{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T16:28:07Z","timestamp":1744820887474},"reference-count":36,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.ejphar.2004.07.070","type":"journal-article","created":{"date-parts":[[2004,8,27]],"date-time":"2004-08-27T18:24:01Z","timestamp":1093631041000},"page":"203-210","source":"Crossref","is-referenced-by-count":3,"title":["Differences in the vascular selectivity and tolerance between the NO donor\/\u03b2-blocker PF9404C and nitroglycerin"],"prefix":"10.1016","volume":"498","author":[{"given":"Ana","family":"Ruiz-Nu\u00f1o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arancha","family":"Rosado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio G.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela G.","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Villarroya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2004.07.070_bib1","doi-asserted-by":"crossref","first-page":"3A","DOI":"10.1016\/S0002-9149(97)00992-2","article-title":"Tolerance: an historical overview","volume":"81","author":"Abrams","year":"1998","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ejphar.2004.07.070_bib2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2165\/00003495-198700334-00013","article-title":"Nitrate tolerance from a biochemical point of view","volume":"33","author":"Axelsson","year":"1987","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2004.07.070_bib3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/00005344-199609000-00004","article-title":"Arterial versus venous metabolism of nitroglycerin to nitric oxide: a possible explanation of organic nitrate venoselectivity","volume":"28","author":"Bauer","year":"1996","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.07.070_bib4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/BF03029770","article-title":"Effect of nitrate tolerance and dipyridamole on the response to SIN1 in the human isolated saphenous vein","volume":"5","author":"Bohyn","year":"1991","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.ejphar.2004.07.070_bib5","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1152\/physrev.1979.59.3.606","article-title":"Mechanism of action of transmitters and other substances on smooth muscle","volume":"59","author":"Bolton","year":"1979","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2004.07.070_bib6","first-page":"608","article-title":"Biotransformation of glyceryl trinitrate occurs concurrently with relaxation of rabbit aorta","volume":"237","author":"Brien","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2004.07.070_bib7","doi-asserted-by":"crossref","first-page":"8306","DOI":"10.1073\/pnas.122225199","article-title":"Identification of the enzymatic mechanism of nitroglycerin bioactivation","volume":"99","author":"Chen","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejphar.2004.07.070_bib8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0006-2952(93)90388-D","article-title":"Relationship between nitroglycerin-induced vascular relaxation and nitric oxide production. Probes with inhibitors and tolerance development","volume":"45","author":"Chung","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.07.070_bib9","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00004872-200203000-00017","article-title":"Nitric-oxide-mediated relaxations in salt-induced hypertension: effect of chronic beta 1-selective receptor blockade","volume":"20","author":"Cosentino","year":"2002","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ejphar.2004.07.070_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2165\/00003495-199754010-00015","article-title":"Carvedilol. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders","volume":"54","author":"Dunn","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2004.07.070_bib11","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1161\/01.CIR.76.3.577","article-title":"Incidence of early tolerance to hemodynamic effects of continuous infusion of nitroglycerin in patients with coronary artery disease and heart failure","volume":"76","author":"Elkayam","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2004.07.070_bib12","first-page":"3","article-title":"History of calcium antagonists","volume":"52","author":"Fleckenstein","year":"1983","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2004.07.070_bib13","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1161\/01.CIR.0000036742.52907.91","article-title":"The puzzle of nitrate tolerance. Pieces smaller than we thought?","volume":"106","author":"Gori","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2004.07.070_bib14","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1161\/01.CIR.0000036743.07406.53","article-title":"Nitrate tolerance. A unifying hypothesis","volume":"106","author":"Gori","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2004.07.070_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0735-1097(97)00104-6","article-title":"Effect of beta-blockade on mortality in patients with heart failure: a meta-analysis of randomized clinical trials","volume":"30","author":"Heidenreich","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2004.07.070_bib16","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1161\/01.CIR.68.6.1247","article-title":"Potentiation of the cardiovascular effects of nitroglycerin by N-acetylcysteine","volume":"68","author":"Horowitz","year":"1983","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2004.07.070_bib17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0304-4165(80)90297-4","article-title":"Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvement of