB112","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0149-7634(05)80004-1","article-title":"Insulin in the cerebrospinal fluid","volume":"15","author":"Plata-Salaman","year":"1991","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB113","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0006-8993(95)00006-C","article-title":"Spatial discrimination learning and choline acetyltransferase activity in streptozotocin-treated rats: effects of chronic treatment with acetyl-l-carnitine","volume":"674","author":"Prickaerts","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00368303","article-title":"What is entropy?","volume":"76","author":"Prigogini","year":"1989","journal-title":"Naturwissenschaften"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB115","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/0020-711X(87)90171-6","article-title":"Evidence of an insulin generated pyruvate dehydrogenase stimulating factor in rat brain plasma membranes","volume":"19","author":"Rinaudo","year":"1987","journal-title":"Ital. J. Biochem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0361-9230(03)00067-4","article-title":"Causative and susceptibility genes for Alzheimer's disease: a review","volume":"61","author":"Rocchi","year":"2003","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB117","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1523\/JNEUROSCI.11-11-03325.1991","article-title":"Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in high stoichiometric ratios","volume":"11","author":"R\u00f6der","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB118","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s007020050216","article-title":"Diminished neuronal metabolic activity in Alzheimer's disease","volume":"106","author":"Salehi","year":"1999","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB119","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/BF01938876","article-title":"Age-related changes in gene expression in the rat brain revealed by differential display","volume":"52","author":"Salehi","year":"1996","journal-title":"Experientia"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB120","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1210\/edrv-7-3-284","article-title":"The Neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis","volume":"7","author":"Sapolsky","year":"1986","journal-title":"Endocr. Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB121","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1074\/jbc.270.10.4967","article-title":"Direct measurement of trans-Golgi pH in living cells and regulation by second messengers","volume":"270","author":"Seksek","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB122","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1471-4159.1983.tb11311.x","article-title":"Presynaptic cholinergic dysfunction in patients with dementia","volume":"40","author":"Sims","year":"1983","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB123","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1111\/j.1471-4159.1983.tb00829.x","article-title":"Metabolic processes in Alzheimer's diseae: adenine nucleotide content and production of 14C02 from (U 14C) glucose in vitro in human neocortex","volume":"41","author":"Sims","year":"1983","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB124","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1096\/fasebj.14.7.1015","article-title":"Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway","volume":"14","author":"Solano","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB125","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ana.410130116","article-title":"Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain","volume":"13","author":"Sorbi","year":"1983","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB126","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/0006-2952(93)90261-T","article-title":"Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion","volume":"45","author":"Sun","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB127","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1046\/j.1471-4159.1994.62031039.x","article-title":"Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II)","volume":"62","author":"Svennerholm","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB128","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1365-2826.1994.tb00635.x","article-title":"Increases in cortisol levels in aging and Alzheimer's disease in post mortem cerebrospinal fluid","volume":"6","author":"Swaab","year":"1994","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ejphar.2004.02.049_BIB129","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1136\/mp.51.6.293","article-title":"Genetic risk factors in Alzheimer's disease","volume":"51","author":"Tilley","year":"1998","journal-title":"J. Clin. Pathol.: Mol. Pathol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB130","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0301-0082(91)90015-S","article-title":"Insulin receptors in the central nervous system: localization, signalling mechanism and functional aspects","volume":"36","author":"Unger","year":"1991","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB131","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1046\/j.1460-9568.1999.00705.x","article-title":"Long-term effects of prenatal stress and postnatal handling on age-related glucocorticoid secretion and cognitive performance: a longitudinal study in the rat","volume":"11","author":"Vall\u00e9e","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB132","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/0264-6021:3460561","article-title":"The PIK3K\u2013PDK1 connection: more than just a road to PKB","volume":"346","author":"Vanhaesebroeck","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB133","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1523\/JNEUROSCI.20-05-01657.2000","article-title":"Neurons regulate extracellular levels of amyloid \u03b2-protein via preteolysis by insulin-degrading enzyme","volume":"20","author":"Vekrellis","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB134","first-page":"267","article-title":"Effect of ATP depletion and DTT on the transport of membrane proteins from the endoplasmic reticulum and the intermediate compartment to the Golgi complex","volume":"67","author":"Verde","year":"1995","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB135","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0169-328X(97)00258-1","article-title":"Amyloid precursor protein potentiates the neurotrophic activity of NGF","volume":"52","author":"Wallace","year":"1997","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB136","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0169-328X(97)00259-3","article-title":"Amyloid precursor protein requires the insulin signaling pathway for neurotrophic activity","volume":"52","author":"Wallace","year":"1997","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB137","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1074\/jbc.270.9.4854","article-title":"Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B","volume":"270","author":"Wang","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB138","doi-asserted-by":"crossref","first-page":"25712","DOI":"10.1016\/S0021-9258(19)74447-0","article-title":"In vivo phosphorylation sites in fetal and adult rat tau","volume":"268","author":"Watanabe","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9258(17)42297-6","article-title":"The insulin signalling system","volume":"269","author":"White","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB140","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1073\/pnas.83.3.817","article-title":"Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system","volume":"83","author":"Whittemore","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB141","doi-asserted-by":"crossref","first-page":"16085","DOI":"10.1074\/jbc.272.26.16085","article-title":"Intracellular generation and accumulation of amyloid \u03b2-peptide terminating at amino acid-42","volume":"272","author":"Wild-Bode","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-0186(93)90062-A","article-title":"The cellular and physiological actions of insulin in the central nervous system","volume":"22","author":"Wozniak","year":"1993","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB143","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF02736859","article-title":"Indentification of a rat brain gene associated with aging by PCR differential display method","volume":"8","author":"Wu","year":"1997","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB144","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0006-3495(96)79243-3","article-title":"Changes in membrane properties during energy depletion-induced cell injury studied with fluorescence microscopy","volume":"71","author":"Wu","year":"1996","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB145","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0166-2236(92)90351-8","article-title":"Choline metabolism as a basis for the selective vulnerability of cholinergic neurons","volume":"15","author":"Wurtman","year":"1992","journal-title":"Trends Neurosci."},{"issue":"RC221","key":"10.1016\/j.ejphar.2004.02.049_BIB146","first-page":"1","article-title":"Alzheimer's \u03b2-amyloid peptides compete for insulin binding to the insulin receptor","volume":"22","author":"Xie","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB147","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1073\/pnas.94.8.3748","article-title":"Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent abscence of vesicle formation","volume":"94","author":"Xu","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2004.02.049_BIB148","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1111\/j.1471-4159.1984.tb02795.x","article-title":"Characterization and regulation of insulin receptors in rat brain","volume":"42","author":"Zahniser","year":"1984","journal-title":"J. Neurochem."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299904002067?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299904002067?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T15:54:00Z","timestamp":1623772440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299904002067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":148,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0014299904002067"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2004.02.049","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}