S-nitrosothiols","volume":"631","author":"Ignarro","year":"1980","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2004.07.070_bib18","first-page":"739","article-title":"Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates","volume":"218","author":"Ignarro","year":"1981","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2004.07.070_bib19","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1172\/JCI112024","article-title":"N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin","volume":"76","author":"Loscalzo","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2004.07.070_bib20","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1161\/circ.104.10.1086","article-title":"Folate and nitrate-induced endothelial dysfunction: a simple treatment for a complex pathobiology","volume":"104","author":"Loscalzo","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2004.07.070_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2165\/00003495-198400282-00004","article-title":"Pharmacology of combined alpha\u2013beta blockade. Haemodynamic effects of labetalol","volume":"28","author":"Lund-Johansen","year":"1984","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2004.07.070_bib22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1476-5381.1977.tb16760.x","article-title":"Comparative effects of glyceryl trinitrate on venous and arterial smooth muscle in vitro: relevance to antianginal activity","volume":"60","author":"Mackenzie","year":"1977","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.07.070_bib23","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2165\/00003495-199345020-00006","article-title":"Carvedilol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy","volume":"45","author":"Mctavish","year":"1993","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2004.07.070_bib24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1172\/JCI117637","article-title":"Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance","volume":"95","author":"Munzel","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2004.07.070_bib25","first-page":"145","article-title":"Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin","volume":"9","author":"Murad","year":"1978","journal-title":"Adv. Cycl. Nucleotide Res."},{"key":"10.1016\/j.ejphar.2004.07.070_bib26","first-page":"489","article-title":"Organic nitrates: relationship between biotransformation and rational angina pectoris therapy","volume":"181","author":"Needleman","year":"1972","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2004.07.070_bib27","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/0735-1097(95)00012-S","article-title":"Carvedilol improves left ventricular function and symptoms in chronic heart failure: a double-blind randomized study","volume":"25","author":"Olsen","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2004.07.070_bib28","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJM199802193380807","article-title":"Nitrate therapy for stable angina pectoris","volume":"338","author":"Parker","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2004.07.070_bib29","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJM198709243171304","article-title":"Prevention and reversal of nitrate tolerance in patients with congestive heart failure","volume":"24","author":"Packer","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2004.07.070_bib30","first-page":"226","article-title":"Different sensitivities of arteries and veins to glyceryltrinitrate-induced relaxation and tolerance: an in vitro study on isolated vessels from rabbits","volume":"285","author":"Rosen","year":"1987","journal-title":"Arch. Int. Pharmacodyn."},{"key":"10.1016\/j.ejphar.2004.07.070_bib31","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/BF00582059","article-title":"A possible Ca2+-induced Ca2+ release mechanism mediated by norepinephrine in vascular smooth muscle","volume":"397","author":"Saida","year":"1983","journal-title":"Pfl\u00fcgers Arch."},{"key":"10.1016\/j.ejphar.2004.07.070_bib32","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/00005344-198401000-00012","article-title":"Nitroglycerin in a transdermal therapeutic system in chronic heart failure","volume":"6","author":"Sharpe","year":"1984","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.07.070_bib33","first-page":"89","article-title":"Experimental and clinical pharmacology of carvedilol and other drugs combining vasodilation and \u03b2-adrenoceptor antagonism in a single molecule","volume":"79","author":"Strein","year":"1990","journal-title":"Z. Kardiol."},{"key":"10.1016\/j.ejphar.2004.07.070_bib34","first-page":"167","article-title":"Sodium\u2013calcium interaction in mammalian smooth muscle","volume":"30","author":"Van Breemen","year":"1978","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2004.07.070_bib35","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1038\/sj.bjp.0702992","article-title":"PF9404C, a new slow NO donor with beta receptor blocking properties","volume":"128","author":"Villarroya","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2004.07.070_bib36","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0002-9149(00)00796-7","article-title":"Treatment of heart failure with celiprolol, a cardioselective beta blocker with beta-2 agonist vasodilatory properties","volume":"85","author":"Witchitz","year":"2000","journal-title":"Am. J. Cardiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299904008052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299904008052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T01:52:08Z","timestamp":1585878728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299904008052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":36,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0014299904008052"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2004.07.070","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}